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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

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京津冀协同发展背景下的县域水资源安全诊断

水利水电技术（中英文） 2021年第10期52卷 59-71页

作者：李想郭丹红刘家宏尹冬勤李志威许凤冉邵薇薇中国水利水电科学研究院流域水循环模拟与调控国家重点实验室北京100038 水利部泥沙科学与北方河流治理重点实验室北京100038 青海大学三江源生态与高原农牧业国家重点实验室青海西宁810016 福建省建研工程顾问有限公司福建省绿色建筑技术重点实验室福建福州350100 中国农业大学土地科学与技术学院北京100083 武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072

本文构建了以县域为基本单元的水资源安全诊断方法体系,开展了京津冀一体化格局初步形成的社会经济发展和需水量预测,测算了多年平均径流量和近、远期调水量,诊断了多情景组合的水资源安全情势。研究表明:一体化情景下,京津冀地区在维... 详细信息

本文构建了以县域为基本单元的水资源安全诊断方法体系,开展了京津冀一体化格局初步形成的社会经济发展和需水量预测,测算了多年平均径流量和近、远期调水量,诊断了多情景组合的水资源安全情势。研究表明:一体化情景下,京津冀地区在维持经济社会快速发展的前提下,区域需水总量将得到有效控制,需水结构不断优化;无调水时,大部分县域水资源压力较大,中南部县域尤为突出;随着调水工程增补,水资源压力明显缓解,但缺水性质未发生根本变化;考虑远期规划调水,京津冀地区仍有近半数县(区)受到不同程度的缺水影响,缺水量约为41亿m^(3)/a。深入推进区域协同、高质量发展,开源和节流并举是不断提升水资源安全保障能力的有效途径。

关键词：京津冀水资源需水预测水短缺指数节水空间分布

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中国医学创新 2024年第20期21卷 163-167页

作者：尹冬琴李欢徐文慧温晓芳上饶市人民医院新生儿科江西上饶334000

目的:探究辅助性T细胞(Th)2及Th17相关细胞因子在新生儿急性呼吸窘迫综合征(ARDS)中的表达及临床意义。方法:回顾性分析2022年11月—2023年11月在上饶市人民医院出生的80例ARDS患儿纳入研究组,将同期80例健康新生儿纳入对照组。比较研... 详细信息

目的:探究辅助性T细胞(Th)2及Th17相关细胞因子在新生儿急性呼吸窘迫综合征(ARDS)中的表达及临床意义。方法:回顾性分析2022年11月—2023年11月在上饶市人民医院出生的80例ARDS患儿纳入研究组,将同期80例健康新生儿纳入对照组。比较研究组和对照组血清Th2及Th17相关细胞因子[白细胞介素(IL)-4、IL-6、IL-10、IL-17]差异;将研究组根据氧合指数(OI)分为轻度组(4≤OI<8,n=30)、中度组(8≤OI<16,n=26)、重度组(OI≥16,n=24),比较血清IL-4、IL-6、IL-10、IL-17差异,并与OI进行相关性分析;将研究组根据28 d生存状态分为存活组(n=57)和死亡组(n=23),比较IL-4、IL-6、IL-10、IL-17差异并使用logistic回归分析验证对预后的影响,使用受试者操作特征(ROC)曲线分析对预后的效能。结果:研究组IL-4、IL-6、IL-10、IL-17水平均高于对照组,差异均有统计学意义(P<0.05),不同OI水平ARDS患儿急性生理学和慢性健康状况评估Ⅱ(APACHEⅡ)评分、序贯器官衰竭评估(SOFA)评分及IL-4、IL-6、IL-10、IL-17比较,差异均有统计学意义(P<0.05);ARDS患儿OI与IL-4、IL-6、IL-10、IL-17均呈正相关(P<0.05);死亡组IL-4、IL-6、IL-10、IL-17水平均高于存活组,差异均有统计学意义(P<0.05),IL-4、IL-6、IL-10、IL-17均为ARDS患儿死亡的危险因素(P<0.05);IL-4、IL-6、IL-10、IL-17及联合检测预测ARDS患儿死亡的AUC分别为0.806、0.879、0.801、0.862、0.991。结论:Th2及Th17相关细胞因子在ARDS患儿中异常升高,与OI明显相关,检测ARDS患儿Th2及Th17相关细胞因子有助于诊疗评估。

关键词：辅助性T细胞 Th2 Th17 新生儿急性呼吸窘迫综合征

极/超低出生体重儿出生后1周内并发高血糖的影响因素分析

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中国医学创新 2024年第13期21卷 125-129页

作者：李欢尹冬琴徐文慧温晓芳上饶市人民医院新生儿科江西上饶334000

目的:分析极/超低出生体重儿出生后1周内并发高血糖的影响因素。方法:回顾2016年8月—2023年8月在上饶市人民医院新生儿科出生的300例极/超低出生体重儿资料,根据出生后1周内是否并发高血糖(空腹血糖>7 mmol/L)分为正常组(n=220)和异常... 详细信息

目的:分析极/超低出生体重儿出生后1周内并发高血糖的影响因素。方法:回顾2016年8月—2023年8月在上饶市人民医院新生儿科出生的300例极/超低出生体重儿资料,根据出生后1周内是否并发高血糖(空腹血糖>7 mmol/L)分为正常组(n=220)和异常组(n=80),比较两组资料。结果:出生后1周内高血糖发生率26.67%(80/300),发生时间多在24 h内,平均高血糖持续时间(3.44±0.52)d,首发高血糖浓度平均(9.34±1.03)mmol/L;异常组体重<1500 g、5 min新生儿Apgar评分≤7分、胎龄<28周比例均高于正常组,差异均有统计学意义(P<0.05);异常组新生儿母亲年龄≥35岁、妊娠期糖尿病、妊娠期高血压疾病比例均高于正常组,差异均有统计学意义(P<0.05);异常组新生儿葡萄糖输注速度4~6 mg/(kg·min)、禁食时长≤1 d比例均低于正常组,机械通气、新生儿窒息比例均高于正常组,差异均有统计学意义(P<0.05);体重、胎龄、5 min新生儿Apgar评分、葡萄糖输注速度、新生儿窒息是极/超低出生体重儿出生后1周内并发高血糖的影响因素(P<0.05)。结论:极/超低出生体重儿出生后1周内高血糖发生率较高,体重、胎龄、5 min新生儿Apgar评分、葡萄糖输注速度、新生儿窒息是其影响因素,临床应针对上述指标针对性预防。

关键词：极/超低出生体重儿新生儿高血糖症影响因素

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi yin Ming Yang Xuxu Chen Xinhua yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions