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Application of Detrital Apatite U-Pb Geochronology and Trace Elements for Provenance Analysis,Insights from a Study on the Yarlung River Sand

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Journal of Earth Science 2024年第4期35卷 1118-1129页

作者： Yufeng Du Guangwei Li Danyang liu Xianyan Wang dongxu Cai Xiaolu Dong Qi Yu State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China School of Geography and Ocean Nanjing UniversityNanjing210023China

Detrital U-bearing minerals(e.g.,zircon,apatite)U-Pb ages with specific trace-element geochemistry,are frequently used in provenance *** this study,we focus on the Yarlung River drainage in South Tibet,characterized by two distinct lithologic units:The Gangdese batholith to the north(mainly granitoids)and the Tethyan Himalaya(mainly sedimentary rocks)to the south,which plays a crucial role in the erosion of the Tibetan *** constrain the provenance of the Yarlung River Basin,we performed trace-element and U-Pb age analyses of detrital apatite from the river sands of the Yarlung River and its *** findings indicate that the detrital apatite U-Pb age patterns of the north tributaries exhibit main peaks at approximately 40 and 60 Ma,consistent with the corresponding U-Pb age patterns of detrital zircon ***,their trace element casts fall mainly in the Type I granite region,also indicating the Gangdese arc-dominated ***,those of the south tributaries(∼60–20 Ma)exhibit a different age distribution from the detrital zircon U-Pb groups(∼110–150,∼500,and 1100 Ma),suggesting that the detailed apatite U-Pb signals can provide excellent constraints on the provenance of igneous and metamorphic rock sources but less so for sedimentary rock *** with previous detrital zircon data in the study area,our detrital apatite information can highlight young metamorphic events from a complex background(i.e.,Niyang and Nianchu rivers),which offers additional constraints on the provenance of the Yarlung River ***,a combination of geochemistry and geochronology of multi-detrital heavy minerals,such as zircon and apatite,can provide powerful tools for provenance analysis.

关键词： apatite detrital apatite U-Pb age trace elements provenance analysis Yarlung River Tibetan Plateau geochronology

Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： Chunjie Wang Lei Zhang Zhijuan Yang dongxu Zhao Zheng Deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO3&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

Flexible multilayer MEMS coils and their application in energy harvesters

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Science China(Technological Sciences) 2024年第4期67卷 1282-1293页

作者： ZHANG Jie HOU XiaoJuan QIAN Shuo BI XiaoXue HU dongxu liu JianJun GENG WenPing MU JiLiang HE Jian CHOU XiuJian Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051China School of Software North University of ChinaTaiyuan 030051China

Electromagnetic vibration energy harvesters are promising for the power supply of wireless sensor nodes,small electronic devices,and wearable *** electromagnetic harvesters usually increase output by increasing the size of coils and magnets,limiting the improvement of energy conversion efficiency and power *** this study,multilayer microelectromechanical system(MEMS)coils were prepared using flexible electronics,and their high integration performance in arbitrary space was utilized to greatly improve the utilization of the space magnetic field by the electromagnetic *** core magnet of the generator was magnetically balanced to achieve levitation,which improved the sensitivity and reduced fatigue damage compared with traditional spring *** wound coils on the top and bottom of the magnet and the flexible coils on the sides worked together to improve the energy efficiency and output of the *** output performance of the device with different number distributions was simulated using mathematical models to obtain the optimal structural *** results show that by introducing flexible multilayer MEMS coils on the side surface of the energy harvester,the open-circuit voltage of the energy generators increased from 7 to 10 V by more than 43%.Flexible multilayer MEMS coils can enhance energy conversion rates and possess compact dimensions,making them suitable for integration onto complex *** the vibration energy harvesting system testing,the maximum peak power of the harvester was 7.1 m W at an acceleration of1 g and a resonant frequency of 11 Hz with a resistor of 3.5 kΩinternal ***,a 470μF capacitor can be charged to 3.5 V within 10 s to drive a hygrothermograph to work for more than 80 s and can supply a light bulb *** strategy shows the great potential of vibration-energy-driven electromagnetic generators for powering small electronics in limited spaces.

关键词： electromagnetic harvester mechanical energy harvesting multilayer MEMS coils magnetic levitation overall space magnetic field flexible planar coils

3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li Yang liu liuqi Peng Dongdong Lu Pinpin Wang dongxu Ke Huilin Yang Xuesong Zhu Changshun Ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

四君子汤对阿尔茨海默病大鼠中枢海马炎症因子及NLRP3小体的影响

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免疫学杂志 2022年第3期38卷 257-262页

作者：吕回刘旭东中国医科大学附属第四医院神经内科沈阳110032 辽宁中医药大学生理心理教研室沈阳110032

目的探讨四君子汤(SiJunZi Decoction,SJZD)治疗大鼠阿尔茨海默病的作用机制。方法将60只雄性SPF级大鼠随机分为正常组,模型组,双氢麦角碱(dihydroergoline,DHE)组,SJZD低、中、高治疗组。采用Morris水迷宫实验检测大鼠记忆功能的变化;E... 详细信息

