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橡胶注射成型设备技术进步及发展动向——橡胶机械技术进步与发展方向(三)

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中国化工装备 2003年第4期5卷 20-22页

作者：吕柏源焦冬梅李晓燕青岛科技大学 266042

橡胶注射成型设备的技术进步主要包括以下几个方面: 橡胶注射成型设备主机的技术进步橡胶注射成型机的发展,经历了柱塞式注射成型机至螺杆柱塞式注射成型机,再至螺杆往复式注射成型机的过程。近年来,各行业对橡胶制品质量提出了更高... 详细信息

橡胶注射成型设备的技术进步主要包括以下几个方面: 橡胶注射成型设备主机的技术进步橡胶注射成型机的发展,经历了柱塞式注射成型机至螺杆柱塞式注射成型机,再至螺杆往复式注射成型机的过程。近年来,各行业对橡胶制品质量提出了更高的要求,市场对大型橡胶制品的需求量也大增。

关键词：橡胶注射成型机成型设备技术进步橡胶机械橡胶注射机大型橡胶制品发展动向传递室螺杆往复柱塞式

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渭河流域甘肃段生态安全评价

甘肃农业大学学报 2024年第4期59卷 236-244页

作者：韩娇周冬梅陈宗敏金银丽张秋建甘肃农业大学资源与环境学院甘肃兰州730070 天津渤化永利化工股份有限公司天津300450

【目的】渭河流域甘肃段在黄河的整治开发中占有非常重要的战略地位,测算其生态安全指数和等级,可为该区域生态文明建设提供理论依据。【方法】基于PSR模型,从压力、状态和响应准则层中选取了20个评价指标,构建生态安全评价指标体系,运... 详细信息

【目的】渭河流域甘肃段在黄河的整治开发中占有非常重要的战略地位,测算其生态安全指数和等级,可为该区域生态文明建设提供理论依据。【方法】基于PSR模型,从压力、状态和响应准则层中选取了20个评价指标,构建生态安全评价指标体系,运用熵权法计算各项指标权重,根据综合指数法计算渭河流域2005、2010、2015、2020年的生态安全指数,最后运用障碍度诊断模型计算障碍因子。【结果】渭河流域甘肃段平均生态安全指数由2005年的0.4252上升到2020年的0.4486,生态安全均处于临界安全级,生态安全总体状况有所提升,研究区域生态安全状况在空间分布上呈现出东北部高,西南部较低的特点,研究区域生态安全的主要障碍因子为经济密度、人均GDP、城市化率、有效灌溉面积、当年造林面积。【结论】2005~2020年渭河流域甘肃段地区的生态安全整体呈现变好趋势,但存在空间差异,其中,东北部生态安全状况有明显提升,西部地区生态安全状况改善较小。

关键词：渭河流域 PSR模型熵权法生态安全评价

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药剂学设计性试验教学模式的教改研究

长春中医药大学学报 2021年第6期37卷 1419-1421页

作者：张炜煜矫冬梅辛宇杨波胡悦长春中医药大学药学院长春130117

结合药剂学课程的特点,为了适应药剂学实验教学的更新,将星点设计—响应面法(BBD)引入到本科设计性试验教学中,试验内容包括响应面优化,使用Design-Expert软件对所得试验数据进行分析和验证试验。实践证明,药剂学设计性试验教学的改革,... 详细信息

结合药剂学课程的特点,为了适应药剂学实验教学的更新,将星点设计—响应面法(BBD)引入到本科设计性试验教学中,试验内容包括响应面优化,使用Design-Expert软件对所得试验数据进行分析和验证试验。实践证明,药剂学设计性试验教学的改革,学生不仅可全面地掌握响应面优化的原理,同时可熟练固体分散体制备技术和溶出度的测定技术。有助于培养大学生的创新能力和综合素养,达到提高学生的理论知识水平和动手实践能力、培养其良好的科研素质和创新能力的教学改革初衷,且对其开阔视野、提高解决问题和团队协作的能力也有促进作用。

关键词：设计性实验实验教学改革响应面法药剂学

中药益肾宁对腹膜透析患者残余肾功能保护作用的研究

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现代中西医结合杂志 2009年第25期18卷 3009-3011页

作者：唐珊珊李伟焦冬梅曹彤武尚文山东中医药大学第二附属医院山东济南250001

目的探讨中药益肾宁对尿毒症腹膜透析患者残余肾功能(RRF)的保护作用。方法将56例腹膜透析患者随机分为2组,均进行腹膜透析,治疗组同时给予中药"益肾宁"口服,定期测定透析相关指标,观察中药益肾宁对于RRF的保护作用。结果治疗后3个月,2... 详细信息

