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血栓弹力图联合抗凝血酶Ⅲ和D-二聚体检测对脑基底节出血患者术后下肢深静脉血栓的预测价值研究

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北京医学 2024年第6期46卷 480-485,490页

作者：赵瑾超王东辉刘晓耘周佩洋任自敬赵建忠李文雄湖北医药学院附属襄阳市第一人民医院检验科 441000 湖北医药学院附属襄阳市第一人民医院重症医学科湖北医药学院附属襄阳市第一人民医院脑血管病临床医学研究中心首都医科大学附属北京朝阳医院SICU

目的探讨血栓弹力图(thrombelastography, TEG)联合抗凝血酶Ⅲ(antithrombinⅢ, AT-Ⅲ)和D-二聚体检测对脑基底节出血患者术后下肢深静脉血栓(deep venous thrombosis, DVT)的预测价值。方法选取2020年4月至2021年10月湖北医药学院附... 详细信息

目的探讨血栓弹力图(thrombelastography, TEG)联合抗凝血酶Ⅲ(antithrombinⅢ, AT-Ⅲ)和D-二聚体检测对脑基底节出血患者术后下肢深静脉血栓(deep venous thrombosis, DVT)的预测价值。方法选取2020年4月至2021年10月湖北医药学院附属襄阳市第一人民医院脑基底节出血术后患者113例,根据术后第3天下肢血管彩色多普勒超声检查是否有DVT分为DVT组(29例)和非DVT组(84例)。比较两组患者术后当天TEG参数、AT-Ⅲ及D-二聚体;采用多因素logistic回归分析脑基底节出血患者术后发生DVT的危险因素,并评估模型的预测效能。结果 113例患者中,男78例,女35例,年龄23~92岁,平均(59.8±12.8)岁,脑基底节出血患者术后DVT发生率为25.7%。TEG R值越低(OR=0.55,95%CI:0.32~0.85,P=0.014)、TEG MA值越高(OR=1.16,95%CI:1.07~1.28,P<0.001)、AT-Ⅲ越低(OR=0.90,95%CI:0.84~0.94,P<0.001)、D-二聚体越高(OR=1.74,95%CI:1.04~3.05,P=0.041)的脑基底节出血患者,术后发生DVT的风险越高。基于上述4个独立危险因素建立患者DVT的预测模型,ROC曲线下面积为0.902(95%CI:0.819~0.985)。结论 TEG R值、MA值联合AT-Ⅲ和D-二聚体检测对脑基底节出血术后患者早期DVT具有很好的预测价值。

关键词：血栓弹力图抗凝血酶Ⅲ D-二聚体下肢深静脉血栓脑基底节出血预测价值

西堠门公铁两用大桥主桥主墩基础施工关键技术

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桥梁建设 2023年第6期53卷 1-9页

作者：张敏王东辉中铁大桥局集团有限公司湖北武汉430050

甬舟铁路西堠门公铁两用大桥主桥为主跨1488 m的斜拉-悬索协作体系桥,公铁平层布置。5号主墩采用18根∅6.3 m超大直径钻孔桩基础,4号主墩采用双壁圆筒形嵌入式设置沉井基础(外径58 m、高37 m)。结合桥位处复杂海洋环境和主体结构特点,5... 详细信息

甬舟铁路西堠门公铁两用大桥主桥为主跨1488 m的斜拉-悬索协作体系桥,公铁平层布置。5号主墩采用18根∅6.3 m超大直径钻孔桩基础,4号主墩采用双壁圆筒形嵌入式设置沉井基础(外径58 m、高37 m)。结合桥位处复杂海洋环境和主体结构特点,5号主墩基础采用导管架式深水栈桥+自浮式钢桁架钻孔平台方案施工,4号主墩基础采用板凳式栈桥+设置沉井方案施工。5号主墩超大直径钻孔桩施工时,设置深水栈桥(采用整体式导管架法建设),自浮式钢桁架钻孔平台(由钢桁架及钢锚桩组成)在船坞整体制造;浮运到桥位后,钻孔桩采用旋挖钻机分级成孔、全回转钻机全断面一次成孔,水下桩基混凝土采用双导管法灌注,解决了深水、浪涌及硬质裸岩下超大直径桩施工难题。4号主墩钢沉井结构在船坞整体制造,整体浮运到桥位后,首先通过定位系统(共设置12个混凝土重力锚)快速定位,然后对平面位置、高程和垂直度进行精确定位,解决了复杂海况下钢沉井整体浮运、精准定位及下沉着床难题。

关键词：公路铁路两用桥斜拉-悬索协作体系桥超大直径钻孔桩嵌入式设置沉井深水栈桥自浮式钻孔平台定位技术施工技术

Association of atherosclerotic renal artery stenosis with major adverse cardiovascular events after acute myocardial infarction

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Chinese Medical Journal 2014年第4期127卷 618-622页

作者： Zheng Bin Liu Jinghua Ma Qin Zhao donghui wang* Xin Zheng Ze Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China

