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Unspecified live kidney donation by urological patients

World journal of Transplantation 2020年第8期10卷 215-222页

作者： Sebastiaan Ceuppens Hendrikus j A N Kimenai Karel W j Klop Willij C Zuidema Michiel G H Betjes Willem Weimar jan N M Ijzermans Frank j M F dor Robert C Minnee Division of Transplant Surgery Department of SurgeryErasmus MC University Medical CenterRotterdam 3015GDNetherlands Department of Internal Medicine Nephrology and Kidney Transplant UnitRotterdam 3000CANetherlands Imperial College Renal and Transplant Unit Hammersmith HospitalImperial College Healthcare NHS TrustLondon W120HSUnited Kingdom

BACKGROUND Individuals with benign kidney disorders undergoing nephrectomy have three possibilities:Autotransplantation,with a certain risk of complications,but without a clear benefit;discarding the kidney;or living kidney *** To investigate whether patients with benign kidney disorders and a medical indication for nephrectomy are suitable as unspecified live kidney *** We searched all clinical data from 1994-2019 for unspecified donors and their transplant recipients(n=160).Nine of these 160 donors had pre-existing kidney disorders necessitating nephrectomy and had decided to donate their kidney anonymously after discussing the possibility of kidney *** studied the clinical course of these nine donating patients and their transplant *** Seven of nine donating patients indicated unbearable loin pain as the main complaint,one donating patient refused ureterocutaneostomy and one had two aneurysms of the renal ***,seven donating patients described absence of pain and one a significant reduction after the *** average 1-year creatinine level in the donating patients was 88μmol/L and after a median of 6.9 years the average creatinine level was 86.6μmol/*** the transplant recipients,one major complication occurred which led to death and in one transplant recipient graft function failed to normalize at first but has been stable for nine years ***,all transplant recipients are off *** Our data show that patients undergoing nephrectomy as part of treatment in selected kidney disorders can function as live kidney donors.

关键词： Unspecified donor Live kidney donation Benign kidney disorder Living donors Kidney Transplantation

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Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance

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World journal of Stem Cells 2015年第2期7卷 281-299页

作者： john D West Natalie j dorà j Martin Collinson Genes and Development Group Centre for Integrative PhysiologyCollege of Medicine and Veterinary MedicineUniversity of Edinburgh Institute of Medical Sciences School of Medical SciencesCollege of Life Sciences and MedicineForesterhillUniversity of Aberdeen

In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the

关键词： Eye Cornea Corneal epithelium Limbalepithelium Stem cell Lineage tracing

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罕见的婴儿肌纤维瘤病伴发溃疡斑

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 50-51页

作者： Delorme N. doréA. j.- L. Verret 王琼 SereM.- X./Crou' vicedeDermatologie CHUAngers49000Angers France

Introduction. Infantile myofibromatosis is a rare fibrovascular- like, isolated or multicentric tumor, occasionally of the bone or an organ and appearing before the age of 2. We report a case of infantile myofibromatosis in a child in an atypical form with a single, ulcerated plaque and having developed after the onset of clusters of papular nodules. Observation. An infant was seen in consultation because of asymptomatic papules that had developed on the back. The histological examination of a partial biopsy revealed a histiocytofibromatus aspect and led to the diagnosis of clusters of multiple histiocytofibromatous. One year later, the papular nodules had converged, forming a large plaque with ulcerated center. The progressive extension and the absence of healing prompted surgical exeresis and the final diagnosis of myofibromatosis. Discussion. Diagnosis of infantile myofibromatosis is difficult histologically and clinically and relies on a clear anatomoclinical confrontation. The clinical aspects are varied. To our knowledge, myofibromatosis with a single ulcerated plaque has never been reported in the literature before.

关键词：婴儿肌纤维瘤病溃疡斑肌纤维瘤无症状性丘疹结节纤维血管活检组织学簇集性组织细胞切除术

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早产儿出生后头围的加速增长

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世界核心医学期刊文摘（儿科学分册） 2006年第A10期2卷 21-22页

作者： Cockerill j. Uthaya S. doré C.j. Modi N. N. Modi 贺莉 Faculty of Medicine Imperial College London Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH United KingdomProf.

Background: Poor growth after preterm birth, particularly poor head growth, is associated with impaired neurodevelopmental outcome. Objective: To evaluate weight gain and head growth between birth and term in a contemporary cohort of preterm infants, taking into account breast milk intake and illness severity. Methods: Subjects were inborn infants ≤ 32 weeks gestation who remained in the neonatal unit up to ≥ 37 weeks postmenstrual age. Weight and head circumference (HC) were expressed as standard deviation score (SDS), growth between birth and discharge as SDS gain (SDSG), and illness severity and breast milk exposure as the number of days of level 1 (full)- intensive care (% L1IC) and the number of days on which breast milk was received (% BM) as a percentage of days from birth to discharge. Results: Infants showed poor postnatal weight gain but accelerated head growth. There was a highly significant fall in mean (SD) weight SDS between birth and discharge (- 0.31 (0.96) and - 1.32 (1.02) respectively, p < 0.001) and a highly significant increase in HC SDS (- 0.52 (0.95) and - 0.03 (1.25) respectively, p = 0.003). % L1IC had a highly significant negative impact on weight SDSG (p = 0.006), and % BM had a significant positive impact on HC SDSG (p = 0.043). Conclusions: Accelerated postnatal head growth suggests catch up after antenatal restraint. This raises the possibility that poor neurocognitive outcomes after extremely preterm birth may in part be consequent on poor intrauterine brain growth. As postnatal head growth may be facilitated by breast milk, there is an urgent need to evaluate the optimal use of breastmilk in preterm neonates. Illness severity is a significant determinant of poor postnatal weight gain.

