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Novel Simulation Workshop Improves Performance in Vacuum Delivery

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Open Journal of Obstetrics and Gynecology 2016年第8期6卷 439-444页

作者： Katrina Calvert Mathias Epee Anne Karzcub Cliff Neppe Michael Allen Wendy Hughes Paul McGurgan Richard King Alexander Maouris dorota Doherty Panos Maouris King Edward Memorial Hospital Perth Australia Joondalup Health Campus Joondalup Australia St John of God Hospital Subiaco Perth Australia Broome Hospital Broome Australia School of Women’s and Infants’ Health University of Western Australia Crawley Australia Bond University Queensland Australia

Background: Operative vaginal delivery is a common obstetric intervention, with the potential to cause harm to mother and baby. Training in operative delivery traditionally comprised junior trainees learning the skills under supervision, then practicing and refining them independently. Recently this model has come under scrutiny, with the advent of simulation-based training suggesting a method by which the skills of safe delivery may be taught without risk. Multiple training courses exist, but few have been subjected to evaluation. Aims: The primary aim was to investigate if a simulation-based training workshop, where the development of a successful technique for vacuum delivery occurs using a collaborative, problem-solving approach, improves the rate of correct vacuum cup placement. The secondary aim was to determine if the workshop leads to improvement in theoretical knowledge of vacuum delivery. Methods: Participants on three workshops were assessed for their performance in vacuum delivery prior to and following a multimodal training program. Participants included general practitioner obstetricians, obstetric trainees and resident medical officers. Evaluation occurred using a standardised Likert-scaled rating sheet and utilising a diagrammatic representation of cup placement. Results: The participants demonstrated significant improvement (median post-pre score 1, p in the accuracy of cup placement, in a variety of practical core skills and in theoretical knowledge of vacuum delivery. Discussion: Participation in a simulation-based vacuum delivery workshop improves the performance of obstetric trainees and GP obstetricians. Further work is required to evaluate the performance of such training modalities on clinically relevant outcomes.

关键词： Vacuum Delivery Simulation Training Patient Safety

2个适宜免套袋栽培的苹果新品种——烟脆1号、烟脆2号

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中国南方果树 2020年第4期49卷 159-161页

作者：孙燕霞赵玲玲唐岩 dorota Ewa Kruczynska 刘大亮刘学卿姜中武宋来庆山东省烟台市农业科学研究院山东烟台265500

套袋和摘袋是苹果生产的主要管理成本,选育不需套袋就着色好的品种,是进行免套袋栽培的关键。以粉红女士和天星、烟富6号和红玉为杂交亲本,分别选育出新品种烟脆1号和烟脆2号。这2个苹果品种果个大、风味浓郁、脆甜爽口,在不套袋栽培条... 详细信息

套袋和摘袋是苹果生产的主要管理成本,选育不需套袋就着色好的品种,是进行免套袋栽培的关键。以粉红女士和天星、烟富6号和红玉为杂交亲本,分别选育出新品种烟脆1号和烟脆2号。这2个苹果品种果个大、风味浓郁、脆甜爽口,在不套袋栽培条件下果实果面光洁、颜色鲜艳,抗病性强,适宜进行免套袋栽培。于2019年10月通过农业农村部非主要农作物品种登记。

关键词：苹果烟脆1号烟脆2号免套袋栽培

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早熟苹果新品种‘烟青玉’

园艺学报 2023年第S01期50卷 3-4页

作者：孙燕霞唐岩刘大亮赵玲玲张学勇刘学卿 dorota Ewa Kruczynska 程志娟 Sylwia Keller-Przybylkowicz 宋来庆山东省烟台市农业科学研究院山东烟台265500 山东农业大学生命科学学院作物生物学国家重点实验室山东泰安271018

苹果‘烟青玉’是以‘金帅’为母本,‘兰蓬王’为父本杂交育成的早熟新品种。果实近圆形,果形指数0.85,平均单果质量226.5g;果皮绿色,果面光滑无锈,果肉黄白色,肉质松脆,香味浓郁,果肉去皮硬度为8.4 kg·cm^(-2),可溶性固形物含量为14.... 详细信息

苹果‘烟青玉’是以‘金帅’为母本,‘兰蓬王’为父本杂交育成的早熟新品种。果实近圆形,果形指数0.85,平均单果质量226.5g;果皮绿色,果面光滑无锈,果肉黄白色,肉质松脆,香味浓郁,果肉去皮硬度为8.4 kg·cm^(-2),可溶性固形物含量为14.2%,维生素C含量为31.9 mg·kg^(-1),可滴定酸含量为0.28%。在山东烟台地区8月下旬果实成熟,果实发育期120 d左右,平均产量4 t·hm^(-2)。抗病性强,高抗苹果枝干轮纹病、腐烂病,适宜免套袋栽培。

