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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian Seong Hoon Goh Yundeok kim Cheol-Su kim doo-Sup kim Kyu-Jae Lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

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Influence of Nitrogen Flow Ratio on the Microstructure, Composition, and Mechanical Properties of DC Magnetron Sputtered Zr-B-O-N Films

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Journal of Materials Science & Technology 2012年第11期28卷 981-991页

作者： Tie-Gang Wang Yanmei Liu Tengfei Zhang doo-in kim KwanKHo kim National Core Research Center for Hybrid Materials Solution Pusan National University Busan 609-735 Korea State Key Laboratory of Corrosion and Protection Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Analysis and Testing Division Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China [Manuscript received May 22 2012 in revised form August 31 2012]

Nanocrystalline ZrB2 film and nanocomposite Zr-B-O-N films were prepared by non-reactive as well as re- active magnetron sputtering techniques, respectively. By means of X-ray diffraction analysis, electron probe microanalysis, X-ray photoelectron spectroscopy, and scanning electron microscopy, the influence of nitrogen flow ratio on the film microstructure and characteristics were investigated systematically, including the depo- sition rate, chemical compositions, phase constituents, grain size, chemical bonding, as well as cross-sectional morphologies. Meanwhile, the hardness and adhesion of above films were also evaluated by micro-indentation method and a scratch tester. With increasing the nitrogen flow ratio, the deposition rate of above films de- creased approximately linearly, whereas the contents of N and O in the films increased gradually and tended to saturation. Moreover, the film microstructure was also altered gradually from a fine columnar microstructure to a featureless glass-structure. As the nitrogen flow ratio was 11.7%, the Zr-B-O-N film possessed an typical nanocomposite structure and presented good mechanical properties. During the process of reactive sputtering of metal borides, the introduction of nitrogen can show a pronounced suppression of columnar grain growth and strong nanocomposite structure forming ability.

关键词： Films DC magnetron sputtering Nanocomposite Microhardness Adhesion

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Numerical Analysis of the Adhesive Forces in Nano-Scale Structure

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Journal of Bionic Engineering 2006年第4期3卷 209-216页

作者： Young-Sam Cho Houkseop Han Wan-doo kim Department of Future Technology Korea Institute of Machinery and Materials Daejeon 305-343 Republic of Korea

Nanohairs, which can be found on the epidermis of Tokay gecko＇s toes, contribute to the adhesion by means of van der Waals force, capillary force, etc. This structure has inspired many researchers to fabricate the attachable nano-scale structures. However, the efficiency of artificial nano-scale structures is not reliable sufficiently. Moreover, the mechanical parameters related to the nano-hair attachment are not yet revealed qualitatively. The mechanical parameters which have influence on the ability of adhesive nano-hairs were investigated through numerical simulation in which only van der Waals force was considered. For the numerical analysis, finite element method was utilized and van der Waals force, assumed as 12-6 Lennard-Jones potential, was implemented as the body force term in the finite element formulation.

关键词： numerical analysis adhesive force nano-scale structure finite element model van der Waals force 12-6 L-J potential

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Effects of Cr interlayer on mechanical and tribological properties of Cr-Al-Si-N nanocomposite coating

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 62-67页

作者： Young Su HONG Se Hun KWON Tiegang WANG doo-in kim Jihwan CHOI Kwang Ho kim School of Materials Science and Engineering Pusan National University National Core Research Center for Hybrid Materials Solution Pusan National University

Cr-A1-Si-N coatings were deposited on SUS 304 substrate by a hybrid coating system. A Cr interlayer was introduced between Cr-A1-Si-N coating and SUS 304 substrate to improve the coating adherence. The effects of Cr interlayer on the microhardness, adhesion, and tribological behavior of Cr-A1-Si-N coatings were systematically investigated. The results indicate that the microhardness of the Cr-A1-Si-N coatings gradually deceases with increasing thickness of Cr interlayers. The adhesion between Cr-A1-Si-N and SUS 304 substrate is improved by addition of the Cr interlayers. A peak critical load of-50 N is observed for the coating containing Cr interlayer of 60 nm as compared - 20 N for the coating without Cr interlayer. The thicker Cr interlayers result in reduced critical load values. Moreover, the wear resistance of the Cr-AI-Si-N coatings is greatly enhanced by introducing the Cr interlayer with thickness of 60 nm in spite of the decreased microhardness. The friction coefficient of the coating system is also moderately reduced.