Background Patients with atherosclerotic renal artery stenosis （ARAS） are in substantial risk of cardiovascular adverse *** investigated whether myocardial infarction patients with ARAS are in additional risk of cardiovascular *** In this retrospective study,257 patients with type 1 myocardial infarction were *** follow-up was 42 *** endpoint events are analyzed by definitions of ARAS as ≥50% or ≥70% diameter *** Defining ARAS as ≥70% diameter stenosis,ARAS was a significant predictor for composite endpoint events including death,non-fatal myocardial infarction,ischaemic stroke and intracranial haemorrhage,rehospitalisation for cardiac failure （HR：4.381; 95% Cl：1.770-10.842） by Cox regression analysis,but not for *** mellitus was also a significant predictor for composite endpoint events （HR：2.756; 95% Cl：1.295-5.863）.However,defining ARAS ≥50% diameter stenosis,ARAS was no longer a significant predictor for composite endpoint events or *** Although not associated with mortality,ARAS ≥70% is associated with major adverse cardiac events after acute myocardial *** prognosis,≥70% diameter stenosis is a more appropriate criteria for ARAS definition than ≥50% diameter stenosis.

关键词： renal artery obstruction atherosclerosis myocardial infarction

Selective synthesis of the B_(11)H_(14)^(-) and B_(12)H_(12)^(2-) borane derivatives and the general mechanisms of the B-H bond condensation

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Science China Chemistry 2024年第3期67卷 876-881页

作者： Yi Jing Xinghua wang Hui Han Xin-Ran Liu Xing-Chao Yu Xi-Meng Chen donghui Wei Lai-Sheng wang Xuenian Chen College of Chemistry Green Catalysis CenterZhengzhou UniversityZhengzhou 450001China School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced Energy MaterialsHenan Normal UniversityXinxiang 453007China Department of Chemistry Brown UniversityProvidenceRI 02912USA

Polyhedral boranes are a class of well-known boron molecular clusters with unique physical and chemical properties,and great efforts have been made in the past decades to find more effective synthetic ***,the established synthetic methods suffer from low efficiency and low selectivity because the mechanism of the B-H bond condensation reaction,critical for the synthesis of the polyhedral boranes,is not well *** we report highly selective and efficient synthetic methods of the salts of the tetradecahydridoundecaborate(1-)(B_(11)H^(-)_(14)) and dodecahydrido-dodecaborates(2-)(B_(12)H_(12)^(2-)) anions by employing commercially available and inexpensive starting *** theoretical and experimental investigations are carried out to elucidate the reaction *** have found that the nature of the B-H bond condensation is the dihydrogen bonding interaction in which the positively charged hydrogens(bridged hydrogens) play a crucial *** current study has not only led to more effective and selective synthetic methods for B_(11)H^(-)_(14) and B_(12)H_(12)^(2-) but also unveiled the nature of the B-H bond condensation and the general formation mechanisms of polyhedral *** finding will facilitate the development of more effective synthetic methods for polyhedral boranes and spur their wide application.

关键词： Boranes polyhedral boranes dihydrogen bond nucleophilicity

A Study on the Algorithms for 2D Texture Mapping and Its Employment in Hardware Design

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A Study on the Algorithms for 2D Texture Mapping and Its Emp...

Modulating the alloying mode in the doping-induced synthesis of Au-Pd nanowires

2012年计算机应用与系统建模国际会议

作者： wang donghui Dong Liang Du Huimin Department of electronic engineering XUPT

Based on a solid analysis of the working principle of graphic processors, this paper puts forward the dual-rail handshake protocol of the data pipeline which is to be proved to improve the architecture of graphics rendering pipeline and thus make the system much closer to that of a graphic processor in real time. Specific algorithms and hardware design methods are as well developed in this work with their focus dwelling on the computation-consuming texture mappings, including two critical techniques: texture coordinate calculation and texture filtering. FPGA result shows that circuits based on textual algorithms can define accurately the textual coordinates and yield precise textual images, bringing significant improvements to the performance of graphics rendering.

关键词： GPU organization pipeline texture mapping

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Nano Research 2024年第4期17卷 3334-3343页

作者： Hui Jin Xiaoliang Wei Lecheng Zhao Jialong Yu Qiao Pan Shumin Li Qian wang Zhaotong Yuan Dan Yang donghui Zhao Hongyu Chen Yawen wang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China School of Science Westlake UniversityHangzhou 310064China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310064China

Heterogeneous doping is one effective strategy for synthesizing metal alloy ***,the heterogeneous doping processes of Pd on the ultrathin Au nanowires were systematically modulated and ***-Pd alloy nanowires with various morphologies and lattice structures can be obtained by adjusting the morphology of the precursor Au nanowires and the kinetics of the heterogeneous doping *** effects of the rate of Pd reduction and the concentration of the ligand oleylamine(OAm)on the Pd deposition and alloying mode were ***,as the Pd deposition rate decreases,the Pd deposition and alloying mode switches from the island-forming Stransky–Krastanov(SK)mode to the epitaxial Frank-van der Merwe(FM)mode,and eventually to an unconventional twisting alloying mode,where the interdiffusion of Pd and Au causes drastic rearrangement of the lattice structure and formation of helical *** kinetics-related variation of alloying mode could also be observed in the Au-Ag nanowires,demonstrating a general design principle for the synthesis of alloy *** addition,the electrocatalytic performance of various Au-Pd nanowires was evaluated,and the alloy nanowire formed via the SK mode was found to be an excellent electrocatalyst for oxygen reduction and ethanol oxidation.

