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Activation of the wnt/β-catenin/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia/reperfusion conditions

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Neural Regeneration Research 2024年第7期19卷 1541-1547页

作者： Xingyong Chen Nannan Yao Yanguang Mao dongyun xiao Yiyi Huang Xu Zhang Yinzhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Cangzhou Central HospitalCangzhouHebei ProvinceChina Fujian Academy of Medical Science FuzhouFujian ProvinceChina Key Testing Laboratory of Fujian Province FuzhouFujian ProvinceChina

Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain barrier.However,the potential links between them following ischemic stroke remain largely unknown.The present study found that cerebral ischemia leads to oxidative stress and repression of the Wnt/β-catenin pathway.Meanwhile,Wnt/β-catenin pathway activation by the pharmacological inhibito r,TWS119,relieved oxidative stress,increased the levels of cytochrome P4501B1(CYP1B1)and tight junction-associated proteins(zonula occludens-1[ZO-1],occludin and claudin-5),as well as brain microvascular density in cerebral ischemia rats.Moreove r,rat brain microvascular endothelial cells that underwent oxygen glucose deprivation/reoxygenation displayed intense oxidative stress,suppression of the Wnt/β-catenin pathway,aggravated cell apoptosis,downregulated CYP1B1and tight junction protein levels,and inhibited cell prolife ration and migration.Overexpression ofβ-catenin or knockdown ofβ-catenin and CYP1B1 genes in rat brain mic rovascular endothelial cells at least partly ameliorated or exacerbated these effects,respectively.In addition,small interfering RNA-mediatedβ-catenin silencing decreased CYP1B1 expression,whereas CYP1B1 knoc kdown did not change the levels of glycogen synthase kinase 3β,Wnt-3a,andβ-catenin proteins in rat brain microvascular endothelial cells after oxygen glucose deprivatio n/reoxygenation.Thus,the data suggest that CYP1B1 can be regulated by Wnt/β-catenin signaling,and activation of the Wnt/β-catenin/CYP1B1 pathway contributes to alleviation of oxidative stress,increased tight junction levels,and protection of the blood-brain barrier against ischemia/hypoxia-induced injury.

关键词： blood-brain barrier CYP1B1 oxidative stress oxygen glucose deprivation/reoxygenation tight junction vascular endothelial cells Wnt/β-catenin pathway β-catenin

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A comparative investigation on wear behaviors of physical and chemical vapor deposited bronze coatings for hydraulic piston pump

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Chinese Journal of Aeronautics 2024年第3期37卷 391-403页

作者： Wei HAO Andrews LARBI Hongkang DONG dongyun WANG Shenghu LI Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology and Equipment Zhejiang Normal UniversityJinhua 321004China College of Engineering Zhejiang Normal UniversityJinhua 321004China Hangzhou Lilong Hydraulic Co. LtdHangzhou 311200China

The cylinder block/valve plate interface is one of the most critical frictional interfaces of the swashplate-type axial piston pump.However,the poor lubrication interface caused rapid wear and high friction loss in an elastohydrodynamic lubrication system,decreasing the pump lifetime.Wear resistant bronze coatings were fabricated on 38CrMoAl substrate by Physical Vapor Deposition(PVD)and Chemical Vapor Deposition(CVD),respectively.Ball-on-disc wear tests were performed to comparatively investigate the wear behaviors of the coatings and bulk ductile iron samples.It can be found that the PVD-bronze coating exhibited better wear resistance than the other two samples.This enhanced wear resistance was attributed to the unique composite microstructure and desired mechanical strength,which could resist to mechanical shear and spallation,decreasing friction loss.The appropriate hardness of(1.33±0.07)GPa could be beneficial for enhancing its wear resistance.The PVD-bronze coating possessed a much lower and stable coefficient of friction(about 0.1)and wear rate(about 6000μm3.N-1.m-1)under the loading forces of about 100 N after 20 min.The wear mechanism was the abrasive wear.

