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The Stochastic Regression Analysis as a Tool in Ecotoxicological QSAR Studies

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Biomedical and Environmental Sciences 1989年第4期2卷 385-393页

作者： J.DEVILLERS D.ZAKARYA M.cHASTRETTE J.c.dore cTIS Laboratoire

correspondence factor analysis(cFA)was used in conjunction with linear regression analysis to examine the structure-activity relationships of 50 benzene derivatives tested on Pimephales *** nine molecular descriptors(numbers of c,H,O,N,Br,cl,NO_2,OH,and NH_2 included in the molecules),cFA made it possible to define five new independent variables which were introduced in a stepwise regression analysis procedure to describe the acute toxicity(96-h Lc_(50))of the aromatic *** model log 1/c=-0.727F_1+1.248F_3+4.052(r=0.918; s=0.270)is more relevant to describe the ecotoxicological behavior of the studied compounds on the fathead minnow than that obtained with principal components(log 1/c=0.151 Pc_1 -0.271 Pc_2+4.124;r=0.737;s=0.460).The heuristic potency of this particular statistical analysis,which is called stochastic regression analysis,is discussed in detail.1989 Academic Press,Inc.

关键词： QSAR The Stochastic Regression Analysis as a Tool in Ecotoxicological QSAR Studies

The effects of water flow and temperature on thermal regime around a culvert built on permafrost

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Research in cold and Arid Regions 2014年第5期6卷 415-422页

作者： Loriane Périer Guy Doré c.R.Burn Loriane Perier Guy dore c. R. Bum Laval University Center for Northern Studies (CEN) 1035 Avenue De la m~decine QuObec Canada G1A OA6 carleton University Dept. of Geography and Environmental Studies Ottawa Ontario Canada K1S 5B6

Temperature and water flow through a culvert beneath the Alaska Highway near Beaver creek,Yukon,were measured at hourly intervals between June and October *** data were used to simulate the effect of the culvert on the thermal regime of the road embankment and subjacent permafrost.A 2-D thermal model of the embankment and permafrost was developed with TEMP/W and calibrated using field *** relations were obtained between water temperatures at the entrance to the culvert,flow into the culvert,and water temperatures inside the *** temperatures at the entrance and inside the culvert had a linear relation,while water temperatures inside the culvert and water flow were associated by a logarithmic relation.A multiple linear regression was used to summarize these *** this relationship,changes in the flow rate and water temperatures at the entrance of the culvert were simulated to obtain predicted water temperatures in the *** temperatures in the culvert were used in the thermal model to determine their effects on the ground thermal regime near the *** of ±10% in water flow rate had no impact on the thermal regime underneath the *** of water temperature at the entrance of the culvert had a noticeable influence on the thermal regime.A final simulation was conducted without insulation beneath the *** thaw depth was 30 cm with insulation,and 120 cm without insulation,illustrating the importance of insulation to the ground thermal regime.

关键词： culvert thermal regime water flow water temperature modeling permafrost

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用辐照花粉杂交培育洋葱的雌核生殖株系

农业新技术新方法译丛 1994年第2期 28-30,32页

作者： dore,c 薛紫华

Differential responses of carbon and water vapor fluxes to climate among evergreen needleleaf forests in the USA

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Ecological Processes 2016年第1期5卷 91-107页

作者： Pradeep Wagle Xiangming Xiao Thomas E.Kolb Beverly E.Law Sonia Wharton Russell K.Monson Jiquan chen Peter D.Blanken Kimberly A.Novick Sabina dore Asko Noormets Prasanna H.Gowda Department of Microbiology and Plant Biology Center for Spatial AnalysisUniversity of OklahomaNormanOK 73019USA Institute of Biodiversity Science Fudan UniversityShanghai 200433China School of Forestry Northern Arizona UniversitylagstaffAZ 86011USA Department of Forest Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA Atmospheric Earth and Energy DivisionLawrence Livermore National LaboratoryLivermoreCA 94550USA School of Natural Resources and the Environment and Laboratory of Tree Ring Research University of ArizonaTucsonAZ 85711USA Department of Geography Michigan State UniversityEast LansingMI 48824USA Department of Geography University of ColoradoBoulderCO 80309USA School of Public and Environmental Affairs Indiana University-BloomingtonBloomingtonIN 47405USA Department of Environmental Science Policyand ManagementUniversity of California BerkeleyBerkeleyCA 94702USA Department of Forestry and Environmental Resources North Carolina State UniversityRaleighNC 27695USA USDA-ARS Grazinglands Research Laboratory El RenoOK 73036USA

Introduction:Understanding the differences in carbon and water vapor fluxes of spatially distributed evergreen needleleaf forests(ENFs)is crucial for accurately estimating regional or global carbon and water budgets and when predicting the responses of ENFs to current and future ***:We compared the fluxes of ten AmeriFlux ENF sites to investigate cross-site variability in net ecosystem exchange of carbon(NEE),gross primary production(GPP),and evapotranspiration(ET).We used wavelet cross-correlation analysis to examine responses of NEE and ET to common climatic drivers over multiple timescales and also determined optimum values of air temperature(T_(a))and vapor pressure deficit(VPD)for NEE and ***:We found larger differences in the NEE spectra than in the ET spectra across sites,demonstrating that spatial(site-to-site)variability was larger for NEE than for *** NEE and ET were decoupled differently across ENF sites because the wavelet cospectra between ET and climate variables were similar at all sites,while the wavelet cospectra between NEE and climate variables were higher(i.e.,closer coupling between NEE and climatic drivers)in semi-arid and Mediterranean sites than in other *** water use efficiency(EWUE)based on annual GPP/ET ranged from 1.3±0.18 to 4.08±0.62 g c mm^(−1) ET,while EWUE based on annual net ecosystem production(NEP)/ET ranged from 0.06±0.04 to 1.02±0.16 g c mm^(−1) ET)among *** of NEE and ET to T_(a) varied across climatic *** particular,for ENF sites in semi-arid and Mediterranean climates,the maximum NEE and ET occurred at lower ranges of T_(a) than in sites with warm and humid *** optimum T_(a) and VPD values were higher for ET than for NEE,and ET was less sensitive to high values of T_(a) and ***:Large spatial variability in carbon and water vapor fluxes among ENFs and large variations in responses of NEE and ET to major climate variables among climatic zones necessitate sub-

关键词： Drought Ecosystem water use efficiency Net ecosystem cO_(2)exchange Spatial variability Wavelet cross-correlation analysis

运用多元性基因库方法揭示克罗恩病患者粪便中微生物种群多样性减少

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 39-40页

作者： Manichanh c. Rigottier-Gois L. Bonnaud E. J. dore. 孟欣颖(译) 王顺涛(校) 不详 dore INRA-UEPSD 78350 Jouy-en-JosasFrance

Background and aim: A role for the intestinal microbial community (microbiota) in the onset and chronicity of crohn’s disease (cD) is strongly suspected. However, investigation of such a complex ecosystem is difficult, even with culture independent molecular approaches. Methods: We used, for the first time, a comprehensive metagenomic approach to investigate the full range of intestinal microbial diversity. We used a fosmid vector to construct two libraries of genomic DNA isolated directly from faecal samples of six healthy donors and six patients with cD. Bacterial diversity was analysed by screening the two DNA libraries, each composed of 25 000 clones, for the 16S rRNA gene by DNA hybridisation. Results: Among 1190 selected clones, we identified 125 non-redundant ribotypes mainly represented by the phyla Bacteroidetes and Firmicutes. Among the Firmicutes, 43 distinct ribotypes were identified in the healthy microbiota, compared with only 13 in cD (p cent in situ hybridisation directly targeting 16S rRNA in faecal samples analysed individually (n = 12) confirmed the significant reduction in the proportion of bacteria belonging to this phylum in cD patients (p conclusion: The metagenomic approach allowed us to detect a reduced complexity of the bacterial phylum Firmicutes as a signature of the faecal microbiota in patients with cD. It also indicated the presence of new bacterial species.

关键词：患者粪便克罗恩病多样性基因库多元性微生物种群基因组DNA文库分子生物学方法肠道微生物

乙型或丙型肝炎病毒感染者的癌症发生率:一项基于社区的大型连锁研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 50-51页

作者： Amin J. dore G.J. O'connell D.L. 陈云茹 National centre in HIV Epidemiology and clinical Research SydneyAustralia

Background/Aims:Risks of hepatocellular carcinoma(Hcc) following hepatitis B and/or hepatitis c virus(HBV/HcV) infection are well known,those for other cancers are less well *** aim was to quantify the risk of cancers among persons diagnosed with HBV/HcV ***:The data from a cohort of 39109 HBV,75834 HcV,and 2604 HBV/HcV co-infected persons notified to the State health department,1990-2002,were probabilistically linked to the cancer Registry and standardised incidence ratios(SIRs) for cancer were ***:The match rate for any cancer was 2.7%,2.3% and 3.3% for HBV,HcV and HBV/HcV co-infected *** for Hcc were 30.6(95% cI 25.7-36.5) ,22.7(95% cI 19.1-26.5) and 30.3(95% cI 13.6-67.5) ,*** risk was detected for Burkitt’s lymphoma and HBV(SIR 12.9,95% cI 5.4-30.9) and immunoproliferative malignancies following HcV(SIR 5.6,95% cI 1.8-17.5) .conclusions:The risk of Hcc in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HcV infection associated *** modest though significant risk of immunoproliferative malignancies associated with HcV infection is consistent with recent findings.

关键词：丙型肝炎病毒肝细胞肝癌感染人群队列研究卫生部门匹配率增生性淋巴瘤

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拟南芥m6A甲基化组的系统鉴定和功能分析

遗传 2015年第3期37卷 314-314页

作者：骆观正 Alice MacQueen 郑冠群段红超 Louis c. dore 卢志科刘君陈凯贾桂芳 Joy Bergelson 何川 Department of chemistry and Institute for Biophysical Dynamics The University of ChicagoIllinois60637USA Howard Hughes Medical Institute USA Department of Ecology and Evolution The University of ChicagoIllinois 60637USA 北京大学化学与分子工程学院化学生物学系合成与功能生物分子中心北京100871

作为mRNA上最丰富的一种甲基化修饰,N6-甲基腺苷（N6-methyl-adenosine,m6A）广泛存在于酵母以及动植物中。然而多年来由于缺乏有效的技术手段,这些甲基化修饰发生在mRNA的什么位置,以及如何行使其生物学功能,却长时间没有定论。近年来... 详细信息

作为mRNA上最丰富的一种甲基化修饰,N6-甲基腺苷（N6-methyl-adenosine,m6A）广泛存在于酵母以及动植物中。然而多年来由于缺乏有效的技术手段,这些甲基化修饰发生在mRNA的什么位置,以及如何行使其生物学功能,却长时间没有定论。近年来,随着mRNA去甲基酶FTO和ALKBH5的发现,

关键词：甲基化修饰 m6A adenosine 功能分析突变型甲基转移酶生物信息学分析终止密码子 RNA 信号通路