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神经重症病房疑似耐碳青霉烯类肺炎克雷伯菌感染暴发的调查与控制

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现代医院 2024年第7期24卷 1130-1133页

作者：王澍琪周萍周美丽陈冬勤苏州大学附属第二医院江苏苏州215004

目的调查某院神经重症病房一起疑似耐碳青霉烯类肺炎克雷伯菌(CRKP)感染暴发的原因,查找传染源与传播途径,为预防和控制医院感染的发生提供依据。方法对某院神经重症病房2020年8月4日—8月20日发生的4例CRKP感染患者进行流行病学调查以... 详细信息

目的调查某院神经重症病房一起疑似耐碳青霉烯类肺炎克雷伯菌(CRKP)感染暴发的原因,查找传染源与传播途径,为预防和控制医院感染的发生提供依据。方法对某院神经重症病房2020年8月4日—8月20日发生的4例CRKP感染患者进行流行病学调查以及病房环境卫生学监测,采取综合措施控制暴发流行。结果4例发生CRKP感染的患者均为医院感染,且分离菌株药敏试验结果一致,为相同克隆株。通过环境卫生学监测,分别从病人床旁物品,吸引装置,氧疗仪,医务人员随身用品的标本中检出了相同克隆株,采取综合整改措施后,未再出现新发CRKP感染病例,随后多次进行物表采样,未再分离出CRKP菌株。结论神经重症病房环境物表污染,消毒环节不到位可能是导致此次CRKP疑似感染暴发的主要原因,及时识别暴发,启动暴发应急预案,制定整改措施是控制多重耐药菌医院感染暴发的重中之重。

关键词：耐碳青霉烯类肺炎克雷伯菌医院感染疑似感染暴发流行病学调查

Dynamic metabolite QTL analyses provide novel biochemical insights into kernel development and nutritional quality improvement in common wheat

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Plant Communications 2024年第5期5卷 42-56页

作者： Bo Yin Jingqi Jia Xu Sun Xin Hu Min Ao Wei Liu Zhitao Tian Hongbo Liu dongqin Li Wenfei Tian Yuanfeng Hao Xianchun Xia Nir Sade Yariv Brotman Alisdair RFernie Jie chen Zhonghu He Wei chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China National Wheat Improvement Center Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijingChina School of Plant Sciences and Food Security The Institute for Cereal Crops ImprovementTel Aviv UniversityTel Aviv 69978Israel Max Planck Institute of Molecular Plant Physiology 14476 Potsdam-GolmGermany Yazhouwan National Laboratory Sanya 572025China

Despite recent advances in crop metabolomics,the genetic control and molecular basis of the wheat kernel metabolome at different developmental stages remain largely ***,we performed widely tar-geted metabolite profiling of kernels from three developmental stages(grain-filling kernels[FKs],mature kernels[MKs],and germinating kernels[GKs])using a population of 159 recombinant inbred *** de-tected 625 annotated metabolites and mapped 3173,3143,and 2644 metabolite quantitative trait loci(mQTLs)in FKs,MKs,and GKs,*** 52 mQTLs were mapped at all three stages,indicating the high stage specificity of the wheat kernel *** candidate genes were functionally vali-dated by in vitro enzymatic reactions and/or transgenic approaches in wheat,three of which mediated the tricin metabolic ***ﬂux efficiencies within the tricin pathway were evaluated,and su-perior candidate haplotypes were identified,comprehensively delineating the tricin metabolism pathway in ***,additional wheat metabolic pathways were re-constructed by updating them to incorporate the 177 candidate genes identified in this *** work provides new information on variations in the wheat kernel metabolome and important molecular resources for improvement of wheat nutritional quality.

关键词： mQTL wheat kernel development gene validation nutritional quality wheat

Biogeochemistry of sedimentary organic matter in the Yongjiang River estuary in the southern part of Hangzhou Bay,China,since the Late Pleistocene

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Journal of Oceanology and Limnology 2024年第3期42卷 772-786页

作者： dongqin HUANG Xiaolong LI Zilong LI Pei Sun LOH Jianxiong HU Jianfang chen Yuan-Pin CHANG Chin-Wen YANG Qin GAO Institute of Marine Geology and Resources Ocean CollegeZhejiang UniversityZhoushan 316021China Ministry of Water Resources of the People’s Republic of China Beijing 100054China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Department of Oceanography Sun Yat-sen UniversityKaohsiung 80424China

A sediment core(YJK19-02)collected from the southern outlet of Hangzhou Bay near the Yongjiang River estuary in East China was analyzed for grain size,lignin,bulk elemental composition,stable carbon isotope,and rare earth elements(REEs)to determine the sources and diagenesis of sedimentary organic matter(OM)of the estuary and adjacent areas since the Late Pleistocene.δ^(13)C values(-24.80‰–-23.60‰),total organic carbon/total nitrogen(TOC/TN)molar ratios(8.00–12.14),and light rare earth element/heavy rare earth element ratios(LREE/HREE=8.34–8.91)revealed the predominance of terrestrial sources of OM,mainly from the Changjiang(Yangtze)*** lignin parameters of syringyl/vanillyl(S/V=0.20–0.73)and cinnamyl/vanillyl(C/V=0.03–0.19)ratios indicate the predominance of nonwoody angiosperms,and the vanillic acid/vanillin ratios[(Ad/Al)_(V)=0.32–1.57]indicate medium to high degrees of lignin *** increasing trend ofΛ(total lignin in mg/100-mg OC)values from ca.14500 a BP to ca.11000 a BP reflected the increase in temperature during the Late ***,a time lag effect of temperature on vegetation abundance was also *** relatively higher and stableΛvalues correspond to the higher temperature during the mid-Holocene from ca.8500 a BP to ca.4500 a BP.Λvalues decreased from ca.4000 a BP to the present,corresponding to historical temperature fluctuations during this *** results show that the vegetation abundance in the Yongjiang River Basin since the Late Pleistocene was related to the temperature fluctuation duo to climate change.