关键词：头围出生后出生胎龄新生儿病房母乳喂养神经发育严重度疾病严重程度出生前重症监护

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链霉素的早期杀菌活性

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国际结核病与肺部疾病杂志 2002年第3期 118-121页

作者： P.R.Donald F.A.Sirgel A.Venter E.Smit D.P.Parkin B.W.Van de Wal C.j.dor D.A.Mitchison 马玙 Department of Paediatrics University of Stellenbosch Cape Town Tuberculosis Research Lead Programme Medical Research Council Tygerberg University of Stellenbosch Cape Town South Africa Pharmacology University of Stellenbosch Cape Town South Africa Internal Medicine University of Stellenbosch Cape Town South Africa Medical Research Council Clinical Trials Unit London Department of Medical Microbiology St George's Hospital Medical School London UK

背景:观察研究Cape城市Tygerburgy医院诊治的新诊涂阳肺结核病人对链霉素的早期治疗效应。目的:测定标准的早期杀菌活性(EBA)即收集链霉素治疗的头2天内16小时的痰标本,观察活菌数的下降情况。设计:病人随机分组接受按对数间隔的不同... 详细信息

背景:观察研究Cape城市Tygerburgy医院诊治的新诊涂阳肺结核病人对链霉素的早期治疗效应。目的:测定标准的早期杀菌活性(EBA)即收集链霉素治疗的头2天内16小时的痰标本,观察活菌数的下降情况。设计:病人随机分组接受按对数间隔的不同剂量的链霉素(7.5mg、15mg、或30mg/kg)。采用标准生物学方法与以往所进行的对巴龙霉素的估算(7.5mg及15mg/kg)的EBA进行比较。结果:30mg/kg SM治疗的EBA为0.133显著高于0(p=0.0009),而15mg/kg及7.5mg/kg的EBA各为0.043及-0.025,则与无显著差异。EBA=0.2587±0.02527 log_(10)剂量的线性回归公式可获显著的坡度(p=0.007)。而巴龙霉素估计为1.745,强于SM,而95％CI为(0.6-28.6),表明不可能认为巴龙霉素比SM有力。结论:链霉素低的EBA是与剂量相关的,SM在空洞内杀菌活性与临床研究结果一致。如系SM耐药菌株,巴龙霉素可能成为选用的氨基糖苷类药物。

关键词：早期杀菌活性 (EBA) 链霉素巴龙霉素肺结核

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Dynamics of sexual development in teleosts with a note on Mugil cephalus

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Aquaculture and Fisheries 2022年第5期7卷 507-518页

作者： j.Logamanya Tilak Angeline Samuel A.Kalarani R.Moses Inbaraj Endocrinology Unit Department of ZoologyMadras Christian CollegeTambaramChennai600059India

The process of sex determination(SD)and sex differentiation(Sd)with associated sex-specific behaviour in teleosts is brought about by genetic factors and environmental factors under the influence of chemical *** is initiated by inherited genes,which in turn influence Sd by the production of *** understand the plasticity of SD in fishes,the functional role of genes must be clearly *** early development,the dimorphic expression of male and female are mediated by the differentially sexualized *** mammals,SD region(SDR)on the Y chromosome(SRY)can be considered as male-specific copy of SOX3 and in the absence of SRY in teleosts suggests SD might be regulated by alternate ***(doublesex/mab)-related genes,AMH(anti-mullerian hormone),TGF-b(transforming growth factor beta),GSDF(gonadal soma derived growth factor)and other genes(around 18)located in chromosomes of teleosts are found to be responsible for *** SD gene,sdY(sexually dimorphic on the Y chromosome)has been detected in more than 15 salmonid species,and in medaka and tilapia SD system is governed by heterogametic *** mullet,Mugil cephalus dor et *** 27 SDR genes and suggested to be potential candidate genes for *** whole-genome sequencing data were produced from mullet and assembled into a draft genome sequence in which>30 loci are potentially associated with *** analysis is required to know the involvement of each sex-biased gene for its functional influence on *** attempted to know the sex-linkage group in tilapia and found that 2 linkage group ***1 and LG22 show SD loci,whereas in mullet it was documented that LG8 is the SD *** study with all male population(YY)or knockout of male marker gene,might give conclusive understanding on SD in *** review highlights the absence of genomic understanding of SD and SDR genes for futuristic direction of research.

