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Mechanosynthesis as a simple Method to Obtain a Magnetic Composite (Activated Carbon/Fe<sub>3sub>O<sub>4sub>) for Hyperthermia Treatment

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Journal of Biomaterials and Nanobiotechnology 2016年第1期7卷 19-28页

作者： Jorge Carlos Ríos-Hurtado Elia Martha Múzquiz-Ramos Alejandro Zugasti-Cruz dora alicia cortés-hernández Facultad de Ciencias Químicas Universidad Autónoma de Coahuila Saltillo México Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad saltillo Ramos Arizpe México

A large number of magnetic nanomaterials have been studied for their hyperthermic potential, such as iron oxide based materials. These are embedded in different matrices to improve their properties. In this paper magnetite was synthesized by the coprecipitation method and an activated carbon/magnetite composite was obtained by mechanosynthesis (400 rpm, 3 h). The samples were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VsM), IR-FT spectroscopy and scanning Electron Microscopy (sEM). Furthermore, composite heating curves as well as hemolysis tests were performed. The composite showed a superparamagnetic behavior due to its low coercivity index (8.92 Oe) and a high saturation magnetization (40.12 emu/g). sEM images showed that the magnetite was observed on the surface of activated carbon and also the IR-FT spectra indicated that oxygenated groups on the activated carbon surface were responsible for the anchoring of magnetite in the surface, with particle sizes between 9 and 14 nm. Heating results indicated that a composite mass of 18 mg reach a temperature of 45.6°C in a low frequency magnetic field (10.2 kA and 200 kHz). Hemolysis tests indicated that the composite is a non-hemolytic material (4.7% hemolysis). These results demonstrate that the material can be used in magnetic hyperthermia techniques for cancer treatment.

关键词： Mechanosynthesis Hyperthermia Magnetite Activated Carbon Composite

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Healing Effect of the Extract of Kombucha in Male Wistar Rats

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Open Journal of Veterinary Medicine 2015年第4期5卷 80-88页

作者： Manuel Rosales-cortés Esther Albarrán-Rodríguez Guillermo Nolasco-Rodríguez David Avíla-Figueroa Raúl Leonel De Cervantes-Mireles Rubén Rosales-Ramírez dora Manuela García-Carrasco División de Ciencias Veterinarias Centro Universitario de Ciencias Biológicas Agropecuarias Universidad de Guadalajara Guadalajara Mexico

In order to assess the impact of the early and late tissue repair of Kombucha extract on incised wounds in animal models, 24 Wistar male rats were used and divided into three groups: one of the groups received a topical cure on the wound with Brosin, and the other received the Kombucha extract. The third group did not receive any treatment, working as a control group. The objective was to evaluate and compare the Kombucha extract with a commercial healing product. Each one of the animals took a 1 cm wound in depth and length at a femur level on a side of the left thigh. The healing process was evaluated on an early and late phase by performing a morphometric and morphological analysis under the assumption of a faster recovery with the use of Kombucha. The results showed that there was a poor recovery in the control group. On the other hand, the other two groups, Brosin and Kombucha, were similar, with little inflammation and a high cell proliferation and migration along with basal array pulls of elastin and collagen which served for angiogenesis, repair and renovation of the new tissue.

关键词： Healing Kombucha Repair and Tissue Regeneration

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