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基于功能近红外光谱的跨受试心理任务识别的深度迁移学习方法

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生物医学工程学杂志 2024年第4期41卷 673-683页

作者：张耀刘东远高峰天津大学精密仪器与光电子工程学院天津300072 天津市生物医学检测技术与仪器重点实验室天津300072

在基于功能近红外光谱(fNIRS)的脑-机接口(BCI)领域中,传统的受试特定解码方法存在校准时间长和跨受试泛化性低等问题,从而限制了BCI系统在日常生活和临床领域中的推广和应用。为解决上述困境,本文提出了一种新颖的深度迁移学习方法,该... 详细信息

在基于功能近红外光谱(fNIRS)的脑-机接口(BCI)领域中,传统的受试特定解码方法存在校准时间长和跨受试泛化性低等问题,从而限制了BCI系统在日常生活和临床领域中的推广和应用。为解决上述困境,本文提出了一种新颖的深度迁移学习方法,该方法联合了改进型启发式残差网络(rIRN)模型和基于模型的迁移学习(TL)策略,简称TL-rIRN。本文开展了跨受试识别心算和心唱任务的试验,以验证TL-rIRN方法的有效性和优越性。结果表明,相较于受试特定解码方法和其他深度迁移学习方法,TL-rIRN方法显著缩短了校准时间,减少了目标模型的训练时间和计算资源的消耗,并增强了跨受试解码性能。综上,本研究为fNIRS-BCI系统的跨受试、跨任务以及实时解码算法的选择提供了依据,在构建便捷通用型BCI系统方面具有潜在应用价值。

关键词：功能近红外光谱脑-机接口深度迁移学习跨受试解码改进型启发式残差网络

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经皮椎体成形后邻近椎体压缩骨折的危险因素

中国组织工程研究 2024年第36期28卷 5884-5891页

作者：柳栋元关海山史浩冉刘晓亮周浩盛山西医科大学第二附属医院骨科山西省太原市030001

背景:经皮椎体成形术是治疗骨质疏松性椎体压缩骨折应用最广泛的方法,多数研究认为经皮椎体成形术会增加继发性邻近椎体压缩骨折的概率。然而,对于经皮椎体成形术后引起的邻椎再骨折相关危险因素仍然存在争议。目的:归纳并总结骨质疏松... 详细信息

背景:经皮椎体成形术是治疗骨质疏松性椎体压缩骨折应用最广泛的方法,多数研究认为经皮椎体成形术会增加继发性邻近椎体压缩骨折的概率。然而,对于经皮椎体成形术后引起的邻椎再骨折相关危险因素仍然存在争议。目的:归纳并总结骨质疏松性椎体压缩骨折患者行经皮椎体成形术后邻近椎体再发骨折的影响因素,为降低其发生风险以及制定相应治疗方案提供一定的参考。方法:以“骨质疏松症,骨折,经皮椎体成形术,邻近椎体压缩骨折,危险因素”为中文检索词,以“osteoporosis,osteoporotic vertebral compression fractures,percutaneous vertebroplasty,adjacent vertebral compression fractures,risk factors”为英文检索词,应用计算机检索中国知网、万方医学网、维普、PubMed、Springer、ScienceDirect及Elsevier数据库收录的相关文献。检索时限重点为2018年1月至2023年9月,同时纳入少数经典远期文献。通过阅读文题和摘要进行筛选,最终纳入83篇文献进行综述。结果与结论:(1)骨质疏松性椎体压缩骨折是骨质疏松症最常见的并发症之一,使老年患者致残和死亡的风险显著增加。经皮椎体成形术是治疗骨质疏松性椎体压缩骨折切实有效的方法。(2)随着经皮椎体成形术的普及,继发椎体压缩性骨折也逐渐增多,以邻近椎体压缩骨折最为常见。(3)以往的研究仅讨论了骨密度、多发椎体骨折、身体质量指数、年龄、性别、骨水泥的用量、骨水泥渗漏及抗骨质疏松治疗等因素对经皮椎体成形术后继发邻近椎体压缩骨折的影响,而对于椎体骨折数量、手术时机、手术方式、骨水泥材料、骨水泥弥散分布、伤椎恢复高度和术后佩戴支具等方面总结的尚不全面,并且对危险因素引起邻椎骨折的具体机制分析也较为少见。(4)文章结果表明,骨密度过低、高龄、围绝经期女性、多发椎体骨折、伤椎高度的过度恢复、骨水泥渗漏、合并基础疾病及不良的生活习惯是经皮椎体成形术后继发邻近椎体压缩骨折的危险因素,保持正常的身体质量指数、早期手术、双侧经皮椎体成形术、使用新型骨水泥材料、适宜的骨水泥注射体积、均匀的骨水泥弥散分布、规律抗骨质疏松治疗和术后佩戴支具是经皮椎体成形术后继发邻近椎体压缩骨折的保护因素。