关键词： Cr-A1-Si-N coating Cr interlayer hardness adhesion wear

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Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation

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Cellular & Molecular Immunology 2018年第2期15卷 111-119页

作者： Huijeong Ahn Seung Goo Kang Sung-il Yoon Pyeung-Hyeun kim doo kim Geun-Shik Lee College of Veterinary Medicine and Institute of Veterinary Science Kangwon National UniversityChuncheon24341GangwonRepublic of Korea Department of Systems Immunology College of Biomedical ScienceKangwon National UniversityChuncheon24341GangwonRepublic of Korea Department of Molecular Bioscience School of Biomedical ScienceKangwon National UniversityChuncheon24341GangwonRepublic of Korea

Poly-gamma-glutamic acid(γ-PGA)is a natural,edible and non-toxic polymer synthesized by Bacillus subtilis and is suggested as a safe biomaterial for the use in hydrogels and vaccine ***,the effect ofγ-PGA on inflammasome activation has not yet been studied in ***,which are intracellular multi-protein complexes,promote acute and chronic inflammation via interleukin-1βor interleukin-18 maturation,and they are known targets for metabolic syndromes and *** this study,we observed thatγ-PGA attenuated NLRP3,NLRC4 and AIM2 inflammasome activation,whereas it upregulated pro-inflammatory cytokine expression in human and murine ***γ-PGA had conflicting effects on cytokine production and maturation,it clearly alleviated the severity of lipopolysaccharide-induced endotoxin shock in an animal ***,we suggestγ-PGA as a candidate to control inflammasome-mediated disorders.

关键词： Cheonggukjang cytokines inflammasome macrophages poly-gamma-glutamate

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Effect of hexagonal-BN on phase transformation of additive-free Si_3N_4 /SiC nanocomposites prepared from amorphous precursor

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Transactions of Nonferrous Metals Society of China 2013年第2期23卷 420-425页

作者： Alfian NOVIYANTO Dang-Hyok YOON Kyungseok LEE Young Moon kim doo-in kim Young-Keun JEONG Kwang Ho kim Sehun KWON Young-Hwan HAN School of Materials Science and Engineering Yeungnam University Gyeongsan 712-749 Korea National Core Research Center for Hybrid Materials Solution Pusan National University Samsung Mobile Display Korea

Si3N4/SiC nanocomposites are well known and attractive for advanced ceramic applications due to excellent mechanlcal and thermal properties, which make them suitable for use in turbine engines, heat exchangers, and other sophisticated applications. However, without the presence of additives, the fabrication of Si3N4/SiC composites is difficult. The additives form a liquid phase during sintering and facilitate the densification of the composite. However, the additives present a drawback at high temperatures since they decrease the mechanical properties of the composites. Recently, Si3N4/SiC composites were fabricated via the polymer precursor route without any additives, using electric field assisted sintering （EFAS）. In this study, fully densified Si3N4/SiC nanocomposites incorporating hexagonal-BN were successfully fabricated by hot pressing without any additives at 1700 ℃ for 2 h under vacuum at a pressure of 50 MPa （via the amorphous precursor route）. Moreover, the incorporation of additives and h-BN is found to decrease the content of SiC. The phase transformation, densification, microstructure, and mechanical properties were discussed and presented.

