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Study on the Changes of Immune Factors in Different Stages of Non-Small Cell Lung Cancer Chemotherapy

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Advances in Lung Cancer 2021年第4期10卷 57-64页

作者： Jingjing Zhang Dianbin Song Yi Dong Lu Bai dongqi gao Yan Guo Fubo Li Xiaolei Yu Shenglin Zhang Department of Oncology The Affiliated Hospital of Chengde Medical University Chengde China Department of Urology The Affiliated Hospital of Chengde Medical University Chengde China

Objective: To analyze various immune cytokines (NKG2D, IL-12, IL-15, IL-18, DC cells, TNF-a, IFN-r) and peripheral blood of patients with non-small cell lung cancer (NSCLC) at different times after chemotherapy. Changes in CD4+, CD8+, Th17 and IgG, IgM, and IgA levels. Methods: A total of 118 NSCLC patients who attended the Oncology Department of the Affiliated Hospital of Chengde Medical College from September 2018 to September 2021 were selected as the research objects, and the patients were analyzed at different time points (before chemotherapy, after the first chemotherapy, and after the second chemotherapy). The effects of NKG2D, IL-12, IL-15, IL-18, DC cells, TNF-A, IFN-r, CD4+, CD8+ Th17, IgG, IgM and IgA levels in peripheral blood at different time points (before chemotherapy, after the first chemotherapy and after the second chemotherapy) were analyzed. The changes of NKG2D, IL-12, IL-15, IL-18, DC cells, TNF-A, IFN-r and the levels of CD4+, CD8+ Th17, IgG, IgM and IgA in peripheral blood were compared at each time point. Results: NKG2D, IL-12, IL-15, IL-18, TNF-a, IFN-r gradually decreased before chemotherapy, one week after chemotherapy, and two weeks after chemotherapy, the difference was statistically significant, but DC cells were not significant Variety. CD4+ and CD8+ both increased significantly, and the levels of Th17, IgG, IgM, and IgA gradually decreased. Conclusion: In the course of chemotherapy, all immune factors except DC cells were significantly decreased compared with those before chemotherapy, and the decrease of immune factors except DC cells was positively correlated with the length of chemotherapy cycle. If additional immunotherapy is needed, it should be carried out in the early stage of chemotherapy.

关键词： Non-Small Cell Lung Cancer Chemotherapy NKG2D IL-12 IL-15 IL-18 DC Cells TNF-a IFN-r Immune Cytokines

Study on the Changes and Correlation of Related Immune Factors before and after Chemotherapy in Non-Small Cell Lung Cancer

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International Journal of Clinical Medicine 2022年第1期13卷 50-56页

作者： Jingjing Zhang Dianbin Song Yi Dong Lu Bai dongqi gao Shenglin Zhang Yan Guo Fubo Li Xiaolei Yu Qingshan Li Department of Oncology The Affiliated Hospital of Chengde Medical University Chengde China Department of Urology The Affiliated Hospital of Chengde Medical University Chengde China

Objective: To investigate the changes of related immune cytokines (Dendritic Cells (DC) cells, CD4+, CD8+, Th17, IgG, IgM, IgA) in patients with non-small cell lung cancer (NSCLC) before and after chemotherapy. Methods: Eighty-five NSCLC patients who were treated in the Oncology Department of the Affiliated Hospital of Chengde Medical College from December 2018 to February 2021 were selected as the research objects, and the patients were analyzed at different time points (before chemotherapy, after the first chemotherapy, and after the second chemotherapy) Changes in the expression levels of DC cells, CD4+, CD8+, Th17, IgG, IgM, IgA in peripheral blood, and explore their correlation. Results: Before chemotherapy, after the first chemotherapy, and after the second chemotherapy, the peripheral blood CD4+ and CD8+ were significantly increased, and the Th17, IgG, IgM, and IgA levels gradually decreased. The difference was statistically significant. But there was no obvious change in DC cells. Conclusion: There is no significant change in DC cells in peripheral blood of NSCLC patients before and after chemotherapy. CD4+ and CD8+ are significantly increased, Th17, IgG, IgM, and IgA levels are all decreased, which is a manifestation of impaired immune function of patients after chemotherapy.

