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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun sun choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Design,fabrication,and structural safety validation of 3D-printable biporous bone augments

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Bio-Design and Manufacturing 2023年第1期6卷 26-37页

作者： Yeokyung Kang Dasol Lim doo-Hoon sun Jong-Chul Park Jungsung Kim Central Research&Development Center Corentec Company Ltd.33-2Banpo-daero 20-gilSeocho-guSeoulRepublic of Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of Medicine50-1 Yonsei-roSinchon-dongSeodaemun-guSeoulRepublic of Korea Department of Orthopaedic Surgery Daejeon Sun Hospital10-7 Mok-dongJung-guDaejeonRepublic of Korea

The use of commercial products such as a cup and liner for total hip arthroplasty for patients with severe bone defects has a high probability of *** these patients the cup alone cannot cover the bone defect,and thus,an additional augment or cage is *** this study,we designed three-dimensional(3D)printable bone augments as an alternative to surgeries using reinforcement ***-five sharp-edged bone augments of various sizes were 3D printed.A biporous structure was designed to reduce the weight of the augment and to facilitate bone *** types of frames were used to prevent damage to the augment’s porous structure and maintain its stability during ***,two types of holes were provided for easy augment fixation at various *** tests were performed on a combination of worst-case sizes derived using finite element *** test results confirmed the structural stability of the specimens at a load of 5340 *** the porosity of the specimens was measured to be 63.70%,it cannot be said that the porous nature was uniformly distributed because porosity tests were performed locally and *** summary,3D-printable biporous bone augments capable of bonding from various angles and bidirectionally through angulation and bottom-plane screw holes are *** mechanical results with bone augments indicate good structural safety in ***,further research is necessary to study the clinical applications of the proposed bone augment.

关键词： Bone augment 3D printing Biporous structure Total hip arthroplasty Metal implant

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Evaluation of vibration and sound quality according to battery voltage change while moving a power seat in an automobile forward or backward

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Journal of Central South University 2014年第10期21卷 3844-3849页

作者： Kang-seok Seo doo-seuk choi Key-sun Kim Department of Mechanical Engineering Graduate School Kongju National University Division of Automotive and Mechanical Engineering Kongju National University

The changes in vibration, sound, and sound quality with changes in the driving voltage of a power seat motor from 12.5 to 14.5 V were measured and analyzed, which was used in real vehicles. BSR(buzz, squeak, rattle), which occurs for the power seat mechanism during sliding operation, was also evaluated. In addition, the results were expressed in terms of sound quality metrics, which measure the RPM change and sound level versus voltage to analyze their statistical correlation. Furthermore, vibration measurement and analysis were conducted simultaneously to determine the noisiest conditions and the source of the noise. The changes in RPM and voltage of a motor, in addition to vibration and noise, were measured at the same time to determine how noise, RPM, and voltage are interrelated.

关键词：振动测量声音质量电池电压电动座椅评价汽车移动驱动电压

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Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： Seung Soo Yoo Shin Yup Lee sun Ha choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** SUMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report

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Simultaneous laparoscopic and arthroscopic excision of a huge juxta-articular ganglionic cyst compressing the sciatic nerve:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9028-9035页

作者： Won-Ku choi Jong-sung Oh sun-Jung Yoon Department of Obstetrics and Gynecology Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National UniversityJeonju 54907South Korea Department of Orthopedic Surgery Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND A large ganglionic cyst extending from the hip joint to the intrapelvic cavity through the sciatic notch is a rare space-occupying lesion associated with compressive lower-extremity neuropathy.A cyst in the pelvic cavity compressing the intrapelvic-sciatic nerve is easily missed in the diagnostic process because it usually presents as atypical symptoms of an extraperitoneal-intrapelvic *** present a case of a huge ganglionic cyst that was successfully excised laparoscopically and endoscopically by a gynecologist and an orthopedic *** SUMMARY A 52-year-old woman visited our hospital complaining of pain and numbness in her left buttock while *** pain began 3 years ago and worsened,while the numbness in the left lower extremity lasted 1 *** was diagnosed and unsuccessfully treated at several tertiary referral centers many years *** resonance imaging revealed a suspected paralabral cyst(5 cm×5 cm×4.6 cm)in the left hip joint,extending to the pelvic cavity through the greater sciatic *** CA-125 and CA19-9 tumor marker levels were within normal ***,the cyst was compressing the sciatic ***,endoscopic and laparoscopic neural decompression and mass excision were performed simultaneously.A laparoscopic examination revealed a tennis-ball-sized cyst filled with gelatinous liquid,stretching deep into the hip *** excisional biopsy performed in the pelvic cavity and deep gluteal space confirmed the accumulation of ganglionic cysts from the hip joint into the extrapelvic intraperitoneal *** Intra-or extra-sciatic nerve-compressing lesion should be considered in cases of sitting pain radiating down the ipsilateral lower *** large juxta-articular ganglionic cyst was successfully treated simultaneously using laparoscopy and arthroscopy.

