检索结果-南通市图书馆

Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up

引用

Regenerative Biomaterials 2020年第1期7卷 77-90页

作者： Wenqiang Yan Xingquan Xu Qian Xu Ziying Sun Qing Jiang dongquan shi State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing 210008JiangsuChina Laboratory for Bone and Joint Disease Model Animal Research Center(MARC)Nanjing UniversityNanjing 210093JiangsuChina

Based on our previous study,the utilization of an ultraviolet light photo-cross-linkable hyaluronic acid(HA)hydrogel integrated with a small molecule kartogenin-encapsulated nanoparticles obtained good reconstruction of osteochondral defects in a rabbit model,indicating the superiority of injectable hydrogel-based scaffolds in cartilage tissue ***-rich plasma(PRP),rich in various growth factors,proteins and cytokines,is considered to facilitate cartilage healing by stimulating cell proliferation and inducing chondrogenesis in cartilage defect *** aim of this study was to test the therapeutic feasibility of autologous PRP combined with injectable HA hydrogel on cartilage *** focal cartilage defects with different critical sizes in the medial femoral condyle of a porcine model were *** 6 months,the minipigs were sacrificed for assessment of macroscopic appearance,magnetic resonance imaging,micro-computed tomography,histology staining and *** HA hydrogel combined with PRP-treated group showed more hyaline-like cartilage exhibited by macroscopic appearance and histological staining in terms of extracellular matrix and type II collagen without formation of hypertrophic cartilage,indicating its capacity to improve cartilage healing in the minipig model evaluated at 6 months,with full-thickness cartilage defect of 8.5mm diameter and osteochondral defect of 6.5mm diameter,5mm depth exhibiting apparent regeneration.

关键词： platelet-rich plasma hyaluronic acid hydrogel cartilage repair regenerative medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances of injectable hydrogel-based scaffolds for cartilage regeneration

引用

Regenerative Biomaterials 2019年第3期6卷 129-140页

作者： Jiawei Li Guojun Chen Xingquan Xu Peter Abdou Qing Jiang dongquan shi Zhen Gu Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower HospitalSchool of MedicineNanjing University321 Zhongshan RoadNanjing 210008JiangsuP.R.China Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos Angeles8-684 Factor BuildingLos AngelesCA 90095USA Center for Minimally Invasive Therapeutics University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA

Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial *** to its avascular,aneural and non-lymphatic features,cartilage has limited self-regenerative *** date,the utilization of biomaterials to aid in cartilage regeneration,especially through the use of injectable scaffolds,has attracted considerable *** materials,therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native *** particular,the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of *** review summarizes recent progress in these efforts,including the structural improvement of scaffolds,network cross-linking techniques and strategies for controlled release,which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

关键词： drug delivery tissue engineering injectable hydrogel cartilage regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerium oxide nanozymes alleviate oxidative stress in tenocytes for Achilles tendinopathy healing

引用

Nano Research 2023年第5期16卷 7364-7372页

作者： Xingquan Xu Rongliang Wang Yixuan Li Rui Wu Wenjin Yan Sheng Zhao Quanyi Liu Yan Du Wenli Gong Weitong Li Hui Wei dongquan shi State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023China

Background:Reactive oxygen species(ROS)is considered as ubiquitous and highly active chemicals that influence tendon integrity and orchestrate tendon *** significant recent advances in nanomaterials,cerium oxide nanoparticles(CeO_(2)NPs)exhibit superoxide dismutase-and catalase-like ***,we introduced a therapeutic approach of CeO_(2)NPs for Achilles tendinopathy(AT)***:CeO_(2)NPs were synthesized to examine their effect as ROS scavengers on AT healing in vitro and in *** mRNA levels of inflammatory factors were evaluated in AT after CeO_(2)NPs treatment in *** mechanisms underlying CeO_(2)NPs-mediated stimulation of NRF2 translocation and ERK signaling were verified through immunofluorescence and Western blot *** efficacy of CeO_(2)NPs was tested in an AT rat model in comparison with the ***:CeO_(2)NPs not only significantly scavenged multiple ROS and suppressed ROS-induced inflammatory reactions but also protected cell proliferation under oxidative stress induced by tert-butyl hydroperoxide(TBHP).Moreover,CeO_(2)NPs could promote NRF_(2)nuclear translocation for anti-oxidation and anti-inflammation through the ERK signaling *** a rat model of collagenase-induced tendon injuries,CeO_(2)NPs showed significant therapeutic efficacy by ameliorating tendon ***:The present study provides valuable insights into the molecular mechanism of CeO_(2)NPs to ameliorate ROS in tenocytes via the ERK/NRF_(2)signaling pathway,which underscores the potential of CeO_(2)NPs for application in the treatment of enthesopathy healing.

