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Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial

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World Journal of Gastroenterology 2019年第40期25卷 6158-6171页

作者： dorit vedel ankersen Petra Weimers Dorte Marker Mette Bennedsen Sanaz Saboori Kristine Paridaens Johan Burisch Pia Munkholm Department of Gastroenterology North Zealand University HospitalFrederikssund 3600Capital regionDenmark Global Medical Affairs Ferring International Center S.A.Saint-Prex 1162Switzerland

BACKGROUND The optimal way to home-monitor patients with inflammatory bowel disease(IBD)for disease progression or relapse remains to be *** To determine whether an electronic health(eHealth)screening procedure for disease activity in IBD should be implemented in clinical practice,scheduled every third month(3M)or according to patient own decision,on demand(OD).METHODS Adult IBD patients were consecutively randomized to 1-year open-label eHealth interventions(3M vs OD).Both intervention arms were screening for disease activity,quality of life and fatigue and were measuring medical compliance with the constant care web-application according to the screening interventions OD or *** activity was assessed using home measured fecal calprotectin(FC)and a disease activity *** In total,102 patients were randomized(n=52/503M/OD)at baseline,and 88 patients completed the 1-year study(n=433M;n=45 OD).No difference in the two screening procedures could be found regarding medical compliance(P=0.58),fatigue(P=0.86),quality of life(P=0.17),mean time spent in remission(P>0.32),overall FC relapse rates(P=0.49),FC disease courses(P=0.61),FC time to a severe relapse(P=0.69)and remission(P=0.88)during 1 ***(interquartile range)numbers of FC home-monitoring test-kits used per patient were significantly different,3M:6.0(5.0-8.0)and OD:4.0(2.0-9.0),P=*** The two eHealth screening procedures are equally good in capturing a relapse and bringing about ***,the OD group used fewer FC home testkits per *** screening procedures can be recommended for adult IBD patients in clinical web-practice.

关键词： Inflammatory bowel disease Electronic health Screening Disease activity

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Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet

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World Journal of Gastroenterology 2014年第21期20卷 6680-6684页

作者： Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen dorit vedel ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm Digestive Disease Centre Medical SectionHerlev University HospitalCopenhagen 2730Denmark Department of Medicine Veszprém Megyei Csolnoky Ferenc KórházVeszprém 8200Hungary Clinical Nutrition Faculty of ScienceUniversity of Copenhagen 1870Denmark Department of Epidemiology Research Statens Serum InstitutCopenhagen 2300Denmark

In the present study we report on changes in irritable bowel syndrome-severity scoring system (IBS-SSS) and irritable bowel syndrome-quality of life (IBS-QoL) in 19 IBS patients, aged 18 to 74 years (F/M: 14/5), during 12 wk registering their symptoms on the web-application (***). During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention. Thereafter, low fermentable oligo-, di-, mono-saccharides and polyols (FODMAP) diet (LFD) was introduced for the next 6 wk while continuing the registration. Though a small sample size a significant improvement in disease activity (IBS-SSS) was observed during both the control period, median: 278 (range: 122-377), P = 0.02, and subsequently during the LFD period, median: 151 (range: 29-334), P < 0.01. The IBS-QoL solely changed significantly during the LFD period, median: 67 (37-120), P < 0.01. The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a “traffic light”. However adding the diet reduced IBS-SSS to < 150, inactive to mild symptoms. In the future results from larger scale trials are awaited.

关键词： Irritable bowel syndrome Low fermentable oligo- di- mono-saccharides and polyols diet Self-management Disease-specific quality of life Disease activity

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Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第18期23卷 3356-3366页

作者： Natalia Pedersen dorit vedel ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm Department of Gastroenterology Slagelse Hospital Gastroenterology Unit North Zealand Hospital Department of Nutrition Exercise and SportsUniversity of Copenhagen Department of Statistics First Department of Medicine Semmelweis University

To investigate the effect of a low-FODMAP diet on irritable bowel syndrome (IBS)-like symptoms in patients with inflammatory bowel disease (IBD).METHODSThis was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms (Rome III) randomly assigned to a Low-FODMAP diet (LFD) or a normal diet (ND) for 6 wk between June 2012 and December 2013. Patients completed the IBS symptom severity system (IBS-SSS) and short IBD quality of life questionnaire (SIBDQ) at weeks 0 and 6. The primary end-point was response rates (at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of ***-nine patients, 67 (75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis (37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group (n = 30, 81%) than in the ND group (n = 19, 46%); (OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBS-SSS (median 115; inter-quartile range [IQR] 33-169) than ND group (median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ (median 60, IQR 51-65) than the ND group (median 50, IQR 39-60), P < *** a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission.

关键词： Inflammatory bowel disease Web-based management Irritable bowel syndrome Low-FODMAP diet

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Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome

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World Journal of Gastroenterology 2014年第43期20卷 16215-16226页

作者： Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen dorit vedel ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm Digestive Disease Centre Medical SectionHerlev University Hospital2730 CopenhagenDenmark Department of Epidemiology Research Statens Serum Institut2300 CopenhagenDenmark Department of Medicine Veszprém Megyei Csolnoky Ferenc Kórház8200 VeszprémHungary Nutrition Department Herlev University Hospital2730 CopenhagenDenmark Clinical Nutrition Faculty of ScienceUniversity of Copenhagen1870 CopenhagenDenmark

AIM: To investigate the effects of a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols diet (LFD) and the probiotic Lactobacillus rhamnosus GG (LGG) in irritable bowel syndrome (IBS).

关键词： Irritable bowel syndrome Web-based management Low FODMAP diet Lactobacillus rhamnosus GG Disease severity Irritable bowel syndrome-quality of life

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