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Effect of Structural Parameters of Double Shielded TIG Torch on the Fusion Zone Profile for 0Cr13Ni5Mo Martensitic Stainless Steel

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Journal of Materials Science & Technology 2014年第9期30卷 922-927页

作者： dongjie li Shanping Lu Dianzhong li Yiyi li Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

The effects of double shielded TIG （tungsten inert gas） torch＇s structural parameters, including the flow rate ratio between the inner and outer layers of gas and the extended length of the electrode （abbreviated as ELE in this work）, on the fusion zone profile have been investigated for OCrl3NiSMo martensitic stainless steel. Results show that the double shielded TIG process yields relatively high penetration of the weld pool in a broad range of the structural parameters. ELE over 3 mm is too large and causes adverse reactions on the protection of electrode. The outer gas with relatively high flow rate or the outer layer with high oxygen content is conducive to the oxygen dissolved into the arc, which results in the oxidation of the weld pool surface and the electrode tip. The double shielded TIG welded metal was tested and presented good impact property.

关键词： Structural parameters Flow rate Electrode extended length Impact energy

Uncertainty Analysis Method of Casing Extrusion Load for Ultra-Deep Wells

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Computer Modeling in Engineering & Sciences 2017年第4期113卷 475-495页

作者： Meng li Kanhua Su Zijian li dongjie li lifu Wan School of Petroleum Chongqing University of Science and TechnologyChongqing401331China Memorial University of Newfoundland St.John'sA1C5S7Canada Engineering Technology Research Institute PetroChina Huabei Oilfield CompanyRenqiu062552China

With the consideration of the randomness of complex geologic parameters for ultra-deep wells,an uncertainty analysis method is presented for the extrusion load on casing in ultra-deep wells through complex formation at a certain confidence level.Based on the extrusion load model for casing in ultra-deep wells and the prerequisite of integrity of formation-cement ring-casing,the probability and statistics theory are introduced and the sensitivity analysis on the uncertainty of extrusion load on casing is conducted.The distribution types of each formation parameters are determined statistically.The distribution type and distribution function of the extrusion load on casing are derived.Then,the uncertainty analysis of the extrusion load on casing is carried out on several ultra-deep wells in Shanqian block as case study.Several conclusions are made regarding to the field trial result.The randomness of formation elasticity modulus and formation Poisson’s ratio are the main influence factors.The equivalent density profile of extrusion load on casing in ultra-deep wells is a confidence interval with a certain confidence level,rather than a single curve;the higher the confidence level is,the larger the bandwidth of the confidence interval of equivalent density profile becomes,and the larger the range of uncertainty interval becomes.Compared with the result of uncertainty analysis,an error exists in the result of traditional single valued calculation method.The error varies with different casing program and can be either positive or negative.The application of uncertainty analysis of extrusion load on casing provides proof for the accurate determination of casing collapse safety factor.Thus,the over engineering design or under engineering design as a result of tradition casing design will be avoided.

关键词： Ultra-deep well formation parameters uncertainty extrusion load confidence interval

Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3650-3666页

作者： Jie Tong dongjie li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang Department of Pharmacy Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Pharmacology School of PharmacyNaval Medical University/Second Military Medical UniversityShanghai 200433China Department of General Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Pharmacy Shanghai Fourth People’s HospitalTongji University School of MedicineShanghai 200081China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325000China Department of Medicinal Chemistry School of PharmacyNaval Medical University/Second Military Medical UniversityShanghai 200433China Institute of Nuclear Medicine Tongji University School of MedicineShanghai 200072China

Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andﬁbrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD.

关键词： Ferroptosis GPX4 Alternative isoform Fatty liver Oligomerization Methionine/choline-deficient diet High fat-fructose/sucrose diet Protein interaction

What Affects Male Sexual Activity: A Comprehensive Review

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Health 2023年第12期15卷 1366-1389页

作者： Jingxuan Peng Boyu Xiang Jianfu Yang Yuxin Tang dongjie li Zhengyan Tang Department of Urology Xiangya Hospital Central South University Changsha China Department of Urology First Affiliated Hospital of Jishou University Jishou China Andrology Center The Third Xiangya Hospital of Central South University Changsha China Department of Urology The Third Xiangya Hospital of Central South University Changsha China Department of Urology The Fifth Affiliated Hospital of Sun Yat-sen University Zhuhai China Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai China

The fundamental importance of sex lies in the need for reproduction and species continuity. For humans, sexual expression is an important source of physical pleasure and emotional intimacy. Healthy sexual expression is closely related to well-being, health and overall quality of life in both men and women. Sexual activity is also considered an important determinant of quality of life. At present, questions about sex are still largely ignored in routine consultations in almost all medical specialties. The factors affecting sexual activity are complex and can be divided into the influence of bio-psycho-sociological factors. Biological influences include anthropometric parameters, sexual function, lifestyle, neuroendocrine system, and diseases;psychological influences include psychological status, mental illness, and sexual attitudes;sociological influences include factors such as marriage, occupation, and economic status. With the epidemic and outbreak of Coronavirus disease 2019 (COVID-19), people’s way of life and work has changed, which also has a great impact on sexual activities. This article will provide a systematic review of factors related to male sexual activity.