目的探讨中药益肾宁对尿毒症腹膜透析患者残余肾功能(RRF)的保护作用。方法将56例腹膜透析患者随机分为2组,均进行腹膜透析,治疗组同时给予中药"益肾宁"口服,定期测定透析相关指标,观察中药益肾宁对于RRF的保护作用。结果治疗后3个月,2组患者血清肌酐清除率(Ccr)、RRF、24 h尿量均下降,2组间无显著性差异;治疗后6个月,对照组患者Ccr、RRF、24 h尿量较治疗组下降明显,有显著性差异(P<均0.05);对照组的透析剂量显著高于治疗组。结论中药益肾宁可以有效保护腹膜透析患者RRF。

关键词：中药腹膜透析残余肾功能

间充质干细胞相关疗法在颞下颌关节骨关节炎中的研究进展

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中华口腔医学杂志 2024年第7期59卷 732-737页

作者：张笑宇何冬梅上海交通大学医学院附属第九人民医院口腔外科、上海交通大学口腔医学院、国家口腔医学中心、国家口腔疾病临床医学研究中心、上海市口腔医学重点实验室、上海市口腔医学研究所上海200011

颞下颌关节骨关节炎(TMJOA)是以滑膜炎症、软骨退变、软骨下骨重塑为主要病理变化的一类器质性病变。目前的治疗以缓解症状为主,尚无法完全阻止病变的进展。间充质干细胞(MSC)具有多向分化潜能,在TMJOA的修复治疗中具有良好前景。关节... 详细信息

颞下颌关节骨关节炎(TMJOA)是以滑膜炎症、软骨退变、软骨下骨重塑为主要病理变化的一类器质性病变。目前的治疗以缓解症状为主,尚无法完全阻止病变的进展。间充质干细胞(MSC)具有多向分化潜能,在TMJOA的修复治疗中具有良好前景。关节内注射骨髓、脂肪、脐带、牙髓等来源的MSC已在大量动物实验中被证实有效。上述外源性MSC亦可作为种子细胞,参与组织工程,修复较严重的缺损。近期研究表明,外泌体是MSC发挥作用的重要媒介,在TMJOA的治疗中亦有一定潜力。随着对TMJOA机制研究的深入,通过局部注射相关药物靶向关节内常驻干细胞,激活内源性修复能力,亦有一定前景。

关键词：颞下颌关节骨关节炎间充质干细胞外泌体

Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe

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Neural Regeneration Research 2010年第22期5卷 1723-1727页

作者： dongmei Duan Ya Tu Shuang jiao Liping Chen Department of TCM of Nan Lou Chinese PLA General Hospital Beijing 100853 China School of Acupuncture and Moxibustion Beijing University of Chinese Medicine Beijing 100029 China

Electroacupuncture （EA） has been clinically used to treat depression and has resulted in favorable effects in China. However, results from animal studies and pathology do not reflect the influence of electroacupuncture treatment on in vivo physiological functions. To thoroughly and dynamically observe pathological changes during depression, the present study established EA ＋ fluoxetine and fluoxetine groups to observe depression in patients. 1H-magnetic resonance spectroscopy was utilized to determine the correlation between hippocampal frontal lobe metabolite changes and mental disorder scale. Results revealed significantly increased N-acetylaspartate （NAA）/creatine （Cr） in the bilateral hippocampus and right frontal lobe of depression patients treated with EA compared with fluoxetine. Changes in NAA/Cr in bilateral hippocampus and right frontal lobe in both groups, before and after treatment, negatively correlated with severity and curative effects. Choline/Cr changes in the bilateral frontal lobes of both groups were significant before and after treatment, but negatively correlated with curative effects. Choline/Cr changes in the bilateral hippocampus were significant in the EA ＋ fluoxetine group before and after treatment, but negatively correlated with severity and the curative effects of depression. These results demonstrate abnormal biochemical metabolism in bilateral frontal lobes and hippocampus of depression patients, and show that EA significantly altered biochemical indices in the frontal lobes and hippocampus compared with fluoxetine.

