检索结果-南通市图书馆

RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim dongmin kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geochemical characteristics,generation,and evolution mechanism of coalbed methane in the south-western Ordos Basin,China

引用

Frontiers of Earth Science 2024年第2期18卷 296-311页

作者： Yabing LIN Yong QIN dongmin MA Shengquan WANG College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Coalbed Methane Resource and Reservoir Formation Process(the Ministry of Education) China University of Mining and TechnologyXuzhou 221008China Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Xi’an 710054China

The south-western Ordos Basin is rich in low-middle rank coalbed methane(CBM)resources;while the geochemical characteristics and genetic mechanism of CBM are not ***,according to geological and geochemical test data from gas and coal seam water from CBM wells in Bingchang,Jiaoxun,Huangling,Yonglong,and Longdong minging areas,we systematically studied the geochemical characteristics,generation,and evolution mechanism of CBM in Jurassic Yan’an Formation in the south-western Ordos *** results show that the CH4 content of whole gas is in the range of 42.01%-94.72%.The distribution ranges of theδ^(13)C-CH_(4)value is−87.2‰to−32.5‰,indicating diverse sources of thermogenic gas and biogenic *** microbial methane is mainly generated by a CO_(2)reduction pathway,with certain methyl-type fermentation ***δ^(13)C-CH_(4)has a positive correlation with burial depth,indicating the obvious fractionation of *** relationship between the genetic types and burial depth of the CBM reservoir indicates that the favorable depth of secondary biogenic gas is less than 660 *** Late Cretaceous Yanshanian Movement led to the uplift of the Ordos Basin,and a large amount of thermogenic gas escaped from the edge of the *** the Paleogene Period,the coal reservoir in the basin margin has received recharge from atmospheric precipitation,which is favorable for the formation of secondary biogenic *** deep area,generally under 1000 m,mainly contains residual thermogenic *** intermediate transition zone is mixed *** by the tectonic background,the genetic types of CBM in different mining areas are controlled by the coupling of burial depth,coal rank,and hydrogeological *** Binchang mining area contains biogenic gas,and the development of CBM has achieved initial success,indicating that similar blocks with biogenic gas formation conditions is key to the efficient development of *** research results provide a scientific basis for

关键词： coalbed methane stable isotopes geochemistry generation and evolution mechanism Ordos Basin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporal and Spatial Trends in HIV Positivity Rate for VCT Clinics—China,2015–2022

引用

China CDC weekly 2024年第1期6卷 6-11页

作者： Yi Liu Rong Su dongmin Li Shaorong Wang Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Human immunodeficiency virus(HIV)voluntary counseling and testing(VCT)clinics play a critical role in identifying and diagnosing HIV *** study aimed to describe the trend of HIV positivity rate(HPR)among Chinese VCT clinics between 2015 and ***:This study utilized data from the China Information System for Disease Control and Prevention to analyze the trend in the HPR for VCT clinics from 2015 to *** HPR was calculated by dividing the number of newly-reported HIV cases by the number of HIV tests,multiplied by 100%.To identify temporal and spatial trends in the HPR,we employed joinpoint regression analysis and the Getis-Ord hotspot ***:From 2015 to 2022,VCT clinics in China performed a total of 22,075,386 HIV tests,leading to the identification of 260,353 HIV cases,resulting in a HPR of 1.18%.The HPR consistently declined over the study period,with an average annual percent change(AAPC)of−7.5%(95%confidence interval:−12.6%,−2.2%,P<0.05).The number of HPR hotspots also decreased from 41 in 2015 to 23 in *** HPR hotspots were primarily located in Yunnan,Sichuan,Guangdong,and Guangxi provincial-level administrative divisions(PLADs).Among the 31 PLADs,16 showed a significant decrease in HPR during the study period(AAPC<0,PAAPC<0.05).Conclusions:VCT clinics in China have played a significant role in identifying HIV *** declining HPR observed in these clinics may indicates the progress has been made in some degree in mitigating HIV among high-risk ***,it is crucial to further improving the utilization of VCT clinics for HIV testing.

