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Prophylaxis and management of perioperative hemorrhage in retropubic radical prostatectomy

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Oncology and Translational Medicine 2017年第4期3卷 171-175页

作者： dongliang pan Department of Urology Peking University Shougang HospitalBeijing 100144China

Retropubic radical prostatectomy(RRP) has commonly been performed for localized prostate cancer. In the past decade, with the development of laparoscopic and robotic techniques, laparoscopic radical prostatectomy(LRP) or robotic-assisted LRP has been widely used due to its less invasive nature along with its shorter recovery, reduced blood loss, and improved visualization of the operative region compared to open techniques. Severe hemorrhage following prostatectomy is relatively rare(0.5% to 1.6%), but it is a serious complication. Here, we summarize circumstances in which perioperative severe hemorrhage can develop and interventions needed to achieve hemostasis.

关键词： cancer prostate prostatectomy hemorrhage management

Research on Modem Enterprise Management Accounting Development Trend and the Influences on Promoting the Enterprise

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International Journal of Technology Management 2016年第1期 89-92页

作者： dongliang pan Jingjing Cao Hebei Polytechnic Institute ShijiazhuangHebei050091 China

In this paper, we conduct basic research on the modem enterprise management accounting development trend and the influences on promoting the enterprise. Management accounting subject refers to the management accounting as the services of a particular unit. Because of the management accounting mainly provides the useful decision information to the internal management of internal accounting need not follow generally accepted accounting standards, thus main body of management accounting can is administrative. Depending on the enterprise internal management needs, the subject of the management accounting can be throughout the enterprise, also can be unit of enterprise interior various levels of responsibility. Management accounting mainly through a series of special methods using financial accounting information and other relevant data sorting, calculation, comparison and analysis, which can make the enterprise management personnel at all levels of all economic activity in the daily planning and control, and to help business leaders to make the whole set of the information processing system of decisions. Our research conducts detailed and in-depth analysis on the related issues that serves as the novel paradigm.

关键词： Management Accounting Development Trend Modem Enterprise Promoting.

Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue microarray immunostaining

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Chinese Medical Journal 2014年第23期127卷 4031-4035页

作者： Ma Ding Yang Bing Zhou Zhe pan dongliang Zhang Xianghua Department of Urology Peking University Shougang Hospital Beijing 100144 China

Background The pathogenesis of benign prostatic hyperplasia （BPH） has been widely studied,and several biomarkers are known to play roles in its *** study aimed to investigate the possible role of cysteine-rich protein 61 （CYR61）,vascular endothelial growth factor （VEGF）,androgen receptor （AR）,interleukin-6 （IL-6）,cytochrome c,caspase-3,and proliferating cell nuclear antigen （PCNA） in the clinical progression of *** Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue *** age,prostate volume,serum prostate-specific antigen （PSA） level,and International Prostate Symptom Score （IPSS） of all BPH cases were collected before *** expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA was examined by immunostaining in the BPH specimens,and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was *** The expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA in the BPH cases was 68.8％（66/96）,77.1％（74/96）,43.8％（42/96）,31.3％（30/96）,35.4％（34/96）,56.3％（54/96）,and 29.2％（28/96）,*** expression of both CYR61 and VEGF was positively correlated with patient age,prostate volume,and serum PSA level （P ＜0.05）.Furthermore,cytochrome c and caspase-3 expression were inversely related to prostate volume （P ＜0.05）,and AR expression was positively related to serum PSA level （P ＜0.05）.Conclusion CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.

关键词： biomarkers risk factors benign prostatic hyperplasia clinical progression tissue microarray

The latest advances of experimental research on targeted gene therapy for prostate cancer

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The Chinese-German Journal of Clinical Oncology 2013年第11期12卷 546-550页

作者： dongliang pan Lianchao Jin Xianghua Zhang Wujieping Urology Medical Center Department of Urology Peking University Shougang Hospital

The absence of effective therapies for castration-resistant prostate cancer(CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect". Consequently, scientists all over the world focus their main experimental research on the following four aspects: targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer.

