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Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer

World Journal of Gastroenterology 2018年第8期24卷 905-916页

作者： Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry donna felmlee-devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman Division of Gastroenterology and Hepatology Mayo Clinic Knowledge and Delivery Center Mayo Clinic Biostatistics and Bioinformatics Health Sciences Research Mayo Clinic Division of Biomedical Statistics and Informatics Health Sciences Research Mayo Clinic Biostatistics and Bioinformatics Health Science Research Center for Individualized Medicine Mayo Clinic Department of Biomedical Informatics Arizona State University Primary Care Internal Medicine Mayo Clinic Center for Innovation Mayo Clinic Department of Laboratory Medicine and Pathology Mayo Clinic

AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality.

关键词： Colon cancer Rectal Cancer Advanced adenoma Sessile serrated adenoma High risk polyps Post-polypectomy colorectal cancer

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Editorial

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CCS Chemistry 2024年第5期6卷 266-270页

作者： Zhang Xi Minton donna J 机构不详

“Our responsibility is to do what we can,learn what we can,improve the solutions,and pass them on.”—Richard ***,Nobel Laureate in Physics(1918–1988)With January behind us,we are well into 2024 and life has fallen back into its familiar *** is resuming,and students and professors alike are back in the lab and *** China,there is buzzing excitement for the Spring Festival and coming of the Year of the Dragon on February *** is said that,“龙行龘龘,前程朤朤”or“The dragon strides forward with determination,and the future is bright.”We have much to look forward to in the coming months.

关键词： has dragon Nobel

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Dysregulated bidirectional epithelial-mesenchymal crosstalk:A core determinant of lung fibrosis progression

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 27-33页

作者： Liudi Yao Zijian Xu donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK

Progressive lung fibrosis is characterized by dysregulated extracellular matrix(ECM)***-ing of disease pathogenesis remains limited and has prevented the development of effective *** an abnormal wound-healing response is strongly implicated in lung fibrosis initiation,factors that determine why fi-brosis progresses rather than regular tissue repair occur are not fully *** human lung fibrosis,there is evidence of altered epithelial and mesenchymal populations as well as cells undergoing epithelial-mesenchymal transition(EMT),a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell-cell adhesion to gain migratory *** review will focus on the role of EMT and dysregulated epithelial-mesenchymal crosstalk in progressive lung fibrosis.

关键词： Lung fibrosis Epithelial-mesenchymal transition(EMT) Crosstalk

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LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

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The vanilloid receptor and hypertension

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Acta Pharmacologica Sinica 2005年第3期26卷 286-294页

作者： donna H WANG Department of Medicine College of Human Medicine East Lansing MI 48825 Michigan State University USA

Mammalian transient receptor potential (TRP) channels consist of six related pro-tein sub-families that are involved in a variety of pathophysiological function,anddisease *** TRPV 1 channel,a member of the TRPV sub-family,isidentified by expression cloning using the"hot"pepper-derived vanilloid com-pound capsaicin as a ***,TRPV1 is also referred as the vanilloidreceptor (VR1) or the capsaicin ***1 is mainly expressed in a subpopula-tion of primary afferent neurons that project to cardiovascular and renal *** capsaicin-sensitive primary afferent neurons are not only involved in theperception of somatic and visceral pain,but also have a"sensory-effector"*** the latter,these neurons release stored neuropeptides through a cal-cium-dependent mechanism via the binding of capsaicin to *** most studiedsensory neuropeptides are calcitonin gene-related peptide (CGRP) and substanceP (SP),which are potent vasodilators and natriuretic/diuretic *** evi-dence using the model of neonatal degeneration of capsaicin-sensitive sensorynerves revealed novel mechanisms that underlie increased salt sensitivity andseveralexperimental models of *** mechanisms include insuffi-cient suppression of plasma renin activity and plasma aldosterone levels subse-quent to salt loading,enhancement of sympathoexcitatory response in the face ofa salt challenge,activation of the endothelin-1 receptor,and impaired natriureticresponse to salt loading in capsaicin-pretreated *** data indicate thatsensory nerves counterbalance the prohypertensive effects of several neurohor-monal systems to maintain normal blood pressure when challenged with *** therapeutic utilities of vanilloid compounds,endogenous agonists,and sensory neuropeptides are also discussed.

关键词： TRP family afferent neurons capsaicin calcitonin gene-related peptide substance P vanilloid receptor renin-angiotensin-aldosterone system endothelin,sympathetic nervous system salt-sensitive hypertension

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Neuroimmune actions in the brain and interactions with the effects of alcohol

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Neural Regeneration Research 2021年第9期16卷 1791-1792页

作者： donna L.Gruol Neuroscience Department The Scripps Research InstituteLa JollaCAUSA

The neuroimmune system of the brain:Early studies(1990’s)on the neurological consequences of human immunodeficiency virus-1(HIV-1)infection in the brain were instrumental in establishing that specific brain cell types can function as an innate immune system within the brain and in that role influence cognitive function(Kaul et al.,2005).

