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Effects of Occupational Noise on the Hearing Ability of Outpatient Clinic Nurses in Different Classes of Hospitals in Guangzhou

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International Journal of Clinical Medicine 2020年第4期11卷 154-162页

作者： donglan liu Xun Zeng Li Wang Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Healthcare The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Background: Occupational noise can induce hearing impairment. Work-related hearing impairment has become a growing threat to medical practitioners who feel anxious about occupational noise exposure and its health outcomes or even experience auditory dysesthesia (including drumming, distending pain in the ears, and otalgia) after long-term exposure to a noisy work environment. Objective: To investigate the effects of occupational noise on the hearing ability of outpatient clinic nurses in Grade III, Level A and Grade II, Level A hospitals in Guangzhou. Methods: During June 2019, noise monitoring was performed by quantifying the noise levels at four measuring points (reception, waiting area, hallway, blood-sampling room) in five Grade III, Level A and five Grade II, Level A hospitals, in Guangzhou, four times a day (8 AM, 10 AM, 2 PM, and 4 PM) for 19 working days, using a professional noise measuring application for smartphones. The measurements were verified and used to create a database in Excel. Data analysis was conducted using SPSS22.0, and questionnaires were distributed to nurses who had been working at outpatient clinics for five years and above to assess the impacts of occupational noise exposure on the hearing ability. Results: In the Grade III, Level A hospitals, the sound levels at the four measuring points during the specific time periods were 4.92 - 6.75 dB above the permissible limit of 55 dB and were all significantly higher than the sound levels at the outpatient clinics of the Grade II, Level A hospitals (P Conclusions: Exposure to excess noise can lead to auditory dysesthesia in outpatient clinic nurses. Compared to those from Grade II, Level A hospitals, outpatient clinic nurses from Grade III, Level A hospitals are at higher risk of auditory dysesthesia. The noise levels at outpatient clinics should be closely monitored, and effective measures should be taken to reduce occupational noise exposure. Outpatient clinic nurses should enhance protectiv

关键词： Noise Outpatient Clinic Nurse Auditory Dysesthesia Survey

Berberine and Metformin in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis of Randomized Clinical Trials

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Health 2021年第11期13卷 1314-1329页

作者： Li Wang donglan liu Guohong Wei Hui Ge Department of Healthcare The First Affiliated Hospital Sun Yat-sen University Guangzhou China Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To assess the effects of berberine and metformin on glucose in patients with type 2 diabets mellitus (T2DM) with a systematic review and meta-analysis. Methods: The databases including PubMed, Excerpta Medica Database (EMBase), Cochrane Library, Chinese National Knowledge Infrastructure database (CNKI), WanFang, the Chinese Scientific and Technical Journals database (VIP), China Doctor Dissertation Full-text Database (CDFD) and China Master Dissertation Full-text Database (CMFD) from the inception to April 2021 in Chinese or English language were searched. Randomized controlled trials (RCTs) of berberine only or combined with metformin versus metformin were included. Data extraction and paper quality assessment were conducted according to the Cochrane Handbook. RevMan 5.4 was used for the meta-analysis. Results: A total of thirteen studies were included, covering 1173 participants. The clinical heterogeneity of the included trials was relatively high. The methodological quality of most trials was generally low with bias in terms of random sequence generation, allocation concealment, blinding method, outcome data and selective reporting. Interventions were divided into two subgroups for analysis. Meta-analysis suggested that there was no statistical significance in the hypoglycemic effect between berberine and metformin for T2DM. However, berberine combined with metformin could reduce fasting plasma glucose (FPG) [MD = −1.49, 95% CI (−2.22, −0.76), P MD = −1.89, 95% CI (−2.94, −0.84), P = 0.0004], glycosylated hemoglobin A1c (HbA1c) [MD

关键词： Berberine Metformin Type 2 Diabetes Mellitus Efficacy Safety Meta-Analysis

Survey and Research on Health Information Assistance Needs of Junior Middle School Students in Different Regions of Guangdong Province

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Journal of Advances in Medicine Science 2020年第2期3卷 5-11页

作者： donglan liu Jinmei Deng Weigao Huang Yongxun Cao Yinghua Long TheFirst Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong510080China Yanggan Middle School in Suixi ZhanjiangGuangdong524386China Dongqu Middle School GuangzhouGuangdongProvince510760China

