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Considerations for Combining High-Protease Extracts in Immunotherapy Vaccines

2016年

作者： (美)唐娜·塔特(donna Tartt)

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Open Journal of Nursing 2014年第4期4卷 251-254页

作者： Carol MLilley donna Jrekkerth Brian FTeske American Society of Allergy Nurses AlbanyUSA GrEEr^(■)Laboratories Inc.LenoirUSA FOrCE Communications IndianapolisUSA

Current practice parameters state that extracts rich in proteases, such as fungal and insect extracts, can be combined during preparation of allergy immunotherapy vaccines. However, until recently, this guideline has not been the subject of investigation. Scientists now have data that shed light on high-protease allergenic extract mixtures used in allergy immunotherapy. A study published in Annals of Allergy, Asthma & Immunology in 2012 reports on the compatibility of combining fungal and insect extracts and emphasizes the importance of understanding how protease activities and total glycerin levels in allergy extracts can affect the stability of allergy immunotherapy vaccine mixtures. This research provides a critical assessment of the mixing compatibilities of several well-characterized high-protease extracts and may influence future immunotherapy practice parameters and immunotherapy extract preparation guidelines.

关键词： Immunotherapy Allergen Extract Compatibility Protease

Crustal Magnetization of Mars: Terra Meridiani and Terra Sirenum

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Journal of Modern Physics 2017年第8期8卷 1275-1293页

作者： renee A. French donna M. Jurdy Department of Earth and Planetary Sciences Northwestern University Evanston IL USA

We examine the crustal magnetization of Terra Meridiani and Terra Sirenum, the region representing the strongest magnetization in the Southern Hemisphere, by downward continuing mapping level data (400 km altitude) from the Mars Global Surveyor (MGS) Magnetometer and Electron reflectometer (MAG/Er). We find that the surface magnetization in both regions can be fit with a small number of sources, with the positive sources stronger than negative ones in both regions. The ratio of the strongest positive to strongest negative source for the regions matches within 2%. For both regions, the locations of strong sources are positioned at the outer rings of ancient impact features. We employ two approaches of source depth estimation. One method employs downward continuation of positive and negative sources from mapping level into the subsurface to extrapolate the depth to magnetization. With this approach, source depths generally range from 80 ±20 km in Terra Meridiani and 65 ±25 km in Terra Sirenum. A graphical approach uses the contour map of surface magnetization to estimate depths ranging from 125 km for thick sources in Terra Meridiani and from 82 km for thick sources in Terra Sirenum. These depths require a low (≤∼20 mW/m2) Martian heat flux to permit magnetite, hematite, and/or pyrrhotite (although limited) as carriers through 100 km or more. The upcoming InSight mission will provide invaluable seismic constraints on both crustal and core structure, in addition to the first Martian heat flow measurements that will constrain magnetization.

关键词： Mars Crustal Magnetization Magnetization Depth InSight Mission Geophysics

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Editorial

CCS Chemistry 2021年第12期3卷 582-584页

作者： Xi Zhang donna J.Minton CCS Publicat Beijing Peoples R China

The Year of the Ox is now upon us,and we are full stride into a new and productive *** optimism is gradually rising as COVID vaccines,developed by researchers in record time,are being administered to populations around the *** with this remarkable accomplishment in medicine,we have recently witnessed great achievements in space exploration,with several successful missions to Mars by China(Tianwen-1 orbiter and soon-to-land Tianwen rover),the United States(NASA Perseverance rover and Ingenuity helicopter),and United Arab Emirates(Hope orbiter).Accomplishments like these show us all that there is infinite excitement and possibility in exploring and understanding our wonderous universe from many different *** also demonstrate to us that scientific research knows no boundaries and boldly pushes ahead in the midst of often trying times.

关键词： universe accomplishment push

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Signs of Love

英语学习 1994年第2期 17-20页

作者： donna C.Moss 夷则

Madeline was a serious girl of 18 when she began discussinglife with her grandmother,who was then *** grandmotherhad very definite ideas about *** example,her grand-mother knew what books and newspapers to read;and sh... 详细信息

关键词：哈得逊 Signs of Love

ADVANCED INTELLIGENT NETWOrK-rEALIZING THE VISION

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ADVANCED INTELLIGENT NETWORK-REALIZING THE VISION

趋磁细菌磁小体及其相关MrI报告基因分子影像学研究

International Conference on Communication Technology(ICCT’94)

作者： donna J.Bastien Bellcore 100 Schultz Drive 5J354 red Bank NJ 07701-6798

＜正＞The Advanced Intelligent Network（AIN） Vision is being realized in North America through multiple releases of AIN,each with the potential for generating impressive *** more releases of AIN are developed,more capabilities are available for creation of new services and customization of existing ones. Development and evolution plans for AIN indicate that the AIN vision will continue to be realized for many more *** this paper,we discuss the motivating factors driving AIN and how the AIN vision is being realized in North America.