关键词： Aircraft hydraulic pump Bronze Coatings Wear resistance Mechanisms

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Toughened (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composites fabricated by one-step reactive sintering with a unique SiB_(6) additive

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Journal of Advanced Ceramics 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe Lu Ling Li Tao Wang Guoliang Ren Huangyue Cai xiaofeng Zhao dongyun Wang Na Ni Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology&Equipment Zhejiang Normal UniversityZhejiang 321004China Key Lab of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent years.However,the low toughness and damage tolerance limit its applications as ultra-high-temperature structural materials.Here we report that a unique SiB_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite though one-step boro/carbothermal reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and SiC secondary phase retarded the grain growth of the(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–51SiC composites.The small grain size was beneficial to shorten the diffusion path for mass transport,thereby enhancing the relative density to~99.3%.These results in an increase of fracture toughness from~5.2 in HEBS-1900 to~7.7 MPa·m^(1/2) in HEBS-2000,which corresponded to a large improvement of 48%.The improvement was attributed to a mixed mode of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from balanced grain boundary strength collectively affected by improved densification,solid solution strengthening,and incorporation of SiC secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbothermal reduction reactive sintering fracture toughness

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中国人工智能研究热点与趋势——基于中文社会科学引文索引(CSSCI)论文的分析

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科技管理研究 2024年第10期44卷 1-12页

作者：朱东云褚建勋中国科学技术大学科技哲学系安徽合肥230026

人工智能对伦理、创新、教育和法律带来的影响日益凸显,但传统上关于人工智能的研究多以定性为主、少有数据分析,少数定量研究关注的维度较为单一。为更准确地把握人工智能研究的前沿热点,对发表于中文社会科学引文索引(CSSCI)数据库中2... 详细信息

人工智能对伦理、创新、教育和法律带来的影响日益凸显,但传统上关于人工智能的研究多以定性为主、少有数据分析,少数定量研究关注的维度较为单一。为更准确地把握人工智能研究的前沿热点,对发表于中文社会科学引文索引(CSSCI)数据库中2017—2023年有关人工智能的文献进行计量分析和系统评述,运用文献分析软件,对文献发表时间、出版期刊、核心作者、发文机构等方面进行可视化分析和知识图谱分析,识别出关于人工智能研究领域的热点。结果发现:中国人工智能的有关研究在2017年进入发展期,2018年进入爆发期,主要从哲学、管理学、教育学和法学的角度开展;人工智能伦理、管理方式变革、教育管理与政策以及人工智能的法律规制成为当前人工智能研究的主要内容;未来人工智能的热点前沿主要包括人工智能与数字经济的结合、人工智能发展的伦理困境、人工智能机器的地位辨析和人工智能对劳动力市场的影响等议题;未来学术界关于人工智能的研究重点会随着技术的进一步迭代和政策的持续深化而变化,研究主题会更为集中且向纵深发展,从识别一般规律到探寻具体对象的可操作化路径,研究路径从理论探索到实践指引演化。

关键词：人工智能知识图谱研究热点发展趋势文献计量文献述评

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饮品:厄德里克《守夜人》中的印第安族裔身份政治隐喻

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河南大学学报（社会科学版） 2024年第2期64卷 72-77,154页

作者：于冬云李曦山东师范大学文学院山东济南250014

饮食与族裔身份政治关系密切,是文化批评的一个重要考察维度。美国女作家露易丝·厄德里克的长篇小说《守夜人》中有大量与印第安人饮食相关的叙述,其中的饮品叙述更是构成了复杂、动态的印第安族裔身份政治隐喻:小说人物对饮品的称呼... 详细信息

饮食与族裔身份政治关系密切,是文化批评的一个重要考察维度。美国女作家露易丝·厄德里克的长篇小说《守夜人》中有大量与印第安人饮食相关的叙述,其中的饮品叙述更是构成了复杂、动态的印第安族裔身份政治隐喻:小说人物对饮品的称呼、态度及饮用细节,隐含着厄德里克对美国社会族裔身份政治的思考,酒与咖啡等外来饮品指涉印第安人在现代社会中遭遇的危机与挑战,以及他们现代身份的多重杂糅状态,茶、水与树汁等自然之水则帮助土著人获得身份认同,找到心灵归属,作家本人也借此达成文学审美救赎。

