检索结果-南通市图书馆

Astronomical Knowledge Entity Extraction in Astrophysics Journal Articles via Large Language Models

Research in Astronomy and Astrophysics 2024年第6期24卷 140-155页

作者： Wujun Shao Rui Zhang Pengli Ji dongwei fan Yaohua Hu Xiaoran Yan Chenzhou Cui Yihan Tao Linying Mi Lang Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China Research Institute of Artificial Intelligence Zhejiang LabHangzhou 311100China Guilin University Guangxi 541006China Xidian University Xi’an 710126China

Astronomical knowledge entities,such as celestial object identifiers,are crucial for literature retrieval and knowledge graph construction,and other research and applications in the field of *** methods of extracting knowledge entities from texts face numerous challenging obstacles that are difficult to ***,there is a pressing need for improved methods to efficiently extract *** study explores the potential of pre-trained Large Language Models(LLMs)to perform astronomical knowledge entity extraction(KEE)task from astrophysical journal articles using *** propose a prompting strategy called PromptKEE,which includes five prompt elements,and design eight combination prompts based on *** select four representative LLMs(Llama-2-70B,GPT-3.5,GPT-4,and Claude 2)and attempt to extract the most typical astronomical knowledge entities,celestial object identifiers and telescope names,from astronomical journal articles using these eight combination *** accommodate their token limitations,we construct two data sets:the full texts and paragraph collections of 30 *** the eight prompts,we test on full texts with GPT-4and Claude 2,on paragraph collections with all *** experimental results demonstrate that pre-trained LLMs show significant potential in performing KEE tasks,but their performance varies on the two data ***,we analyze some important factors that influence the performance of LLMs in entity extraction and provide insights for future KEE tasks in astrophysical articles using ***,compared to other methods of KEE,LLMs exhibit strong competitiveness in multiple aspects.

关键词： astronomical databases:miscellaneous virtual observatory tools methods:data analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways

引用

Genes & Diseases 2021年第6期8卷 882-890页

作者： dongwei fan Daoyang fan Wanqiong Yuan Department of Orthopedics Peking University Third Hospital49 North Garden Rd.Haidian DistrictBeijing100191PR China Beijing Key Laboratory of Spinal Disease 49 North Garden Rd.Haidian DistrictBeijing100191PR China

Osteoporosis,fracture,large-scale craniofacial defects and osteonecrosis are hot topics and are still underdiagnosed and undertreated in the *** is urgent to understand the molecular mechanisms corresponding to the regulation of bone ***3(CKLF-like MARVEL transmembrane domain containing 3)connects the classic chemokine to the transmembrane 4 superfamily and plays an important role in intracellular vesicles transport,EGF receptor function maintenance and cancer ***,its expression and function in bone remain *** this paper,we found that the bone volume/total volume,trabecular number,trabecular thickness and bone surface area/bone volume of Cmtm3 KO mice increased significantly,and trabecular separation and trabecular pattern factor decreased in Cmtm3 KO mice compared with WT mice by microcomputed ***,the bone mineral content,bone mineral density,ultimate force and stiffness were also increased in Cmtm3 KO *** in vitro analysis,we showed that CMTM3 expression decreases during the differentiation of hBMSCs to *** of CMTM3 promoted ALP and mineralization of hBMSCs and facilitated osteoblastic differentiation with increasing RUNX2 ***,overexpression of CMTM3 got the opposite *** results proved that CMTM3 was essential for osteogenic *** addition,knockdown of CMTM3 enhanced p-Erk1/2,but had no significant effect on p-Akt or p-STAT3 in hBMSCs and MC3T3-E1 *** together,our results indicated that Erk1/2 and RUNX2 pathways mediated by CMTM3 were involved in the process of osteogenic differentiation,and CMTM3 might be a new potential target in the treatment of bone formation-related disease.