目的探讨四君子汤(SiJunZi Decoction,SJZD)治疗大鼠阿尔茨海默病的作用机制。方法将60只雄性SPF级大鼠随机分为正常组,模型组,双氢麦角碱(dihydroergoline,DHE)组,SJZD低、中、高治疗组。采用Morris水迷宫实验检测大鼠记忆功能的变化;ELISA法检测IL-1β、IL-6及IL-10含量;免疫组化法检测caspase11蛋白表达变化;Western blot法检测海马组织NLRP3、caspase-1、caspase-4、caspase-5蛋白表达。结果与正常组比较,模型组大鼠潜伏逃避期时间增加(P<0.01)、穿越次数减少(P<0.01),IL-1β、IL-6含量升高(P<0.01),IL-10含量降低(P<0.01),NLRP3、caspase-1、caspase-4、caspase-5、caspase-11(P<0.01)表达上调;DHE与模型组比较,潜伏逃避期减少(P<0.01),穿越次数增加(P<0.01),IL-1β减少(P<0.01),NLRP3、caspase-1表达下调(P<0.01)。SJZD中剂量组和高剂量组与模型组比较,潜伏逃避期时间减少(P<0.01)、穿越次数增加(P<0.01),caspase-11蛋白表达下调;SJZD低剂量组、中剂量组和高剂量组与模型组比较IL-1β、IL-6含量降低(P<0.01),IL-10含量升高(P<0.01),NLRP3、caspase-1、caspase-4、caspase-5蛋白表达下调(P<0.01)。结论四君子汤治疗阿尔茨海默病可能与纠正中枢海马相关炎症因子紊乱及调控NLRP3有关。

关键词：四君子汤阿尔茨海默海马炎症因子 NLRP3

Analysis of the Relation between Sun Motion Law and the Change of Earth’s Environment

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International Journal of Geosciences 2016年第3期7卷 249-256页

作者： Zhe Yin dongxu liu Mathematics Department Yanbian University Yanji China

We deduce and obtain the law of the motion of the sun by analyzing the law of motion between the moon, the earth, the sun, and the Polaris. Then we obtain the root of the change of earth’s environment from the law. Meanwhile we analyze the form of the present state of the universe movement and the conditions of energy homeostasis. It may provide reference value for related research.

关键词： Sun Motion Earth Environment

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基于无序纳米颗粒的光子晶体有机薄膜

光学学报 2023年第7期43卷 269-276页

作者：付宸锐祝明刘东旭赵达北京航空航天大学航空科学与工程学院北京100191 北京航空航天大学无人系统研究院北京100191

无序光子晶体有机物薄膜的制备是实现光阻隔材料量产的关键。设计了无序多级光子晶体结构有机物薄膜,以热塑性聚氨酯作为膜材基质,将二氧化钛颗粒作为反射隔光材料填入基质中。采用时域有限差分法进行了模拟,结果表明,增加填充因子导致... 详细信息

无序光子晶体有机物薄膜的制备是实现光阻隔材料量产的关键。设计了无序多级光子晶体结构有机物薄膜,以热塑性聚氨酯作为膜材基质,将二氧化钛颗粒作为反射隔光材料填入基质中。采用时域有限差分法进行了模拟,结果表明,增加填充因子导致了反射峰和光谱禁带的蓝移,而增加颗粒直径造成了光谱禁带红移。将单一直径均匀分布的阵列作为对比,分析了粒径多级性和结构聚结性对光谱的影响。对于横电波和横磁波,在0°~70°的宽入射角范围内实现了高效禁带效应。这种无序光子晶体结构的有机薄膜为宽角度光阻隔材料提供了参考。

关键词：薄膜无序光子晶体有机物薄膜光阻隔材料二氧化钛颗粒时域有限差分法

Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network(LUCCN):First Integrated Campaign in China

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Advances in Atmospheric Sciences 2024年第1期41卷 1-7页

作者： dongxu YANG Tonghui ZHAO Lu YAO Dong GUO Meng FAN Xiaoyu REN Mingge LI Kai WU Jing WANG Zhaonan CAI Sisi WANG Jiaxu GUO Liangfu CHEN Yi liu Carbon Neutrality Research Center(CNRC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Middle Atmospheric Physics and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China National Remote Sensing Center of China Beijing 100036China The Administrative Center for China’s Agenda 21 Beijing 100862China

In this study,we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network(LUCCN)*** LUCCN primarily consists of two categories of instruments,including ground-based and UAV-based in-situ *** use the GMP343,a low-cost non-dispersive infrared sensor,in both ground-based and UAV-based *** first integrated measurement campaign took place in Shenzhen,China,4 May *** the campaign,we found that LUCCN’s UAV component presented significant data-collecting advantages over its ground-based counterpart owing to the relatively high altitudes of the point emission sources,which was especially obvious at a gas power plant in *** emission flux was calculated by a crosssectional flux(CSF)method,the results of which differed from the Open-Data Inventory for Anthropogenic Carbon dioxide(ODIAC).The CSF result was slightly larger than others because of the low sampling rate of the whole emission cross *** LUCCN system will be applied in future carbon monitoring campaigns to increase the spatiotemporal coverage of carbon emission information,especially in scenarios involving the detection of smaller-scale,rapidly varying sources and sinks.

关键词： CO_(2) measurement networks power station carbon emission cross-sectional flux method

习近平关于高校党建重要论述的概括、特征及价值

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国家教育行政学院学报 2023年第9期309卷 17-24页

作者：黄蓉生刘东旭西南大学重庆400715

党的十八大以来,习近平围绕高校党建作出一系列重要论述,形成了高校党建的“四论”概括表达。习近平关于高校党建的重要论述是习近平关于党的建设的重要思想的组成部分,具有引领高校党建目标的战略前瞻性、指向高校党建问题的现实针对... 详细信息

党的十八大以来,习近平围绕高校党建作出一系列重要论述,形成了高校党建的“四论”概括表达。习近平关于高校党建的重要论述是习近平关于党的建设的重要思想的组成部分,具有引领高校党建目标的战略前瞻性、指向高校党建问题的现实针对性、把握高校党建大局的发展历史性等本质特征;体现出强调坚持党对高校工作的全面领导,指明落实高校党建根本任务的前行方向,提供批判高校历史虚无主义锐利武器的时代价值。

关键词：习近平新时代中国特色社会主义思想高校党建重要论述价值