关键词： Non-Small Cell Lung Cancer Chemotherapy Immune-Related Factors

Effect of Chemotherapy on Immune Factors in Patients with Non-Small Cell Lung Cancer

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Journal of Biosciences and Medicines 2021年第12期9卷 110-117页

Objective: To analyze the effects of different stages of chemotherapy on the immune cytokines (NKG2D, IL-12, IL-15, IL-18, DC cells, TNF-a, IFN-r) in patients with non-small cell lung cancer (NSCLC). Methods: 106 patients who met the research requirements in the Department of oncology of the Affiliated Hospital of Chengde Medical College from September 2018 to June 2021 were included in the study. The blood levels of interleukin-12 (IL-12), interleukin-15 (IL-15), interleukin-18 (IL-18), dendritic cells (DC cells), tumor necrosis factor A (TNF-a) and the levels of immune interferon (IFN-r) and NK cell activating receptor (NKG2D) in blood before chemotherapy, after the first chemotherapy and after the second chemotherapy were analyzed. Results: Except for the viability of DC cells and DC cells, all other immune factor groups showed statistical differences. Conclusion: Chemotherapy will have a negative effect on all immune factors except DC cells. The effect of immune factors will be weakened according to the increase of the chemotherapy cycle. Therefore, immunotherapy for non-small cell lung cancer needs to be carried out before chemotherapy or in the early stage of chemotherapy to achieve better results.

关键词： Non-Small Cell Lung Cancer Chemotherapy Immune Cytokines

Effects of Chemotherapy on Peripheral Blood NK Cell Receptor NKG2D and Related Immune Cytokines in Patients with Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2022年第11期13卷 631-639页

作者： Jingjing Zhang Dianbin Song Yi Dong Lu Bai dongqi gao Shenglin Zhang Yan Guo Fubo Li Man Ao Qingshan Li Department of Oncology the Affiliated Hospital of Chengde Medical University Chengde China Department of Urology the Affiliated Hospital of Chengde Medical University Chengde China

Objective: To analyze the effect of chemotherapy on peripheral blood NK cell receptor NKG2D and related immune cytokines (IL-12, IL-15, IL-18) in patients with non-small cell lung cancer (NSCLC). Methods: A total of 48 patients with NSCLC who visited the Oncology Department of the Affiliated Hospital of Chengde Medical College from September 2018 to September 2019 were selected as the study subjects. Changes in the expression levels of NKG2D, IL-12, IL-15 and IL-18 in peripheral blood of patients at different time points (before chemotherapy, after the first chemotherapy and after the second chemotherapy) were analyzed to investigate the correlation between NKG2D and IL-12, IL-15 and IL-18 in peripheral blood at each time point. Results: The expression levels of NKG2D, IL-15, and IL-18 in the peripheral blood of the patient before chemotherapy, after the first chemotherapy, and after the second chemotherapy gradually decreased. After the first chemotherapy and the second chemotherapy, the peripheral blood IL-12 was significantly lower than before chemotherapy, and IL-12 in peripheral blood after the second chemotherapy was slightly increased compared with that after the first chemotherapy. The comparison of each factor at different time points was statistically significant (all P0.05). Pearson correlation analysis showed that after the first chemotherapy, NKG2D in peripheral blood was positively correlated with IL-18 (r = 0.342, P = 0.031);after the second chemotherapy, NKG2D in peripheral blood was positively correlated with IL-18 (r = 0.411, P = 0.023), negatively correlated with IL-15 (r = -0.451, P = 0.001). Conclusion: There was no significant change in the number of NK cells in the peripheral blood of NSCLC patients after chemotherapy, while NKG2D and related immune cytokines decreased, which may be one of the mechanisms for the suppression of immune function in patients, and this provides a potential target for immunotherapy in pat