关键词： Si3N4/SiC hot pressing hexagonal-BN additives sintering

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Thyrotoxicosis induced cardiogenic shock rescued by extracorporeal membrane oxygenation

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Journal of Geriatric Cardiology 2018年第2期15卷 203-204页

作者： Seunghwan kim Sang-Hoon Seol Yun-Seok kim Dong-Kie kim Ki-Hun kim doo-Il kim Department of Internal Medicine INJE University College of Medicine Haeundae Paik hospital Busan South Korea

Cardiomyopahty is one of complications of thyrotoxicosis. About 6% of thyrotoxic patients develop heart failure, but less than 1% of the patients progress dilated cardiomyopathy with systolic left ventricular dysthnct... 详细信息

关键词： Cardiogenic shock Extracorporeal membrane oxygenation Thyrotoxic cardiomyopathy

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Transient severe mitral regurgitation after paroxysmal supraventricular tachycardia in patient with WPW syndrome

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Journal of Geriatric Cardiology 2017年第10期14卷 652-653页

作者： Yun-Seok Song Sang-Hoon Seol Dong-Kie kim Ki-Hun kim doo-Il kim Division of Cardiology Department of lnternal Medicine Inje University College of Medicine Haeundae Paik hospital Busan South Korea

A 65-year-old woman was presented with acute ab- dominal pain. The initial heart rate was 170 beats/min and the ECG showed supraventricular tachycardia （Figure IA）. After intra-venous adenosine administered, it recovered to sinus rhythm and the follow-up ECG showed WPW pattern （Figure 1B）. The echocardiography revealed mitral valve prolapse of mid portion of anteromedial valve leaflet （A2） with severe mitral regurgitation （MR）（Figure 2）.

关键词： Tachycardia Transient mitral regurgitation WPW syndrome

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Coronary-Cameral Fistula appeared after coronary artery intervention

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Journal of Geriatric Cardiology 2019年第3期16卷 307-308页

作者： Yeo-Jeong Song Sang-Hoon Seol Yun-Seok Song Seunghwan kim Dong-Kie kim Ki-Hun kim doo-Il kim Department of Internal Medicine Inje University College of Medicine Haeundae Paik Hospital

A 63-year-old male with old myocardial infarction was referred to cardiology department with cardiac *** revealed Q wave in the precordial leads demonstrating ischemia of anterior left ventricular *** pulmonary edema was documented on chest *** echocardiography showed severely reduced left ventricular function (EF: 28%) with enlarged left atrium and *** angiography was performed showing a total occlusion of the proximal portion of the left anterior descending artery (LAD)(Figure 1) with chronic total occlusion in the proximal portion of right coronary *** stent 2.75 × 23 mm (Abbott) was implanted in the proximal LAD *** angiography after percutaneous coronary intervention (PCI) revealed no definite coronary fistula (Figure 2).Two weeks later,follow-up coronary angiography demonstrated multiple coronary-left ventricular fistulas (Figure 3) which were absent in the previous angiography.

关键词： Left anterior descending artery Myocardial infarction Percutaneous coronary intervention

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Delayed asymptomatic progressive aortic dissecting aneurysm in patient with STEMI

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Journal of Geriatric Cardiology 2017年第6期14卷 425-426页

作者： Yun-Seok Song Sang-Hoon Seol Dong-Kie kim Ki-Hun kim doo-Il kim Division ofCardiology Department of Internal Medicine Inje University College of Medicine Haeundae Paik hospital Busan South Korea

An 80-year-old woman visited emergency room because of resting chest pain for one hour. She had history of hypertension for 10 years. The blood pressure was 80/50 mmHg and the pulse rate was 51 beats/min. The electrocardiogram demonstrated Junctional bradycardia and ST elevation in lead Ⅱ, Ⅲ and aVF. Chest X-ray indicated cardiomegaly （Figure 1A）. Coronary angiography revealed near total occlusion of proximal right coronary artery （RCA）. She underwent percutaneous coronary intervention （PCI） for the RCA lesion successfully. Echocardiography showed hypokinesia of RCA territory （Figure 2A）.

关键词： Delayed Dissecting aneurysm STEMI

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