关键词： Sexual Activity Andrology Sexual Health Influencing Factors

主动电磁轴承支承的高速电动机总成热平衡分析

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轴承 2024年第7期 28-35页

作者：王鹏鹏孙进华李栋杰张钢上海大学机电工程与自动化学院上海200444

以一台由主动电磁轴承支承的某型卧式离心鼓风机为研究对象,对其电动机总成的电磁场进行仿真,得到电动机和主动电磁轴承的损耗分布,根据该鼓风机的三维模型提取空气域,分析不同风冷散热方式下冷却空气在其内部的流动情况,再运用Fluent... 详细信息

以一台由主动电磁轴承支承的某型卧式离心鼓风机为研究对象,对其电动机总成的电磁场进行仿真,得到电动机和主动电磁轴承的损耗分布,根据该鼓风机的三维模型提取空气域,分析不同风冷散热方式下冷却空气在其内部的流动情况,再运用Fluent对电动机总成温度场进行仿真,将得到的温度场仿真结果与试验结果进行对比,结果表明:电动机、径向主动电磁轴承、轴向主动电磁轴承的铜损耗率最高分别为768180,124590,281700 W/m^(3);双口直接通风加水冷散热和单口混合通风加水冷散热的仿真结果与试验结果的最大误差分别为4.15%和5.48%,单口混合通风加水冷的散热效果更好,验证了单向磁-热耦合温度场分析方法的合理性。

关键词：滑动轴承磁力轴承电动机温度场能量损耗散热有限元分析

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花生半喂入联合收获二次清选机构研究

中国农机化学报 2024年第3期45卷 117-125页

作者：李冬杰王东伟何晓宁左百强张春晓李绪青岛农业大学机电工程学院山东青岛266109

针对目前半喂入花生联合收获机其清选环节存在清选损失率高、荚果含杂率高等问题,基于花生一次清选后花生荚果破损机理,设计一种二次清选装置,主要包括输送链、栅条筛、筛架、液压缸、滑土板,并确定该装置的基本参数。通过ADAMS软件分析... 详细信息

针对目前半喂入花生联合收获机其清选环节存在清选损失率高、荚果含杂率高等问题,基于花生一次清选后花生荚果破损机理,设计一种二次清选装置,主要包括输送链、栅条筛、筛架、液压缸、滑土板,并确定该装置的基本参数。通过ADAMS软件分析,建立清选过程中花生与装置碰撞模型,确定以筛子转速、筛子安装高度、筛子倾角为主要影响因素,并针对“宇花14号”花生品种进行试验研究。结果表明:筛子安装高度为29 cm、筛子转速为147 r/min、筛子安装角度为19°,对应的荚果含杂率为1.65%、清选损失率为1.37%。试验结果表明,应用该装置的两垄四行花生联合机作业效果明显提高。

关键词：花生联合收获半喂入二次清选 ADAMS

铂类药物敏感BRCA突变卵巢癌复发患者奥拉帕利与含铂类药物方案治疗效果比较

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肿瘤研究与临床 2024年第3期36卷 177-183页

作者：陈婧唐楠吴圆圆田原刘彤王艳丽李冬杰李润浦保定市第二中心医院肿瘤科保定072750

目的探讨奥拉帕利与含铂类药物方案治疗的对铂类药物敏感的BRCA突变卵巢癌复发患者肿瘤特异性生长因子、细胞免疫功能及疗效的差异。方法回顾性队列研究。回顾性选取2017年9月至2020年3月保定市第二中心医院100例对铂类药物敏感的BRCA... 详细信息

目的探讨奥拉帕利与含铂类药物方案治疗的对铂类药物敏感的BRCA突变卵巢癌复发患者肿瘤特异性生长因子、细胞免疫功能及疗效的差异。方法回顾性队列研究。回顾性选取2017年9月至2020年3月保定市第二中心医院100例对铂类药物敏感的BRCA突变卵巢癌复发患者,分析患者临床资料。根据治疗方案分为奥拉帕利组(以奥拉帕利片治疗)和含铂方案组(紫杉类药物+铂类药物治疗6个周期后服用奥拉帕利片维持治疗),各50例。比较两组临床疗效及治疗前、治疗2、4、6个周期后肿瘤特异性生长因子[糖类抗原(CA)125、CA199、人附睾蛋白4(HE4)]水平、细胞免疫功能相关指标[T细胞亚群(CD3^(+)细胞、CD4^(+)细胞比例)、CD4^(+)细胞与CD8^(+)细胞比值(CD4^(+)/CD8^(+))]、生命质量评分及安全性。获得随访3年的数据,采用Kaplan-Meier法分析两组患者无进展生存(PFS)情况,组间比较采用log-rank检验。结果奥拉帕利组和含铂方案组患者年龄分别为(53±7)岁、(56±7)岁。两组间年龄、体质量指数及美国东部肿瘤协作组(ECOG)体能状态评分、原发肿瘤位置、病灶大小、病理分期、病理类型、胚系BRCA突变、既往化疗反应患者构成差异均无统计学意义(均P>0.05)。治疗结束后,奥拉帕利组客观缓解率(ORR)[58.0%(29/50)比38.0%(19/50)]、疾病控制率(DCR)[80.0%(40/50)比56.0%(28/50)]均高于含铂方案组,差异均有统计学意义(均P0.05)。结论奥拉帕利治疗对铂类药物敏感的BRCA突变卵巢癌复发患者效果优于含铂方案,且其提高患者T细胞水平、抑制肿瘤特异性生长因子表达效果更强,提高生命质量,对提高治疗安全性具有积极作用。