关键词：骨质疏松症骨折经皮椎体成形术邻近椎体压缩性骨折危险因素骨密度骨水泥高龄女性抗骨质疏松治疗

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足下垂型腰椎退行性疾病研究进展

国际骨科学杂志 2024年第3期45卷 199-202页

作者：周浩盛柳栋元刘晓亮关海山山西医科大学第二临床医学院山西太原030000

腰椎退行性疾病是脊柱外科常见疾病,而由腰椎退行性疾病引起的足下垂也屡见不鲜。近年来,对于腰椎退行性疾病所致足下垂的基础及临床研究取得了新进展,其治疗方式主要包括腰椎减压手术、足踝矫形手术及康复疗法等。在许多腰椎减压治疗中... 详细信息

腰椎退行性疾病是脊柱外科常见疾病,而由腰椎退行性疾病引起的足下垂也屡见不鲜。近年来,对于腰椎退行性疾病所致足下垂的基础及临床研究取得了新进展,其治疗方式主要包括腰椎减压手术、足踝矫形手术及康复疗法等。在许多腰椎减压治疗中,足下垂时间、胫骨前肌肌力、疼痛情况、足下垂病因、患者年龄等因素与疾病预后有一定相关性。该文对腰椎退行性疾病所致足下垂的定义及诊断标准、损伤机制、治疗及影响预后的因素等进行综述。

关键词：足下垂腰椎退行性疾病胫骨前肌手术治疗

A cost accounting method of the Li-ion battery energy storage system for frequency regulation considering the effect of life degradation

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Protection and Control of Modern Power Systems 2018年第1期3卷 43-51页

作者： Gangui Yan dongyuan liu Junhui Li Gang Mu Department of Electrical Engineering Northeast Electric Power UniversityJilinChina

The cost of Energy Storage System(ESS)for frequency regulation is difficult to calculate due to battery’s degradation when an ESS is in grid-connected *** solve this problem,the influence mechanism of actual operating conditions on the life degradation of Li-ion battery energy storage is analyzed.A control strategy of Li-ion ESS participating in grid frequency regulation is constructed and a cost accounting model for frequency regulation considering the effect of battery life degradation is *** estimated operating life and annual average cost of the Li-ion ESS under different dead bands and SOC set-points are *** case studies show that the estimated operating life of the Li-ion ESS under the actual operating condition differs significantly from the nominal life provided by the manufacturer under the standard condition and the full discharge *** paper provides an accurate costing method for the ESS participating in grid frequency regulation to help the promotion of the ESS to participate in the ancillary service market.

关键词： Energy storage system Estimated operating life Cost accounting method Frequency regulation Dead band

Effects and mechanisms of three kinds of chemical inducers on the expression of rat GST-P gene

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Chinese Science Bulletin 2000年第8期45卷 725-729页

作者： Mingxiang Liao dongyuan liu Jin Zuo Hongyun Zhang Fude Fang Chinese Acad Med Sci Peking Union Med Coll Inst Basic Med Sci Natl Lab Med Mol Biol Beijing 100005 Peoples R China

The expression of rat Glutathione S-transferase P (GST-P) gene can be induced by many kinds of chemical inducers. We have studied the mechanisms of the expression of GST-P gene induced by 3 kinds of Chemical inducers using the induction of the gene expression by chemical inducers, transient transfection, reporter gene assays, electrophoretic mobility shift assays (EMSA) and Northern blot analysis. The results indicate that the effects and mechanisms of chemical inducers on the expression of GS7'-Pgene are different. The interaction of AP-1 or other corresponding transcription factors activated by phorbol ester (TPA) or glycidyl methatylate (GMA) and GPEl enhancer element induces the expression of GST-P gene, while some unknown factors activated by H2O2 interact with GPEII enhancer element.

关键词： glutathione S-transferase P chemical inducers control of gene expression.

Pd/N-doped carbon dots@dendritic mesoporous silica nanospheres:A highly efficient catalyst for the hydrogenation of 4-nitrophenol

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Nano Research 2024年第9期17卷 7967-7974页

作者： Weiruo liu Yanbin Zhu Jiwei Wang Haisong Feng Yunpu Zhai Wei Li dongyuan Zhao College of Chemistry Zhengzhou University100 Kexue AvenueZhengzhou 450001China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative Materialsand State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Highly dispersed Pd/N-doped carbon dots(Pd/NCDs)were successfully immobilized in the mesoporous channels of amino-functionalized dendritic mesoporous silica nanospheres(NMS).The synthesized Pd/NCDs@NMS catalyst exhibits outstanding performance in the catalytic reduction of 4-nitrophenol(4-NP),achieving a turnover frequency of 1461.8 mol·molPd^(-1)·h^(-1),with the conversion rate remaining above 80%after 11 *** and density functional theory calculations reveal that the NCDs significantly affect the electronic structure of Pd nanoparticles,leading to changes in the energy barriers for the adsorption of 4-NP at the Pd sites and the conversion of 4-NP reaction intermediates,which is a key factor contributing to the catalytic *** study offers a new strategy for synthesizing carbon-dot-modified metal-based catalysts.