关键词： Neuroimmune actions in the brain and interactions with the effects of alcohol

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Increased salt sensitivity induced by sensory denervation: role of superoxide

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Acta Pharmacologica Sinica 2004年第12期25卷 60-66页

作者： Alex F CHEN,donna H WANG Department of Medicine and Pharmacology & Toxicology Michigan State University East Lansing MI 48824 USA Department of Medicine and Pharmacology & Toxicology Michigan State University East Lansing MI 48824 USA

AIM: To test the hypothesis that production of superoxide in mesenteric resistance arteries is increased and con- tributes to the development of hypertension induced by sensory denervation plus high salt intake. METHODS: Newborn Wistar rats were given capsaicin 50 mg/kg sc on the 1st and 2nd d of life. After weaning, male rats were grouped as follows and treated for 3 weeks with: capsaicin pretreatment plus normal sodium diet (0.5 %, CAP-NS), CAP plus high sodium diet (4 %, CAP-HS), control plus NS (CON-NS), or CON-HS. Both tail-cuff systolic blood pressure and mean arterial pressure (MAP) were measured in each of the groups. Western blot analysis was used for measurement of manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) in the mesenteric resistance arteries. Lucigenin chemiluminescence assay was used for superoxide production in the mesenteric resistance arteries. The Griess method was used for measurement of nitrite/nitrate levels in plasma. RESULTS: Both tail-cuff pressure and MAP were higher in CAP-HS compared with CAP-NS, CON-HS, and CON- NS rats (P<0.05). Both MnSOD and eNOS in the mesenteric resistance arteries were increased in CAP-HS compared with CAP-NS, CON-HS, and CON-NS (P<0.05). However, nitrite/nitrate levels in plasma were not different among 4 groups. Acute iv administration of tempol, a membrane-permeable superoxide scavenger, de- creased MAP in both CAP-HS and CON-HS when compared with their respective controls. However, the de- creases of MAP between these two groups were not different. Chronic treatment with tempol failed to prevent the development of hypertension in CAP-HS rats. Superoxideproduction in the mesenteric resistance arteries was increased in CAP-HS compared with CAP-NS, CON-HS, and CON-NS (P<0.05). However, chronic treatment with tempol did not prevent the increase of mesenteric superoxideproduction in CAP-HS rats. CONCLUSIONS: Regardless of increased vascular MnSOD levels, salt

关键词： superoxides tempol afferent neurons capsaicin denervation dietary sodium chloride nitric oxide

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Energy tunnels:concept and design aspects

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Underground Space 2018年第4期3卷 268-276页

作者： Marco Barla Alice Di donna Department of Structural Building and Geotechnical EngineeringPolitecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

Geotechnical structures are increasingly employed as energy geostructures in Europe and *** being constructed for their primary structural role,they are equipped to exchange heat with the ground and supply thermal energy for heating and cooling of buildings and de-icing of *** technology can play a fundamental role in the current challenge of addressing the increasing need for clean and renewable sources of *** study investigates the possibility of thermal activation of tunnel ***,attention will be paid on a new energy segment,which can be used together with tunnel boring machine tunneling to create so-called energy *** and mechanical designs need to be developed by making effective use of computational methods to quantify the exploitable heat and assess the possible consequences on the surrounding ground and the structure *** on how to proceed in this direction will be provided in this study,showing how thermo-hydro and thermo-mechanical numerical analyses can be used to achieve a proper and effective design of energy *** examples of possible applications will also be presented.

关键词： Energy tunnel Geothermal energy Heating and cooling Geotechnical design

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High energy femtosecond mid-infrared generation pumped by a two-color Ti:sapphire multipass amplifier

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Chinese Science Bulletin 2008年第5期53卷 664-670页

作者： donna T. Strickland Department of Physics Guelph-Waterloo Physics Institute University of Waterloo 200 University Ave. W. Waterloo Ontario N2L 3G1 Canada

Intense mid-infrared was generated by direct frequency mixing two pulses from a dual-wavelength Ti:sapphire system. From a multipass amplifier we generated two tunable wavelength femtosecond pulses with a total energy of 15 mJ. Pulse energy of 1.6 μJ and 7.4 μJ of mid-infrared light is achieved with and without its multipass amplifier at 9-11 μm, with pulse duration of 500 fs.

关键词：兰宝石激光器红外激光远红外激光超速激光激光放大器

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Markov cellular automata models for chronic disease progression

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International Journal of Biomathematics 2015年第6期8卷 259-280页

作者： Jane Hawkins donna Molinek Department of Mathematics University of North Carolina at Chapel HillCB #3250 Chapel Hill North Carolina 27599-3250 USA Department of Mathematics and Computer Science Davidson College Davidson North Carolina 28035 USA

We analyze a Markov cellular automaton that models the spread of viruses that often progress to a chronic condition, such as human immunodeficiency virus （HIV） or hep- atitis C virus （HCV）. We show that the complex dynamical system produces a Markov process at the later stages, whose eigenvectors corresponding to the eigenvalue 1 have physical significance for the long-term prognosis of the virus. Moreover we show that drug treatment leads to chronic conditions that can be modeled by Markov shifts with more optimal eigenveetors.

关键词： HIV cellular automata Markov process HCV.

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