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Brain delivery of fibronectin through bioactive phosphorous dendrimers for Parkinson’s disease treatment via cooperative modulation of microglia

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Bioactive Materials 2024年第8期38卷 45-54页

作者： Waicong Dai Mengsi Zhan Yue Gao Huxiao Sun Yu zou Regis Laurent Serge Mignani Jean-Pierre Majoral Mingwu Shen Xiangyang Shi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai201620PR China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneCEDEX 431077ToulouseFrance Universit´e Toulouse 118 Route de NarbonneCEDEX 431077ToulouseFrance CQM-Centro de Química da Madeira Universidade da MadeiraCampus Universit´ario da Penteada9020-105FunchalPortugal

Effective treatment of Parkinson’s disease(PD),a prevalent central neurodegenerative disorder particularly affecting the elderly population,still remains a huge *** present here a novel nanomedicine formulation based on bioactive hydroxyl-terminated phosphorous dendrimers(termed as AK123)complexed with fibronectin(FN)with anti-inflammatory and antioxidative *** created optimized AK123/FN nanocomplexes(NCs)with a size of 223 nm display good colloidal stability in aqueous solution and can be specifically taken up by microglia through FN-mediated *** show that the AK123/FN NCs are able to consume excessive reactive oxygen species,promote microglia M2 polarization and inhibit the nuclear factor-kappa B signaling pathway to downregulate inflammatory *** the abundant dendrimer surface hydroxyl terminal groups,the developed NCs are able to cross blood-brain barrier(BBB)to exert targeted therapy of a PD mouse model through the AK123-mediated anti-inflammation for M2 polarization of microglia and FN-mediated antioxidant and anti-inflammatory effects,thus reducing the aggregation ofα-synuclein and restoring the contents of dopamine and tyrosine hydroxylase to normal levels in *** developed dendrimer/FN NCs combine the advantages of BBB-crossing hydroxyl-terminated bioactive per se phosphorus dendrimers and FN,which is expected to be extended for the treatment of different neurodegenerative diseases.

关键词： Phosphorous dendrimers Fibronectin Parkinson’s disease Blood brain barrier Combination therapy

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不同厚度石墨烯表面的纳米摩擦各向异性研究

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摩擦学学报 2023年第3期43卷 283-292页

作者：孔然邹鲲东华大学机械工程学院上海201620

考察石墨烯表面的纳米摩擦各向异性,研究厚度对其摩擦各向异性的影响.采用原子力显微镜和高精度旋转台分析不同厚度石墨烯表面在不同方向的纳米摩擦特性.结果表明:厚度为3.6 nm的石墨烯表面纳米摩擦表现出显著的各向异性但无周期性规律... 详细信息

考察石墨烯表面的纳米摩擦各向异性,研究厚度对其摩擦各向异性的影响.采用原子力显微镜和高精度旋转台分析不同厚度石墨烯表面在不同方向的纳米摩擦特性.结果表明:厚度为3.6 nm的石墨烯表面纳米摩擦表现出显著的各向异性但无周期性规律,原因是褶皱效应的产生增大了摩擦力.厚度为7.5和14.7 nm的石墨烯表面纳米摩擦呈现180°和90°的周期性各向异性规律,归因于晶格结构取向和褶皱效应的共同作用.厚度为24.5 nm的石墨烯主要受到晶格结构取向的作用,表面纳米摩擦呈现60°的周期性各向异性规律且沿扶手椅型晶格取向的摩擦力大于锯齿型晶格取向的摩擦力.

关键词：石墨烯厚度摩擦各向异性原子力显微镜旋转台

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急性胆道梗阻肝脏损伤的实验研究

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中国普通外科杂志 2012年第2期21卷 178-182页

作者：元海成秦鸣放邹富胜李东华天津市南开医院微创外科中心天津300100 天津市南开医院中西医结合急腹症研究所天津300100

目的：探讨大鼠急性胆道梗阻后肝脏损伤的变化。方法：雄性Wistar大鼠，随机分为实验组（胆总管结扎）和对照组（假手术），观察术后不同时间点动物的一般情况、黄疸、生化指标和肝脏病理学变化。结果：对照组术后各项观察指标均无明显... 详细信息

