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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Formation building and collision avoidance for a fleet of NAOs based on optical sensor with local positions and minimum communication

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Science China(Information Sciences) 2019年第5期62卷 214-236页

作者： Xiaomin WANG Lorenzo BeNOZZI benoit ZeRR Zexiao XIe Hélène THOMAS benoit CLeMeNT engineering college Ocean University of China

Multi-robot system has become a research hotspot because of low demand on the sensors’ accuracy, high reliability, and high efficiency. To put all the robots together, formation control is a crucial problem. In this paper, we propose a local position-based method to plan trajectories and build a pyramid pattern for a fleet of NAOs in the obstacle-free environment by refering to the position-based method and giving an O(n log n) collision avoidance strategy inspired from one graph theory, where the local positions are estimated from optical sensors. To get the local positions, an integrated image processing method is developped. Firstly a mask-base is generated to store the features of NAOs, and a cross-correlation method is introduced to recognize the NAO. Subsequently, the distance and angle models are proposed to get the local information from a single image. Then, a visual compass is introduced to obtain the orientation of one NAO. After the local information exchange by the WiFi communication, a neighbor-check method is put foward to distinguish the homogeneous NAOs(all the NAOs look like the same). Further, a common frame is constructed as an artificial global frame, and straight non-intercrossing trajectories are planned according to the O(n log n) collision avoidance strategy. At last, the performance of our proposed local position-based method is verified by the simulations with up to 15 robots and the indoor experiments with 3 NAOs in a real environment. The convergence of the method has been demonstrated in both obstacle-free and static obstacle environments.

关键词： formation building a fleet of NAOs optical sensor visual compass local positions

event analysis in social multimedia： a survey

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Frontiers of Computer Science 2016年第3期10卷 433-446页

作者： Xueliang LIU Meng WANG benoit HUeT School of Computer and Information Hefei University of Technology Hefei 230009 China Department of Multimedia EURECOM sophia-antipolis Nice 06560 France

Recent years have witnessed the rapid growth of social multimedia data available over the Internet. The age of huge amount of media collection provides users facihties to share and access data, while it also demands the revolution of data management techniques, since the exponential growth of social multimedia requires more scalable, effective and ro- bust technologies to manage and index them. The event is one of the most important cues to recall people＇s past memory. The reminder value of an event makes it extremely helpful in organizing data. The study of event based analysis on so- cial multimedia data has drawn intensive attention in research community. In this article, we provide a comprehensive sur- vey on event based analysis over social multimedia data, in- cluding event enrichment, detection, and categorization. We introduce each paradigm and summarize related research ef- forts. In addition, we also suggest the emerging trends in this research area.

关键词： event enrichment event detection event categorization

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

采用低马赫数方法对空气射流破坏氦气分层现象的数值模拟

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核动力工程 2015年第6期36卷 61-66页

作者：侯炳旭俞冀阳 dorothée Sénéchal 江光明闵皆昇清华大学工程物理系北京100084 法国电力公司研发中心法国沙图78400 中国核动力研究设计院核反应堆系统设计技术重点实验室成都610041 法国电力公司中国研发中心北京100005

在对低速气体进行计算流体力学(CFD)数值模拟时,通常忽略气体的可压缩性。当计算体系中存在较大温差和较大组分浓度差时,不可压缩近似会因带来很大计算误差而失效。针对此问题,低马赫数方法通过将实际压力拆分为热力学压力和动力学压力... 详细信息

在对低速气体进行计算流体力学(CFD)数值模拟时,通常忽略气体的可压缩性。当计算体系中存在较大温差和较大组分浓度差时,不可压缩近似会因带来很大计算误差而失效。针对此问题,低马赫数方法通过将实际压力拆分为热力学压力和动力学压力的方式,将物性参数与热力学压力联系起来,在对不可压缩流动求解器进行较小改造后,较准确地处理低马赫数下的可压缩流问题。利用Code_Saturne程序实现该模型,并针对空气射流破坏轻密度气体分层现象进行模拟。首先通过网格敏感性分析,选定中等密度网格为计算网格;然后在比较不同算法的模拟结果中发现,采用低马赫数方法可以明显提高计算精度。最后,利用模拟结果,对空气射流破坏氦气分层实验中氦气的水平分布情况进行分析和讨论。

关键词：计算流体力学低马赫数方法空气射流氦气分层破坏

Ubiquitination-mediated regulation of receptor-like kinases in symbiosis and immunity

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Molecular Plant 2024年第9期17卷 1335-1337页