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中国医学影像技术 2019年第4期35卷 625-629页

作者：张薇薇 donna E.Goldhawk 李海龙甘肃中医药大学医学影像教研室甘肃兰州730000 罗森健康研究所医学影像项目组西安大略大学医学生物物理学系甘肃中医药大学临床诊断检验教研室甘肃兰州730000 甘肃中医药大学甘肃省中医方药挖掘与创新转化重点实验室甘肃兰州730000

趋磁细菌受基因调控形成纳米Fe_3O_4颗粒——磁小体,自带天然脂性包膜,其独特结构与特性受到分子影像学研究的重视,特别是纯化磁小体在磁性粒子成像中的应用和磁小体相关调控基因在MrI报告基因的分子影像学中的应用。相关研究逐年增多,... 详细信息

趋磁细菌受基因调控形成纳米Fe_3O_4颗粒——磁小体,自带天然脂性包膜,其独特结构与特性受到分子影像学研究的重视,特别是纯化磁小体在磁性粒子成像中的应用和磁小体相关调控基因在MrI报告基因的分子影像学中的应用。相关研究逐年增多,但有关MrI报告基因的研究尚处于初级阶段。本文对趋磁细菌磁小体及其相关基因在MrI报告基因的分子影像学研究进行综述。

关键词：磁小体磁共振报告基因分子影像学

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First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment

2008北京国际生理科学学术大会

作者： LAI donna ALLEN David School of Medical Sciences Bosch instituteUniversity of SydneyAustralia

The sinoatrial node(SAN)is the primary pacemaker of the mammalian *** of the SAN increases exponentially with *** age-related remodelling of pacemaker currents and pacemaker action potential may contribute to age-related slowing of the heart rate and reduction in conduction velocity which result in *** recently discovered that store-operated Ca channel(SOCC)activity is present in the mouse sinoatrial node leading to Ca *** the present study we tested the hypotheses that changes in SOCC activity might play a significant role in aging related SAN *** experiments were carried out in intact mouse SAN preparations from either adult(2 months)or old(>18 months)*** Ca was detected with the fluorescent Ca indicator *** SOCC activity was determined from the influx of Ca following depletion of the sarcoplasmic reticulum Ca *** found that the Ca influx was reduced in old mice compare to adult mice (2 month)(Pral believed that the transient receptor potential channel(TrPCs)gene family are candidates for encoding *** CellDirect one-step qrT-PCr method,we detected a downregulation of the mrNA expression of TrPCs(TrPC1,3,and 4)in the SANs from old mice(20-24 months),compare to the ones from young mice(1 month).However,the differences so far are not *** may reflect limited sample size or increased variability of the reference gene expression in aging mouse *** preliminary data suggest that changes in SOCC activity and expression of TrPC genes might play a role in SAN dysfunction, specifically in the aging heart.

关键词： store-operated Ca2+channel TrPC sinoatrial node aging

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Chinese Science Bulletin 2011年第32期56卷 3361-3371页

作者： HONEr William G LANG donna J KOPALA Lili C MACEWAN G William SMITH Geoffrey N CHEN Eric Y H CHAN raymond C K Department of Psychiatry University of British Columbia Vancouver BC Canada Department of radiology University of British Columbia Vancouver BC Canada Department of Psychiatry Dalhousie University Halifax NS Canada Department of Psychiatry University of Hong Kong Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Extrapyramidal movement disorders are common in chronic schizophrenia, and may be an intrinsic feature of the illness as well as related to antipsychotic drug treatment. Similar dysfunctions at illness onset may have implications for outcome, and for under- standing the mechanisms of illness. The objectives were to examine the clinical correlates of pre-treatment movement disorders at first episode of psychosis, and determine associations with neuropsychological function and striatal structure. Never medicated subjects were recruited from consecutive admissions to Early Psychosis Programs with defined catchment areas in Hong Kong, China, and Halifax, Canada. Standardized clinical, neuropsychological and brain imaging assessments were carried out at baseline and following acute and long term treatment with typical or atypical antipsychotic drugs. At the Hong Kong site, we studied 84 subjects with first episode psychosis (n = 10 with EPS). At the Halifax site, we studied 40 subjects with first episode psychosis (n = 17 with EPS), and 23 healthy comparison subjects. Subjects with movement disorders prior to treatment (EPS+) had higher total PANSS scores at baseline (mean elevation 19.9% Hong Kong, P = 0.016; 14.7% Halifax, P = 0.049). In subjects treated with atypical antipsychotics (all Halifax), EPS+ status at baseline predicted more movement disorders at long term follow up (P = 0.0005). In both cohorts, EPS+ subjects had poorer acute symptomatic treatment response assessed with the PANSS (Hong Kong P = 0.005; Halifax P = 0.017). Neuropsychological impairment related to executive dysfunction appeared greater in a small sam- ple of EPS+ subjects (Hong Kong, effect size 0.26-0.27, P re 4.5% larger in EPS+ compared with EPS-subjects (Halifax P = 0.042), and correlations between striatal volumes and age were different in the EPS+ group. In conclu- sion, pre-treatment EPS is present in a substantial minority of subjects with first episode psych

关键词：药物治疗精神病体外症状运动障碍每股收益神经功能精神分裂症

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Editorial

CCS Chemistry 2022年第12期4卷 2167-2171页

作者： Xi Zhang donna J.Minton 不详 CCS

We have just passed the summer solstice,and for thoseof us in the Northern Hemisphere,summer is in full *** is always a"feel good"time filled with outdoorgatherings under the warmth and radiance of the *** sun does so much for us-from boosting our serotonin levels to being the original source of our food andalmost all energy we consume.

关键词： gathering boosting filled