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红景天苷对AD模型小鼠大脑线粒体功能和海马细胞增殖的影响

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广西中医药 2024年第3期47卷 61-66页

作者：廖冬燕李宝莹彭莉芹盛宏丽甘绣凤黄钟颖屈泽强广西中医药大学基础医学院广西南宁530200 广西中医药大学瑞康临床医学院广西南宁530011 广西高发传染病中西医结合转化医学重点实验室广西南宁530200 广西特色实验动物模型重点实验室广西南宁530200

目的:探讨红景天苷对D-半乳糖联合亚硝酸钠注射所致AD模型小鼠大脑组织线粒体功能和海马齿状回细胞增殖的作用。方法:将45只小鼠随机分为正常组、模型组、红景天苷组,每组15只。红景天苷组、模型组小鼠每日腹腔注射亚硝酸钠(50 mg/kg)... 详细信息

目的:探讨红景天苷对D-半乳糖联合亚硝酸钠注射所致AD模型小鼠大脑组织线粒体功能和海马齿状回细胞增殖的作用。方法:将45只小鼠随机分为正常组、模型组、红景天苷组,每组15只。红景天苷组、模型组小鼠每日腹腔注射亚硝酸钠(50 mg/kg)和皮下注射D-半乳糖(150 mg/kg),连续造模60 d,正常组则进行腹腔和皮下注射等体积生理盐水。造模期间,红景天苷组小鼠同时皮下注射红景天苷(40 mg/kg),正常组和模型组小鼠注射等体积生理盐水。给药结束后,检测小鼠大脑组织线粒体功能和海马齿状回神经干细胞增殖水平。采用JC-1荧光探针检测线粒体膜电位,采用Clark-type氧电极法测定线粒体呼吸控制率(RCR),采用荧光素酶生物化学发光法检测腺苷三磷酸(ATP)含量,以BrdU标记增殖细胞并采用BrdU免疫组化技术检测海马干细胞增殖水平。结果:与正常组比较,模型组小鼠大脑线粒体膜电位水平、RCR和ATP含量明显降低,BrdU阳性细胞计数明显减少,差异有显著性意义(P<0.05);与模型组比较,红景天苷组小鼠大脑线粒体膜电位水平、RCR和ATP含量明显升高,BrdU阳性细胞计数明显增加,差异有显著性意义(P<0.05)。结论:红景天苷对AD模型小鼠脑组织线粒体功能具有一定程度的保护作用,能改善海马齿状回颗粒下层细胞增殖水平,提示其可能具有促进神经发生的作用。

关键词：红景天苷老年性痴呆线粒体功能海马细胞神经发生实验研究

南水北调进京后平谷平原区地下水资源调蓄涵养研究

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北京水务 2024年第2期 23-28页

作者：张景华杨利锦王新娟李阳卢艳华张冬燕孙少游北京市工程地质研究所北京100048 北京市水文地质工程地质大队北京100195 北京市平谷区水务局北京101299 北京市市政工程设计研究总院有限公司北京100082

在南水北调进京前,平谷平原区属于地下水超采区。“南水”进京后,为了加快恢复平谷区地下水资源储量,在分析区域水文地质条件、地下水动态及可利用回补水源等基础上,制订了2种地下水调蓄方案,并利用数值模拟技术预测了不同方案的实施效... 详细信息

在南水北调进京前,平谷平原区属于地下水超采区。“南水”进京后,为了加快恢复平谷区地下水资源储量,在分析区域水文地质条件、地下水动态及可利用回补水源等基础上,制订了2种地下水调蓄方案,并利用数值模拟技术预测了不同方案的实施效果。结果表明:若不实行地下水人工回补,仅靠地下水减采,地下水位亦可逐步恢复;若地下水减采的同时,在泃河、洳河上游实行人工回补,地下水位恢复效果更加显著。研究成果为指导平谷区地下水资源储量增加、促进区域水资源可持续利用服务。

关键词：地下水调蓄涵养南水北调工程应急水源地

Epitaxial growth of large-area and highly crystalline anisotropic ReSe2 atomic layer

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Nano Research 2017年第8期10卷 2732-2742页

作者： Fangfang Cui Xiaobo li Qingliang Feng Jianbo Yin lin Zhou dongyan.liu Kaiqiang liu Xuexia He Xing liang Shengzhong liu Zhibin Lei Zonghuai liu Hailin Peng Jin Zhang Jing Kong Hua Xu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China Center for Nanochemistry Beijing National Laboratory for Molecular Sciences Key Laboratory for the Physics and Chemistry of Nanodevices College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Department of Electrical Engineering and Computer Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA School of Chemistry and Chemical Engineering Shaanxi Normal University Xi' an 710119 China