关键词： CeO_(2)nanozymes enthesiopathy NRF2 translocation ERK signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strong dual-crosslinked hydrogels for ultrasound-triggered drug delivery

引用

Nano Research 2019年第1期12卷 115-119页

作者： Wenxu Sun Heting Jiang Xin Wu Zhengyu Xu Chen Yao Juan Wang Meng Qin Qing Jiang Wei Wang dongquan shi Yi Cao Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructureand Department of PhysicsNanjing UniversityNanjing 210093China Department of Sports Medicine and Adult Reconstructive surgery Drum Tower HospitalMedical SchoolState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210008China Joint Research Center far Bone and Joint Disease Model Animal Research Center(MARC)School of Chemistry and Chemical Engineeringand State Key Laboratory of Analytical Chemistry far Life ScienceNanjing UniversityNanjing 210093China

Hydrogels that can respond to dynamic forces either from endogenous biological activities or from external mechanical stimuli show great promise as novel drug delivery systems (DDS).However,it remains challenging to engineer hydrogels that specifically respond to externally applied mechanical forces with minimal basel drug leakage under normal stressful physiological *** we present an ultrasound responsive hydrogel-based DDS with special dual-crosslinked nanoscale network *** covalent crosslinks endow the hydrogel high mechanical stability and greatly suppress deformation-triggered drug ***,the dynamic covalent boronate ester linkages between hydrogel backbone and the anti-inflammation compound,tannic acid (TA),allow effective ultrasound-triggered pulsetile release of *** such,the hydrogel shows distinct drug release profiles under compression and ultrasound.A proof-of-principle demonstration of the suppression of inflammation activation of macrophage upon ultrasound-triggered release of TA was also *** anticipate that this novel hydrogel-based drug delivery system can be used for the treatment of inflammatory diseases on load-bearing tissues,such as muscle and cartilage.

关键词： hydrogel dynamic covalent bond mechanical force drug release

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanomotor-based adsorbent for blood Lead(II)removal in vitro and in pig models

引用

Bioactive Materials 2021年第4期6卷 1140-1149页

作者： Meng Wang Tianyi Bao Wenqiang Yan Dan Fang Yueqi Yu Zhiyong Liu Guoyong Yin Mimi Wan Chun Mao dongquan shi National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023PR China Department of Sports Medicine and Adult Reconstructive Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008PR China Department of Orthopaedics the First Affiliated Hospital of Nanjing Medical University Nanjing210029PR China

Blood lead(Pb(II))removal is very important but *** main difficulty of blood Pb(II)removal currently lies in the fact that blood Pb(II)is mainly complexed with hemoglobin(Hb)inside the red blood cells(RBCs).Traditional blood Pb(II)removers are mostly passive particles that do not have the motion ability,thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively ***,a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on Fe3O4 nanoparticle modified with meso-2,3-dimercaptosuccinic acid(DMSA)was prepared and a blood Pb(II)removal strategy was further *** the removal process,the nanomotor adsorbent can enter the RBCs,then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of *** the strong coordination of functional groups in DMSA,the nanomotor adsorbent can adsorb Pb(II),and finally be separated from blood by permanent magnetic *** in vivo extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II)in pig models,which may provide innovative ideas for blood heavy metal removal in the future.

关键词： Heavy metal poisoning Blood lead(II)poisoning Magnetic nanomotor adsorbent Alternating magnetic field meso-2 3-Dimercaptosuccinic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

引用

Acta Pharmaceutica Sinica B 2022年第7期12卷 3073-3084页

作者： Ziying Sun Qianqian Liu Zhongyang Lv Jiawei Li Xingquan Xu Heng Sun Maochun Wang Kuoyang Sun Tianshu shi Zizheng Liu Guihua Tan Wenqiang Yan Rui Wu Yannick Xiaofan Yang shiro Ikegawa Qing Jiang Yang Sun dongquan shi State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Laboratory for Bone and Joint Disease Model Animal Research Center(MARC)Nanjing UniversityNanjing 210093China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life ScienceNanjing UniversityNanjing 210023China Drum Tower of Clinical Medicine Nanjing Medical UniversityNanjing 210008China Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Science(IMSRIKEN)Tokyo 108-8639Japan