关键词： CMTM3 Erk1/2 hBMSCs Osteoporosis RUNX2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The first comprehensive Milky Way stellar mock catalogue for the Chinese Space Station Telescope Survey Camera

引用

中国科学:物理学、力学、天文学英文版 2023年第11期66卷 206-220页

作者： Yang Chen Xiaoting Fu Chao Liu Piero Dal Tio Léo Girardi Giada Pastorelli Alessandro Mazzi Michele Trabucchi Hao Tian dongwei fan Paola Marigo Alessandro Bressan School of Physics and Optoelectronic Engineering Anhui UniversityHefei230601China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China Purple Mountain Observatory Chinese Academy of SciencesNanjing210023China Dipartimento di Fisica e Astronomia Galileo Galilei Universitàdi PadovaPadovaI-35122Italy INAF-Osservatorio Astronomico di Padova PadovaI-35122Italy National Astronomical Data Center Beijing100101China SISSA via Bonomea 365TriesteI-34136Italy

The Chinese Space Station Telescope(CSST)is a cutting-edge two-meter astronomical space telescope currently under *** primary Survey Camera(SC)is designed to conduct large-area imaging sky surveys using a sophisticated seven-band photometric *** resulting data will provide unprecedented data for studying the structure and stellar populations of the Milky *** support the CSST development and scientific projects related to its survey data,we generate the first comprehensive Milky Way stellar mock catalogue for the CSST SC photometric system using the TRILEGAL stellar population synthesis *** catalogue includes approximately 12.6 billion stars,covering a wide range of stellar parameters,photometry,astrometry,and kinematics,with magnitude reaching down to g=27.5 mag in the AB magnitude *** catalogue represents our benchmark understanding of the stellar populations in the Milky Way,enabling a direct comparison with the future CSST survey ***,it sheds light on faint stars hidden from current sky *** crowding limit analysis based on this catalogue provides compelling evidence for the extension of the CSST Optical Survey(OS)to cover low Galactic latitude *** strategic extension of the CSST-OS coverage,combined with this comprehensive mock catalogue,will enable transformative science with the CSST.

关键词： The Chinese Space Station Telescope(CSST) stellar content and populations Milky Way sky surveys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

引用

Acta Pharmaceutica Sinica B 2024年第1期14卷 87-109页

作者： Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng dongwei Kang fan Yi Jin-Peng Sun Luis Menéndez-Arias Johan Neyts Xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Shenzhen Research Institute of Shandong University Shenzhen 518057China The Key Laboratory of Infection and Immunity of Shandong Province Department of PharmacologySchool of Basic Medical SciencesShandong UniversityJinan 250012China Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Centro de Biologı´a Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientı´ficas&Autonomous University of Madrid) Madrid 28049Spain KU Leuven Department of Microbiology and ImmunologyRega Institute for Medical ResearchLaboratory of Virology and ChemotherapyLeuven 3000Belgium

The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life *** covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic *** antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable *** non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available *** viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed.

关键词： COVID-19 SARS-CoV-2 Main protease Non-covalent inhibitors Medicinal chemistry strategies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

丰子恺和商务印书馆

引用

嘉兴学院学报 2020年第5期32卷 26-35页

作者：樊东伟上海开卷文化传播有限公司上海200080

从少年时代到作品逐渐享誉出版界的过程中,丰子恺与商务印书馆之间有着全方位紧密的合作关系:处女作《寓言四则》刊发在商务印书馆的《少年杂志》上,商务印书馆成为其创作道路上的第一个舞台;从崭露头角到盛名远播,丰子恺为商务印书馆... 详细信息

从少年时代到作品逐渐享誉出版界的过程中,丰子恺与商务印书馆之间有着全方位紧密的合作关系:处女作《寓言四则》刊发在商务印书馆的《少年杂志》上,商务印书馆成为其创作道路上的第一个舞台;从崭露头角到盛名远播,丰子恺为商务印书馆旗下的期刊供稿计142篇之多,与商务印书馆在书籍上的合作也有十多次,并将自己的第一本译作交由其出版。二者有如此密切合作的重要基础是丰子恺在商务印书馆内有较为广泛的人脉网络等,由此可见民国时期出版社同作者之间互惠互利的本质联系。

