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Inhibiting scar formation via wearable multilayer stacked electret patch:Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction

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InfoMat 2024年第3期6卷 66-80页

作者： Sung-Won Kim Sumin cho Donghan Lee Jiyu Hyun Sunmin Jang Inwoo Seo Hyun Su Park hee Jae Hwang Hyung-Seop Han Dae Hyeok Yang Heung Jae Chun Suk Ho Bhang Dongwhi choi School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee UniversityYonginGyeonggiRepublic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Medical Life Sciences College of MedicineInstitute of Cell and Tissue EngineeringThe Catholic University of KoreaSeoulRepublic of Korea

Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical set***,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing ***,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply *** addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret *** confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical *** further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in *** findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.

关键词： DC electric field dermal fibroblasts electret scar formation restriction self-creation of electrical stimulation

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Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis

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Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan Kim Minjeong Sung Myong-Suk Park Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-hee cho Ik-Joo Chung Department of Internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Department of Internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial Tumor Immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunotherapy Innovation Center HwasunSouth Korea BioMedical Sciences Graduate Program Chonnam National UniversityHwasunSouth Korea Department of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Department of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(TGF-β1)in the emergence of these diseases,the present study tested the hypothesis that LGALS3BP regulates the TGF-β1 signaling ***:The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LGALS3BP-TGF-β1 *** effects of altered TGF-β1 signaling by LGALS3BP were investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:In patients with MASH and HCC,the levels of LGALS3BP and TGFB1 exhibited positive *** of LGALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LGALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LGALS3BP-knockin mice,with increased TGFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active TGF-β1 from extracellular latent complex with the rearranged F-actin *** released TGF-β1 activated JunB transcription factor,which in turn promoted the TGF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated TGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TGF-β***:LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TGF-β1 signaling pathway,making it a promising therapeutic target in TGF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis IntegrinαV Interferonα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-β1

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Gender-and Age-Group Specific Association of Persistent Organic Pollutants(POPs)Exposure with Diabetes Mellitus:Korean National Environmental Health Survey(KoNEHS)2015−2017

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Environment & Health 2024年第5期2卷 322-331页

作者： Inae Lee Min Joo Kim Sohyeon choi Young Joo Park Jeongim Park Gökçe Nur Ayaz Gowoon Lee Yoon hee cho Hye Li Jeon Chulwoo Lee Gi Jeong Cheon Min Kyong Moon Kyungho choi Graduate School of Public Health Seoul National UniversitySeoul 08826Republic of Korea Institute of Health and Environment Seoul National UniversitySeoul 08826Republic of Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 03080Republic of Korea Seoul National University Hospital Healthcare System Gangnam Center Seoul 06236Republic of Korea Department of Environmental Health Sciences Soonchunhyang UniversityAsan 31538Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826Republic of Korea Center for Environmental Health Sciences Department of Biomedical and Pharmaceutical SciencesUniversity of MontanaMissoulaMontana 59812United States Environmental Health Research Division National Institute of Environmental ResearchMinistry of EnvironmentIncheon 22689Republic of Korea Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Endocrinology Department of Internal MedicineSeoul National University Boramae Medical CenterSeoul 07061Republic of Korea

Exposure to persistent organic pollutants(POPs)has been reported as a potential risk factor for diabetes in ***,effect modifications by sex and age,especially among Asian populations,have seldom been *** the present study,we assessed associations of major POPs exposure including organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polybrominated diphenyl ethers(PBDEs),with diabetes in Korean adults(n=1,295),a subset of the Korean National Environmental Health Survey(KoNEHS)Cycle 3(2015−2017).In the adult population,serum levels of dichlorodiphenyltrichloroethanes(DDTs)and PCB167 showed an increased odds ratio(OR)for *** stratified by gender,associations became stronger and more consistent in women:In women,serum levels of OCPs including p,p′-DDT,p,p′-dichlorodiphenyldichloroethylene(p,p′-DDE),andΣOCPs and mono-ortho PCBs,such as PCB118 and PCB157,were significantly associated with *** the male participants,however,no significant positive associations were *** stratified by a cutoff age of 50 years,most studied POPs except PBDEs,i.e.,p,p′-DDT,p,p′-DDE,PCB118,PCB157,PCB167,PCB138,and PCB153,showed significant associations with diabetes,in the older *** the younger group,however,no measured POPs showed a significant positive *** of endogenous sex hormones or interaction of POPs on aryl hydrocarbon receptors may partly explain the observed differences by gender and age,although further experimental confirmations should *** findings show that POPs exposure at the current levels is associated with diabetes among general Korean adults,and such associations could be modified by gender and age.