关键词： VCT dividing Spatial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional morphological and fluorescent imaging of zebrafish with a continuous-rotational light-sheet microscope

引用

Journal of Innovative Optical Health Sciences 2024年第2期17卷 59-66页

作者： dongmin Zhang Guang Yang Yao Tan Chong Chen Jie Zhang Hui Li School of Biomedical Engineering(Suzhou)Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese A cademy of Sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3D)structures and functions of various millimeter-size bio-specimen such as ***,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3D image of thick ***,we report a continuous-rotational light-sheet microscope(CR-LSM)that enables simultaneous 3D bright-field and fluorescence *** a high-accuracy rotational stage,CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation ***,3D morphology and fluorescent structure were reconstructed with a developed *** CR-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Isolable Phosphinogermylyne as a Synthon of One-Coordinate GeⅠRadical

引用

Chinese Journal of Chemistry 2024年第7期42卷 736-742页

作者： dongmin Wang Haonan Chen Yuhao He Xiaodan Chen Li Zhang Gengwen Tan Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education Guangdong Basic Research Center of Excellence for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-Sen UniversityGuangzhouGuangdong 510275China School of Electronic Engineering Guangxi Universityof Science and TechnologyLiuzhouGuangxi 545000China College of Chemistry and Material Jinan UniversityGuangzhouGuangdong 510632China Innovation Center for Chemical Science College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal UniversityHangzhouZhejiang 311121China

Reduction of chlorogermylene MsFluindtBu-GeCl 1 with potassium graphite(KC8)afforded putative germylyne radical MsFluindtBu-Ge 2 as confirmed by electron paramagnetic resonance(EPR)***,it slowly decayed via C—H bond activation at the fluorenyl moiety to yield a bis(germylene)3 at room *** using a Lewis base to stabilize the unoccupied p orbital at the GeⅠradical center,acyclic two-coordinate GeⅠradicals MsFluindtBu-Ge(IMe4)4(IMe4=1,3,4,5-tetramethyl-imidazolin-2-ylidene),MsFluindtBu-Ge(IiPr)5(IiPr=1,3-diisopropyl-4,5-dimethyl-imidazolin-2-ylidene),MsFluindtBu-Ge(PMe3)6 were isolated in crystalline *** unpaired electron in 4-6 mainly resides at the Ge 4p orbital as revealed by EPR spectroscopic studies and theoretical ***,facile ligand exchange of PMe3 in 6 with IMe4 and IiPr was observed to afford 4 and 5,***,phosphinogermylyne 6 reacted with PhEEPh(E=S,Se),4-tetrabutylphenylacetylene(Ar'CCH),[CpMo(CO)3]2 and nBu3SnH to furnish germylenes MsFluindtBu-GeEPh(E=S 7,Se 8),MsFluindtBu-GeCH=CHAr'9,a germylyne complex MsFluindtBu-Ge≡Mo(CO)2Cp 10 and a Ge(Ⅳ)compound MsFluindtBu-GeH2SnnBu311,*** reactivity studies demonstrate that 6 can act as a synthon of one-coordinate germylyne radical attributing to labile coordination of trimethylphosphine.

关键词： Phosphinogermylyne Germanium Radicals Donor-acceptor systems Radical reactions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design and fabrication of Nd-Fe-B magnet with excellent thermal stability

引用

Journal of Rare Earths 2024年第5期42卷 980-986,I0006页

作者： Rui Han Shengzhi Dong Dong Li dongmin Zhang Hongsheng Chen Jiyuan Xu George CHadjipanayis Zhuolin Li Ying Zhang Wei Li Division of Functional Materials Research Central Iron and Steel Research InstituteBeijing100081China Department of Physics and Astronomy Sharp Lab University of DelawareNewarkDE19716USA Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China

A novel Nd-Fe-B type permanent magnet with excellent thermal stability was designed by Co replacing Fe in the main phase and the grain boundary *** remanence and coercivity temperature coefficient reach 0.058%/℃and 0.465%/℃in the te mperature range from 25 to 100℃,which are much lower than those of commercial Nd-Fe-B *** enhanced Curie temperature is obtained for the novel magnet due to the Co substitution,which significantly improves the operating *** microstructure result reveals that an amorphous phase exists in the intergranular grains which is probably responsible for the deterioration of intrinsic *** work can provide a reference for the design and optimization of components of sintered Nd-Fe-B magnets with excellent thermal stability.

