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基于响应面法的单辊筒机头参数优化设计

机械设计 2024年第6期41卷 25-30页

作者：吴程旺焦冬梅王同坤战梦青岛科技大学机电工程学院山东青岛266061

在生产轮胎气密层的过程中,挤出制品的均匀性是首要保证的目标,常被作为评判轮胎质量优劣的关键因素。但过度提高制品均匀性会导致挤出效率严重下降,不利于企业的实际生产。为解决上述问题,文中采用有限元法和响应面法相结合的方式对单... 详细信息

在生产轮胎气密层的过程中,挤出制品的均匀性是首要保证的目标,常被作为评判轮胎质量优劣的关键因素。但过度提高制品均匀性会导致挤出效率严重下降,不利于企业的实际生产。为解决上述问题,文中采用有限元法和响应面法相结合的方式对单辊筒机头进行优化分析,分别以出口截面中间层挤出方向的速度均值和标准差为目标函数,通过部分因子试验、爬坡试验、Box-Behnken设计及响应曲面分析构造显著因子与目标函数的回归方程来确定最佳优化组合。对回归方程及优化后的流场模型进行了试验验证。结果表明:单辊筒机头挤出均匀性和稳定性得到改善,响应面法可以用于单辊筒机头的结构和工艺参数的优化设计。

关键词：响应曲面分析单辊筒机头挤出均匀性优化

苯唑嗪纳米乳的制备优化及其药动学与体内分布研究

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中国医院药学杂志 2024年第10期44卷 1160-1168页

作者：李冬冬孙敬蒙矫冬梅霍文凯孔繁铭张炜煜长春中医药大学药学院吉林长春130117 吉林大学第一医院临床药学部吉林长春130021

目的:制备苯唑嗪纳米乳(Q808-NE),并进行工艺优化及体内外评价。方法:以包封率(EE)、载药量(DL)和离心稳定常数(K)为考察指标,通过单因素、Plackett-Burman design(PBD)及Box-Behnken design(BBD)试验对其进行工艺优化,并进行表征、药... 详细信息

目的:制备苯唑嗪纳米乳(Q808-NE),并进行工艺优化及体内外评价。方法:以包封率(EE)、载药量(DL)和离心稳定常数(K)为考察指标,通过单因素、Plackett-Burman design(PBD)及Box-Behnken design(BBD)试验对其进行工艺优化,并进行表征、药动学及体内分布评价研究。结果:最佳处方工艺:水相比例为83.33%,搅拌条件为400 r·min^(–1)、40℃、2 h,水相加入速度为2秒/滴,油相(油酸)与混合乳化剂(聚山梨酯80与泊洛沙姆188比例为5∶4)比例为3∶7,混合乳化剂与助乳化剂比例为3∶1。Q808-NE的平均粒径、PDI、Zeta电位分别为(38.54±2.22)nm,0.26±0.01,(–27.63±0.96)mV。与Q808相比,Q808-NE在水中溶解度提高了1046.11倍。Q808-NE的口服相对生物利用度为230.83%,体内分布试验显示其在脑中的相对摄取率为2.91,表明将Q808制成纳米乳后具有一定的脑靶向趋势。结论:该研究制备的Q808-NE有效提高了药物的溶解度、体外释放率及生物利用度,并实现脑靶向,为后续用药提供了新的选择。

关键词： 6-(4-氯苯氧基)-四唑并(5,1-a)酞嗪药动学体内分布纳米靶向

RoBGP:A Chinese Nested Biomedical Named Entity Recognition Model Based on RoBERTa and Global Pointer

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Computers, Materials & Continua 2024年第3期78卷 3603-3618页

作者： Xiaohui Cui Chao Song dongmei Li Xiaolong Qu jiao Long Yu Yang Hanchao Zhang School of Information Science and Technology Beijing Forestry UniversityBeijing100083China Engineering Research Center for Forestry-Oriented Intelligent Information Processing of National Forestry and Grassland Administration Beijing100083China Division of Biostatistics Department of Population HealthGrossman School of MedicineNew York UniversityNew York10016USA

Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity *** process can provide basic support for the automatic construction of knowledge *** contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER *** address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial *** then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance ***,the Global Pointer model is employed to comprehensively recognize all nested entities in the *** conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline *** research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.

关键词： Biomedicine knowledge base named entity recognition pretrained language model global pointer

Multi-modal knowledge graph inference via media convergence and logic rule

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 211-221页

作者： Feng Lin dongmei Li Wenbin Zhang Dongsheng Shi Yuanzhou jiao Qianzhong Chen Yiying Lin Wentao Zhu School of Information Science and Technology Beijing Forestry UniversityBeijingChina Engineering Research Center for Forestry-oriented Intelligent Information Processing National Forestry and Grassland AdministrationBeijingChina Michigan Technological University HoughtonMichiganUSA

Media convergence works by processing information from different modalities and applying them to different *** is difficult for the conventional knowledge graph to utilise multi-media features because the introduction of a large amount of information from other modalities reduces the effectiveness of representation learning and makes knowledge graph inference less *** address the issue,an inference method based on Media Convergence and Rule-guided Joint Inference model(MCRJI)has been *** authors not only converge multi-media features of entities but also introduce logic rules to improve the accuracy and interpretability of link ***,a multi-headed self-attention approach is used to obtain the attention of different media features of entities during semantic ***,logic rules of different lengths are mined from knowledge graph to learn new entity ***,knowledge graph inference is performed based on representing entities that converge multi-media *** experimental results show that MCRJI outperforms other advanced baselines in using multi-media features and knowledge graph inference,demonstrating that MCRJI provides an excellent approach for knowledge graph inference with converged multi-media features.

