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BIOCELL 2023年第4期47卷 825-836页

作者： YIFAN XU dongmei cheng LEI HU XIN DONG LIYING LV CHEN ZHANG JIAN ZHOU Beijing Laboratory of Oral Health School of StomatologyCapital Medical UniversityBeijing100050China Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Department of VIP Dental Service School of StomatologyCapital Medical UniversityBeijing100050China Laboratory for Oral and General Health Integration and Translation Beijing Tian Tan HospitalCapital Medical UniversityBeijing100070China

The Wnt/β-catenin signaling pathway is the main target of tooth regeneration *** of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway,yet the function of this pathway in tooth regeneration remains ***,we found that AZD2858 promotes the accumulation ofβ-catenin in the nuclei of stem cells from the apical papilla(SCAPs)and enhances cell ***-cell sequencing was performed on SCAPs treated with *** clusters were identified,namely SCAPs-CNTNAP2,SCAPs-DTL,SCAPs-MYH11,SCAPs-MKI67,SCAPs-CXCL8,SCAPs-TPM2,SCAPs-IFIT2 and *** pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11,SCAPs-CNTNAPs and SCAPs-NEK10 clusters via up-regulation of PRKCA,SMURF2,MAGI2,RBMS3,EXT1,CAMK2D,PLCB4,and *** results demonstrate that AZD2858 enhances the proliferation of SCAPs-TPM2 cluster by activating the non-canonical Wnt/β-catenin signaling pathway.

关键词： AZD2858 Cell proliferation Stem cells Single-cell sequencing Wnt/β-catenin signaling pathway

Different B-Type Methionine Sulfoxide Reductases in Chlamydomonas May Protect the Alga against High-Light, Sulfur-Depletion, or Oxidative Stress

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Journal of Integrative Plant Biology 2013年第11期55卷 1054-1068页

作者： Lei Zhao Mei Chen dongmei cheng Haomeng Yang Yongle Sun Heyi Zhou Fang Huang Key Laboratory of Photobiology Institute of Botany the Chinese Academy of Sciences University of Chinese Academy of Sciences

The genome of unicellular green alga Chlamydomonas reinhardtii contains four genes encoding B-type methionine sulfoxide reductases, MSRBI.1, MSRB1.2, MSRB2.1, and MSRB2.2, with functions largely unknown. To understand the cell defense system mediated by the methionine suifoxide reductases in Chlamydomonas, we analyzed expression and physiological roles of the MSRBs under different abiotic stress conditions using immunoblotting and quantitative polymerase chain reaction （PCR） analyses. We showed that the MSRB2.2 protein was accumulated in cells treated with high light （1,300 μE-/m2 per s）, whereas MSRBI.1 was accumulated in the cells under 1 mmol/L H2O2 treatment or sulfur depletion. We observed that the cells with the MSRB2.2 knockdown and overexpression displayed increased and decreased sensitivity to high light, respectively, based on in situ chlorophyll a fluorescence measures. We also observed that the cells with the MSRBI.1 knockdown and overexpression displayed decreased and increased tolerance to sulfur-depletion and oxidative stresses, respectively, based on growth and H2- producing performance. The physiological implications revealed from the experimental data highlight the importance of MSRB2.2 and MSRBI.1 in protecting Chlamydomonas cells against adverse conditions such as high-light, sulfur-depletion, and oxidative stresses.

关键词： Chlamydomonas high light MSRB oxidative stress sulfur deprivation.

Analysis of Osteoporosis Risk Factors in 148 Retired Employees Based on Physical Examination Results

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Proceedings of Anticancer Research 2024年第4期8卷 116-123页

作者： Sunhang Cao Zhengfeng Liu Guiyu cheng dongmei Zhai Peng Li Chunshui Huang Physical Examination and Rehabilitation Centre Civil Aviation General HospitalBeijing 100123China Department of Vascular Surgery Civil Aviation General HospitalBeijing 100123China China TravelSky Holding Co.Ltd. Beijing 101318China