The anisotropic two-dimensional （2D） layered material rhenium disulfide （ReSe2） has attracted considerable attention because of its unusual properties and promising applications in electronic and optoelectronic devices. However, because of its low lattice symmetry and interlayer decoupling, anisotropic growth and out-of-plane growth occur easily, yielding thick flakes, dendritic structure, or flower-like structure. In this stud34 we demonstrated a bottom-up method for the controlled and scalable synthesis of ReSe2 by van der Waals epitaxy. To achieve controllable growth, a micro-reactor with a confined reaction space was constructed by stacking two mica substrates in the chemical vapor deposition system. Within the confined reaction space, the nucleation density and growth rate of ReSe2 were significantly reduced, favoring the large-area synthesis of ReSe2 with a uniform monolayer thickness. The morphological evolution of ReSe2 with growth temperature indicated that the anisotropic growth was suppressed at a low growth temperature （〈600 ℃）. Field-effect transistors employing the grown ReSe2 exhibited p-type conduction with a current ON/OFF ratio up to 10s and a hole carrier mobility of 0.98 cm^2/（V·s）. Furthermore, the ReSe2 device exhibited an outstanding photoresponse to near-infrared light, with responsivity up to 8.4 and 5.1 A/W for 850- and 940-nm light, respectively. This work not only promotes the large-scale application of ReSe2 in high-performance electronic devices but also clarifies the growth mechanism of low-lattice symmetry 2D materials.

关键词： rhenium diselenide (ReSe2) epitaxial growth high crystal quality anisotropy optoelectronics

Particle Recognition in Dust Imagery Using Fractional Calculus and Discriminative Features

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Particle Recognition in Dust Imagery Using Fractional Calcul...

A New Route Optimization Approach of Cold Chain Logistics Distribution Based on Fresh Agricultural Products

第三十九届中国控制会议

作者： Zheng Wang Helin Zhang dongyan.li School of Electric and Control Engineering Xi’an University of Science and Technology

The coal dust measurement technologies which had the poor stabilization, low accuracy and being difficult to save data don’t consider the coal dust physical characteristics in the coal mine safety environment. The application of the coal dust image recognition method was constrained. This paper is proposed to apply image processing techniques for studying coal particle classification measurement problem. The change regularity of coal dust characteristic parameters is thoroughly studied. The mathematical models of fractional order variational image denoising and coal dust image recognition are developed. The effects of regularization parameter and fractional order derivative on the coal dust image recognition parameters are discussed. The relationship between image parameters and coal dust characteristic parameters are determined. And the inner mechanisms of coal dust imagery analysis characteristic parameters are revealed. The simulation result indicated that the recognition error rate achieved 3.31% in particle size 250 m, 3.84% in(120 m, 250 m] and 5.41% in particle size 120 m, respectively. The proposed approach outperforms all other widely used approaches. The proposed approach can accurately identify particle groups, and has strong compatibility with images.

关键词： Dust particle Image recognition Fractional calculus Discriminative feature

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A New Route Optimization Approach of Cold Chain Logistics Di...

A Dynamic Event-Triggered Method to Distributed Filtering with Switching Nonlinearities and Redundant Channels

第30届中国控制与决策会议

作者： li Jiayang Fan linan Dong dongyan School of Information Engineering Shenyang University School of Business Administration Northeastern University

The transportation safety of agricultural products is very important in the process of cold chain logistics distribution because of the perishable nature of agricultural *** to the characteristics of agricultural products cold chain distribution,this paper put the cost of carbon emissions to the total cost. Considering the minimize the total cost as the objective function, this paper constructed considering carbon emissions with time window of agricultural products cold chain logistics path optimization ***, we improved genetic algorithm to solve the problem. The simulation results show that the improved genetic algorithm is an effective method to solve considering the carbon emissions of agricultural products cold chain logistics route optimization. It is the reference significance to choose the distribution route of low carbon environmental protection.

关键词： Fresh agricultural products Cold chain logistics Route optimization Carbon emission

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A Dynamic Event-Triggered Method to Distributed Filtering wi...

病例03(2024):产后溶血性尿毒综合征1例

第三十九届中国控制会议

作者： Zehao li Jun Hu dongyan.Chen Department of Mathematics Harbin University of Science and Technology Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and Technology School of Engineering University of South Wales

This paper is concerned with the dynamic event-triggered distributed filtering problem for a class of time-varying stochastic systems with switching nonlinearities and redundant channels. A random variable that obeys Bernoulli distribution is used to characterize the switching nonlinearities, and moreover, a set of random variables are used to described redundant channels, which are introduced to increase the probability of successful deliver of the data packets. A dynamic event-triggered scheme is introduced to further reduce the number of excessive executions of the signal transmissions. The aim of this paper is to design a locally optimal time-varying filter such that, for switching nonlinearities and redundant channels, an upper bound on the filtering error covariance is derived and such an upper bound is minimized by properly designing the filter gain based on the solution of a Riccati-like difference equation. In addition, the performance analysis of the proposed filtering algorithm is conducted and a sufficient condition is given to verify the boundedness of the filtering error. Finally, an illustrative example is given to demonstrate the effectiveness of the proposed filter design scheme.