关键词：苹果早熟抗病品种

神经元蜡样质脂褐质沉积病(NCL)的基因型与表型相关性研究(英文)

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北京大学学报（医学版） 2006年第1期38卷 41-48页

作者： Weina JU Anetta WRONSKA dorota N. MOROZIEWICZ Rocksheng ZHONG Natalia WISNIEWSKI Anna JURKIEWICZ Michael FIORY Krystyna E. WISNIEWSKI Lance JOHNSTON W. Ted BROWN Nanbert ZHONG SCL-Molecular Neurogenetic Diagnostic Laboratory Department of Human Genetics Department of Pathological Neurobiology Department of Infant Development New York State Institute for Basic Research in Developmental Disabilities Staten Island NY Department of Neurology SUNY Downstate Health Center Brooklyn NY Summer Student Harvard University Boston MA Batten Disease Support and Research Association Columbus OH 北京大学医学遗传中心、北京大学基础医学院医学遗传学系北京100083

Objective:Genotype-phenotype associations were studied in 517 subjects clinically affected by classical neuronal ceroid lipofuscinosis (NCL). Methods:Genetic loci CLN1-3 were analyzed in regard to age of onset, initial neurological symptoms, and electron microscope (EM) profiles. Results: The most common initial symptom leading to a clinical evaluation was developmental delay (30%) in NCL1, seizures (42.4%) in NCL2, and vision problems (53.5%) in NCL3. Eighty-two percent of NCL1 cases had granular osmiophilic deposits (GRODs) or mixed-GROD-containing EM profiles; 94% of NCL2 cases had curvilinear (CV) or mixed-CV-containing profiles; and 91% of NCL3 had fingerprint (FP) or mixed-FP-containing profiles. The mixed-type EM profile was found in approximately one-third of the NCL cases. DNA mutations within a specific CLN gene were further correlated with NCL phenotypes. Seizures were noticed to associate with common mutations 523G>A and 636C>T of CLN2 in NCL2 but not with common mutations 223G>A and 451C>T of CLN1 in NCL1. Vision loss was the initial symptom in all types of mutations in NCL3. Surprisingly, our data showed that the age of onset was atypical in 51.3% of NCL1 (infantile form) cases, 19.7% of NCL2 (late-infantile form) cases, and 42.8% of NCL3 (juvenile form) ***:Our data provide an overall picture regarding the clinical recognition of classical childhood NCLs. This may assist in the prediction and genetic identification of NCL1-3 via their characteristic clinical features.

关键词：神经元蜡样质脂褐质沉积病基因型表型基因 CLN 突变

产科患者硬膜外血补丁的适宜容量：一项随机、盲法的临床试验

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麻醉与镇痛 2013年第4期9卷 52-60页

作者： Michael J. Paech dorota A. Doherty Tracey Chris tmas 张鹏(译) School of Medicine and Pharmacology University of Western Australia Crawley Australia School of Women's and Infants' Health University of Western Australia Crawley Australia Women and Infants Research Foundation Perth Australia Department of Anaesthesia and Pain Medicine King Edward Memorial Hospital for Women Perth Australia and Department of Anesthesiology Northwestern University Feinberg School of Medicine Chicago Illinois 不详

背景本研究为一项多国家、多中心的随机、单盲试验，目的是在3个容量中确定自体血硬膜外血补丁（epidural blood patch，EBP）的最适容量。方法选择硬膜外穿刺时意外导致硬脊膜穿破的产科患者，随机注射15ml、20ml或30ml自体血。分层设... 详细信息

背景本研究为一项多国家、多中心的随机、单盲试验，目的是在3个容量中确定自体血硬膜外血补丁（epidural blood patch，EBP）的最适容量。方法选择硬膜外穿刺时意外导致硬脊膜穿破的产科患者，随机注射15ml、20ml或30ml自体血。分层设计EBP操作的时间及中心。参与研究的患者随访5天。主要的研究指标是头痛完全或部分缓解率，次要研究指标包括头痛完全缓解率、部分缓解率、持续头痛的严重程度、在EBP治疗当时及随后的腰背疼情况。结果120例女性患者完成了研究。注射量的中位数（四分位距）是15ml（15）、20ml（20）和30ml（22～30）。在15ml、20ml、30ml组分别有98％、81％和54％的患者接受预定的注射容量。3组中分别有61％、73％、67％的患者完全或部分头痛缓解，分别有10％、32％、26％的患者头痛完全缓解。根据头痛评分与时间曲线，可见15ml组0～48小时的曲线下面积最大。虽然15ml组在EBP后腰背痛的评分最高，但3组在行EBP当时及术后的腰背痛有相似的较低发生率，均无严重并发症报道。结论虽然最适的EBP注射容量仍待确定，但本研究的结果支持20ml自体血补丁治疗适合发生硬膜穿破后头痛（postdural puncture headache，PDPH）的产科患者。