关键词：露易丝·厄德里克饮品族裔身份政治隐喻

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Erratum to:Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 360-360页

作者： Jinru WENG Shuo YANG Jinkang SHEN Hongsen LIU Yuzi XU dongyun HAO Shan WANG Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhou 310000China Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education Jilin UniversityChangchun 130021China Institute of Agricultural biotechnology Jilin Academy of Agricultural Sciences(JAAS)Changchun 130033China

Erratum to:J Zhejiang Univ-Sci B(Biomed&Biotechnol)202324(10):883-895 https://doi.0rg/10.1631/jzus.B2200634.The original version of this article(Weng et al.,2023)unfortunately contained a mistake.In Acknowledgments,the number(No.226-2022-00213)of the Fundamental Research Funds for the Central Universities is wrong.The correct number should be No.2022FZZX01-33.

关键词： mechanism dynamics Molecular

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May Traditional Chinese Medicine Reduce the Risk of Developing Rheumatoid Arthritis?An One-armed Prospective Study

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 10-18页

作者： Kaixin Gao Qi Liang dongyun Li Chuanning Li Maojie Wang Xiumin Chen Qingchun Huang Zehuai Wen Per-Johan Jakobsson Runyue Huang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510006GuangdongChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510006GuangdongChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120GuangdongChina Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510403GuangdongChina Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou 510000GuangdongChina The key unit of methodology of clinical research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000GuangdongChina Rheumatology Unit Department of Medicine SolnaKarolinska InstituteKarolinska University HospitalStockholm 17177Sweden Department of Doctor-Patient Relationship The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongChina

Background:Rheumatoid arthritis(RA)is a worldwide public health problem.Intervention and prevention before the onset of rheumatic diseases is a new direction in current research.Objective:The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine(TCM)in the prevention of RA.Methods:This was a single-armed prospective clinical trial.All participants were recruited from a single center in Guangdong,China.Adults who were tested positive for anti-cyclic citrullinated peptide antibody(anti-CCP)and/or rheumatoid factor(RF),had no synovitis and never been treated with disease-modifying anti-rheumatic drugs(DMARDs),were enrolled to take the Huayu-Qiangshen-Tongbi(HQT)decoction orally twice daily,200 mL each time for 24 weeks.Primary outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism)classification criteria of RA during observation.Secondary outcomes included levels of anti-CCP,RF,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),assessment of signs and symptoms,and radiographic progression by magnetic resonance imaging(MRI).Results:19 individuals were enrolled in the study,4 of which withdrew because of the epidemic of COVID-19.During the observation period,3 individuals(20%)developed RA and they had longer morning stiffness(P=0.009)and more obvious synovial enhancement in MRI(P=0.041)at baseline when compared with those who did not develop RA.After 24 weeks of intervention,there were improvements in 28-swollen joint count(SJC28)(P=0.046),Visual Analog Scale(VAS)(P=0.019),Patient’s Global Assessment(PtGA)(P=0.019)and Physician’s Global Assessment(PGA)(P=0.031),but no statistical significance was observed in the levels of anti-CCP,RF,ESR,CRP,morning stiffness,28-tender joint count(TJC28),Health Assessment Questionnaire(HAQ)and magnetic resonance imaging(MRI)analysis(P>0.05).Conclusion:The HQT formula is safe and could improve joint symptoms and signs in these at-risk individuals,but it remains

关键词： Rheumatoid arthritis(RA) Prevention Traditional Chinese medicine(TCM) Huayu-Qiangshen-Tongbi decoction(HQT) Clinical trial

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基于GeoGebra曲线的图案设计及其应用

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毛纺科技 2024年第3期52卷 81-87页

作者：朱永慧刘冬云张毅江南大学设计学院江苏无锡214122

为提升图案设计效率、丰富图案设计方法,基于GeoGebra软件进行图形提取和二次设计。在GeoGebra软件中调节曲线表达式中的参数数值,使曲线产生动态变化并生成曲线图形。根据图形构成特征进行因子提取,引入形状文法将所提取因子进行重构... 详细信息