关键词： gold nanowires Au-Pd alloy oleylamine post-synthetic modification

“Petal effect”-inspired superhydrophobic and highly adhesive coating on magnesium with enhanced corrosion resistance and biocompatibility

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Science China Materials 2018年第4期61卷 629-642页

作者： Feng Peng donghui wang* Xiaohan Ma Hongqin Zhu Yuqin Qiao Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China

With properties of complete degradation and favorable mechanical behavior, Mg and its alloys are regarded as the next generation medical metal materials. However, fast degradation and poor surface biocompatibility hinder their clinical applications. Inspired by the ＂petal effect＂, we successfully constructed a superhydrophobic and highly adhesive coating on pure Mg via a simple hydrothermal treatment in a solution containing sodium oleate. The superhydrophobicity of the fabricated coating results from its flake-like micro-nanostructure and the low-surface-energy oleate group. Water droplet on the superhydrophobic coating cannot roll off even when the sample is turned upside down, owing to the sealed air-pockets and the van der Waals’ attraction at the solidliquid interface, indicating a highly adhesive force. The chemical and mechanical stability of the superhydrophobic coating were measured. Potentiodynamic polarization and electrochemical impedance spectroscopy measurements suggest enhanced corrosion resistance of the as-prepared ***, cell cytotoxicity, migration and adhesion data of human umbilical vein endothelial cells（HUVECs） reveal an improved cytocompatibility of the modified surface. Finally,hemolysis assay and platelet adhesion assay suggest an improved hemocompatibility. It is believed that the facile and low-cost method can expand the new application of superhydrophobic surface with highly adhesive on Mg in biomedical fields.

关键词： magnesium petal-effect superhydrophobic corrosion resistance biocompatibility

Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration

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Regenerative Biomaterials 2021年第1期8卷 10-24页

作者： Feng Peng Shi Cheng Ruiying Zhang Mei Li Jielong Zhou donghui wang* Yu Zhang Department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

Infection and insufficient osteointegration are the main causes of orthopedic implant ***,activating favorable inflammation response is vital to the fast osteointegration of ***,endowing the implants with multifunctions(antibacterial,anti-inflammation,and pro-osteointegration)is a promising strategy to improve the performance of orthopedic *** this study,a Zn-contained polydopamine(PDA)film was fabricated on AZ31 *** film possessed a stable Zn ion release in 14 *** results of electrochemical analysis implied the favorable corrosion protection of the film,and thus,leading to a suitable hemolysis ratio(below 1%).The in vitro antibacterial assessment revealed that the film exhibited excellent resistance against Staphylococcus aureus(nearly 100%),which can be ascribed to the release of Zn *** cell-culture evaluation revealed that the extract of Zn-contained PDA-coated sample can activate RAW264.7 polarization to an anti-inflammatory phenotype,as well as enhance the osteogenic dif-ferentiation ability of MC3T3-E ***,the femoral osteomyelitis model indicated that the as-prepared film had a high antibacterial capability at early stage of the implantation,and showed better osteogenesis and osteointegration after 8 weeks of *** favorable antibacte-rial,anti-inflammation,and pro-osteogenesis abilities,the novel designed Zn-contained PDA film is promising to be used in Mg-based orthopedic implants.

关键词： magnesium alloy zinc polydopamine antibacte rial anti-inflammation osteointe gration

Biogenic amines detection in meat and meat products:the mechanisms,applications,and future trends

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未来食品学报(英文) 2024年第1期4卷 21-36页

作者： Yanan Liu Yongqiang He Huan Li donghui Jia Linglin Fu Jian Chen Dequan Zhang Yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China The Technical Center of Hangzhou Customs of China Hangzhou 310016China National Risk Assessment Laboratory of Agro-products Processing Quality and Safety Ministry of Agriculture and Rural AffairsInstitute of Food Science and TechnologyChinese Academy of Agricultural SciencesBeijing 100193China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Biogenic amine is one of the main categories of hazardous compounds in meat and meat products,making its detection methods vital for the assurance of edible *** this sense,many biogenic amine detection techniques such as chromatographic,electrophoretic,and electrochemical methods have been developed,which play an irreplaceable role in ensuring the safety of meat and meat *** to the increasing demand for fast and on-site detection techniques,visual detection methods have been gradually developed compared with non-visual methods such as chromatography and ***,we comprehensively review the mechanism and the latest progress of these biogenic amine detection methods;besides,we put forward the prospects for the future development of biogenic amine detection techniques,with a view to providing support for the establishment of more accurate and efficient detection,prevention and control strategies of biogenic amines.

关键词： Biogenic amines Meat and meat products Food safety Non-visual detection techniques Visual detection techniques