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Effect of mixed infection on TB dynamics

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International Journal of Biomathematics 2019年第5期12卷 301-323页

作者： doreen Mbabazi Ssebuliba Rachid Ouifki Faculty of Science Kabale University P.O.Box 317KabaleUganda South African Centre for Epidemiological Modelling and Analysis 19 JonkershoekMostertdrift Stellenbosch7600Cape TownWestern CapeSouth Africa Department of Mathematics and Applied Mathematics University of Pretoriaf Private baq X20 Hatfield 0028 PretoriaSouth Africa

Poor living conditions,overcrowding and strain diversity are some of the factors that influence mixed infection in Tuberculosis (TB) at the population *** formulate a mathematical model for mixed infection in TB using nonlinear ordinary differential equa-tions where such factors were represented as probabilities of acquiring mixed infection.A qualitative analysis of the model shows that it exhibits multiple endemic equilibria and backward bifurcation for certain parameter *** reactivation rate and trans-mission rate of individuals with mixed infection were of importance as well as the prob-abilities for latent individuals to acquire mixed *** calculate the prevalence of mixed infection from the model and the effect of mixed infection on TB incidence,TB prevalence and Mycobacterium tuberculosis (MTB) infection *** simu-lations show that mixed infection may explain high TB incidences in areas which have a high strain diversity,poor living conditions and are overcrowded even without HIV.

关键词： Tuberculosis mixed infection mathematical model

Protein synthesis,degradation,and energy metabolism in T cell immunity

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Cellular & Molecular Immunology 2022年第3期19卷 303-315页

作者： Julia M.Marchingo doreen A.Cantrell Cell Signalling and Immunology Division School of Life SciencesUniversity of DundeeDundeeDD15EHUK

T cell activation,proliferation,and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino *** synthesis is an energy-and resource-demanding process;as such,changes in T cell energy production are intrinsically linked to proteome *** this review,we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy *** highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

关键词： T lymphocyte Protein Translation Proteomics Immunometabolism Protein degradation

Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles

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Bioactive Materials 2023年第9期27卷 98-112页

作者： Yanmeng Yang Yingnan Wu Dahou Yang Shu Hui Neo Nurul Dinah Kadir doreen Goh Jian Xiong tan Vinitha Denslin Eng Hin Lee Zheng Yang Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore NUS Tissue Engineering Program Life Sciences InstituteNational University of SingaporeSingapore Critical Analytics for Manufacturing Personalised-Medicine Singapore-MIT Alliance for Research and TechnologySingapore

Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as the physiologic environment of MSCs, has great potential to enhance MSCs paracrine therapeutic effect. In our study, the paracrine effects of secretome derived from MSCs preconditioned in normoxia and hypoxia was compared through both in vitro functional assays and an in vivo rat osteochondral defect model. Specifically, the paracrine effect of total EVs were compared to that of soluble factors to characterize the predominant active components in the hypoxic secretome. We demonstrated that hypoxia conditioned medium, as well as the corresponding EVs, at a relatively low dosage, were efficient in promoting the repair of critical-sized osteochondral defects and mitigated the joint inflammation in a rat osteochondral defect model, relative to their normoxia counterpart. In vitro functional test shows enhancement through chondrocyte proliferation, migration, and matrix deposition, while inhibit IL-1β-induced chondrocytes senescence, inflammation, matrix degradation, and pro-inflammatory macrophage activity. Multiple functional proteins, as well as a change in EVs’ size profile, with enrichment of specific EV-miRNAs were detected with hypoxia preconditioning, implicating complex molecular pathways involved in hypoxia pre-conditioned MSCs secretome generated cartilage regeneration.

关键词： Hypoxia preconditioned MSCs Secretome Extracellular vesicles Cartilage regeneration Joint inflammation

Stachel-mediated activation of adhesion G protein-coupled receptors:insights from cryo-EM studies

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2636-2637页

作者： Ines Liebscher Torsten Schöneberg doreen Thor Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig University04103 LeipzigGermany

Recently,a set of cryo-electron microscopy(cryo-EM)structures of different adhesion G protein-coupled receptors(aGPCRs)has been published by Xiao et al.1,Ping et al.2,Qu et al.3,and Barros-Álvarez et al.4 shedding light on the activation of the seven-helix transmembrane domain(7TMD)via their tethered peptide *** GPCRs are an evolutionary old class of receptors that play a key role in several physiological processes including neuron and synapse formation,immune response,and *** are unique within the superfamily of GPCRs because they combine the structural features of adhesive molecules,mediating cell–cell or cell–matrix interaction,with intracellular G protein-mediated *** long extracellular N terminus of the receptor harbours distinct functional domains including the highly conserved GPCR autoproteolysis-inducing(GAIN)domain with the GPCR proteolysis site(GPS).Many,but not all aGPCRs are autoproteolytically cleaved at the GPS into a N-and a C-terminal fragment(NTF and CTF,respectively),which remain non-covalently attached.