关键词： Paralabral cyst Ganglion cyst Intrapelvic sciatic nerve compression syndrome Deep gluteal syndrome Hip joint Laparoscopy Case report

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Decomposition behavior of yttria-stabilized zirconia and its effect on directed energy deposited Ti-based composite material

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Journal of Materials Science & Technology 2022年第17期112卷 138-150页

作者： Gwanghyo choi Won Seok choi Yoon sun Lee Dahye Kim Ji Hyun sung Seungjun An Chang-Seok Oh Amine Hattal Madjid Djemai Brigitte Bacroix Guy Dirras Pyuck-Pa choi Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea 3D Additive Manufacturing Application Tech.Center Korea Institute of Industrial TechnologyDaegu 42994Republic of Korea InssTek Co. Daejeon 04763Republic of Korea Korea Institute of Materials Science 797 ChangwondaeroChangwon 51508Republic of Korea UniversitéSorbonne Paris Nord Laboratoire des Sciences des Procédés et des MatériauxLSPMCNRSUPR 3407F-93430VilletaneuseFrance Z3Dlab Parc Technologique26 Rue des SablonsMontmagny 95360France CNRS UPR3407Laboratoire des Sciences des Procédés et des MatériauxLSPMUniversitéSorbonne Paris NordF-93430VilletaneuseFrance

We report on the microstructure and the strengthening mechanisms of additively manufactured parts fabricated by directed energy deposition of Ti-6Al-4V(Ti64)powders blended with yttria-stabilized zirconia(YSZ)*** specimens showed refined microstructures as compared to bare as-deposited Ti64,where theαand columnar priorβgrain sizes decreased with increasing YSZ *** YSZ nanoparticles decomposed during the deposition process and led to the formation of yttrium oxide and some excess oxygen in the Ti64 *** decrease in the sizes of the priorβgrains could be attributed to the increasing amount of dissolved oxygen and yttrium,which promoted constitutional ***,the reduction in the size of theαgrains could be ascribed to a shift of the onset of theβ→α+βtransformation to a higher temperature and shorter time with increasing concentration of dissolved ***,the contributions of the underlying strengthening mechanisms for the as-deposited specimens were quantitatively determined.

关键词： Additive manufacturing Directed energy deposition Metal matrix composites Titanium alloys Yttrium-stabilized zirconia

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Congenital stapes suprastructure fixation presenting with fluctuating auditory symptoms:A case report

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World Journal of Clinical Cases 2023年第1期11卷 249-254页

作者： sun choi Seok Hyun Park Ji Su Kim Jiwon Chang Department of Otolaryngology-Head and Neck Surgery Kangnam Sacred Heart HospitalHallym University College of MedicineSeoul 07441South Korea

BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported *** usually visit the clinic with non-progressive conductive hearing loss that typically began in the early years of *** SUMMARY Herein,we report a case of a 37-year-old female with an isolated stapedial suprastructure *** patient presented with unusual fluctuating auditory symptoms of tinnitus,ear fullness and mixed hearing ***-operative temporal bone computed tomography findings and operative findings revealed an isolated stapedial suprastructure fixation with monopod stapes caused by elongated pyramidal *** hearing threshold recovered completely,and fluctuating auditory symptoms disappeared after the *** This is the first report of stapedial suprastructure fixation with fluctuating auditory *** results are expected with surgical treatment.