关键词： logic rule media convergence multi-modal knowledge graph inference representation learning

Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection

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Chinese Herbal Medicines 2024年第1期16卷 151-161页

作者： Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren jiao Xiao dongmei Wang Xiaoqiu Liu Yingni Pan School of Chinese Materia Medica Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic ***: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular ***: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory ***: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin.

关键词： anti-hyperglycemic activity anti-oxidant flowers of Xanthoceras sorbifolia Bunge NADPH oxidase off-line UPLC-QTOF-MS/MS-free radical scavenging

MgO对Co-Mo/Al_2O_3-MgO催化剂性能的影响

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石油化工 2012年第4期41卷 405-409页

作者：焦冬梅吴立报曹发海华东理工大学化工学院上海200237

采用尿素螯合剂法制备了不同MgO含量的Co-Mo/Al2O3-MgO催化剂,采用N2吸附-脱附法、TPR、HRTEM等技术对催化剂进行了表征,在管式固定床反应器中以二苯并噻吩(DBT)的二甲苯溶液为模型化合物对催化剂的加氢脱硫活性进行了评价。实验结果表... 详细信息

采用尿素螯合剂法制备了不同MgO含量的Co-Mo/Al2O3-MgO催化剂,采用N2吸附-脱附法、TPR、HRTEM等技术对催化剂进行了表征,在管式固定床反应器中以二苯并噻吩(DBT)的二甲苯溶液为模型化合物对催化剂的加氢脱硫活性进行了评价。实验结果表明,添加MgO可显著改善Co-Mo/Al2O3催化剂的结构和性能,Co-Mo/Al2O3-MgO催化剂呈现出多孔径中心的特点;随MgO添加量的增加,Co-Mo/Al2O3-MgO催化剂中的Co-O-Mo物相增多,硫化后易形成更多高活性Co-Mo-S物相。与Co-Mo/Al2O3和Co-Mo/Al2O3-TiO2催化剂相比,Co-Mo/Al2O3-MgO-0.8(载体中MgO的质量分数为0.8)催化剂在氢烃体积比为300时即呈现出很高的DBT脱除率(97.0%),具有低氢烃比下即可实现高加氢脱硫活性的优点。

关键词：氧化镁载体加氢脱硫催化剂二苯并噻吩

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注塑模型腔壁厚计算公式讨论

工程塑料应用 2005年第9期33卷 52-54页

作者：张惠敏焦冬梅青岛科技大学青岛266042

凹模安装在定模上、凸模安装在动模上的注塑模结构,其凹凸模的受力情况与凹模安装在动模上、凸模安装在定模上不同,因此注塑模型腔壁厚的计算公式也不同。针对凹模安装在定模上、凸模安装在动模上的注塑模结构,对矩形型腔模具进行了受... 详细信息

凹模安装在定模上、凸模安装在动模上的注塑模结构,其凹凸模的受力情况与凹模安装在动模上、凸模安装在定模上不同,因此注塑模型腔壁厚的计算公式也不同。针对凹模安装在定模上、凸模安装在动模上的注塑模结构,对矩形型腔模具进行了受力分析和型腔壁厚计算。

关键词：注塑模型腔壁厚计算公式注塑模型腔壁厚计算公式凹凸模受力情况受力分析型腔模具

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实芯轮胎生产方法探讨

橡塑技术与装备 2007年第5期33卷 17-22页

作者：焦冬梅青岛科技大学机电工程学院山东青岛266042

探讨了实芯轮胎的生产方法。首先阐述了传统的模压法、缠绕法和离心浇注方法的工作原理及其优缺点,然后研究了实芯轮胎的注射成型及为了实现注射的3种轮胎结构,并对未来的发展趋势进行了展望。

关键词：实芯轮胎注射成型一步法轮胎结构

碱土金属离子(Mg^(2+),Ca^(2+),Ba^(2+))掺杂对长余辉荧光粉SrAl_2O_4:Eu^(2+),Dy^(3+)发光性能的影响

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中国稀土学报 2008年第5期26卷 561-565页

作者：冯杨刘振何地平焦冬梅刘可非焦桓陕西师范大学化学与材料科学学院陕西省大分子科学重点实验室陕西西安710062 中国石油化工有限公司洛阳分公司河南洛阳471012

采用高温固相法制备了碱土金属离子(Mg2+,Ca2+,Ba2+)掺杂的SrAl2O4∶Eu2+,Dy3+长余辉荧光粉。XRD谱分析表明,随着基质中掺入的碱土金属离子(Mg2+,Ca2+,Ba2+)浓度增加,基质晶格常数也随之发生变化。Mg2+,Ca2+和Ba2+3种碱土离子在SrAl2O4... 详细信息

采用高温固相法制备了碱土金属离子(Mg2+,Ca2+,Ba2+)掺杂的SrAl2O4∶Eu2+,Dy3+长余辉荧光粉。XRD谱分析表明,随着基质中掺入的碱土金属离子(Mg2+,Ca2+,Ba2+)浓度增加,基质晶格常数也随之发生变化。Mg2+,Ca2+和Ba2+3种碱土离子在SrAl2O4中的固溶范围分别为40%,15%和30%。光谱分析则表明在固溶范围内随着掺杂Mg2+,Ca2+和Ba2+浓度的增大,样品的发射峰值会在480~530 nm范围出现规律性移动。适当浓度的Mg2+,Ba2+掺杂会不同程度地提高样品的发光强度,而Ca2+的掺杂则会降低发光强度。但是碱土金属离子(Mg2+,Ca2+,Ba2+)的掺杂并不能延长SrAl2O4∶Eu2+,Dy3+荧光粉的余辉时间。

关键词：碱土金属离子 SrAl2O4:Eu^2+ Dy^3+ 掺杂发射光谱稀土