Osteoarthritis(OA),in which M1 macrophage polarization in the synovium exacerbates disease progression,is a major cause of cartilage degeneration and functional *** strategies of OA designed to interfere with the polarization of macrophages have rarely been ***,we report that SHP099,as an allosteric inhibitor of src-homology 2-containing protein tyrosine phosphatase 2(SHP2),attenuated osteoarthritis progression by inhibiting M1 macrophage *** demonstrated that M1 macrophage polarization was accompanied by the overexpression of SHP2 in the synovial tissues of OA patients and OA model *** to wild-type(WT)mice,myeloid lineage conditional Shp2 knockout(c KO)mice showed decreased M1 macrophage polarization and attenuated severity of synovitis,an elevated expression of cartilage phenotype protein collagen II(COL2),and a decreased expression of cartilage degradation markers collagen X(COL10)and matrix metalloproteinase3(MMP3)in OA *** mechanistic analysis showed that SHP099 inhibited lipopolysaccharide(LPS)-induced Toll-like receptor(TLR)signaling mediated by nuclear factor kappa B(NF-κB)and PI3K—AKT ***,intra-articular injection of SHP099 also significantly attenuated OA progression,including joint synovitis and cartilage *** results indicated that allosteric inhibition of SHP2 might be a promising therapeutic strategy for the treatment of OA.

关键词： SHP2 SHP099 Osteoarthritis Synovitis Toll-like receptor signaling Macrophage Cartilage degradation M1 macrophage polarization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Niobium carbide(MXene)reduces UHMWPE particle-induced osteolysis

引用

Bioactive Materials 2022年第2期7卷 435-448页

作者： Kuo-Yang Sun Yizhang Wu Jia Xu Wenfang Xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv XSWu Qing Jiang Hong-Ling Cai dongquan shi State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing210008JiangsuPR China Collaborative Innovation Center of Advanced Microstructures Laboratory of Solid State Microstructures and School of PhysicsNanjing UniversityNanjing210093China Drum Tower of Clinical Medicine Nanjing Medical UniversityNanjing210008JiangsuPR China Department of Gastroenterology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing210008JiangsuPR China

Joint replacement surgery is one of the orthopedic surgeries with high successful rates;however,wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the *** implant-derived particulate debris such as ultrahigh molecular weight polyethylene(UHMWPE)can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species(ROS).ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of *** this work,we develop the few-layered Nb_(2)C(FNC)as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS ***,local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial *** sum,our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.

关键词： Periprosthetic osteolysis MXene Niobium carbide Osteoclastogenesis Reactive oxygen species(ROS)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算机导航下与传统人工全膝关节置换术的疗效比较

引用

中国修复重建外科杂志 2014年第9期28卷 1066-1071页

作者：徐志宏陈东阳史冬泉戴进蒋青南京大学医学院附属鼓楼医院骨科南京210008

目的通过与传统人工全膝关节置换术（totalkneearthroplasty，TKA）比较，探讨计算机导航技术在TKA中的应用价值。方法回顾分析2010年5月-2011年12月符合选择标准的45例单膝初次TKA患者临床资料，其中22例术中采用计算机导航技术（A组）... 详细信息

目的通过与传统人工全膝关节置换术（totalkneearthroplasty，TKA）比较，探讨计算机导航技术在TKA中的应用价值。方法回顾分析2010年5月-2011年12月符合选择标准的45例单膝初次TKA患者临床资料，其中22例术中采用计算机导航技术（A组），23例采用传统术式（B组）。两组患者性别构成、年龄、体重指数、侧别、病因、病程及术前膝关节活动度、美国特种外科医院（Hss）评分比较，差异均无统计学意义（P〉0．05）。比较两组手术时间、术中出血量、术中髌股外侧支持带松解情况、术后引流量、并发症发生情况以及随访期间假体松动、膝关节活动度及HSS评分。结果术中A组3例（13．6％）、B组1例（4．3％）行髌股外侧支持带松解，比较差异无统计学意义（χ2=1．198，P=0．346）。与B组比较，A组手术时间延长（t=7．557，P=-0．000），术中出血量无显著差异（t=-0．295，P=-0．769），术后引流量明显减少（t=-2．419，P=-0．020）。A组发生术中骨裂1例，术后急性感染1例；B组无并发症发生；并发症发生率比较差异有统计学意义（z=-0．509，P=-0．000）。两组患者均获随访，随访时间27～46个月。两组膝关节内、外翻及股骨、胫骨假体内、外翻偏移比较，差异均无统计学意义（P〉0．05）；末次随访时HSS评分及膝关节活动度比较，差异亦无统计学意义（P〉0．05）。均无假体松动发生。结论与传统TKA相比，计算机导航下行TKA在下肢力线准确度方面无明显差异，但手术时间延长，且存在感染和定位针部位骨裂的风险。

关键词：计算机导航技术人工全膝关节置换术下肢力线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive Space Expansion for Fast Motion Planning

引用

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

No Reference Image Sharpness Assessment Based on Global Color Difference Variation

引用

Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：