Objective:To study the health information assistance needs of junior high school students in 8 different regions of Guangdong Province in a cluster,to understand the current situation of junior high school students'health information assistance needs,and to collect feasibility data for hospitals and schools to jointly promote the healthy development of ***:In June 2019,a group of junior high school students from 8 different regions in Guangdong Province[678 students(in 2 towns),352 students(in 2 counties and prefecture-level cities),and 1098 students(in 4 provincial-level cities)]were selected in a group.A questionnaire survey was conducted by 2128 people,the results of the questionnaire survey were collected,and statistical analysis was ***:Of the 2128 junior high school students in 8 different regions,only 52.07% had confidence in their health,and there were no regional *** information for students seeking professional medical assistance includes:1578 person-times(74.15%)of nutritional diets,1084 person-times(50.94%)to eliminate tiredness,1190 person-times(55.92%)to improve sleep quality,1002 person-times(47.09%)to reduce anxiety,making him happier and stronger 1164 person-times(54.70%).Students in different regions asked for help on how to make their hearts happier and *** results suggest that provincial and county-level students have greater needs than urban ***:The results of this research show that junior high school students in different regions of Guangdong Province have insufficient awareness of health,and there is a large demand for various health help information,and the focus is on *** is of practical significance to strengthen and meet the health information needs of junior high school students.

关键词： Junior high school students Health information Assistance Needs

Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model

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Virologica Sinica 2024年第3期39卷 414-421页

作者： Yuming Li Yanhong Tang Xiaoqian Wang Airu Zhu Dongdong liu Yiyun He Hu Guo Jie Zheng Xinzhuo liu Fengyu Chi Yanqun Wang Zhen Zhuang Zhaoyong Zhang donglan liu Zhao Chen Fang Li Wei Ran Kuai Yu Dong Wang Liyan Wen Jianfen Zhuo Yanjun Zhang Yin Xi Jingxian Zhao Jincun Zhao Jing Sun School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal UniversityHunan Normal UniversityChangsha410005China Guangzhou National Laboratory GuangzhouGuangdong510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghai Tech UniversityShanghai201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518005China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of COVID-19,encodes several accessory proteins that have been shown to play crucial roles in regulating the innate immune ***,their expressions in infected cells and immunogenicity in infected humans and mice are still not fully *** study utilized various techniques such as luciferase immunoprecipitation system(LIPS),immunofluorescence assay(IFA),and western blot(WB)to detect accessory protein-specific antibodies in sera of COVID-19 *** antibodies to proteins 3a,3b,7b,8 and 9c can be detected by LIPS,but only protein 3a antibody was detected by IFA or *** against proteins 3a and 7b were only detected in ICU patients,which may serve as a marker for predicting disease ***,we investigated the expression of accessory proteins in SARS-CoV-2-infected cells and identified the expressions of proteins 3a,6,7a,8,and *** also analyzed their ability to induce antibodies in immunized mice and found that only proteins 3a,6,7a,8,9b and 9c were able to induce measurable antibody productions,but these antibodies lacked neutralizing activities and did not protect mice from SARS-CoV-2 *** findings validate the expression of SARS-CoV-2 accessory proteins and elucidate their humoral immune response,providing a basis for protein detection assays and their role in pathogenesis.

关键词： SARS-CoV-2 Accessory protein Humoral immune responses COVID-19 Mouse model

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绿色技术与森林可持续经营

北京林业大学学报 2000年第1期22卷 99-100页

作者：刘东兰北京林业大学资源与环境学院

1绿色技术的概念绿色技术不仅是技术的一类,而且又有其独特的内涵和外延,可以说是人们对传统技术反思与发展的结果.绿色技术有广义和狭义两种说法.广义的绿色技术是从改善人-技术-自然之间的关系出发定义的,如'绿色技术就是旨在恢复因... 详细信息

1绿色技术的概念绿色技术不仅是技术的一类,而且又有其独特的内涵和外延,可以说是人们对传统技术反思与发展的结果.绿色技术有广义和狭义两种说法.广义的绿色技术是从改善人-技术-自然之间的关系出发定义的,如'绿色技术就是旨在恢复因人类的生产和社会活动而遭到破坏的自然环境的技术'.狭义的绿色技术则是从技术活动本身出发的,如'绿色技术是减轻环境污染或减少使用原材料、自然资源和能源的技术、工艺或产品的总称.'

关键词：森林可持续发展绿色技术经营环境保护

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美国国有林生态系统经营

世界林业研究 1999年第3期12卷 47-54页

作者：刘东兰北京林业大学资源与环境学院

介绍美国国有林以生态系统经营为目标的改革。进入９０年代美国国有林的经营方针发生了根本性转变，转入以生态系统经营为基础。为实现生态系统经营进行了组织和规划决策的改革，并开展了大规模的实验。

关键词：美国国有林改革生态系统经营职业多样性

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Novel arylaminopropanoate compounds induced cell apoptosis in osteosarcoma cells

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Novel arylaminopropanoate compounds induced cell apoptosis i...