关键词： depression electroacupuncture fluoxetine hippocampus frontal lobe traditional Chinese medicine magnetic resonance spectroscopy neural regeneration

Expression analysis of the R2R3-MYB gene family in upland cotton and functional study of GhMYB3D5 in regulating Verticillium wilt resistance

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Journal of Integrative Agriculture 2024年第10期23卷 3294-3310页

作者： Jie Liu Zhicheng Wang Bin Chen Guoning Wang Huifeng Ke Jin Zhang Mengjia jiao Yan Wang Meixia Xie Yanbin Li dongmei Zhang Xingyi Wang Qishen Gu Zhengwen Sun Liqiang Wu Xingfen Wang Zhiying Ma Yan Zhang State Key Laboratory of North China Crop Improvement and Regulation/North China Key Laboratory for Germplasm Resources of Education Ministry/College of Agronomy Hebei Agricultural University Baoding 071001 China

Improving plant resistance to Verticillium wilt (VW), which causes massive losses in Gossypium hirsutum , is a global challenge. Crop needs to efficiently allocate their limited energy resources to balance growth and defense. However, few transcriptional regulators specifically response to V. dahliae and the underlying mechanism in cotton has not been identified. In this study, we found that the that expression of the majority R2R3-MYB in cotton is significantly changed relative to other MYB types by V. dahliae infection. Of which, a novel R2R3-MYB TF GhMYB3D5 , specifically response to V. dahliae , was identified. GhMYB3D5 did not express across 15 cotton tissues at normal condition, but drastically induced by V. dahliae stress. We functionally characterized its positive role and underlying mechanism in VW resistance. Upon V. dahliae infection, the up-regulated GhMYB3D5 bound the GhADH1 promoter and activated GhADH1 expression, moreover, GhMYB3D5 physically interacted with GhADH1 and furtherly enhanced the transcriptional activation to GhADH1 . Consequently, the transcriptional regulatory module GhMYB3D5-GhADH1 promoted lignin accumulation via improving the transcriptional levels of genes related to lignin biosynthesis ( GhPAL, GhC4H, Gh4CL , and GhPOD/GhLAC ) in cotton, thereby enhancing the cotton VW resistance. Taken together, our results demonstrated that the GhMYB3D5 promoted a defense-induced lignin accumulation, which regarded as an effective manner in orchestrating plant immunity and growth.

关键词： cotton Verticillium wilt resistance GhMYB3D5, GhADH1 transcriptional regulatory module 1

Al homogeneous deposition induced by N-containing functional groups for enhanced cycling stability of Al-ion battery negative electrode

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Nano Research 2021年第3期14卷 646-653页

作者： Handong jiao Shuqiang jiao Wei-Li Song Xiang Xiao dongmei She Na Li Haosen Chen Jiguo Tu Mingyong Wang Daining Fang Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing100081China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China

Rechargeable Al-ion batteries(AIBs)are considered as one of the most fascinating energy storage systems due to abundant Al resource and low ***,the cycling stability is subjected to critical problems for using Al foil as negative electrode,including Al dendrites,corrosion and *** addressing these problems,here a lightweight self-supporting N-doped carbon rod array(NCRA)is demonstrated for a long-life negative electrode in *** analysis and first-principle calculations reveal the storage mechanism involving the induced deposition of N-containing function groups to Al as well as the ideal skeleton of the NCRA matrix for Al plating/stripping,which is favorable for regulating Al nucleation and suppressing dendrites *** with the Al foil,the NCRA exhibits lower areal mass density(∼72%of Al foil),smaller thickness(40%of Al foil),but much longer cycle life(>4 times of Al foil).Benefiting from the remarkable stability of the array structure,symmetric cells show excellent cycling stability with small voltage hysteresis(∼80 mV)and meanwhile there are no corrosion and pulverization problems even after cycled for 120 ***,full cells also manifest long lifespan(1,500 cycles)and increased Coulombic efficiency(100±1%).

关键词： Al-ion batteries Al homogeneous deposition negative electrode lightweight long cycle life

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姬塬油田北红井子地区长8油藏沉积相研究

石油化工应用 2014年第3期33卷 76-80页

作者：张永平刘玉峰焦冬梅王云枫黄文芳中国石油长庆油田分公司第三采油厂宁夏银川750006

红井子地区从2005年开始进行深层勘探开发至今,已发现并建成了盐67、池97、黄36等长8油藏开发区块。随着勘探程度的不断提高,对油藏认识也在不断深入,但是,目前对本区长8油层组沉积相归属还无定论。本文通过对长8油层组岩性特征、沉积... 详细信息

红井子地区从2005年开始进行深层勘探开发至今,已发现并建成了盐67、池97、黄36等长8油藏开发区块。随着勘探程度的不断提高,对油藏认识也在不断深入,但是,目前对本区长8油层组沉积相归属还无定论。本文通过对长8油层组岩性特征、沉积特征的深入分析,明确了该区沉积相类型,对下步石油勘探开发具有指导意义。

关键词：岩石特征沉积构造沉积相