目的：探讨大鼠急性胆道梗阻后肝脏损伤的变化。方法：雄性Wistar大鼠，随机分为实验组（胆总管结扎）和对照组（假手术），观察术后不同时间点动物的一般情况、黄疸、生化指标和肝脏病理学变化。结果：对照组术后各项观察指标均无明显异常。实验组术后出现体质量降低、活动减少和明显的黄疸，但3d后均有所改善；术后血清总胆红素（TBIL）和直接胆红素（DBlL）水平明显升高，3d达到高峰，之后缓慢降低；术后谷丙转氨酶（ALT）迅速增加，1-2d达到高峰，3d后迅速下降；碱性磷酸酶（ALP）于术后2d达到高峰，3d后逐渐下降；术后肝组织Metavir评分逐渐增加，3d时开始出现明显胶原纤维增生。结论：肝脏急性损伤期在急性胆道梗阻后1周内期间2-3d进展达高峰，并出现纤维化。

关键词：黄疸阻塞性胆汁淤积肝脏损伤疾病模型动物

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Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies

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Cancer Communications 2018年第1期38卷 632-642页

作者： Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong zou Shanshan Guo Peiyu Huang donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineGuangzhou 510060P.R.China Department of Information Sun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China Department of Radiology Sun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China Precision Medicine Center Sun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China Department of Radiotherapy Sun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou 510060P.R.China

Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial ***,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep ***:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and ***,a total of 28,966 qualified images were *** these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple ***,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist *** dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the ***:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign *** eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test *** the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in

关键词： Nasopharyngeal malignancy Deep learning Differential diagnosis Automatic segmentation

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西天山云杉林生物量与植被指数关系研究

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北京师范大学学报（自然科学版） 2011年第3期47卷 321-325页

作者：陈冬花邹陈李滨勇李虎张新时新疆维吾尔自治区卫星应用工程中心乌鲁木齐830000 北京师范大学资源学院北京100875 中国气象局乌鲁木齐沙漠气象研究所乌鲁木齐830000 国家海洋环境监测中心大连116023 福建师范大学地理科学学院福州350007 中国科学院植物研究所北京100093

基于遥感和地面调查数据,以新疆西天山巩留林区为研究区,提取不同龄级云杉林信息及简单比值植被指数、归一化植被指数及其他植被指数共18种,研究云杉林生物量与各指数的相关性.研究结果表明:总体(全林分)生物量与各植被指数关系相关拟... 详细信息

基于遥感和地面调查数据,以新疆西天山巩留林区为研究区,提取不同龄级云杉林信息及简单比值植被指数、归一化植被指数及其他植被指数共18种,研究云杉林生物量与各指数的相关性.研究结果表明:总体(全林分)生物量与各植被指数关系相关拟合都比分龄级的低,分龄级研究生物量与植被指数关系能够达到较好的结果;各龄级云杉林生物量大多与简单比值指数中的ITM4/3和归一化指数INDV相关性较高,其中幼龄林的生物量与ITM4/3相关性最强,其相关系数达-0.794;中龄林的生物量与INDV、转换型指数ITV具有最高的相关性,其相关系数为0.506,与图象转换指数IVISI123呈很高的负相关,相关系数达-0.506;近熟林生物量与ITM4/3具有最高的相关性,相关系数达到0.647;成熟林生物量与ITM4/3、INDV及其ITV具有最高的相关性,相关系数达0.532;过熟林生物量与ITM4/3具有最高的相关性,相关系数达到0.715.

关键词：西天山云杉生物量植被指数

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Influence of liquid film shape on evaporation performance of agitated thin film evaporator

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Chinese Physics B 2024年第8期33卷 305-314页

作者：顾鑫强黄瑶邹鲲彭倚天 College of Mechanical Engineering Donghua UniversityShanghai 201620China

