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Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent

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Journal of Rare Earths 2024年第2期42卷 278-285,I0002页

作者： Yongxiu li Feng Guo Siwei Wei Duofu li Jun Zhang Kai Xu dongping li Department of Chemistry Nanchang UniversityNanchang330031China Key Laboratory of Functional Molecule Design and Interface Process Anhui Jianzhu UniversityHefei230601China Department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Nanchang UniversityNanchang330006China

The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination *** from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been *** rein,we introduced a series of lanthanide tetrahedral cages,(Eu_(n)Gd_(4-n)L_(4))(sol)_8(n=0,1,2,3 and 4,where L=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological *** the good luminescent and magnetic properties of Eu^(3+) and Gd^(3+) ions,Eu_(4)L_(4) and Gd_(4)L_(4) complexes show a high luminescence quantum yield of 29% in DMSO and large longitudinal relaxivity(r_(1)) of 11.4(mmol/L)^(-1)/s at 0.5 T in water containing 1 vol% DMSO,*** heterobimetallic Eu-Gd complexes achieve a dual imaging mode by combining luminescent and magnetic centers in one *** the Gd:Eu ratio increases from 1:3 to 3:1,the r_(1) values increases from 5.33 to 8.64(mmoI/L)^(-1)/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mmol/L)^(-1)/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the selfassembled Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the multimodal imaging contrast agent.

关键词： Lanthanide organic cage Luminescence Cell imaging Contrast agents Rare earths

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3D-structured carbon nanotube fibers as ultra-robust fabrics for adaptive electromagnetic shielding

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Nano Research 2024年第9期17卷 8521-8530页

作者： dongping li Ping Wang Yuanyuan li Zhenzhong Yong Kunjie Wu Yan Zhang Jin Wang Dongmei Hu Key Laboratory of Multifunctional and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Textile and Clothing Engineering of Soochow University Suzhou 215021China

Wireless communication technology is indispensable in our daily lives,but it also results in serious electromagnetic radiation ***,developing smart electromagnetic interference shielding materials with adjustable electromagnetic wave(EMW)responses holds significant promise for future electromagnetic shielding *** this study,we propose an electromagnetic shielding switch(ESS)characterized by tunable electromagnetic shielding performance achieved by fabricating a three-dimensional(3D)carbon nanotube-based spacer fabric(CNT-SF)and modifying CNT-SF with chemical vapor deposition(CCNT-SF).The CCNT-SF displays direction-dependent electrical conductivity by manipulating the warp and weft density,measuring 128 S/m transversely and 447 S/m *** characteristic allows the CCNT-SF to transmit or shield EMW by adjusting the angle of EMW incidence through fabric rotation,resulting in anisotropic electromagnetic shielding performance(33 dB transversely and 87 dB vertically).This feature enables switchable shielding with an on/off ratio of ***,the unique 3D structure confers excellent mechanical properties on the fabric,with compressive strength reaching 120 *** a flexible,lightweight,and mechanically robust ESS,the CCNT-SF holds promising prospects for mitigating the challenges of increasingly severe and intricate electromagnetic environments.

关键词： carbon nanotube spacer fabric electromagnetic shielding impact resistance joule heating electromagnetic shielding switch

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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： dongping li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin li Meiling Chen Ruofan liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty Selva Nandakumar Yong Jiang Hongwei Zhou Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis

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基本公共服务可及性如何影响农户获得感——基于湖北省1036个农户样本的实证分析

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中国农村观察 2024年第1期 22-44页

作者：李东平田北海华中农业大学农村社会建设与管理研究中心

本文以基本公共服务均等化建设的主观福祉效应为分析视角,依据2021年湖北省7个地级市1036份农户问卷调查数据,系统考察了基本公共服务可及性对农户获得感的影响及其作用机制。基准回归结果表明,基本公共服务可及性能够显著提升农户的获... 详细信息