为提升图案设计效率、丰富图案设计方法,基于GeoGebra软件进行图形提取和二次设计。在GeoGebra软件中调节曲线表达式中的参数数值,使曲线产生动态变化并生成曲线图形。根据图形构成特征进行因子提取,引入形状文法将所提取因子进行重构并构建设计因子库,最后结合图案设计理念对设计因子库的可行性进行验证。研究表明:对GeoGebra曲线进行因子提取与重构,可以将数字化图形的生成方式融入图案设计中;运用设计因子库进行图案设计,将创新图案应用于设计实践,可以实现现代图案的创新设计,丰富图案设计方式在产品中的表达。

关键词：数学曲线图形 GeoGebra 提取与重构设计因子库图案设计

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风险管理策略的护理干预模式在妇科恶性肿瘤化疗患者中的应用效果

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实用妇科内分泌电子杂志 2024年第14期11卷 108-110页

作者：刘东云南京医科大学第四附属医院京新院区妇科江苏南京210031

目的分析妇科恶性肿瘤化疗患者接受风险管理策略护理干预的效果。方法选择进行妇科恶性肿瘤化疗的患者50例,采用随机数字表法分为对照组及观察组。对照组25例采用常规护理,观察组25例采用风险管理策略的护理干预模式。对比两组患者对于... 详细信息

目的分析妇科恶性肿瘤化疗患者接受风险管理策略护理干预的效果。方法选择进行妇科恶性肿瘤化疗的患者50例,采用随机数字表法分为对照组及观察组。对照组25例采用常规护理,观察组25例采用风险管理策略的护理干预模式。对比两组患者对于化疗风险护理的满意度,并对比两组患者化疗期间的不良反应发生情况。结果观察组各项护理满意度评分均明显高于对照组(P<0.05)。在化疗期间的不良反应发生率方面,观察组的4.00%低于对照组的24.00%(P<0.05)。结论在妇科恶性肿瘤化疗患者中实施风险管理策略护理干预模式的效果良好,可明显提高患者的满意度,降低化疗期间风险事件的发生率,值得临床推广使用。

关键词：风险管理策略护理干预模式妇科恶性肿瘤

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基于语义Web的金融类创新创业网络资源反批量爬取方法

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计算机应用文摘 2024年第13期40卷 165-168页

作者：郭冬云广西现代职业技术学院广西河池547000

传统的金融类创新创业网络资源反批量爬取方法存在一些问题,如只能提取相同频率成分的原始网络资源数据,导致数据不完整,且反批量爬取所需时间较长。因此,设计了一种基于语义Web的金融类创新创业网络资源反批量爬取方法。该方法将网络... 详细信息

传统的金融类创新创业网络资源反批量爬取方法存在一些问题,如只能提取相同频率成分的原始网络资源数据,导致数据不完整,且反批量爬取所需时间较长。因此,设计了一种基于语义Web的金融类创新创业网络资源反批量爬取方法。该方法将网络资源数据的初始信息加入到语义Web中,并进行调度、解析互连信息,成功获取网络资源数据。随后,将已获取的原始网络资源信息转换到小波域,从中抽取可能涉及的各个频谱成分,实现了对网络资源信息的分时分频,去除了噪声。以非线性时间顺序为节点,形成对应的反批量爬取空间布局,确保在抓取时对金融类创新创业网络资源进行全面检索。同时,利用内置的脚手架命令构建项目架构,生成自定义反批量爬取文件,运行反批量爬取命令,成功实现了基于语义Web的金融类创新创业网络资源反批量爬取。实验结果表明,设计的基于语义Web的金融类创新创业网络资源反批量爬取方法具有较高的效率,反批量爬取时间小于60s,更适合用于金融类创新创业网络资源的反批量爬取。

关键词：语义 Web 网络资源

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