The agitated thin film evaporator(ATFE),which is known for its high efficiency,force the material to form a film through the scraping process of a scraper,followed by evaporation and *** complex shape of the liquid film inside the evaporator can significantly affect its evaporation *** work explores how change in shape of the liquid films affect the evaporation of the materials with non-Newtonian characteristics,achieved by changing the structure of the *** the distribution of circumferential temperature,viscosity,and mass transfer of the flat liquid film shows that the film evaporates rapidly in shear-thinning *** wavy liquid films are developed by using shear-thinning theory,emphasizing the flow condition in the thinning area and the factors contributing to the exceptional evaporation *** exploration is conducted on the spread patterns of the wavy liquid film and flat liquid film on the evaporation wall throughout the *** is noted that breaking the wavy liquid film on the evaporating wall during evaporation is challenging due to its film-forming *** which the fundamental causes are demonstrated by acquiring the data regarding the flow rate and temperature of the liquid *** definitive findings of the analysis reveal a significant improvement in the evaporation capability of the wavy liquid *** enhancement is attributed to increasing the shear-thinning areas and maintaining the overall shape of the film throughout the entire evaporation process.

关键词： liquid film shape shear-thinning fluids flow characteristics evaporative heat transfer

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Simulation Study on the New Average Heat Flux Method to Determine U-Value of a Wall

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Journal of donghua University(English Edition) 2021年第4期38卷 367-375页

作者： CAO Jieling YANG Jiankun YU Haigang LIU Yun zou Yue College of Environmental Science and Engineering Donghua UniversityShanghai 201620China Guangzhou Institute of Building Science Co. Ltd.Guangzhou 510440China Dianwei Science Co. Ltd.Shanghai 201620China

The U-value is a very important parameter for evaluating the energy efficiency when refurbishing the existing *** in-situ test methods to determine the U-value usually require a very long time to filter weather fluctuations and other boundary condition *** this paper,the possibility of a new method to reduce the time necessitated for measuring the accurate U-value of a wall is *** proposed method recommends measuring the temperatures and heat flux on both sides of the wall and thereby utilising the average values of the internal and external heat flux to calculate the *** the idealised sinusoidal internal and external air temperature boundary conditions,four walls with different U-values were simulated according to the admittance procedure(AP).Results show that the proposed method could improve the maximum error level for most of the walls in *** was not sensitive to the measurement start time and it was more stable even in less controlled boundary conditions involving large inner temperature variations or out of phase temperature ***,the error of the average heat flux method(within 10%)could be estimated earlier than that of traditional method.

关键词： building envelope U-value in-situ admittance procedure(AP) heat flux

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响应面试验优化玉米油二次脱皂新工艺

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中国油脂 2017年第10期42卷 18-21页

作者：王俊国邹德智王东华王彤赵岩于殿宇吉林工商学院粮油食品深加工吉林省高校重点实验室长春130507 东北农业大学食品学院哈尔滨150030 东北农业大学园艺学院哈尔滨150030 哈尔滨天通农业科技开发有限公司哈尔滨150001

利用玉米油含蜡特性,即在低温脱蜡过程中,皂粒以晶核状态吸附蜡质结晶脱蜡,同时完成了一次脱皂。在脱色过程中,加入活性白土脱色,同时残余的微量皂被活性白土进一步吸附,达到了二次脱皂的效果。考察了碱炼油中含皂量、碱炼油中含水量、... 详细信息

利用玉米油含蜡特性,即在低温脱蜡过程中,皂粒以晶核状态吸附蜡质结晶脱蜡,同时完成了一次脱皂。在脱色过程中,加入活性白土脱色,同时残余的微量皂被活性白土进一步吸附,达到了二次脱皂的效果。考察了碱炼油中含皂量、碱炼油中含水量、养晶时间和活性白土添加量对二次脱皂后脱色油中残皂量的影响。通过单因素试验和响应面优化试验确定玉米油精炼脱皂的最优工艺条件为:碱炼油中含皂量300 mg/kg,碱炼油中含水量0.4%,养晶时间24 h,活性白土添加量0.5%。在最优工艺条件下进行脱皂,得到脱色油中残皂量为0.19 mg/kg,脱皂率为99.9%。新工艺脱皂效果更好,而且不经过水洗过程,无废水排放,符合节能环保的工艺要求,而且简化了加工工艺。

关键词：玉米油脱皂脱皂率残皂量无废水

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Preparation and Performance of Fluorescein Isothiocyanate⁃Labeled Fluorescent Starch and Polyvinyl Alcohol for Warp Sizing

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Journal of donghua University(English Edition) 2021年第5期38卷 424-433页

