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Observation on the clinical instructive significance of pacemakers' home monitoring function

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Observation on the clinical instructive significance of pace...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： hao yang,feifei zhang,xinhui peng,zhongbo xiao,donghua zhao,jian peng 南方医科大学附属南方医院心内科

Objective The present paper studies the instruction of pacemaker Home Monitoring(HM) function in the clinical. Methods The study analyzed 14 cases,implanting pacemakers with HM function.7 patients implanted common pacemakers,4 ICD,2 CRTP,and 1 *** the real time monitor of arrhythmia and the changes of statistical data,the medicine used was decided and the curative effect after the adjustment of drug dosage anticipated. Results①Four patients did not follow the doctors’ instructions,having never turned on the Cardio *** had a sudden cardiac death,providing no record.②Mode switched frequently in one *** fibrillation was observed when the patient was program *** switch deceased significantly when treated by amiodarone.③Two cases implanted CRTP and CRTD *** prompted ventricular rates above 80 *** the resting *** treated with increased dosage of diuretic and βblockers,their cardiac function became better,not warning any more.④1 case implanted *** warned that ventricular pacing percentage was more than 30%in 24 *** adjusting the dosage of βblockers,ventricular arrhythmias and ventricular pacing reduced.⑤One case implanted pace maker for mixed types of inhibition vasovagal *** prompted that the mode switched above 20 times within 24 *** atrial arrhythmias was not found. Conclusions Some patients do not have clinical *** can lower their frequencies to see the doctors,and save time and *** can recognize the problems timely and judge the drug *** is significantly important to guide the clinical medicining and adjust the dosage,especially for those suffering from complications and heart *** patients implanting ICD,adjusting the drug dosage to treat ventricular arrhythmias,can avoid discharge and prolong their services *** amounts of prospective researches are needed to testify its validity and reliability.

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Special management of a case about left ventricular PTCA wire leading to diaphragmatic muscle stimulation in cardiac resynchronization therapy

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Special management of a case about left ventricular PTCA wir...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： feifei zhang,xinhui peng,hao Yao,donghua zhao,zhongbo xiao,jian peng 南方医科大学南方医院心内科

A patient with dilated cardiomyopathy,heart failure were done *** implanted method of the left ventricular electrodes:coronary sinus(CS0 intubation CS and heart vein retrograde imaging RCV choose target vein and implanted electrodes RCV vein anatomical characteristics choose according to target the veins,implanted left ventricular electrode,is not easy to be fixed so did not retreat filar guide,

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Follow-up in 5 patients with Brugada syndrome inlpanted with ICD

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Follow-up in 5 patients with Brugada syndrome inlpanted with...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： xinhui peng,feifei zhang,hao yang,donghua zhao,zhongbo xiao,jian peng Nanfang Hospital 510000

Objective To evaluate clinic features of Brugada syndrome patients with ICD. Methods 5 consecutive Brugada syndrome patients were enrolled in this study between January 2009 and April 2012 in the Southern Hospital and all the 5 patients were successfully implanted with ICD. All of them were evaluated before being discharged,and after 3 months,6 months and 12 months respectively through telephone interviews,manufacturer or remote monitoring[’Home Monitoring’ (HM)].The patient’s clinical information(including syncope history,medicine,psychological problems,) and the ICD parameters,(events,threshold,impedance,R wave amplitude ) were collected. Results 5 patients(all males),average of 42 years,were implanted Single-chamber ICDs(3 from Medtronic and 2 from Biotronik) under normal condition,before being discharged from *** a mean follow-up of 21 months,no one dead,one patient with syncope received appropriate antitachycardiac pacing(ATP) therapy,another one developed dizziness,flustered,and mild *** there was no malignant arrhythmia captured by *** of regular Metoprolol and psychological counseling improved the quality of *** were no complications or mistaken identifications in all of them. Conclusions ICD implantation can effectively prevent sudden cardiac death in these patients with Brugada syndrome,drug therapy and psychological counseling are also indicated.

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Clinical outcomes with Fondaparinux or low-molecular-weight heparin as bridging therapy in patients with atrial fibrillation ablation

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Clinical outcomes with Fondaparinux or low-molecular-weight ...

中华医学会第十五次全国心血管病学大会

作者： feifei zhang donghua zhao jian peng Department of Cardiology Nanfang Hospital Southern Medical University

Objective Catheter ablation has been proven to be an effective treatment for patients with atrial fibrillation. Patients undergoing this procedure are at risk of thromboembolism or bleeding complications during periprocedural period. We sought to elucidate long term outcomes of efficacy and safety of bridging with

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Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration

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Biomaterials Translational 2021年第2期2卷 91-142页

作者： Yizhong peng Xiangcheng Qing Hongyang Shu Shuo Tian Wenbo yang Songfeng Chen Hui Lin xiao Lv Lei zhao Xi Chen feifei Pu donghua Huang Xu Cao Zengwu Shao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopaedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Orthopaedic Surgery Institute for Cell EngineeringJohns Hopkins UniversityBaltimoreMDUSA.