关键词：丰子恺商务印书馆合作

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

悬吊运动训练对脑卒中偏瘫患者康复结局的影响

引用

中国实用乡村医生杂志 2020年第12期27卷 49-51,55页

作者：范东巍沈阳市第二中医医院沈阳110101

目的探讨悬吊运动训练对脑卒中偏瘫患者康复结局的影响。方法选择2019年1月1日—12月31日沈阳市第二中医医院收治的120例脑卒中偏瘫患者为研究对象,随机分为对照组和观察组各60例。对照组患者接受常规康复训练方案,观察组在其基础上采... 详细信息

目的探讨悬吊运动训练对脑卒中偏瘫患者康复结局的影响。方法选择2019年1月1日—12月31日沈阳市第二中医医院收治的120例脑卒中偏瘫患者为研究对象,随机分为对照组和观察组各60例。对照组患者接受常规康复训练方案,观察组在其基础上采用悬吊运动训练,比较两组的平衡功能、步行能力、日常生活能力以及神经缺损情况。结果训练干预前两组BBS评分、改良Bathel指数评分和NIHSS评分组间差异无统计学意义(P>0.05);训练干预后两组BBS评分、改良Bathel指数评分和NIHSS评分组间差异有统计学意义(P<0.05)。训练干预后观察组Holden步行功能分级量表0级比例低于对照组,差异有统计学意义(P<0.05)。结论针对脑卒中偏瘫患者,悬吊运动训练能够提升患者的平衡功能、日常生活能力,并改善其步行能力与神经缺损情况,可促进患者更好地康复,值得推广应用。

关键词：脑卒中偏瘫悬吊运动训练平衡功能步行能力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

核心稳定性训练在脑卒中偏瘫患者康复中的应用效果

引用

中国实用乡村医生杂志 2021年第2期28卷 53-55,58页

作者：范东巍沈阳市第二中医医院沈阳110101

目的探讨核心稳定性训练(CST)在脑卒中偏瘫(SIH)患者康复中的临床应用效果.方法选择2019年1月1日—12月31日沈阳市第二中医医院收治的SIH患者88例为研究对象,随机分为观察组和对照组各44例.对照组接受常规康复训练,观察组在对照组基础... 详细信息

目的探讨核心稳定性训练(CST)在脑卒中偏瘫(SIH)患者康复中的临床应用效果.方法选择2019年1月1日—12月31日沈阳市第二中医医院收治的SIH患者88例为研究对象,随机分为观察组和对照组各44例.对照组接受常规康复训练,观察组在对照组基础上采用CST,比较两组患者的希望水平、步行功能和平衡状态.结果观察组高希望水平占93.18%,高于对照组的77.28%,差异有统计学意义(P0.05),康复训练干预后两组FAC评分、BBS评分均高于干预前,差异有统计学意义(P<0.05),且组间比较观察组高于对照组,差异有统计学意义(P<0.05).结论针对SIH患者,在其康复过程中开展CST能够改善患者步行功能,提高其平衡性,提高患者信心,值得推荐.

关键词：脑卒中偏瘫康复训练核心稳定性训练步行功能平衡状态临床效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

骨质疏松与认知障碍关系的研究进展

引用

中国全科医学 2022年第11期25卷 1406-1410页

作者：任昀陶立元范东伟北京大学第三医院妇产科北京市100191 北京大学第三医院生殖医学中心北京市100191 北京大学第三医院临床流行病学研究中心北京市100191 北京大学第三医院骨科北京市100191 脊柱疾病研究北京市重点实验室北京市100191 北京大学“骨与关节精准医学教育部工程中心” 北京市100191

近年研究显示,在老年共病患者中,骨质疏松与认知障碍共病的发病率逐年上升,表现为跌倒发生率高,骨折风险增加,从而引起致残、致死率升高,严重危害共病患者的健康和生活质量,同时也给家庭和社会带来沉重的经济负担,成为目前社区慢性病管... 详细信息