作者： LI Manli JI Zhihao zou Zhuanyong HU Qiaoling JIN Enqi Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province Shaoxing UniversityShaoxing 312000China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China

In order to solve the problems of low accuracy and poor variety adaptability of the current measurement method of the permeability and coating property of sizing paste in textile industry, taking starch and polyvinyl alcohol(PVA) as the representatives of the most commonly used textile sizes, various concentrations of fluorescent molecules fluorescein isothiocyanate(FITC) were used to label starch and PVA to prepare fluorescein(F)-starch and F-PVA fluorescent sizes with different degrees of labeling(DLs) for the first time, respectively. Then the starch and PVA derivatives were employed to size pure cotton warp yarns. After preparing the sections of the sized yarns, the permeability and coating percentage of starch and PVA paste to the yarns were calculated by using a fluorescence microscope and the Photoshop software, respectively. The results demonstrate that F-starch and F-PVA with appropriate DL of 0.791% and 0.161%, respectively, exhibit good fluorescence property and similar sizing performance to the sizing performance of unlabeled starch and PVA. It is considered that fluorescence labeling of sizing agents with fluorescein units can provide an innovative way for the accurate determination of the permeability and coating property of sizing paste to warp yarns.

关键词： fluorescence labeling fluorescein isothiocyanate(FITC) permeability coating property textile size

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参苓白术散对克罗恩病大鼠肠黏膜屏障的影响

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湖南中医药大学学报 2023年第11期43卷 2034-2040页

作者：邹巍莹刘密余炼宾东华湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

目的观察参苓白术散对克罗恩病(Crohn's disease,CD)大鼠肠黏膜屏障的影响。方法60只SD大鼠随机均分为空白组、模型组、美沙拉秦组(0.21 g·kg^(-1)·d^(-1))及参苓白术散高、中、低剂量组(5.88、11.76、23.52 g·kg^(-1)·d^(-1))。采... 详细信息

目的观察参苓白术散对克罗恩病(Crohn's disease,CD)大鼠肠黏膜屏障的影响。方法60只SD大鼠随机均分为空白组、模型组、美沙拉秦组(0.21 g·kg^(-1)·d^(-1))及参苓白术散高、中、低剂量组(5.88、11.76、23.52 g·kg^(-1)·d^(-1))。采用2,4,6-三硝基苯磺酸(2,4,6-three nitrobenzene sulfonic acid,TNBS)灌肠液制作CD模型。给药各组予以相应药物灌胃,空白组、模型组予以等剂量灭菌注射用水。监测每组大鼠在用药期间的体征变化,14 d后进行结肠黏膜损伤指数(colon injury morphology index,CMDI)评分、组织病理学观察,qPCR检测闭合蛋白(Occludin)、闭锁连接蛋白-1(zonulaoccludens-1,ZO-1)及E-钙黏蛋白(E-cadherin)的mRNA表达水平,Western blot法检测各组大鼠结肠组织中Occludin、ZO-1、E-cadherin蛋白表达水平。结果与空白组对比,模型组大鼠体质量明显下降,活动能力减弱,普遍出现稀便情况,少量大鼠出现便血及黏液便情况;CMDI评分显著升高(P<0.01);黏膜可见上皮坏死脱落,内部腺体坏死,大量炎性细胞浸润;Occludin、ZO-1、E-cadherin的mRNA水平及蛋白表达均明显降低(P<0.01)。与模型组对比,美沙拉秦组及参苓白术散低、中、高剂量组大鼠体质量不同程度升高,大便基本成形,个别大鼠有少量便血,无明显黏液便;美沙拉秦组及参苓白术散高、中剂量组CMDI评分均降低(P<0.01),结肠黏膜损伤明显减轻;参苓白术散高剂量组Occludin、ZO-1、E-cadherin的mRNA水平及蛋白表达显著升高(P<0.01或P<0.05)。结论参苓白术散可能通过调控Occludin、ZO-1及E-cadherin mRNA及蛋白的表达,促进CD大鼠结肠黏膜屏障功能的修复,有效缓解CD大鼠肠黏膜屏障损伤。

关键词：参苓白术散克罗恩病美沙拉秦闭合蛋白 E-钙黏蛋白闭锁连接蛋白-1

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