关键词： persistent organic pollutants diabetes age gender toxicity equivalency factor

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Bidirectional rotating direct-current triboelectric nanogenerator with self-adaptive mechanical switching for harvesting reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan Lee Joonmin Chae Sumin cho Jong Woo Kim Awais Ahmad Mohammad Rezaul Karim Moonwoo La Sung Jea Park Dongwhi choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,owing to the working mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,we propose a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of swinging doors and waves were demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

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Performance Improvements in Temperature Reconstructions of 2-D Tunable Diode Laser Absorption Spectroscopy(TDLAS)

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Journal of Thermal Science 2016年第1期25卷 84-89页

作者： doo-Won choi Min-Gyu Jeon Gyeong-Rae cho Takahiro Kamimoto Yoshihiro Deguchi Deog-hee Doh Tokushima University 2-1 Minamijyosanjima TokushimaJapan Korea Maritime&Ocean University Dongsam-dong 1 Youngdo-guBusan 606-791Korea

Performance improvement was attained in data reconstructions of 2-dimensional tunable diode laser absorption spectroscopy(TDLAS). Multiplicative Algebraic Reconstruction Technique(MART) algorithm was adopted for data reconstruction. The data obtained in an experiment for the measurement of temperature and concentration fields of gas flows were used. The measurement theory is based upon the Beer-Lambert law, and the measurement system consists of a tunable laser, collimators, detectors, and an analyzer. Methane was used as a fuel for combustion with air in the Bunsen-type burner. The data used for the reconstruction are from the optical signals of 8-laser beams passed on a cross-section of the methane flame. The performances of MART algorithm in data reconstruction were validated and compared with those obtained by Algebraic Reconstruction Technique(ART) algorithm.

关键词： Data Reconstruction TDLAS MART ART

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A Study of the Influence of Air-knife Tilting on Coating Thickness in Hot-dip Galvanizing

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Journal of Thermal Science 2009年第3期18卷 262-267页

作者： Tae-Seok cho Young-doo KWON Soon-Bum KWON School of Mechanical Engineering Kyungpook National University

Gas wiping is a decisive operation in hot-dip galvanizing process. In special, it has a crucial influence on the thickness and uniformity in coating film, but may be subsequently responsible for the problem of splashing. The progress of industry demands continuously the reduction of production costs which may relate directly with the increase of coating speed, and the speed up of coating results in the increase of stagnation pressure in gas wiping system in final. It is known that the increase of stagnation pressure may accompany a harmful problem of splashing in general. Together with these, also, from the view point of energy consumption, it is necessary to design a nozzle optimally. And there is known that the downward tilting of nozzle using in air knife system is effective to prevent in somewhat the harmful problem of splashing. In these connections, first, we design a nozzle with constant expansion rate. Next, for the case of actual coating conditions in field, the effects of tilting of the constant expansion rate nozzle are investigated by numerical analysis. Under the present numerical conditions, it was turned out that the nozzle of constant expansion rate of p = having a downward jet angle of 5^0 is the most effective to diminish the onset of splashing, while the influence of small tilting of the nozzle on impinging wall pres- sure itself is not so large.