关键词： Isolated stapes ankylosis Stapes suprastructure fixation Elongated pyramidal eminence Stapes monopod Fluctuating auditory symptoms Exploratory tympanotomy Case report

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Gradient Si-and Ti-doped Fe_(2)O_(3) hierarchical homojunction photoanode for efficient solar water splitting:Effect of facile microwave-assisted growth of Si-FeOOH on Ti-FeOOH nanocorals

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Journal of Energy Chemistry 2023年第2期77卷 27-37,I0002页

作者： Tae Sik Koh Periyasamy Anushkkaran Weon-Sik Chae Hyun Hwi Lee sun Hee choi Jum Suk Jang Division of Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

The construction of a homojunction is an effective approach for addressing issues such as slow charge separation and charge-transfer kinetics in *** the present work,we designed a gradient Si-and Ti-doped Fe_(2)O_(3) homojunction photoanode to improve the photoelectrochemical(PEC)performance of a Ti-doped Fe_(2)O_(3) ***-FeOOH nanocorals were synthesized using a hydrothermal process,and Si-FeOOH was grown on Ti-FeOOH nanocorals using a rapid and facile microwaveassisted(MW)*** varying the MW irradiation time,the thickness of the Si/Ti:Fe_(2)O_(3) photoanode was adjusted and an optimized 3-Si/Ti:Fe_(2)O_(3) photoelectrode was achieved with a significantly enhanced photocurrent density(1.37 mA cm^(-2) at 1.23 V ***)and a cathodic shift of the onset potential(150 mV)compared with that of bare Ti-Fe_(2)O_(3).This enhanced PEC performance can be ascribed to homojunction formation and Si gradient *** Si dopant increased the donor concentration and the formation of a homojunction improved the intrinsic built-in electric field,thereby promoting charge separation and charge ***,the as-formed homojunction passivated the surfacetrapping states,consequently improving the charge transfer efficiency(60%at 1.23 VRHE)at the photoanode/electrolyte *** findings could pave the way for the microwave-assisted fabrication of diverse efficient homojunction photoanodes for PEC water splitting applications.

关键词： Homojunction Microwave-assisted Hematite Gradient doping PEC water splitting

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Importance of Adaptive Photometric Augmentation for Different Convolutional Neural Network

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Computers, Materials & Continua 2022年第9期72卷 4433-4452页

作者： Saraswathi Sivamani sun Il Chon Do Yeon choi Dong Hoon Lee Ji Hwan Park AI Reliability Lab ThinkforBL Consultancy ServicesGangnamSeoulKorea Department of Biosystems Engineering Chungbuk National UniversityCheongju-siChungcheongbuk-do28644Korea

Existing segmentation and augmentation techniques on convolutional neural network(CNN)has produced remarkable progress in object ***,the nominal accuracy and performance might be downturned with the photometric variation of images that are directly ignored in the training process,along with the context of the individual CNN *** this paper,we investigate the effect of a photometric variation like brightness and sharpness on different *** observe that random augmentation of images weakens the performance unless the augmentation combines the weak limits of photometric *** approach has been justified by the experimental result obtained from the PASCAL VOC 2007 dataset,with object detection CNN algorithms such as YOLOv3(You Only Look Once),Faster R-CNN(Region-based CNN),and SSD(Single Shot Multibox Detector).Each CNN model shows performance loss for varying sharpness and brightness,ranging between−80%to 80%.It was further shown that compared to random augmentation,the augmented dataset with weak photometric changes delivered high performance,but the photometric augmentation range differs for each ***,we discuss some research questions that benefit the direction of the *** results prove the importance of adaptive augmentation for individual CNN model,subjecting towards the robustness of object detection.

关键词： Object detection photometric variation adaptive augmentation convolutional neural network

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COVID-19 Stay-At-Home Orders and Older Adults’ Cognitive Health — United States, June 2018–February 2022

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China CDC weekly 2022年第45期4卷 1002-1006,I0003页

作者： Nam sun choi Tianzi Li Jingxiang Pan Selena Yue Jing Li Department of Population Health Sciences Weill Cornell Medical CollegeCornell UniversityNew YorkNYU.S. The Comparative Health Outcomes Policy and Economics(CHOICE)InstituteSchool of PharmacyUniversity of WashingtonSeattleWAU.S.

What is already known about this topic?Lack of social activities is known to negatively impact cognitive functioning and increase risk of cognitive impairment,including dementia,among older *** is added by this report?Coronavirus disease 2019(COVID-19)stay-at-home orders implemented in the *** during the pandemic were not found to negatively affect cognitive functioning of older *** are the implications for public health practice?There may have been no severe,unintended consequences of the COVID-19 stay-at-home orders in terms of their impact on cognitive functioning and risk of dementia among older adults,lending further support to use of such orders.

关键词： impairment consequences COV

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