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Estimation of Burden of Kidney Dysfunction in HIV-Infected Pediatrics and Adolescents by Use of Urinary Neutrophil Gelatinase-Associated Lipocalin: A Single Center Experience in Kenya

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Infectious Diseases & Immunity 2022年第1期2卷 9-14页

作者： Anne P.Lomole william M.Macharia Mary S.Limbe doris w.kinuthia Samuel K.Kabinga Aga Khan University Medical College East AfricaAga Khan University HospitalNairobiKenya University of Nairobi East African Kidney InstituteNairobiKenya

Background:About 75%of patients infected with human immunodeficiency virus(HIV)live in sub-Saharan *** Kenya,about 1.5 million Kenyans are living with HIV,of whom almost 100,000 are children and *** active antiretroviral therapy(HAART)has converted HIV infection to a chronic illness with its attendant *** disease is a common complication of HIV infection and its *** disease in HIV-infected persons can be asymptomatic,insidious onset and may lack specific clinical *** can only be detected on active *** urine albumin-to-creatinine ratio and estimated glomerular filtration rate(eGFR)using serum creatinine are not sensitive in identification of early kidney *** neutrophil gelatinase-associated lipocalin(uNGAL)has been used as marker of early kidney ***:This cross-sectional study used uNGAL and serum creatinine to determine the prevalence of kidney dysfunction in HIVinfected children and adolescents with HAART at Gertrude’s Children’s Hospital,Nairobi,Kenya,from March 2016 to February *** samples were assayed for uNGAL using the Bio Porto®enzyme-linked immunosorbent *** creatinine was assayed using the Jaffe reaction in the Cobas®6000 biochemistry analyzer and eGFR calculated using the Schwartz *** plot of eGFR against log uNGAL levles was performed by Statistical Package for Social Sciences and Pearson correlation coefficeint between log uNGAL levles and eGFR was ***:Ninety-three patients were *** mean age was 11.8±3.6 years and the median duration on HAART was 72.6 *** were 47(50.5%).The prevalence of kidney dysfunction using uNGAL was 15.1%(95%CI 7.6%–22.5%)and 5.4%(95%CI 1.8%–12.1%)by *** mean eGFR was 131±25mL·min1·1.73m2 and median uNGAL was 10 ng/*** every one ng/mL increase in uNGAL value above the normal value,eGFR decreases by 4.8mL·min1·1.73m2(P=0.038).Patients with elevated uNGAL were older when co

关键词： HIV Estimated glomerular filtration rate Highly active antiretroviral therapy Kidney disease Serum creatinine uNGAL

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