本文以基本公共服务均等化建设的主观福祉效应为分析视角,依据2021年湖北省7个地级市1036份农户问卷调查数据,系统考察了基本公共服务可及性对农户获得感的影响及其作用机制。基准回归结果表明,基本公共服务可及性能够显著提升农户的获得感。在利用条件混合过程估计法缓解模型内生性问题以及进行稳健性检验后,上述结论依然成立。本文还探讨了不同类型的基本公共服务可及性对农户获得感的影响。研究结果表明:公共教育服务可及性、医疗卫生服务可及性和劳动就业服务可及性的获得感提升效应较为突出,公共文体服务可及性则没有显著提升农户的获得感。在作用机制方面,基本公共服务可及性可以通过增进农户的生活福祉和公平认知提升其获得感。异质性分析表明:与一般农户相比,基本公共服务可及性对脱贫户获得感的提升作用更大;与低财政投入水平的村相比,基本公共服务可及性对农户获得感的提升效应在高财政投入水平村更大。本文的研究有助于审视并理清基本公共服务均等化建设在推动共享发展进程中的政策效应,为以基本公共服务均等化建设为抓手、提升农户民生福祉、实现共享发展提供证据支撑。

关键词：获得感基本公共服务可及性生活福祉公平认知

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影响井下煤矿采矿工程质量安全的技术因素

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当代化工研究 2024年第16期 107-109页

作者：李东平内蒙古平庄煤业(集团)有限责任公司六家煤矿内蒙古024076

井下煤矿开采面临的地质条件极为复杂,整体开采难度较大,特别是随着开采深度的持续增加,井下采矿作业环境会更加恶劣,在技术层面上也会有更多的因素会对采矿工程质量安全带来影响。本文从井下煤矿采矿工程质量安全入手展开分析,介绍井... 详细信息

井下煤矿开采面临的地质条件极为复杂,整体开采难度较大,特别是随着开采深度的持续增加,井下采矿作业环境会更加恶劣,在技术层面上也会有更多的因素会对采矿工程质量安全带来影响。本文从井下煤矿采矿工程质量安全入手展开分析,介绍井下煤矿采矿工程的复杂性,并分析了影响采矿工程质量安全的一些技术因素,在这一基础上提出具体的应对策略。

关键词：井下煤矿采矿工程质量安全技术因素

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新疆乌什7.1级地震人口热力及其应急响应功能分析

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地震工程学报 2024年第4期46卷 992-1000页

作者：李环宇李东平尹晶飞李敏孙海青浙江省地震局浙江杭州310013

2024年1月23日2时9分,新疆阿克苏地区乌什县发生7.1级地震。为快速了解震区人口分布情况,判定此次地震极震区范围,分别采集震区内2时及2时30分手机位置数据。利用核密度空间评估方法得到震前及震后人口分布状态与变化情况,并对变化的原... 详细信息

2024年1月23日2时9分,新疆阿克苏地区乌什县发生7.1级地震。为快速了解震区人口分布情况,判定此次地震极震区范围,分别采集震区内2时及2时30分手机位置数据。利用核密度空间评估方法得到震前及震后人口分布状态与变化情况,并对变化的原因进行分析。研究表明:基于手机位置信息评估得到的震后人口热力数据在城市中心会出现与以往震例不同的“反常”升高现象;人口热力数据对地震诱发的公路边坡地质灾害有很好的响应;部分通信基站退服导致个别村庄人口热力“斑点式”减少,该现象有助于判别基站退服点的地震破坏程度。由于样本数据分布不均且地震发生在凌晨2时9分,人口变化率在刻画地震影响场的能力方面稍显不足。人口热力数据可以在震后应急响应阶段快速获取灾区人口分布与动态变化情况,为灾情信息的获取及地震初期救援力量的科学分配提供有效的数据支持。

关键词：乌什县7.1级地震人口热力 “反常”升高应急响应阶段

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参芪地黄汤加减联合缬沙坦胶囊治疗慢性肾小球肾炎的效果及对肾功能和免疫功能的影响

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临床合理用药杂志 2024年第29期17卷 20-22页

作者：李董平李聪饶杰广东省深圳市盐田区人民医院中西医结合肾病科 518000

目的观察参芪地黄汤加减联合缬沙坦胶囊治疗慢性肾小球肾炎(CGN)的效果及对肾功能和免疫功能的影响。方法选取2021年3月—2023年3月于深圳市盐田区人民医院诊治的CGN患者80例,根据单双号随机分为观察组40例和对照组40例。对照组给予缬... 详细信息