关键词： Sensor networks Dynamic event-triggered protocol Switching nonlinearities Redundant channels Performance analysis

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中华围产医学杂志 2024年第4期27卷 322-327页

作者：杨红英冯烨李东言魏玉梅赫英东张广意任志菲常聪慧赵静周福德李楠耿妍王文生王茫桔丁欢田娜马淑琴孙伟杰杨慧霞北京大学第一医院宁夏妇女儿童医院(宁夏回族自治区妇幼保健院)产科银川750011 北京大学第一医院妇产生殖医学中心北京100034 北京大学第一医院肾内科北京100034 北京大学第一医院重症医学科北京100034 北京大学第一医院风湿免疫科北京100034 北京大学第一医院血液科北京100034 宁夏医科大学总医院重症医学科银川750011 宁夏医科大学总医院肾内科银川750011 宁夏医科大学总医院产科银川750011

本文报告了1例足月妊娠因重度子痫前期行剖宫产,术后出现产后溶血性尿毒综合征(postpartum hemolytic uremic syndrome,pHUS)的病例。患者孕39周因重度子痫前期在北京大学第一医院宁夏妇女儿童医院行急诊剖宫产,术后即刻发生微血管病性... 详细信息

本文报告了1例足月妊娠因重度子痫前期行剖宫产,术后出现产后溶血性尿毒综合征(postpartum hemolytic uremic syndrome,pHUS)的病例。患者孕39周因重度子痫前期在北京大学第一医院宁夏妇女儿童医院行急诊剖宫产,术后即刻发生微血管病性溶血性贫血、血小板减少、乳酸脱氢酶升高、肝功能异常(转氨酶及胆红素升高)、肾功能异常(少尿、血尿及肌酐进行性升高)。经多学科会诊,考虑重度子痫前期并发pHUS,需行血液透析及血浆置换治疗,转诊至宁夏医科大学总医院。经血液透析及血浆置换治疗,患者病情好转出院。出院后定期肾内科随诊,肾功能术后1个月恢复正常。

关键词：产后溶血性尿毒综合征重度子痫前期 HELLP综合征妊娠

适于酿造红肉苹果酒的非酿酒酵母的研究及筛选

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酿酒科技 2024年第8期 30-37页

作者：王哲史佳茹王文慧孙化滕周东彦张玉刚李静媛孙晓红青岛农业大学生命科学学院山东青岛266109 青岛农业大学食品科学与工程学院山东青岛266109 青岛农业大学园艺学院山东青岛266109 东营青岛农业大学盐碱地高效农业技术产业研究院山东东营257091

为研究非酿酒酵母在红肉苹果酒酿造中的作用并筛选出适宜的非酿酒酵母,本研究采用东方伊萨酵母、季也蒙有孢汉逊酵母和发酵毕赤酵母为试验菌,与酿酒酵母混合发酵制备红肉苹果酒,分析发酵酒液的香气和抗氧化能力,并对酒体进行感官评价。... 详细信息

为研究非酿酒酵母在红肉苹果酒酿造中的作用并筛选出适宜的非酿酒酵母,本研究采用东方伊萨酵母、季也蒙有孢汉逊酵母和发酵毕赤酵母为试验菌,与酿酒酵母混合发酵制备红肉苹果酒,分析发酵酒液的香气和抗氧化能力,并对酒体进行感官评价。结果表明,与单纯酿酒酵母组发酵相比,添加东方伊萨酵母组能够提高发酵酒液的自由基清除能力,提高红肉苹果酒酯类物质的种类(23种),酯类含量是单纯酿酒酵母组的1.67倍,降低了酸类(7.37%)和其他类物质的含量(2.03%);东方伊萨酵母组感官评价得分最高。表明东方伊萨酵母可作为红肉苹果酒酿造专用的非酿酒酵母。

关键词：红肉苹果混菌发酵筛选非酿酒酵母

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大国竞争下联合国改革的特点与前景

当代世界 2022年第10期 22-27页

作者：李东燕中国社会科学院世界经济与政治研究所

大国竞争加剧,特别是俄乌冲突的爆发,加之新冠肺炎疫情、气候变化、极端自然灾害等全球性挑战叠加,增添了联合国改革的紧迫性和不确定性,联合国的地位和作用也面临新的考验。一方面,唱衰联合国的声音渐强;另一方面,对联合国的支持和需... 详细信息

大国竞争加剧,特别是俄乌冲突的爆发,加之新冠肺炎疫情、气候变化、极端自然灾害等全球性挑战叠加,增添了联合国改革的紧迫性和不确定性,联合国的地位和作用也面临新的考验。一方面,唱衰联合国的声音渐强;另一方面,对联合国的支持和需求依然存在。在《纪念联合国成立75周年宣言》中,会员国表达了对联合国改革升级的支持。在第七十七届联合国大会一般性辩论开幕式讲话中。

关键词：联合国成立全球性挑战联合国大会气候变化自然灾害不确定性大国竞争竞争加剧

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