关键词： Yongjiang River estuary sedimentary organic matter lignin environmental change Late Pleistocene

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Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

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建筑施工技术课程思政“五步法”设计与实践

湖北成人教育学院学报 2023年第4期29卷 49-54页

作者：陈冬琴长江职业学院湖北武汉430074

建筑施工技术是土建专业的一门核心课程,将课程思政融入课堂教学,实现课程教学与课程思政同步高效课堂,潜移默化地培养人,是教学改革的新挑战。以建筑施工技术项目化教学为例,探讨课程教学“导入”“学习”“实操”“评价”和“反思”模... 详细信息

建筑施工技术是土建专业的一门核心课程,将课程思政融入课堂教学,实现课程教学与课程思政同步高效课堂,潜移默化地培养人,是教学改革的新挑战。以建筑施工技术项目化教学为例,探讨课程教学“导入”“学习”“实操”“评价”和“反思”模式,契合课程思政“引导”“思考”“践行”“领悟”和“改进”的“五步法”教学设计与实践。课程教学与课程思政同步,实现“理实一体”与“项目化”教学,使学生的思想政治教育“知行合一”系统化,通过课堂主渠道精准高效培养人才。并提出培育课程思政教师队伍和课程思政资源库建设的改进思路,为同类课程思政教学提供借鉴。

关键词：建筑工程技术课程思政课堂教学

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岩溶塌陷影响因素综述研究

城市建筑 2014年第20期11卷 391-392页

作者：陈冬琴湖北城市建设职业技术学院

我国岩溶塌陷地质灾害频发，是社会可持续发展的一大障碍。近年来，我国的岩溶塌陷研究发展较快。根据国内岩溶塌陷的研究现状，本文总结了岩溶塌陷的四大影响因素，并归纳了岩溶塌陷的致塌机理及地质概化模型。

关键词：岩溶塌陷影响因素致塌机理地质概化模型

高职教育推行“双证书”制度实践过程中的问题与对策

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科教导刊 2014年第1S期 20-21页

作者：陈冬琴湖北城市建设职业技术学院湖北武汉430205

实施"双证书"制度以来,推动了高职高专的教育改革,为社会培养了高素质的技能型人才,但随着改革的不断深入,在取得成绩的同时,也凸现了不少问题。为提高教学质量,更新教学观点,促进"双证书"制度的长熟发展,本文总结了实施过程中存在的一... 详细信息

实施"双证书"制度以来,推动了高职高专的教育改革,为社会培养了高素质的技能型人才,但随着改革的不断深入,在取得成绩的同时,也凸现了不少问题。为提高教学质量,更新教学观点,促进"双证书"制度的长熟发展,本文总结了实施过程中存在的一些问题,并提出了建议对策,具有一定的借鉴性意义。

关键词： “双证书”制度问题对策

“互联网+建筑”模块化教学内容及实践路径研究

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成才之路 2021年第31期 112-114页

作者：陈冬琴长江职业学院湖北武汉430074

在“互联网+建筑”转型升级的大潮中,为了顺应行业转型升级的潮流,各高校的建筑专业应积极进行教学改革,努力培养出满足“互联网+建筑”行业实际岗位需求的综合职业型人才。文章从“互联网+建筑”模块化教学内容入手,指出“互联网+建筑... 详细信息

在“互联网+建筑”转型升级的大潮中,为了顺应行业转型升级的潮流,各高校的建筑专业应积极进行教学改革,努力培养出满足“互联网+建筑”行业实际岗位需求的综合职业型人才。文章从“互联网+建筑”模块化教学内容入手,指出“互联网+建筑”模块化教学面临的难题,对“互联网+远程试验”“互联网+BIM技术”“互联网+建筑施工与管理”“互联网+建筑智能化”四大模块的教学内容和实践路径的具体应用策略进行详细的探索研究。

关键词：互联网+建筑模块化教学内容实践路径教学模式双创工匠型人才

Characterization of DNA damage response deficiency in pancreatic cancer patients from China

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Cancer Communications 2022年第1期42卷 70-74页

作者： Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao dongqin chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang State Key Laboratory of Oncogenes and Related Genes Department of OncologyShanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China The Medical Department 3D Medicines Inc.Shanghai 201321P.R.China Head of Laboratory of Cancer Progression and Translational Medicine Shanghai Institute of Nutrition and Health Chinese Academy of SciencesShanghai 200031P.R.China Department of Interventional Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pancreatic Surgery Huashan HospitalPancreatic Disease InstituteShanghai Medical CollegeFudan UniversityShanghai 200040P.R.China

To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic ***,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3].

关键词： damage patients chemotherapy