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中华高血压杂志 2021年第3期29卷 232-232页

作者：刘青(译) 练桂丽(摘/审校) Boguslavskyi A Tokar S Prysyazhna O Rudyk O Sanchez-Tatay D Lemmey HA dora ka Garland CJ Warren HR Doney A Palmer CNA Caulfield MJ Vlachaki Walker J Howie J Fuller W Shattock MJ 不详

平滑肌钠-钾-ATP酶(Na+-K+-ATPase, Nka)可调节血管张力和血压早已为人熟知,但其辅助蛋白phospholemman(PLM)的作用尚未明确。该研究的目的是验证如下假说:在体外,PLM磷酸化可调节血管张力;在体内和人体的实验模型中,这一机制对血管功... 详细信息

平滑肌钠-钾-ATP酶(Na+-K+-ATPase, Nka)可调节血管张力和血压早已为人熟知,但其辅助蛋白phospholemman(PLM)的作用尚未明确。该研究的目的是验证如下假说:在体外,PLM磷酸化可调节血管张力;在体内和人体的实验模型中,这一机制对血管功能和血压的调节起着重要作用。

关键词：血管张力血管功能实验模型 PLM 高血压平滑肌磷酸化调节

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Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains

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Neural Regeneration Research 2012年第24期7卷 1859-1865页

作者： ka Keung Yip Samuel CL Lo Kwok-fai So dora MY Poon Mason CP Leung Department of Rehabilitation Sciences the Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Department of Applied Biology and Chemical Technology the Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Department of Anatomy the University of Hong KongPokfulamHong Kong Special Administrative RegionChina

The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion *** current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli（ST36）and Fengchi（GB20） *** were divided into five groups：uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes（3 times or 18 times）of electro-acupuncture stimulation before experimental cerebral ischemia was ***-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments（P〈0.05）.The production was higher with 18 electro-acupuncture treatments in the ST36 groups（P〈0.05）.In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments（P〈0.05）.No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint ***,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups（P〈0.05）.The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment.

关键词： cerebral ischemia stroke prevention electro-acupuncture transforming growth factor-beta 1 Bcl-2 acupoint

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Intraperitoneal Chemotherapy for Gastric Cancer with Peritoneal Carcinomatosis: Is HIPEC the Only Answer?

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Modern Chemotherapy 2014年第2期3卷 11-19页

作者： ka-On Lam Betty Tsz-Ting Law Simon Ying-Kit Law dora Lai-Wan Kwong Department of Clinical Oncology LKS Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery LKS Faculty of Medicine The University of Hong Kong Hong Kong China

Gastric cancer with peritoneal carcinomatosis is notorious for its dismal prognosis. While the pathophysiology of peritoneal dissemination is still controversial, the rapid downhill course is universal. Patients usually suffer abdominal distension, intestinal obstruction and various complications before they succumb after a median of 3 - 6 months. Although not adopted in most international treatment guidelines, intraperitoneal chemotherapy has growing evidence compared with conventional systemic chemotherapy for the treatment of peritoneal carcinomatosis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is well-established for clinical benefit but is technically demanding with substantial treatment-related morbidities and mortality. On the other hand, normothermic intraperitoneal chemotherapy in the form of bidirectional neoadjuvant treatment is promising with various newer chemotherapeutic agents. Regardless of the treatment technique applied, the essential element of success is meticulous patient selection and availability of expertise. Future direction is along the line of personalized treatment with the application of translational science.

关键词： Gastric Cancer Peritoneal Carcinomatosis Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Neoadjuvant Intraperitoneal/Systemic Chemotherapy (NIPS) Cytoreductive Surgery

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Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma

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Journal of Biomedical Science and Engineering 2014年第11期7卷 857-865页

作者： ka-Wai Wong dora Lai-Wan Kwong Pek-Lan Khong Victor Ho-Fun Lee Sherry Chor-Yi Ng Martin Wai-Ming Law The Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong China The Department of Clinical Oncology Queen Mary Hospital Hong Kong China The Department of Clinical Oncology The University of Hong Kong Hong Kong China The Department of Diagnostic Radiology Queen Mary Hospital Hong Kong China The Department of Diagnostic Radiology The University of Hong Kong Hong Kong China

Objective: To develop an auto-segmentation method for delineating the biological tumor volume of nasopharyngeal carcinoma from positron emission tomography images. Methods: A phantom consisting of a water tank with fixed background fluorodeoxyglucose [18F-FDG] activity and spheres with diameters ranging from 2.1 to 5 cm with varying activities of FDG were used to simulate tumors of different sizes and FDG uptake. The phantom was scanned with a PET/CT scan at different sphere to background intensity ratios. An optimum fixed percentage threshold (FT) approach and a signal-to-background ratio (SBR) approach were developed to estimate the true size of the spheres from the PET images. Both approaches were further evaluated in patient images for validation. Twenty-two patients with NPC from stage T1 to T4 were included. The PET based biological tumor volumes (BTV) were delineated with both FT (BTVFT) and SBR (BTVSBR) approaches and compared with the gross tumor volume localized from MRI (GTVMR). The mean volumes of BTVFT and BTVSBR were compared and the degree of overlap between GTVMR and both BTVs was evaluated. Paired t-tests were used for statistical analysis. Results: The optimal FT value was 36.5% of maximal intensity, and SBR approach was represented by an inverse linear regression model. The estimated volume of spheres segmented by both approaches shows no significant difference from the true volume of spheres (p > 0.05), but the average absolute errors were smaller from SBR approach than FT approach (p = 0.008). GTVMR was larger than both BTVFT (p = 0.003) and BTVSBR (p SBR with GTVMR is significantly larger than with BTVFT (0.52 and 0.42 respectively, p MR for radiotherapy planning purpose.

关键词： Segmentation Approach SBR Fixed Threshold NPC PET

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Mechanosynthesis as a Simple Method to Obtain a Magnetic Composite (Activated Carbon/Fe₃O₄) for Hyperthermia Treatment

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Journal of Biomaterials and Nanobiotechnology 2016年第1期7卷 19-28页

作者： Jorge Carlos Ríos-Hurtado Elia Martha Múzquiz-Ramos Alejandro Zugasti-Cruz dora Alicia Cortés-Hernández Facultad de Ciencias Químicas Universidad Autónoma de Coahuila Saltillo México Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Saltillo Ramos Arizpe México

A large number of magnetic nanomaterials have been studied for their hyperthermic potential, such as iron oxide based materials. These are embedded in different matrices to improve their properties. In this paper magnetite was synthesized by the coprecipitation method and an activated carbon/magnetite composite was obtained by mechanosynthesis (400 rpm, 3 h). The samples were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), IR-FT spectroscopy and Scanning Electron Microscopy (SEM). Furthermore, composite heating curves as well as hemolysis tests were performed. The composite showed a superparamagnetic behavior due to its low coercivity index (8.92 Oe) and a high saturation magnetization (40.12 emu/g). SEM images showed that the magnetite was observed on the surface of activated carbon and also the IR-FT spectra indicated that oxygenated groups on the activated carbon surface were responsible for the anchoring of magnetite in the surface, with particle sizes between 9 and 14 nm. Heating results indicated that a composite mass of 18 mg reach a temperature of 45.6°C in a low frequency magnetic field (10.2 ka and 200 kHz). Hemolysis tests indicated that the composite is a non-hemolytic material (4.7% hemolysis). These results demonstrate that the material can be used in magnetic hyperthermia techniques for cancer treatment.

关键词： Mechanosynthesis Hyperthermia Magnetite Activated Carbon Composite

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