关键词： Air-knife Constant expansion rate nozzle Impinging pressure Wall shear stress Hot-dip galvanizing Coating thickness Splashing

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Numerical Analysis of the Adhesive Forces in Nano-Scale Structure

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Journal of Bionic Engineering 2006年第4期3卷 209-216页

作者： Young-Sam cho Houkseop Han Wan-doo Kim Department of Future Technology Korea Institute of Machinery and Materials Daejeon 305-343 Republic of Korea

Nanohairs, which can be found on the epidermis of Tokay gecko＇s toes, contribute to the adhesion by means of van der Waals force, capillary force, etc. This structure has inspired many researchers to fabricate the attachable nano-scale structures. However, the efficiency of artificial nano-scale structures is not reliable sufficiently. Moreover, the mechanical parameters related to the nano-hair attachment are not yet revealed qualitatively. The mechanical parameters which have influence on the ability of adhesive nano-hairs were investigated through numerical simulation in which only van der Waals force was considered. For the numerical analysis, finite element method was utilized and van der Waals force, assumed as 12-6 Lennard-Jones potential, was implemented as the body force term in the finite element formulation.

关键词： numerical analysis adhesive force nano-scale structure finite element model van der Waals force 12-6 L-J potential

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Generation of Discrete Bicubic G^1 B-Spline Ship Hullform Surfaces from a Given Curve Notwork Using Virtual Iso-Parametric Curves

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Journal of Computer Science & Technology 2006年第2期21卷 265-271页

作者： Joong-Hyun Rhim doo-Yeoun cho Kyu-Yeul Lee Tao-Wan Kim EzGragh Co.Ltd.Seoul 135-080 Koren Department of Naval Architecture & Ocean Engincering Seoul National UniversitySeoul 151-744Korea Department of Naval Architecture & Ocean Engincering and Research Institute of Macine Systems Engineering Seoul National University Seoul 151-744Korea

We propose a method that automatically generates discrete bicubic G^1 continuous B-spline surfaces that interpolate the curve network of a ship ***,the curves in the network are classified into two types;boundary curves and ＂reference curves＂,The boundary curves correspond to a set of rectangular（or triangular）topological type that can be representes with tensot-product （or degenerate）B-spline surface ***,in the interior of the patches,surface fitting points and cross boundary derivatives are estimated from the reference curves by constructing ＂virtual＂isoparametric ***,a discrete G^1 continuous B-spline surface is gencrated by a surface fitting *** smooth ship hullform surfaces generated from curve networks corresponding to actual ship hullforms demonstrate the quality of the method.

关键词： curve netowork interpotation discrete G^1 continuous B-spline surface,iso-parametric curve,ship hullform

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Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 341-350页

作者： Dechao Feng Yuhan Xiao Jie Wang Ruicheng Wu Zhouting Tuo Koo Han Yoo Wuran Wei Dilinaer Wusiman Zhipeng Wang Dengxiong Li Yubo Yang William C.cho Mang Ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Science University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of Comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for *** this situation,we summarized the current research actuality and problems in this field using the bibliometric *** in the PubMed and Web of Science databases were ***,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of *** from USA,Germany,Italy,China and England have greater studies than *** three publication institutions are University of California System,UDICE-French Research Universities and University of Texas *** research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κ*** conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in *** established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

关键词： Aging circadian rhythm human cancer bibliometric analysis oxidative stress

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Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer

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World Journal of Gastroenterology 2011年第48期17卷 5310-5316页

作者： Chan Ho Park hee Cheol Kim Yong Beom cho Seong Hyeon Yun Woo Yong Lee Young Suk Park doo Ho choi Ho-Kyung Chun Departmentof Surgery Samsung Medical Center Sungkyunkwan Univer-sity School of Medicine Irwon-dong 50 Gangnam-gu Seoul135-710 South Korea Division of Hematology-Oncology Depart-ment of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Irwon-dong 50 Gangnam-guSeoul 135-710 South Korea Department of Radiation Oncology SamsungMedical Center Sungkyunkwan University School of MedicineIrwon-dong 50 Gangnam-gu Seoul 135-710 South Korea

AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete ***: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information.

关键词： Rectal cancer Preoperative chemoradiotherapy Downstaging Tumor regression Validation

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