关键词： activation insight attached

Knowledge and Practices on Relationship between Visual Identity and Opportunities for Sustainable SME Growth in Uganda

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Knowledge and Practices on Relationship between Visual Ident...

作者： Beatrice doreen Namirimu 上海交通大学

学位级别：硕士

This qualitative study explored the role of visual identity(VI)in creating opportunities for sustainable SME growth in Uganda and,as such,moved to design a corporate visual identity for Cathy's spices,which is a small scale company for spices in *** study used wave media graphics and Safe Boda as case study *** independent variable was corporate visual identity,whereas the dependent variable was sustainable SME *** that the study lies in the design realm and was being conducted by a Master of Design student,corporate visual identity was analyzed in terms of brand positioning by communicating its uniqueness to create an image or brand identity in the target *** SME growth was measured by retaining valuable customers and brand equity and finally achieving *** main objective of the study was;to assess SME" knowledge and attitudes on corporate designing for sustainable business growth;to understand the corporate visual identity approaches used by SMEs for sustainable business growth,and know the opportunities for SMEs that practice corporate visual *** study employed interviews,visual research,and documentary analysis methods to collect *** such,the primary data collection tools used in the field were interview guides for the staff of both wave media graphics and Safe Boda and for the customers of Safe Boda that were accidentally *** study concluded that Visual Identity(VI)plays a role in creating sustainable SME growth opportunities in *** comes from the communication about the business and the products influenced by VI,customer loyalty,and development of the company influenced by corporate visual *** is a combination of factors that lead to these results,and these include;attraction to a brand's visual appearance,a brand meeting a customer's aesthetic standard,easy recognition of the brand by its visual appearance,easy inference of brand's functional attributes,and

关键词： Visual Identity(VI) Sustainable SME growth Cathy's Spices

Histopathology of hepatocellular carcinoma-when and what

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Hepatoma Research 2022年第1期8卷 35-49页

作者： doreen Maria Gisder Andrea tannapfel Iris Tischoff Institut der Pathologie Ruhr Universität BochumBochum 44789Germany

When do you need to take biopsies of the liver,and what information will you get is the topic of this review on hepatocellular carcinoma(HCC).If,clinically,the differential diagnosis of HCC after imaging is suggested,a biopsy has become obligatory as a diagnostic confirmation of HCC in the non-cirrhotic liver prior to definitive therapeutic interventions,as well as in a palliative therapy *** the case of hepatic lesions with an uncharacteristic contrast uptake,a biopsy should be performed immediately to confirm the diagnosis of *** diagnosing HCC,a treatment strategy is ***,the biopsy,or in case of surgical treatment,the resected tissue,shows us the different subtypes of HCC,with the steatohepatitic subtype being the most common and the lymphocyte-rich subtype being the least ***,the histological grade of HCC is determined according to the grading system of the WHO or the Edmonson and Steiner *** biopsies,HCC can be differentiated from intrahepatic cholangiocarcinoma or combined hepatocellular-cholangiocarcinoma or metastases of other malignant tumors,especially metastases of the gastrointestinal *** summary,biopsies are fundamental in the diagnosis of HCC.