目的观察参芪地黄汤加减联合缬沙坦胶囊治疗慢性肾小球肾炎(CGN)的效果及对肾功能和免疫功能的影响。方法选取2021年3月—2023年3月于深圳市盐田区人民医院诊治的CGN患者80例,根据单双号随机分为观察组40例和对照组40例。对照组给予缬沙坦胶囊治疗,观察组给予参芪地黄汤加减联合缬沙坦胶囊治疗,2组均治疗8周。比较2组疗效,治疗前后肾功能指标[血肌酐(SCr)、血尿素氮(BUN)、24 h尿蛋白定量(24 h-Upro)]、免疫指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平及不良反应。结果观察组治疗总有效率为95.00%,高于对照组的77.50%(χ^(2)=5.165,P=0.023);治疗8周后,2组SCr、BUN水平、24 h-Upro及CD8^(+)低于治疗前,CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,且观察组低/高于对照组(P<0.05或P<0.01);观察组与对照组不良反应总发生率比较差异无统计学意义(5.00%vs.10.00%,χ^(2)=0.180,P=0.671)。结论参芪地黄汤加减联合缬沙坦治疗CGN效果较好,可有效调节T淋巴细胞水平,改善肾功能,且安全性高。

关键词：慢性肾小球肾炎参芪地黄汤缬沙坦治疗效果肾功能指标免疫指标

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Coupling mechanism between mining-induced deformation and permeability of coal

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International Journal of Mining Science and Technology 2013年第6期23卷 783-787页

作者： Xue Dongjie Zhou Hongwei Wang Chaosheng li dongping School of Mechanics&Civil Engineering China University of Mining&Technology State Key Laboratory of Coal Resources and Safe Mining China University of Mining&Technology

The coupling mechanism between mining-induced mechanical behavior and gas permeability of coal is effectively obtained in *** study means significant understanding of the prevention of coal-gas *** testing samples of coal were drilled from the 14120 mining face at the depth of690 *** on the redistribution of stress during the excavation,the coupling test between mechanical state and seepage has been designed using the triaxial servo-controlled seepage equipment for thermofluid-solid coupling of coal containing *** is the result that there are two main factors influencing the mining-induced mechanical behavior of coal,such as the change ofσ_1-σ_3 andΔσ_1-Δσ_*** failure mode mainly depends on the value ofσ_1-σ_3,and the peak strength value mainly depends on the value ofΔσ_1-Δσ_*** difference of mechanical response between geostress and mining-induced stress has been obtained,which can be a theoretical support for safe mining such as reasonable gas drainage,prevention of coal-gas outburst and gas over-limit.

关键词： Mining-induced mechanical behavior Coal deformation Seepage Coupling test

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Occlusion of the middle cerebral artery Guidance by screen imaging using an EDA-H portable medium-soft electronic endoscope

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Neural Regeneration Research 2011年第23期6卷 1806-1809页

作者： Xingbao Zhu Junli Luo Song liu dongping li Min li Quanshui Fan Department of Neurosurgery Kunming General Hospital Chengdu Military Command of Chinese PLA Kunming 650032 Yunnan Province China Disease Prevention ＆ Control Centre Chengdu Military Command of Chinese PLA Kunming 650032 Yunnan Province China

The present study aimed to verify the practicability of performing screen-based surgical operations under the guidance of a real-time viewing and recording system （RTVRS） using a portable medium-soft electronic endoscope （pmsEE）. The middle cerebral artery in rats was occluded under screen-imaging guidance using a pmsEE RTVRS to reproduce an animal model of human cerebral infarction. The screen imaging of the pmsEE RTVRS was clear, life-like, stereoscopic and synchronous with the actual operation. Screen-imaging guidance led to an accurate, smooth, minimally invasive and comparatively easy surgical procedure. The surgical success rate, time of model establishment, neurological function scores, and infarct volume were similar to those using an operating microscope. These results indicate that the self-designed pmsEE RTVRS could be utilized for portable endoscopic screen-based surgical operations.

关键词： portable medium-soft endoscope screen-based surgical operation occlusion of middle cerebral artery cerebral infarction

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FERONIA Receptor Kinase Controls Seed Size in Arabidopsis thaliana

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Molecular Plant 2014年第5期7卷 920-922页

作者： Feng Yu Jian li Yuan Huang li liu dongping li liangbi Chen Sheng Luan College of life Sciences Hunan Normal University Changsha 410081 RR. China Hunan Province Key Laboratory of Plant Functional Genomics andDevelopmental Regulation Hunan University Changsha 410082 RR. China Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA

Dear Editor, Plants have evolved elaborate mechanisms by which cell elongation regulation is coupled to the environmental signals. The plasma membrane receptor kinase FERONIA （FER） has emerged as an important regulatory node in controlling cell elongation and hormone crosstalk （Guo et al., 2009; Deslauriers and Larsen, 2010; Duan et al., 2010; Yu et al.,

关键词： CELL ELONGATION

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