“双碳”目标下森林公园植被空间配置对降温效果的影响——以福州森林公园为例

第十届全国化学生物学学术会议

作者： Jia Kaili liu donglan Wu Yixin Lei Ruirui liu Shunying Hu Wenhao Dong Suzhen Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal University

Our phenotypic screening of anti-cancer compounds in a library of multi-component reaction products found that a series of novel α-propiolamino-β-arylaminopropanoates have potent inhibitive activity on cancer cells. The most potent compound LR4 inhibits the proliferation of many cancer cell lines, of which the most sensitive cell line is SJSA-1, human osteoscarcoma cell line(IC= 9.6 nM). To elucidate the action mechanism of LR4, its effects on the cell cycle distribution, cell apoptosis, mitochondria membrane potential, ATP synthesis and cancer-related signaling pathways were thoroughly analyzed in SJSA-1 cells. The results revealed that LR4 induced significant cell apoptosis in a dose-and time-dependent manner. LR4 had no obvious effects on cell cycle arrest, but caused decreased mitochondrial potential and reduced ATP synthesis, suggesting a kind of mitochondrial-dependent apoptosis. A screening of anti-tumor signaling pathway was performed and found that increased activation of NFKB signaling pathway occurred in SJSA-1 cells and LR4 could inhibit NFKB activation. Further western blotting experiments conformed LR4 compromised TNF-α-induced NFKB phosphorylation. These results indicate that LR4 induced cancer cell apoptosis possibly by inhibiting NFKB pathway, which might provide insights for further development of new drugs for cancer. More experiments should be performed to elucidate the target of LR3 and its accurate mechanisms.

关键词： arylaminopropanoate SJSA-1 apoptosis NFKB

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科技导报 2024年第15期42卷 82-90页

作者：刘东兰戴忠炜福建农业职业技术学院园艺园林学院福州350002 同济大学建筑与城市规划学院上海200092

以福州森林公园为例,使用微气候模型ENVI-met模拟分析不同植被空间配置类型对降温效果的影响,旨在提出森林公园植被降温成效的提升策略。根据不同植被空间配置和降温效果的相关性,设计了18种理想化场景。这18种场景代表了具有3种不同碎... 详细信息

以福州森林公园为例,使用微气候模型ENVI-met模拟分析不同植被空间配置类型对降温效果的影响,旨在提出森林公园植被降温成效的提升策略。根据不同植被空间配置和降温效果的相关性,设计了18种理想化场景。这18种场景代表了具有3种不同碎片化程度的植被空间配置类型(块状绿地、稀疏点状绿地、密集点状绿地)和6种植被类型(裸地、草地、灌木、小乔木+草地、大乔木+草地、大乔木+灌木)。结果显示,大乔木是影响降温效果的重要因素,而草地和灌木由于热辐射的累积,并不会导致周围空气降温;此外,对于乔木,植被空间配置类型的碎片化程度越高,会导致降温效果的显著降低,而对于草地和灌木,植被空间配置类型影响不显著。进而得出结论,在森林公园的植被营建和管理过程中,应重视乔木所发挥的降温作用,同时避免乔木组团空间碎片化,应让乔木组团高度聚集。

关键词： “双碳”目标植被空间配置降温效果 ENVI-met 森林公园

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TheEstimationofStemTaperCurvefromtheRadialInformationatThreeLocationsontheStem

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Forest Ecosystems 1996年第1期 79-86页

作者： Zheng Xiaoxian liu donglan College of Forest Resources and Environment, Beijing Forestry University, Beijing 100083, P.R.China

该文探讨了不用编制削度表直接建立高精度立木干曲线的方法．当采用干曲线是３次多项式时，通常根据１０分法测定树干各部位直径，用最小二乘法求出该方程式的参数．从数学角度，只要知道树干任意３个部位的直径，就可以用最小二乘法或... 详细信息

该文探讨了不用编制削度表直接建立高精度立木干曲线的方法．当采用干曲线是３次多项式时，通常根据１０分法测定树干各部位直径，用最小二乘法求出该方程式的参数．从数学角度，只要知道树干任意３个部位的直径，就可以用最小二乘法或联立方程式求解干曲线参数．本文以樟子松为例，探讨用树干哪３个部位直径拟合的干曲线最接近实际干曲线，为建立立木干曲线提供有效方法．利用９个部位半径（方法Ⅰ）和利用其中３个部位半径（方法Ⅱ，２８种组合）分别拟合干曲线，结果表明方法Ⅱ的６种半径组合的精度良好，其中的３种组合，（ｒ１．３，ｒ０．３，ｒ０．７），（ｒ１．３，ｒ０．４，ｒ０．７）和（ｒ１．３，ｒ０．４，ｒ０．８）是拟合现实干曲线的有效方法．

关键词：樟子松干曲线 3次多项式