Objective:To investigate and thoroughly understand the physical examination results of retired employees from a certain unit in Beijing,analyze their bone mineral density(BMD),and identify risk factors that may indicate *** provides a reference for the individualized prevention,identification,and control of osteoporosis among retired ***:The bone mineral density and potential factors of 148 retired employees from a unit in 2023 were analyzed and categorized into osteoporosis and non-osteoporosis *** factors from the physical examinations of the two groups were ***’s correlation analysis was used to determine the correlation between key factors and *** key factors were included in a regression analysis.A multivariate binary logistics regression was employed to identify risk factors indicative of ***:Correlation analysis revealed that gender,age,and ECG ST-segment length were significantly associated with *** analysis showed that for each additional year of age,the likelihood of developing osteoporosis increased by 1.058 times;females were 2.865 times more likely to develop osteoporosis compared to males;the longer the ECG ST-segment,the higher the likelihood of ***:Gender,age,and ECG ST-segment length are significantly associated with *** indicators can provide reference points for early identification,early intervention,and reducing the incidence of osteoporosis in clinical settings.

关键词： Osteoporosis Gender Age ECG ST-segment Correlation analysis

中国式现代化视域下铸牢中华民族共同体意识的内在逻辑与实践进路

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商丘职业技术学院学报 2023年第6期22卷 1-6页

作者：成冬梅昭通学院云南昭通657000

铸牢中华民族共同体意识是党带领全国各族人民推进中国式现代化过程中做出的必然选择。铸牢中华民族共同体意识为推进中国式现代化提供思想基础、安全屏障和价值远见,中国式现代化为铸牢中华民族共同体意识提供性质、内容和价值指向,二... 详细信息

铸牢中华民族共同体意识是党带领全国各族人民推进中国式现代化过程中做出的必然选择。铸牢中华民族共同体意识为推进中国式现代化提供思想基础、安全屏障和价值远见,中国式现代化为铸牢中华民族共同体意识提供性质、内容和价值指向,二者之间存在着极强的逻辑关联。在推进中国式现代化的伟大进程中,必须铸牢中华民族共同体意识,做到既要增强“五个认同”,又要促进公平正义,达到建设共有精神家园的目的。

关键词：中国式现代化铸牢中华民族共同体意识内在逻辑实践进路

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国际化企业全面风险管理体系构建研究

当代石油石化 2022年第4期30卷 51-54页

作者：成冬梅中国石化燃料油销售有限公司风险管理部北京100029

随着国际政治经济形势变化,国际化企业经营环境日渐复杂,企业对风险管理更趋重视,构建并实施全面风险管理体系成为国际化企业持续健康发展的必要保障。文章辨析了全面风险管理与企业管理的关系,以某企业全面风险管理体系实践为例,提出... 详细信息

随着国际政治经济形势变化,国际化企业经营环境日渐复杂,企业对风险管理更趋重视,构建并实施全面风险管理体系成为国际化企业持续健康发展的必要保障。文章辨析了全面风险管理与企业管理的关系,以某企业全面风险管理体系实践为例,提出国际化企业全面风险管理体系构建与实施需要解决的问题和对策,为同类型企业提供参考。

关键词：国际化企业全面风险管理体系企业管理

情景模拟结合CBL对提升产科住院医师医患沟通能力的效果分析

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医学教育管理 2024年第1期10卷 80-85页

作者：赵瑞芬程冬梅尉建霞黄诗韵周莉首都医科大学附属北京妇产医院/北京妇幼保健院围产医学部北京100026

目的探讨在产科住院医师规范化培训(简称住培)中进行情景模拟结合以案例为基础的教学对医患沟通技能培训的效果。方法选取50名在产科规范化培训的住院医师为研究对象。培训前进行学员调查和医患沟通能力SEGUE测评。基于产科住培大纲选择... 详细信息