关键词： Sex determination SRY sdY Sex differentiation Mugil cephalus

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剪切波弹性成像提高乳腺超声特异性:939个肿块的BE1多国研究

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国际医学放射学杂志 2012年第2期 177-177页

作者： W.A.Berg D.O.Cosgrove C.j.doré F.K.W.Schfer W.E.Svensson R.j.Hooley 肖立志 Magee-Womens Hospital University of Pittsburgh School of Medicine300 Halket StPittsburghPA 15213

目的确定增加剪切波弹性成像特征是否提高乳腺肿块超声评价的准确性。材料与方法这项多中心前瞻性研究得到了机构审查委员会批准且方案符合HIPAA,2008年9月—2010年10月,958名女性同意重复标准乳腺超声

关键词：剪切波弹性成像 BE1 肿块乳腺超声特异性

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Esophagogastric junction outflow obstruction successfully treated with laparoscopic Heller myotomy and dor fundoplication: First case report in the literature

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World journal of Gastrointestinal Surgery 2019年第2期11卷 112-116页

作者： Pedro F Pereira Andre RP Rosa Leonardo A Mesquita Marcelle j Anzolch Rafael N Branchi Augusto L Giongo Francisco C Paix?o Marcio F Chedid Cleber DP Kruel Division of Gastrointestinal Surgery and Liver Transplantation Hospital de Clinicas de Porto AlegreFederal University of Rio Grande do Sul

BACKGROUND Esophagogastric junction outflow obstruction(EGjOO) is a rare syndrome,characterized by an elevation of the integrated relaxation pressure of the lower esophageal sphincter, not accompanied by alterations in esophageal motility that may lead to the criteria for achalasia. We were unable to find any prior report of the combination of Heller myotomy with anterior partial fundoplication(dor) as the treatment for EGjOO. We herein report a case of EGjOO treated with laparoscopic Heller myotomy combined with dor *** SUMMARY A 26-year-old man presented with a 3-year history of solid dysphagia and a 30-kg weight loss. He was treated with oral nifedipine, isosorbide, and omeprazole,without resolution of symptoms. An upper gastrointestinal series(barium swallow) revealed a "bird's beak" sign. Esophagogastroduodenoscopy was positive for Los Angeles grade A peptic esophagitis. High-resolution esophageal manometry was compatible with EGjOO. Esophageal pH monitoring showed pathological acid reflux both in orthostatic and decubitus position. An 8-cm laparoscopic Heller myotomy combined with an anterior 220° dor fundoplication was performed. Solid diet was introduced on postoperative day 2, and the patient was discharged home the same day. At 17-mo follow-up, he reported no symptoms. Barium swallow was compatible with complete radiologic *** esophageal manometry and upper endoscopy showed normal findings 9 mo after the *** Surgical treatment with Heller myotomy and dor fundoplication is a potential treatment option for EGjOO refractory to medical treatment.

关键词： Esophagogastric junction outflow obstruction Heller myotomy Partial fundoplication dor fundoplication Case report

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SPIRIT 2013声明：定义临床研究方案的标准条目

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中国循证医学杂志 2013年第12期13卷 1501-1507页

作者： An-Wen Chan jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin jesse A.Berlin Caroline j.doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹郑颂华吴泰相李幼平商洪才张伯礼唐旭东吕爱平卞兆祥 SPIRIT中文工作組

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（Standard Protocol Items：Recommendations for Interventional Tri... 详细信息

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（Standard Protocol Items：Recommendations for Interventional Trials 2013 ）,简称SPIRIT2013声明，一个临床研究方案必须报告的条目指引的系统建立和范围。

关键词：临床研究条目标准

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MRI形态学标准对于头部和颈部鳞状细胞癌淋巴结转移检测的改进:颈部淋巴结MRI特征的多因素logistic回归分析法

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国际医学放射学杂志 2009年第3期 299-299页

作者： R.B.j.de Bondt P.j.Nelemans F.Bakers j.W.Casselman C.Pecutz-Koostra B.Kremer 周炳 Department of Radiology Maastricht University Medical CenterP.Debyelaan 256202 AZ Maastrichtthe Netherlands

本研究目的是评价除大小标准外,形态学标准是否能够使MRI更好地诊断头部及颈部鳞状细胞癌(HNSCC)淋巴结转移。2位放射学专家评价了连续的44例病人,其淋巴结的特征已经由被认为是金标准的组织病理学评估。评估标准是短轴直径和形态学特点... 详细信息

本研究目的是评价除大小标准外,形态学标准是否能够使MRI更好地诊断头部及颈部鳞状细胞癌(HNSCC)淋巴结转移。2位放射学专家评价了连续的44例病人,其淋巴结的特征已经由被认为是金标准的组织病理学评估。评估标准是短轴直径和形态学特点,如边界不规则和在T2WI上及T1增强扫描像上的信号强度均匀性。进行多因素logistic回归分析:诊断胜算比(dor)采用95%CI和受试者工作特征曲线(ROC)下面积(AUC)确定。

关键词：头颈部淋巴结转移 MRI

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