关键词：卵巢肿瘤铂复发奥拉帕利生物学标记,肿瘤免疫,细胞治疗结果

基于行波理论和改进Hausdorff距离的多端混合直流输电线路保护方案

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武汉大学学报（工学版） 2024年第5期57卷 608-618页

作者：武一鸣樊友平王子江许洵黄宗武李东杰武汉大学电气与自动化学院湖北武汉430072

多端混合直流输电系统输电容量大、拓扑结构复杂,具有“多送点、多受端”的特征,线路容易发生故障且故障后的影响范围广,因此对保护的可靠性要求极高。为保证多端混合直流输电系统安全稳定运行,提出了一种基于行波理论和改进Hausdorff... 详细信息

多端混合直流输电系统输电容量大、拓扑结构复杂,具有“多送点、多受端”的特征,线路容易发生故障且故障后的影响范围广,因此对保护的可靠性要求极高。为保证多端混合直流输电系统安全稳定运行,提出了一种基于行波理论和改进Hausdorff距离的保护方案。根据行波理论测算线模分量与地模分量,并应用输电线路的贝瑞隆模型,由线路一侧的线模分量推演线路对侧线模电流;引入改进的Hausdorff距离算法来量化推演值与真实值的差异并构造判据以识别故障线路,同时根据地模波的大小与变化率确定故障极、根据行波检测时间计算故障位置,实现故障精准定位。采用乌东德三端混合直流输电工程模型,通过PSCAD/EMTDC进行仿真验证,结果表明该保护方案能在5 ms内识别全线范围的故障且能够耐受过渡电阻与噪声干扰,兼具可靠性、选择性、速动性与灵敏性。

关键词：多端混合直流输电行波理论贝瑞隆模型改进Hausdorff距离可靠性

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玉屏风颗粒联合脐贴治疗小儿汗证临床效果

深圳中西医结合杂志 2024年第1期34卷 64-67页

作者：朱小晴李冬杰商晓式平顶山市妇幼保健院河南平顶山467000

目的:探究玉屏风颗粒联合脐贴治疗小儿汗证的临床效果。方法:在2020年3月至2022年3月期间,于平顶山市妇幼保健院接受治疗的小儿汗证患儿中选取104例作为研究对象,并按随机分组法分成对照组(52例)和观察组(52例)。对照组患儿口服玉屏风颗... 详细信息

目的:探究玉屏风颗粒联合脐贴治疗小儿汗证的临床效果。方法:在2020年3月至2022年3月期间,于平顶山市妇幼保健院接受治疗的小儿汗证患儿中选取104例作为研究对象,并按随机分组法分成对照组(52例)和观察组(52例)。对照组患儿口服玉屏风颗粒,观察组患儿在口服玉屏风颗粒的基础上结合脐贴疗法,治疗时限均为4周。比较两组患儿的治疗效果、中医临床症状的主症(出汗)和次症(发热咳嗽、食欲不振、睡眠不足、大小便异常、烦躁不安)评分、血清乙酰胆碱(Ach)含量和不良反应发生情况等指标的变化。结果:观察组患儿治疗总有效率为94.23%,高于对照组的80.77%,差异具有统计学意义(P<0.05)。治疗后两组患儿主症及各项次症评分均低于治疗前,且治疗后观察组患儿主症及各项次症评分低于对照组,差异具有统计学意义(P<0.05)。治疗后两组患儿血清Ach水平均低于治疗前,且治疗后观察组患儿血清Ach水平低于对照组,差异具有统计学意义(P<0.05)。治疗期间对照组患儿无明显不良反应发生,观察组中出现3例患儿的脐部皮肤红胀,但在隔日敷贴后情况均有所改善。结论:玉屏风颗粒联合脐贴对汗证患儿治疗效果较为显著,能缓解临床症状,改善患儿出汗情况。

关键词：汗证玉屏风颗粒脐贴儿童