目的探讨在产科住院医师规范化培训(简称住培)中进行情景模拟结合以案例为基础的教学对医患沟通技能培训的效果。方法选取50名在产科规范化培训的住院医师为研究对象。培训前进行学员调查和医患沟通能力SEGUE测评。基于产科住培大纲选择5个典型病例情景,由教师录制5个典型病例病情医患沟通的示范视频,并梳理相关背景知识,在产科住院医师中依次开展培训课程,即视频示范、小组讨论、病例背景知识梳理讲解、分角色演练、演练后反馈和评价以及临床实践。培训后再次进行学员调查和医患沟通能力SEGUE测评。使用配对样本的非参数检验方法评价培训效果。结果情景模拟结合以案例为基础的教学的医患沟通技能培训后,学员医患沟通能力SEGUE测评总分提高[13.00(11.00~16.00)vs.22.00(20.00~24.00)],差异具有统计学意义(Z=-6.159,P<0.001);医患沟通能力SEGUE测评总体合格率提高[36.0%(18/50)vs.98.0%(49/50)],差异具有统计学意义(χ^(2)=43.464,P<0.001)。结论情景模拟结合以案例为基础的教学的医患沟通技能培训可有效提高学员医患沟通能力,调动学员的学习主动性,激发学员内在学习动力,建议在产科住培中纳入此类课程。

关键词：情景模拟病例教学医患沟通产科住院医师规范化培训

基于CiteSpace对近10年国内外护理不良事件的可视化分析

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卫生职业教育 2024年第4期42卷 152-156页

作者：唐可欣楚鑫吴晨曦程冬梅任良娟成都中医药大学护理学院四川成都610075 成都中医药大学附属医院四川成都610032

为了解国内外近10年护理不良事件的研究热点与前沿,为医院管理和临床护士提供参考,保障患者安全,通过检索中国期刊全文数据库(CNKI)和Web of Science(WOS)数据库,检索时限为2012年1月—2022年8月,导入CiteSpace进行可视化分析。研究显示... 详细信息

为了解国内外近10年护理不良事件的研究热点与前沿,为医院管理和临床护士提供参考,保障患者安全,通过检索中国期刊全文数据库(CNKI)和Web of Science(WOS)数据库,检索时限为2012年1月—2022年8月,导入CiteSpace进行可视化分析。研究显示,从发文量看,国内外学者对护理不良事件的关注度整体较高,可视化分析结果并未发现作者之间、机构之间的联系。未来减少护理不良事件的方法一定会越来越紧贴科学技术,越来越多的新型信息化平台、App等会用于医疗行业,降低护理不良事件预防的难度,但护理人员仍要重视护理安全。

关键词：护理不良事件患者安全护理质量 Cite Space

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泰山区“十四五”时期水利发展策略研究

灌溉排水学报 2022年第S1期41卷 119-123页

作者：孙庆磊程冬梅山东农业大学勘察设计研究院山东泰安271018 宁阳县水务局山东宁阳271400

【目的】解决泰山区水资源短缺、城市防洪标准低、水生态退化、水管理落后等问题,推进水利事业发展。【方法】采取节水开源、贯通水系、系统治理、两手发力4项措施。【结果】构建了共建共享、互联互通、城乡融合的区域骨干水系网络。【... 详细信息

【目的】解决泰山区水资源短缺、城市防洪标准低、水生态退化、水管理落后等问题,推进水利事业发展。【方法】采取节水开源、贯通水系、系统治理、两手发力4项措施。【结果】构建了共建共享、互联互通、城乡融合的区域骨干水系网络。【结论】项目实施后,泰山区节水型生产和生活方式将基本建立,水资源供给体系将基本建成,水安全保障能力将得到有效提升,水生态良性循环将基本建立,水行业管理体系将基本完善,水利信息化将逐步推广应用,泰山区水治理能力和现代化水平将得到稳步提升。

关键词：泰山区 “十四五” 生态保护水系网络发展策略

Patterns of Gestational Weight Gain among women with obesity and its correlation with Hypertensive Disorders of Pregnancy in China

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Patterns of Gestational Weight Gain among women with obesity...