关键词： Thermal stability Remanence temperature coefficient Operating temperature Atomic substitution Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrocatalytic Reduction of CO_(2)to CO with Almost 100%Faradaic Efficiency Using Oxygen-Vacancy Enriched Two-Dimensional MgO

引用

CCS Chemistry 2024年第6期6卷 1477-1486页

作者： Yu Han Sunggi An Xinyu Zhan Leiduan Hao Liang Xu Song Hong dongmin Park Yuxin Chen Yiwen Xu Jiwen Zhao Xinyi Tan Alex W.Robertson Yousung Jung Zhenyu Sun State Key Laboratory of Organic-Inorganic Composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Department of Chemical and Biomolecular Engineering(BK21four) Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141 Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081 Department of Physics University of WarwickCoventry

The design and development of cheap,abundant,and efficient electrocatalysts for selective CO_(2)electroreduction is highly desirable yet remains an ongoing ***,we report on our discovery of the use of two-dimensional MgO rich in oxygen vacancies(VO)as an electrocatalyst for the efficient reduction of CO_(2)to yield CO in 1-butyl-3-methylimidazolium hexafluorophosphate dissolved in *** faradaic efficiency toward CO reaches as high as 99.6±0.24%with a current density of up to 40.8 mA cm−*** functional theory calculations illustrate that the introduction of VO in MgO substantially lowers the reaction-free energy for the transformation of ^(*)COO^(−) to ^(*)COOH,the potential determining step,which greatly boosts CO_(2)conversion *** work opens the way to realizing economic and efficient CO_(2)electrolysis of group II metals.

关键词： CO_(2)reduction electrocatalysis CO MgO ionic liquid oxygen-vacancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

财政监管如何影响债券市场发行定价？——基于融资平台转型政策的准自然实验

引用

财经研究 2024年第6期50卷 34-48页

作者：姚东旻董鸿儒孟境罗文淇中央财经大学中国财政发展协同创新中心

财政监管会对金融市场产生何种影响是财政政策与金融政策协调的重要内容。文章利用始于2015年各地发布的“融资平台转型”专项文件作为财政监管政策的典型冲击和事件窗口,借助2010—2021年全国3 269家地方融资平台及其所在地级市综合面... 详细信息

财政监管会对金融市场产生何种影响是财政政策与金融政策协调的重要内容。文章利用始于2015年各地发布的“融资平台转型”专项文件作为财政监管政策的典型冲击和事件窗口,借助2010—2021年全国3 269家地方融资平台及其所在地级市综合面板数据,系统使用了因果推断的多种方法,试图探究针对债券发行主体的财政强监管如何作用于债券一级市场。研究发现,该类文件传递了明确的“不兜底”“强监管”“促转型”信号,会对不同风险状况的地方融资平台潜在信用风险产生不同影响,并表现为债券发行“溢价”（或“折价”）效应：财政监管政策传递的“不兜底”“强监管”“促转型”信号在短期显著提升了地方融资平台在债券一级市场的加权平均发行利差；在债务率水平较高且发生过债券违约情况的地区,地方融资平台加权平均发行利差在政策信号影响下显著上升；而在债务率水平较低且未发生过债券违约的地区,则其定价表现相反。这一发现验证了财政监管有助于加强债券一级市场对地方融资潜在信用风险的差异化精确识别,提供了财政监管对于金融市场定价效率提升的佐证。