近年研究显示,在老年共病患者中,骨质疏松与认知障碍共病的发病率逐年上升,表现为跌倒发生率高,骨折风险增加,从而引起致残、致死率升高,严重危害共病患者的健康和生活质量,同时也给家庭和社会带来沉重的经济负担,成为目前社区慢性病管理中较为棘手的问题。本文对骨质疏松与认知障碍关系的进展进行综述。重点讨论骨质疏松与认知障碍的共病机制、共病临床危险因素及共病临床特征。发现骨质疏松与认知障碍关系密切,并严重危害老年人群健康。希望本文能为探索骨质疏松与认知障碍共病新的风险因素提供思路,为有效预防和管理骨质疏松与认知障碍共病提供帮助。

关键词：骨质疏松认知障碍认知功能障碍骨质疏松性骨折慢性病共病骨-脑轴

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于体感互动的综合平衡训练在脑卒中偏瘫患者中的应用效果

引用

中国实用乡村医生杂志 2021年第1期28卷 72-74页

作者：范东巍沈阳市第二中医医院沈阳110101

目的探讨在脑卒中偏瘫患者中采用基于体感互动的综合平衡训练(体感互动技术)的临床效果。方法选择2018年7月1日-2019年12月31日沈阳市第二中医医院收治的76例脑卒中偏瘫患者,依据随机数字表法随机分为观察组和对照组各38例。观察组采用... 详细信息

目的探讨在脑卒中偏瘫患者中采用基于体感互动的综合平衡训练(体感互动技术)的临床效果。方法选择2018年7月1日-2019年12月31日沈阳市第二中医医院收治的76例脑卒中偏瘫患者,依据随机数字表法随机分为观察组和对照组各38例。观察组采用基于体感互动的综合平衡训练(体感互动技术),对照组采用常规康复训练。观察并比较两组的康复效果。结果康复训练后观察组平衡功能、神经功能、运动功能和上下肢肌力评分均优于对照组,差异均有统计学意义(P<0.05)。结论脑卒中偏瘫患者进行基于体感互动的综合平衡1川练有利于改善其肢体运动和平衡功能。

关键词：脑卒中并发症偏瘫体感互动综合平衡训练康复效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two sex pheromone receptors for sexual communication in the American cockroach

引用

Science China(Life Sciences) 2024年第7期67卷 1455-1467页

作者： Na Li Renke Dong Huanchao Zeng Yan Zhang Run Huang Wei Liu Fengming Cao Jincong Yu Mingtao Liao Jingyou Chen Wenlei Zhang Zejian Huang Jiahui Wang Li Li Shen Zhu Danyan Huang Zining Li Xiaoshuai Zhang dongwei Yuan Nan Chen Yongliang fan Guirong Wang Coby Schal Yufeng Pan Sheng Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514589China Lingnan Guangdong Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of AgricultureNorthwest A&F UniversityYangling 712100China Department of Entomology and Plant Pathology North Carolina State UniversityRaleigh 27695USA The Key Laboratory of Developmental Genes and Human Disease School of Life Science and TechnologySoutheast UniversityNanjing 210096China

Volatile sex pheromones are vital for sexual communication between males and *** of the American cockroach,Periplaneta americana,produce and emit two sex pheromone components,periplanone-A(PA)and periplanone-B(PB).Although PB is the major sex attractant and can attract males,how it interacts with PA in regulating sexual behaviors is still *** this study,we found that in male cockroaches,PA counteracted PB *** identified two odorant receptors(ORs),OR53 and OR100,as PB/PA and PA receptors,***53 and OR100 were predominantly expressed in the antennae of sexually mature males,and their expression levels were regulated by the sex differentiation pathway and nutrition-responsive *** localization of OR53 and OR100 in male antennae further revealed that two types of sensilla coordinate a complex two-pheromone-two-receptor pathway in regulating cockroach sexual *** findings indicate distinct functions of the two sex pheromone components,identify their receptors and possible regulatory mechanisms underlying the male-specific and age-dependent sexual behaviors,and can guide novel strategies for pest management.

关键词： sex pheromone odorant receptor sexual attraction sex differentiation cockroach

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：