作者： David Landry benoit Lefebvre Laboratory of Plant-Microbe-environment Interactions(LIPMe) Universite de ToulouseINRAECNRS31326 Castanet-TolosanFrance

Receptor-like kinases(RLKs)are plasma membrane(PM)proteins that monitor the extracellular environment and regulate various processes such as biotic *** motif(LysM)RLKs are a specific class of RLKs involved in the recognition of chitin-derived molecules produced by microorganisms(Buendia et al.,2018).Notably,the LysM-RLK heterocomplex LjNFR1/LjNFR5 recognizes lipochitooligosaccharides(LCOs,also called Nod factors)leading to root nodule symbiosis(RNS)in Lotus japonicus,whereas the heterocomplexes AtLYK5/AtCeRK1 and OsCeBIP/OsCeRK1 recognize chitooligosaccharides(COs)leading to defense responses in Arabidopsis thaliana and rice,respectively(Buendia et al.,2018).These receptors function as *** ligand binding activates the intracellular kinase activity of LjNFR1,AtCeRK1,and OsCeRK1,which mediate phosphorylation-dependent signaling *** mechanisms are essential to tightly control RLK homeostasis and signaling,allowing cells to respond efficiently while preventing constitutive *** PM-resident pool of RLKs must be maintained for rapid response,while RLK endocytosis and ultimately degradation in lytic vacuoles is critical for both signaling and downregulation of the *** addition to its role in proteasome-dependent degradation,ubiquitination,a post-translational protein modification,has emerged as a key regulator of PM proteins by inducing their internalization and degradation in lytic vacuoles(Romero-Barrios and Vert,2018).

关键词： extracellular immunity kinases

Optimization of a Solar Chimney with a Horizontal Absorber for Building Ventilation:A Case Study

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Fluid Dynamics & Materials Processing 2023年第4期19卷 901-910页

作者： el Hadji I Cisse Baye Alioune Ndiogou Soumaïla Tigampo Ababacar Thiam dorothéAzilinon (L3ePI)Laboratory of eSP-UCAD DakarSenegal Center for energy Research and Sustainability DAUSTDakarSenegal Universiy Alioune Diop of Bambey BambeySenegal

A study is conducted to optimize the geometry of a solar chimney equipped with a horizontal absorber in order to improve its performances in relation to the provision of *** problem is tackled through numerical solution of the governing equations for mass,momentum and energy in their complete three-dimensional and unsteady *** numerical framework also includes a turbulence model(k-ε)and a radiant heat transfer(DO)***,a Multi-Objective Genetic Algorithm(MOGA)is employed to derive the optimal configuration of the considered solar *** is shown that an air velocity of 0.2 m/s can be *** value is the minimum allowed air velocity according to the ASHRAe’s(American Society of Heating,Refrigerating and Air-Conditioning engineers)adaptive comfort approach.

关键词： Natural ventilation adaptative comfort solar chimney fluent MOGA

eclipses and Occultations of Galilean Satellites Observed at Yunnan Observatory in 2003

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Chinese Journal of Astronomy and Astrophysics 2007年第2期7卷 317-324页

作者： Qing-Yu Peng benoit Noyelles Department of Computer Science Jinan University Guangzhou 5106321 Institut de mecanique celeste et de calcul des ephemerides - Observatoire de Paris UMR 8028 du CNRS 77 avenue Denfert-Rochereau F-75014 Paris France Joint Laboratory for Optical Astronomy Chinese Academyof Sciences Kunming 650011

We describe and analyze observations of mutual events of Galilean satellites made at the Yunnan Observatory in February 2003 from CCD imaging for the first time in China. Astrometric positions were deduced from these photometric observations by modelling the relative motion and the photometry of the involved satellites during each event.

关键词： planets and satellites individual Jupiter- astrometry - eclipse - occultation

Boundary parametrization of planar self-affine tiles with collinear digit set

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Science China Mathematics 2010年第9期53卷 2173-2194页

作者： AKIYAMA Shigeki LORIDANT benoit Department of Mathematics Faculty of ScienceNiigata UniversityIkarashi 28050 Niigata9502181Japan

We consider a class of planar self-affine tiles T = M-1 a∈D(T + a) generated by an expanding integral matrix M and a collinear digit set D as follows:M =(0-B 1-A),D = {(00),...,(|B|0-1)}.We give a parametrization S1 →T of the boundary of T with the following standard *** is H¨older continuous and associated with a sequence of simple closed polygonal approximations whose vertices lie on T and have algebraic *** derive a new proof that T is homeomorphic to a disk if and only if 2|A| |B + 2|.

关键词： self-similar tile boundary disk-likeness fractal parametrization