关键词： Non-Small Cell Lung Cancer Chemotherapy NKG2D Immune Cytokines

Effect of Chemotherapy on Peripheral Blood DC Cells and Related Immune Cytokines in Patients with Non-Small Cell Lung Cancer

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Open Journal of Internal Medicine 2021年第4期11卷 275-282页

Objective: To analyze the effects of chemotherapy on peripheral blood DC cells and related immune cytokines (NKG2D, DC cells, TNF-a, IFN-r, HMGB-1) in patients with non-small cell lung cancer (NSCLC). Methods: Ninety-five NSCLC patients who attended the Oncology Department of the Affiliated Hospital of Chengde Medical College from September 2018 to February 2021 were selected as the research objects, and the changes in the expression levels of DC cells, NKG2D, TNF-a, IFN-r, HMGB-1 in the peripheral blood of patients at different time points (before chemotherapy, after the first chemotherapy, and after the second chemotherapy) were analyzed, and the correlation between DC cells in blood and NKG2D, TNF-a, IFN-r, HMGB-1 at each time point was explored. Results: The expression levels of NKG2D, TNF-a, IFN-r, and HMGB-1 in the peripheral blood of the patient before chemotherapy, after the first chemotherapy, and after the second chemotherapy gradually decreased, and there was no significant change in DC cells, except for DC cells at different times. The difference between each factor of each point was statistically significant (all P Conclusion: The decrease of other immune cytokines except DC cells in peripheral blood of patients with NSCLC after chemotherapy may be one of the mechanisms by which the patient’s immune function is suppressed. There is no correlation between DC cells and other factors.

关键词： Non-Small Cell Lung Cancer Chemotherapy NKG2D TNF-a IFN-r HMGB-1 DC Cells Immune Cytokines

基于WebGIS的航空器飞行监控应急管理系统设计与实现

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城市勘测 2020年第3期 54-58页

作者：高东琦山东省国土测绘院山东济南250013

为解决民航应急系统管理效率低、日常飞行监控与应急管理相对独立的现状,本文基于WebGIS技术,采用SOA架构模型设计了航飞器飞行监控应急管理系统,将日常飞行监控与应急管理进行有机结合,实现了飞行实时监控可视化、突发事件预测分析、... 详细信息

为解决民航应急系统管理效率低、日常飞行监控与应急管理相对独立的现状,本文基于WebGIS技术,采用SOA架构模型设计了航飞器飞行监控应急管理系统,将日常飞行监控与应急管理进行有机结合,实现了飞行实时监控可视化、突发事件预测分析、航空器搜索救援等辅助决策功能和地理信息服务功能,提高了民航应急管理的效率。

关键词：民航飞行监控应急管理 WebGIS

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高校有组织科研:内涵、难点堵点与化解对策

科技进步与对策 2024年第16期41卷 150-160页

作者：赵立雨朱白雪高冬祺中国矿业大学公共管理学院江苏徐州221116

高校是基础研究与科技创新的主力军,在实施有组织科研中发挥着至关重要的作用,其主要面向国家科技战略需求,促进我国实现高水平科技自立自强。当前,高校有组织科研在体制机制、保障条件、成果评价、行政与学术权力协调等方面存在一定问... 详细信息

高校是基础研究与科技创新的主力军,在实施有组织科研中发挥着至关重要的作用,其主要面向国家科技战略需求,促进我国实现高水平科技自立自强。当前,高校有组织科研在体制机制、保障条件、成果评价、行政与学术权力协调等方面存在一定问题,亟待关注难点何解、堵点何疏。通过案例分析,围绕政府、高校、企业、科研院所等多元主体,从机制优化、顶层设计、平台建设、项目统筹、经费投入、成果转化、人员管理等方面提出解决高校有组织科研难点堵点的对策建议,为促进高校深入实施有组织科研、加速实现高水平科技自立自强提供参考和指导。

关键词：高校科研有组织科研新型举国体制科技自立自强

大直径盾构浅覆土下穿铁路桥涵的影响分析及施工控制

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上海交通大学学报 2019年第3期53卷 297-304页