关键词：财政监管债券定价地方融资平台潜在信用风险发行利差

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

美债减持与国际货币体系多元化路径

引用

中国社会科学 2024年第5期 51-71,205页

作者：刘东民宋爽中国社会科学院大学应用经济学院北京102488 中国社会科学院世界经济与政治研究所北京100732

以美元为中心的国际货币体系作为一种霸权体系具有内在不稳定性,而国际货币体系一直未能形成真正的多元格局。通过对霸权稳定论、均势理论和国际货币权力理论的批判,结合国际金融理论的定性与定量分析,从美国政府债务压力与美元国际信... 详细信息

以美元为中心的国际货币体系作为一种霸权体系具有内在不稳定性,而国际货币体系一直未能形成真正的多元格局。通过对霸权稳定论、均势理论和国际货币权力理论的批判,结合国际金融理论的定性与定量分析,从美国政府债务压力与美元国际信用的相互影响这一视角出发开展研究,可以发现国际货币体系变革存在一条和平、渐进的市场演化路径。在市场条件下,美国政府不断加重的公共债务成为导致美元国际信用下降的重要因素之一,而美元国际信用下降与其他国际货币的持续崛起将推动各国官方减持美国国债、降低美元储备,从而引起美国中长期国债利率上升、财政压力增大,最终形成国际货币体系从霸权走向多元的自我增强型循环。情景模拟即展现了市场条件下美债减持对美国财政产生的潜在冲击及其推动国际货币体系多元化的动态路径。

关键词：美债减持货币国际化国际货币体系美元霸权

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is it necessary to stop glucagon-like peptide-1 receptor agonists prior to endoscopic procedure? A retrospective study

引用

World Journal of Gastroenterology 2024年第26期30卷 3221-3228页

作者： Haider Ghazanfar Nismat Javed Abeer Qasim Franklin Sosa Faryal Altaf Shazia Khan Jaydeep Mahasamudram Abhilasha Jyala Sameer Datta Kandhi dongmin Shin Nikhitha Mantri Haozhe Sun Siddarth Hanumanthu Harish Patel Jasbir Makker Bhavna Balar Anil Dev Sridhar Chilimuri Division of Gastroenterology Department of Internal MedicineBronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States Department of Internal Medicine BronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States

BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1 RA)are effective in diabetes and obesity,reducing hyperglycemia by increasing insulin release and delaying gastric ***,they can cause gastroparesis,raising concerns about aspiration during *** guidelines advise discontinuing GLP-1 RA before surgery to reduce the risk of pulmonary *** To evaluate the effect of GLP-1 RAs on gastric residual contents during endosco-pic *** A retrospective chart review at BronxCare Health System,New York,from January 2019 to October 2023,assessed gastric residue and aspiration in GLP-1 RA patients undergoing endoscopic *** groups were compared based on dietary status before the *** included demographics,symptoms of gastroparesis,opiate use,hemoglobin A1c,GLP-1 agonist indication,endo-scopic details,and aspiration *** SPSS was used for analysis,cal-culating means,standard deviations,and applying Pearson’s chi-square and t-tests for associations,with P<0.05 as being *** During the study,306 patients were included,with 41.2%on a clear liquid/low residue diet and 58.8%on a regular diet before *** patients(63.1%)were male,with a mean age of 60±12 *** majority(85.6%)were on GLP-1 RAs for diabetes,and 10.1%reported digestive symptoms before *** those on a clear liquid diet,1.5%had residual food at endoscopy compared to 10%on a regular diet,which was statistically significant(P=0.03).Out of 31 patients with digestive symptoms,13%had residual food,all from the regular diet group(P=0.130).No complications were reported during or after the *** The study reflects a significant rise in GLP-1 RA use for diabetes and obesity.A 24-hour liquid diet seems safe for endoscopic procedures without *** with upper gastrointestinal symptoms might have a higher residual food risk,though not statistically *** research is needed

关键词： Glucagon-like peptide-1 agonists Gastroparesis Endoscopic procedures Residual food Complications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：