关键词： Hepatocellular carcinoma biopsies histology

Analysis of licensure examination anxiety and its influencing factors among undergraduate nursing students

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Journal of Integrative Nursing 2021年第3期3卷 110-116页

作者： doreen Asantewa ABEASI Frank Bediako AGYEI Department of Nursing and Midwifery Presbyterian University CollegeAsante‑AkyemGhana

Background:Examination anxiety is a concern for educational policymakers because of the impact it can have on the overall outcome of the performance of the candidates who partake in such ***:The aim of this study is to determine the examination anxiety level of students of Nursing and Midwifery College,Agogo,and Presbyterian University College and to evaluate the factors affecting *** and Methods:A total of 160 undergraduate nursing students comprising 80 degree and 80 diploma students were conveniently sampled for the *** study was conducted in September 2019 using a descriptive cross-sectional *** Westside Test Anxiety Scale was used to measure examination anxiety among the participants.A researcher-designed questionnaire in which participants responded to a three-point Likert scale was used to assess factors influencing examination ***:The findings of the study showed that test anxiety was higher among the diploma candidates(M=3.60)than the degree candidates(M=2.95)and the difference was statistically significant(P=0.024).Demographic characteristics such as age(P=0.009),sex(P=0.003),study hours per day(P=0.001)were found to be significantly associated with test *** factors found to influence examination anxiety among students were volume of materials to study(P=0.044),level of preparation(P=0.005)perceived difficulty of the questions(P=0.033)and myth about examinations(P=0.000).The perceived importance of the examination(P=0.057)and schedule of the exams(P=0.68)did not influence examination ***:Candidates for the licensure examination organized by the Nursing and Midwifery Council of Ghana should be assessed for test anxiety and offered the necessary psychological support where necessary.

关键词： Education Ghana licensure nursing test anxiety undergraduate

On the impact of grinding conditions in the flotation of semi-soluble salt-type mineral-containing ores driven by surface or particle geometry effects?

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International Journal of Mining Science and Technology 2023年第7期33卷 855-872页

作者： Lucas Pereira Nathalie Kupka Duong Huu Hoang Bruno Michaux Sondos Saquran doreen Ebert Martin Rudolph Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource TechnologyFreiberg 09599Germany Maelgwyn Mineral Services Ltd Cardiff CF244PAUnited Kingdom

Grinding and flotation processes are often studied independently, despite the well-established grinding influence on flotation performance, which affects not only particle size and thus liberation but also shape and leads to complex changes in pulp chemistry affecting the particle surface properties relevant for selective bubble attachment. Yet, no study jointly investigated these possible causes and many are limited to single mineral flotation. We relate grinding conditions to changes in pulp chemistry and particle surface properties and assess their impact on upgrading. We studied three non-sulfide ores with different feed grades and valuables: scheelite, apatite, and fluorite. These were dry-, wet-, and wet conditionedground before flotation in a laboratory mechanical cell. Results were evaluated with bulk-and particle-specific methodologies. The selectivity of the process is higher after dry grinding for the fluorite and apatite ores and irrelevant for the scheelite ore. Variations in flotation kinetics of individual particles associated to their size and shape are not sufficient to explain these results. The higher concentration of Ca2+and Mg2+observed in the pulp after wet grinding, altering particle surface properties, better explains the phenomenon. Additionally, we demonstrate how particle shape impacts are system specific and related to both entrainment and true flotation.

关键词： Grinding-flotation interactions Semi-soluble salt-type minerals Geometallurgy Particle-based separation modelling Surface interactions

An Ontology Based Cyclone Tracks Classification Using SWRL Reasoning and SVM

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Computer Systems Science & Engineering 2023年第3期44卷 2323-2336页

作者： N.Vanitha C.R.Rene Robin D.doreen Hephzibah Miriam Sri Sai Ram Engineering College Chennai600044TamilnaduIndia Director of Computational Intelligence Research Foundation Chennai600023TamilnaduIndia

Tropical cyclones(TC)are often associated with severe weather conditions which cause great losses to lives and *** precise classification of cyclone tracks is significantly important in thefield of weather *** this paper we propose a novel hybrid model that integrates ontology and Support Vector Machine(SVM)to classify the tropical cyclone tracks into four types of classes namely straight,quasi-straight,curving and sinuous based on the track *** Cyclone TRacks Ontology(TCTRO)described in this paper is a knowledge base which comprises of classes,objects and data properties that represent the interaction among the TC characteristics.A set of SWRL(Semantic Web Rule Language)rules are directly inserted to the TCTRO ontology for reasoning and inferring new knowledge from ***,we propose a learning algorithm which utilizes the inferred knowledge for optimizing the feature *** to experiments on the IBTrACS dataset,the proposed ontology based SVM classifier achieves an accuracy of 98.3%with reduced classification error rates.

关键词： Tropical cyclones classification support vector machine ontology SWRL reasoning SVM classification