金龟子绿僵菌生物学特性及其对草地贪夜蛾的侵染

中国营养学会第十五届全国营养科学大会

作者： Wei Song Zhi Zhang Wei Zheng Lei Gao Shengnan Liang dongmei cheng Xiaoxin Wang Cuimei Guo Xiaowei Liu Guanghui Li Beijing Obstetrics and Gynecology Hospital Capital Medical UniversityBeijing Maternal and Child Health Care Hospital Cangzhou People's Hospital Beijing Obstetrics and Gynecology Hospital Capital Medical UniversityBeijing Maternal and Child Health Care Hospital

Gestational weight management in women with obesity is critical in clinical work, and improper gestational weight gain relates to adverse pregnancy outcomes. However, the pattern of gestational weight gain(PGWG) and its correlation with HDP was still unclear in women with obesity(PPBMI ≥28 kg/m2) in China. Thus, we designed this study. Methods This study is retrospective cohort study and collected clinical data of 799 women at Beijing Obstetrics and Gynecology Hospital from 2014 Jan to 2016 Dec. Multivariate Linear/Logistics Regression analysis and Trajectory analysis were used for statistical analysis. Results The PGWG was stratified by the weight gain category during the 1 st trimester into three groups(Inadequate-1 st as 2.0 kg) and described by weekly weight gain during each gestational period. The weight gain during the 1 st trimester was negatively related to PPBMI and positively associated with GWG. 78.4% of the participants got an excess of the total GWG in Excessive-1 st, which differed from Inadequate-1 st(32.7%) and Adequate-1 st(48.2%). After 20 wks of gestation, weekly weight gain rapidly accelerated and 77.3% had a weekly weight gain exceeding the IOM recommendations. The weight gain during the 1 st trimester did not relate to the risk of HDP, but weekly weight gain after 20 wks did(aOR 4.453, 95%CI 2.545-7.793). Weight gain category during the 1 st trimester combined with weekly weight gain after 20 wk to further elevate the correlation between PGWG and the risk of HDP. As an improper PGWG, in participants with excessive weight gain during the 1 st trimester(≥2.0 kg), weekly weight gain after 20 wks less than 0.32 kg/w was negatively related to HDP(0.61 kg/w, aOR 5.362, 95%CI 1.719-16.729), and more than 0.61 kg/w positively related to early-onset pre-eclampsia(>0.61 kg/w vs. 0.32-0.61 kg/w, aOR 7.774, 95%CI 1.989-30

关键词： pre-pregnancy obesity pattern of gestational weight gain gestational hypertension pre-eclampsia hypertension disorder in pregnancy

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江西农业大学学报 2022年第2期44卷 386-392页

作者：梁超鹏梁洁容何俊烺程东美仲恺农业工程学院资源与环境学院广东广州510225

【目的】探究金龟子绿僵菌(Metarhizium anisopliae,ZKJGL)生长发育所需要的营养条件以及对草地贪夜蛾(Spodoptera frugiperda)幼虫的侵染力,为草地贪夜蛾生物防治研究以及生防菌剂的开发提供参考。【方法】室内测定温度、光周期、pH以... 详细信息

【目的】探究金龟子绿僵菌(Metarhizium anisopliae,ZKJGL)生长发育所需要的营养条件以及对草地贪夜蛾(Spodoptera frugiperda)幼虫的侵染力,为草地贪夜蛾生物防治研究以及生防菌剂的开发提供参考。【方法】室内测定温度、光周期、pH以及氮源、碳源对金龟子绿僵菌菌株ZKJGL菌丝生长和产孢的影响,并测定其对草地贪夜蛾2龄幼虫的活性。【结果】金龟子绿僵菌ZKJGL菌丝生长和产孢的适宜温度为20~25℃、pH=7、全黑暗条件,对碳源和氮源要求不高,麦芽糖、酵母膏或蛋白胨的利用率较好。孢子浓度为5×10;cfu/mL的金龟子绿僵菌ZKJGL菌株侵染草地贪夜蛾后累计死亡率达77.78%,LC;为4.406×10;cfu/mL,LT;少于4 d。【结论】金龟子绿僵菌ZKJGL易于培养,对营养条件、光照要求不高,对草地贪夜蛾的幼虫具有较强的致病力,可作为优良菌株进一步研发生物农药应用于防治草地贪夜蛾。

关键词：金龟子绿僵菌生物学特性草地贪夜蛾毒力测定

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