作者：杨俊龙门燕青廖少明高东奇苏逢彬同济大学地下建筑与工程系上海200092 上海城建置业发展有限公司上海200030 济南轨道交通集团有限公司济南250101

为揭示大直径盾构浅覆土下穿施工对铁路桥涵的影响,结合杭州环北地下快速路大直径泥水平衡盾构隧道工程实践,采用数值分析的方法对盾构穿越引起的运营铁路桥涵力学行为进行预测,并结合工程实测分析了盾构施工参数的变化规律、控制方法... 详细信息

为揭示大直径盾构浅覆土下穿施工对铁路桥涵的影响,结合杭州环北地下快速路大直径泥水平衡盾构隧道工程实践,采用数值分析的方法对盾构穿越引起的运营铁路桥涵力学行为进行预测,并结合工程实测分析了盾构施工参数的变化规律、控制方法和桥涵变形的实施效果.数值分析结果表明:未进行桥涵区域的土体加固时,若直接穿越铁路桥涵施工,桥涵的最大沉降可以达到21.6 mm,且在桥涵中隔墙的顶部和底部出现应力集中,最大拉应力可达1.60 MPa;进行土体加固后,穿越铁路桥涵施工时桥涵的最大沉降为9.3 mm,部分区域的最大拉应力为1.46 MPa.工程实践中,常规情况下切口压力较静止土压力大15 kPa,为确保盾构穿越铁路桥涵结构的安全,切口压力调大至25 kPa.考虑上覆水土荷载降低约13%,盾构总推力降低约10%,转矩降低约10%,盾尾注浆量处于150%～200%之间可确保穿越铁路桥涵盾构施工安全.现场实测表明:当盾构机将要穿越桥涵时,桥涵结构产生3～4 mm的预隆起;待盾构穿越后,又产生约4 mm的沉降;盾构机通过3 d后,差异沉降降低并较快趋于稳定,最终稳定在0.01%左右.

关键词：盾构隧道大直径盾构浅覆土穿越施工

血脑钠肽及肌钙蛋白Ⅰ水平与胸部放疗后放射性心脏损伤发生率的关系

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东南大学学报（医学版） 2018年第4期37卷 682-686页

作者：高东奇承德医学院附属医院肿瘤科河北承德067000

目的:探讨胸部恶性肿瘤放射治疗患者血清脑钠肽(BNP)和肌钙蛋白Ⅰ(cTnⅠ)水平与放射性心脏损伤(RⅠHD)发生的相关性。方法:对60例胸部恶性肿瘤患者采用三维适形放疗;放疗前、放疗6周和放疗3个月检测血清cTnⅠ和BNP水平。结果:RⅠHD 43例... 详细信息

目的:探讨胸部恶性肿瘤放射治疗患者血清脑钠肽(BNP)和肌钙蛋白Ⅰ(cTnⅠ)水平与放射性心脏损伤(RⅠHD)发生的相关性。方法:对60例胸部恶性肿瘤患者采用三维适形放疗;放疗前、放疗6周和放疗3个月检测血清cTnⅠ和BNP水平。结果:RⅠHD 43例(71.7%),1级RⅠHD 40例,2级RⅠHD 3例;心电图异常22例中17例于放疗结束后即出现异常,5例于放疗3个月后出现异常。患者血清BNP和cTnⅠ水平在放疗第6周发生显著上升,放疗后3个月回落,放疗第6周BNP和cTnⅠ水平均显著高于放疗前和放疗后3个月(P<0.05);放疗第6周RⅠHD组cTnⅠ和BNP水平均显著高于无RⅠHD组(P<0.05),与放疗前比较RⅠHD组BNP显著上升(P<0.05)。结论:RⅠHD患者血清BNP和cTnⅠ水平在放疗早期显著升高,两者可作为潜在早期预测指标。

关键词：放射性心脏损伤脑钠肽肌钙蛋白Ⅰ 放射治疗