关键词：硬膜外穿刺产科患者自体血容量随机临床试验完全缓解率硬膜穿破后头痛

Management Tasks of Assessing Subjective Road Traffic Noise With Using Acoustic Maps—A New Approach

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Management Studies 2018年第6期6卷 434-443页

作者： Waldemar Paszkowski dorota Palka Silesian University of Technology SilesiaPoland

At present,acoustic maps are used in management tasks of assessing the acoustic climate of the *** methods of modeling and simulation of noise assessment indices are used for this *** indicators represent the quantitative spatial distribution of the sound *** on the perception of sounds has been carried out for many years and it has been found out that subjective acoustic impressions are of significant *** paper proposes a quantitative and qualitative approach to the assessment of noise in the urbanized environment using acoustic *** features of sound quality and their importance in the modeling of noise annoyance assessment have been *** measurements were made on the example of the selected case study in the *** results of modeling physical indicators of road noise in the environment with the use of acoustic maps are *** on the registered acoustic measurements,the results of the sound quality features of the acoustic signals in the time and frequency domain are presented *** determined values of sound quality features are a valuable source of information in the field of noise perception assessment.A model for assessing road noise has been *** includes sound quality features which can be used in acoustic *** part of the discussion of the results,it was found that the obtained results of quantitative and qualitative analysis of the acoustic signal parameters can be the basis for the development of the road traffic noise annoyance assessment model using acoustic maps technology.

关键词： acoustic climate acoustic map noise annoyance noise management sound features

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常压冷冻干燥实验研究(一)

干燥技术与设备 2007年第1期5卷 47-51页

作者： Jan Stawczyk 李胜 dorota Witrowa-Rajchert Anna Fabisiak 杨彬彬罗兹技术大学过程与环境工程学院热质传递系华沙农业大学食品工程与加工管理系中国农业大学工程学院

实验研究了常压冷冻干燥(AFD)动力学对苹果切块质量(复水率、收缩率、色泽、抗氧化性)的影响,并与对流干燥和真空冷冻干燥进行了比较,确定了合适的操作参数。实验在因特网控制的全自动热泵干燥系统中进行。设计建立了基于National Instr... 详细信息

实验研究了常压冷冻干燥(AFD)动力学对苹果切块质量(复水率、收缩率、色泽、抗氧化性)的影响,并与对流干燥和真空冷冻干燥进行了比较,确定了合适的操作参数。实验在因特网控制的全自动热泵干燥系统中进行。设计建立了基于National Instruments FieldPoint平台的数据采集及控制系统,其自动控制器具有先进的嵌入式控制、数据记录以及以太网连接等功能。

关键词：常压冷冻干燥动力学实验对比分析

Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

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World Journal of Gastroenterology 2013年第27期19卷 4363-4373页

作者： Piotr M Wierzbicki Krystian Adrych dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec Department of Histology Faculty of MedicineMedical University of Gdansk Department of Hepatology and Gastroenterology Faculty of MedicineMedical University of Gdansk Department of Human Histology and Embryology Faculty of Medical SciencesUniversity of Varmia and Masuria Department of General Surgery Hospital Ministry Internal Affairs Department of Gastroenterology Medical University of Lublin 1st Department of General Surgery Jagiellonian University Endoscopy Unit St. Adalbert Hospital

AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC.

关键词： Large tumor suppressor 1 Colorectal cancer Quantitative polymerase chain reaction Reduced expression Promoter hypermethylation Microsatellite instability Salvador-Warts-Hippo pathway

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中国墨的选定问题研究

年画研究 2020年第1期7卷 135-139页

作者： [波兰]多洛塔波兰华沙美术学院

墨,身为中国(和亚洲其他国家或地区)发明的主要黑色颜料,无论是在绘画、书法或者印刷等方面皆占有举足轻重的地位。历年来所用的墨分为两种:以松烟为主的松烟墨和燃烧植物油,例如桐油的油烟墨。古时更是在墨里添加了珍珠粉或一些香料,... 详细信息

墨,身为中国(和亚洲其他国家或地区)发明的主要黑色颜料,无论是在绘画、书法或者印刷等方面皆占有举足轻重的地位。历年来所用的墨分为两种:以松烟为主的松烟墨和燃烧植物油,例如桐油的油烟墨。古时更是在墨里添加了珍珠粉或一些香料,麝香、丁香等来增加香气。墨条内的烟炱黏合剂则利用动物性胶。

关键词：墨条华沙波兰中国