关键词： cancer prostate targeted gene therapy experimental research

Salvage treatments for prostate-specific antigen relapse of cT3N0M0 prostatic adenocarcinoma after radical prostatectomy combined with neoadjuvant androgen deprivation

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Oncology and Translational Medicine 2020年第6期6卷 272-276页

作者： Lufang Zhang dongliang pan Ludong Liu Yunjiang Zang Ningchen Li Department of Urology Weifang People’s HospitalShandong 261000China Department of Urology Peking University Shougang HospitalWujieping Urology Medical Center of Peking UniversityBeijing 100144China

Objective The aim of the study was to evaluate the efficiency of salvage treatments for prostate specific antigen(PSA)relapse of cT3N0M0 prostatic adenocarcinoma(PCa)after radical prostatectomy(RP)combined with neoadjuvant androgen deprivation(ADT).Methods A total of 332 patients with cT3N0M0 PCa were enrolled in the prospective study and received RP and pelvic lymph node dissection with neoadjuvant ADT for 3 *** patients with PSA relapse were treated with salvage external beam radiation therapy(RT)and ADT for 6 *** The 5-year postoperative PSA relapse rate was 40.96%(136/332).The patients have been divided into the PSA relapse and PSA relapse-free groups in order to compare patient *** ratio of patients with Gleason score≥8 and positive surgical margin in the PSA relapse group were significantly higher than those of in the PSA relapse-free group(P=0.01).The mean duration between the start of operative treatment and PSA relapse was 31 *** treatment to all 136 PSA relapse patients led to favorable *** relapse was not observed after salvage treatment by the end of *** 5-year overall survival rates of the PSA relapse and PSA relapse-free groups were 94.9%and 93.9%,*** In pursuit of curative treatment,our study showed that RP combined with neoadjuvant ADT is an aggressive multimodality strategy associated with lower PSA relapse and better survival outcomes for stage cT3N0M0 PCa *** with PSA relapse after RP may benefit from early aggressive salvage RT combined with short-term ADT.

关键词： prostatic adenocarcinoma(PCa) radical prostatectomy(RP) neoadjuvant androgen deprivation(ADT) external beam radiation therapy salvage treatment prostate specific antigen(PSA)relapse

基于智能视觉的铁路大桥人员入侵防护系统设计研究

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铁路计算机应用 2023年第9期32卷 48-53页

作者：潘东亮国能包神铁路集团有限责任公司科技信息部包头014010

铁路桥梁监测是保障铁路运输安全的重要手段。为提升现有监测系统对铁路大桥人员入侵的检测能力,设计了基于智能视觉的铁路大桥人员入侵防护系统,该系统由视频平台、智能视觉平台及业务管理平台组成。采用YOLOv5目标检测模型进行人员入... 详细信息

铁路桥梁监测是保障铁路运输安全的重要手段。为提升现有监测系统对铁路大桥人员入侵的检测能力,设计了基于智能视觉的铁路大桥人员入侵防护系统,该系统由视频平台、智能视觉平台及业务管理平台组成。采用YOLOv5目标检测模型进行人员入侵检测;同时,采用多种图像数据增强技术,扩增训练数据集,进一步提升目标检测模型的泛化能力和场景适应能力。在包神铁路集团有限公司万南站区黄河大桥对该系统进行了部署和测试。测试结果表明,该系统对人员入侵检测的准确率为95.3%,检测实时性为2 ms;人员入侵检测的准确率与实时性均满足实际应用要求。

关键词：铁路大桥人员入侵防护系统智能视觉目标检测模型光学相机

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4种异黄酮抗氧化活性的构效关系

食品科学 2016年第23期37卷 1-6页

作者：刘科梅聂挺潘栋梁胡川陆豫余勃南昌大学资源环境与化工学院鄱阳湖环境与资源利用教育部重点实验室江西南昌330031 南昌大学中德联合研究院江西南昌330047

为探究异黄酮类化合物抗氧化活性的构效关系,以染料木素、大豆苷元、橙桑黄酮、奥沙京4种异黄酮类分子为代表展开研究。测定了4种分子的体外抗氧化活性,并与文献报道进行分析比对。对4种分子进行分子模拟,得到稳定的优势构象并对其进行... 详细信息

为探究异黄酮类化合物抗氧化活性的构效关系,以染料木素、大豆苷元、橙桑黄酮、奥沙京4种异黄酮类分子为代表展开研究。测定了4种分子的体外抗氧化活性,并与文献报道进行分析比对。对4种分子进行分子模拟,得到稳定的优势构象并对其进行相关量子化学计算。结果分析表明,4种异黄酮分子清除自由基能力与其酚羟基位置电子转移和脱氢能力有关,前线分子轨道能直观地展现抗氧化物的分子活性部位,而能隙和自由基生成热能准确表征4种异黄酮分子抗氧化活性顺序,对于4种分子的多羟基位自由基生成热分析可知,4’-OH是染料木素和大豆苷元最主要的羟基活性部位,3’-OH是橙桑黄酮和奥沙京最主要的羟基活性部位,4’-OH和3’-OH可分别作为表征这4种分子清除自由基活性的位点。