关键词： palladium nanoparticles nitrogen-doped carbon dots dendritic mesoporous silica catalytic hydrogenation 4-nitrophenol reduction

CAS-R-2无框架脑立体定向仪辅助钻孔引流术治疗高血压基底节区脑出血60例临床疗效分析

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中国医师进修杂志 2024年第7期47卷 631-635页

作者：刘东远王浩王森侯哲邰军利张洪兵首都医科大学附属北京潞河医院神经外科北京101149

目的探讨CAS-R-2无框架脑立体定向仪辅助钻孔引流术在高血压基底节区脑出血治疗中的意义。方法回顾性分析2018年1月至2022年12月首都医科大学附属北京潞河医院60例行CAS-R-2无框架脑立体定向仪辅助钻孔引流术治疗的高血压基底节区脑出... 详细信息

目的探讨CAS-R-2无框架脑立体定向仪辅助钻孔引流术在高血压基底节区脑出血治疗中的意义。方法回顾性分析2018年1月至2022年12月首都医科大学附属北京潞河医院60例行CAS-R-2无框架脑立体定向仪辅助钻孔引流术治疗的高血压基底节区脑出血患者的临床资料。记录手术相关指标和不良反应。术后6个月随访,采用格拉斯哥预后评分(GOS)评估预后。结果60例患者均顺利完成CAS-R-2无框架脑立体定向仪辅助钻孔引流术。手术时间(53±18)min;术后穿刺道血肿2例(3.3%),保守治疗后均吸收;术后脑内血肿均无扩大;术后保持引流管时间≤2 d 44例(73.3%),3~4 d 16例(26.7%),术后均未出现颅内感染;术后合并重症肺炎15例(25.0%),因重症肺炎合并多器官功能衰竭死亡2例(3.3%)。术后随访6个月,良好17例(28.3%),轻度残疾19例(31.7%),重度残疾16例(26.7%),植物生存状态6例(10.0%),死亡2例(3.3%)。结论CAS-R-2无框架脑立体定向仪辅助钻孔引流术治疗高血压基底节区脑出血具有操作简便、定位准确、创伤小及并发症少等特点,是治疗高血压基底节区脑出血的一种安全有效的方法。

关键词：颅内出血,高血压性脑血管基底神经节出血引流术无框架立体定向

Amphipathicity mediated endocytosis of mesoporous silica nanoparticles with tunable frameworks

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Nano Research 2024年第9期17卷 8350-8359页

作者： Runfeng Lin Tiancong Zhao Liang Chen Minchao liu Hongyue Yu Ruicong Wang Minjia Yuan Xiaomin Li dongyuan Zhao Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Shanghai Qiran Biotechnology Co. Ltd.Shanghai 201702China

Due to the amphiphilic nature of phospholipids in the cell membrane,the amphipathicity of the nanomedicine plays a crucial role in the ***,limited biological characterization methods restrict the study of the state of nanoparticles with different amphiphilicities on cell *** understanding of interaction of amphiphilic particle with cell membrane is still ***,by combining the dissipative particle dynamics(DPD)with the framework construction of mesoporous silica nanoparticles(MSNs),we demonstrate the enhanced endocytosis induced by the *** results confirm that the presence of hydrophobic groups on the surface of nanoparticles can disturb the integrity of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)membrane and induce activation of phospholipids to a higher energy level,thereby facilitating the wrapping of *** validate the simulation findings,uniform MSNs with hydrophilic pure silica framework and two types of amphiphilic MSNs with varying hydrophilic organic groups in the framework are rationally synthesized by using different silane *** obtained three kinds of MSNs show similar diameter(~100 nm)and mesopores(~2 nm),but distinct hydrophobicity/hydrophilicity *** phenyl-bridged MSN with a carbon content of 27.1%exhibits enhanced cellular uptake,consistent with the theoretical simulation *** work sheds light on how the surface amphipathicity influences endocytosis through the interaction with cell membrane.

关键词： mesoporous silica nanoparticles mesoporous organosilica endocytosis cell membrane amphipathicity

Application of Combined Cycle in Modernized Retrofit of Old Thermal Power Plants

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Electricity 2000年第2期 37-41页

作者： Jia Nansong liu dongyuan Longyuan Electric Power Group Corporation

This article expounds the advantages and three schemes of applying combined cycle to the modernized retrofit of old thermal power plants. Through analyzing and comparing technical economics of these three schemes, it is concluded that to use feedwater heating and heat recovery steam generator (HRSG) is suitable for the units with unit capacity below 100 MW, while to use exhaust gas reburning is suitable for units with unit capacity of 125 MW, 200 MW and above.

关键词： combined cycle retrofit of old thermal power plants analysis of technical economy