关键词：异黄酮量子化学计算清除自由基前线分子轨道自由基生成热

Serum testosterone suppression and potential for agonistic stimulation during chronic treatment with monthly depot formulation of domestic substitute of leuprorelin acetate microspheres for metastatic prostate cancer

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The Chinese-German Journal of Clinical Oncology 2014年第7期13卷 320-322页

作者： dongliang pan Liming Dong Lianchao Jin Bing Yang Zhe Zhou Kai Zhang Xianghua Zhang Ningchen Li Department of Urology Peking University Shougang Hospital Wujieping Urology Medical Center of Peking University Department of Urology Weihai Wendeng Center Hospital

Objective： We aimed to evaluate the efficiency of serum testosterone suppression as well as the potential for agonistic stimulation of serum testosterone during chronic treatment with monthly （3.75 mg） depot formulation of domestic substitute of leuprorelin acetate microspheres for patients with metastatic prostate cancer. Methods： A total of 23 patients with metastatic prostate cancer were enrolled in the prospective study and received 6 monthly intramuscular depot injections of domestic substitute of leuprorelin acetate microspheres. Their levels and patterns of serum testosterone suppression and the potential for agonistic stimulation of serum testosterone were monitored following injection monthly （3.75 rag） depot formulation of domestic substitute of leuprorelin acetate microspheres for 24 weeks. Results： Mean testosterone was 431.4 ng/dL, 119.3 ng/dL, 28.2 ng/dL by week 1, 2, 3 and decreased to less than 15.6 ng/dL by week 4 where it remained throughout the treatment period. Median time to suppression of serum testosterone was 20.7 days. No transient minor ＂escape＂ from suppression occurred in all patients which was defined as a single testosterone value greater than 50 ng/dL once suppression was achieved. Assessment of agonistic stimulation following the second depot injection revealed no pattern of stimulation. Conclusion： We concluded that monthly （3.75 mg） depot formulation of domestic substitute of leuprorelin acetate microspheres could provide persistent, stable suppression of serum testosterone throughout the dosing intervals, and that the initial depot injection of this formulation also could provide sufficient pituitary desensitization to prevent agnostic stimulation of serum testosterone during chronic treatment.

关键词： prostatic neoplasms, metastatic testosterone leuprorelin domestic substitute

羟苯磺酸钙对糖尿病肾病患者的疗效及血清hs-CRP和Hcy水平的影响

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贵州医科大学学报 2019年第3期44卷 365-368页

作者：曲铎潘东亮鞍山市中心医院全科病房一病房辽宁鞍山114000 北京大学首钢医院泌尿外科北京100144

目的:探讨羟苯磺酸钙治疗糖尿病肾病(DKD)的疗效及对患者血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平的影响。方法:82例早期DKD患者随机均分为对照组与观察组,A组口服血管紧张素转化酶抑制剂(ACEI)及血管紧张素受体拮抗剂(ARB)... 详细信息

目的:探讨羟苯磺酸钙治疗糖尿病肾病(DKD)的疗效及对患者血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平的影响。方法:82例早期DKD患者随机均分为对照组与观察组,A组口服血管紧张素转化酶抑制剂(ACEI)及血管紧张素受体拮抗剂(ARB)治疗、B组在此基础上联合应用羟苯磺酸钙治疗、疗程12周,选取同期40例健康体检者为对照组;观察对照组及治疗前后早期DKD患者血清Hcy、hs-CRP水平及尿白蛋白排泄率(UAER)。结果:治疗前,两组早期DKD患者UAER及血清Hcy、hs-CRP水平均显著高于对照组,差异有统计学意义(P <0. 05);治疗后,两组早期DKD患者尿UAER及血清Hcy、hs-CRP水平均较治疗前显著降低,且B组降低更加明显,差异有统计学意义(P <0. 05)。结论:羟苯磺酸钙治疗DKD可有效降低血清Hcy、hsCRP水平,并降低尿微量白蛋白水平,延缓肾脏病进展。

关键词：糖尿病肾病羟苯磺酸钙超敏C反应蛋白同型半胱氨酸尿微量白蛋白