Low back pain is a vital musculoskeletal disease that impairs life quality,leads to disability and imposes heavy economic burden on the society,while it is greatly attributed to intervertebral disc degeneration(IDD).However,the existing treatments,such as medicines,chiropractic adjustments and surgery,cannot achieve ideal disc ***,advanced bioactive therapies are implemented,including stem cells delivery,bioreagents administration,and implantation of biomaterials *** these researches,few reported unsatisfying regenerative ***,these advanced therapies have barely achieved successful clinical *** main reason for the inconsistency between satisfying preclinical results and poor clinical translation may largely rely on the animal models that cannot actually simulate the human disc *** inappropriate animal model also leads to difficulties in comparing the efficacies among biomaterials in different ***,animal models that better simulate the clinical charateristics of human IDD should be *** addition,in vivo regenerative outcomes should be carefully evaluated to obtain robust ***,many researches neglect certain critical characteristics,such as adhesive properties for biomaterials blocking annulus fibrosus defects and hyperalgesia that is closely related to the clinical manifestations,e.g,low back ***,in this review,we summarized the animal models established for IDD,and highlighted the proper models and parameters that may result in acknowledged IDD ***,we discussed the existing biomaterials for disc regeneration and the characteristics that should be considered for regenerating different parts of ***,well-established assays and parameters for in vivo disc regeneration are explored.

关键词： animal model biomaterials intervertebral disc preclinical evaluation translational medicine

心房颤动导管射频消融术桥接使用磺达肝癸钠或低分子肝素的临床结局(英文)

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南方医科大学学报 2014年第4期34卷 448-452页

作者：张飞飞赵冬华彭新辉杨浩朱庭延黄福美彭健南方医科大学南方医院心内科广东广州510515

目的比较心房颤动消融桥接治疗使用磺达肝癸钠与低分子肝素两者的安全陛及有效眭。方法对2009年1月～2013年7月接受射频消融术的房颤患者进行分析。患者在术前停用华法林5d，皮下注射磺达肝癸钠或低分子肝素的桥接治疗直到至消融后国际... 详细信息

目的比较心房颤动消融桥接治疗使用磺达肝癸钠与低分子肝素两者的安全陛及有效眭。方法对2009年1月～2013年7月接受射频消融术的房颤患者进行分析。患者在术前停用华法林5d，皮下注射磺达肝癸钠或低分子肝素的桥接治疗直到至消融后国际标准化比值为2．0～3．0。对两组患者术后抗凝相关并发症进行比较。并发症识别和归类为血栓栓塞和出血事件。结果共有465名患者，68％的男性，年龄52．3＋15（25～80）岁参加了这项研究。磺达肝癸钠组纳入265名患者，低分子肝素组纳入200名患者。在磺达肝癸钠组观察到3例抗凝相关并发症，而低分子肝素组有13例（P=0．002），但是血栓栓塞方面两组无统计学差异（P=0．111）。在磺达肝癸钠组有2例出血并发症，低分子肝素组有8例（P=0．039）。随访观察3个月两组均没有心血管死亡病例。结论房颤导管消融期间使用磺达肝癸钠作为桥接治疗与低分子肝素相比，血栓栓塞并发症的风险无统计学差异，但略减少出血风险。磺达肝癸钠在房颤患者导管消融围手术期抗凝管理方面是安全有效的。

关键词：磺达肝癸钠低分子肝素心房颤动导管消融抗凝

家族性心脏传导疾病并房颤一家系报道及其治疗

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南方医科大学学报 2012年第1期32卷 128-130页

作者：刘福强李岩谢勇赵冬华萧钟波周桂芳彭健南方医科大学南方医院心内科广东广州510515

目的探讨一个家族性心脏传导疾病并房颤家系的临床特征及其有效的治疗方案。方法对先证患者所在家系的家族成员进行常规临床体检和心电图、超声心动图、动态心电图、X线胸片、生化、自身抗体等检查。同时对先证者行双腔起搏器安置术联... 详细信息

目的探讨一个家族性心脏传导疾病并房颤家系的临床特征及其有效的治疗方案。方法对先证患者所在家系的家族成员进行常规临床体检和心电图、超声心动图、动态心电图、X线胸片、生化、自身抗体等检查。同时对先证者行双腔起搏器安置术联合口服胺碘酮治疗3个月,期间监测患者甲功及肺部情况,治疗完成后随访3个月,并对相关文献进行回顾。结果家系中所有成员均无器质性心脏病的临床证据。先证者反复头晕、胸闷,以活动后较明显,静息心电图表现为心房纤颤伴高度房室传导阻滞;其叔叔于30岁时因晕厥发现"心房纤颤,三度房室传导阻滞"而安置起搏器治疗;其爷爷死于"心脏病"(具体不详);其他家族成员心电图检查未见明显异常,既往亦未发生明显的心脏事件(晕厥、猝死)。患者经治疗后症状明显好转,心电图及动态心电图均未见心房纤颤,起搏器工作良好。结论心脏传导性疾病并心房纤颤可呈家族聚集性发病,双腔起搏器联合胺碘酮治疗可作为家族性心脏传导疾病并心房纤颤患者安全有效的治疗措施。

关键词：家族性心律失常房颤心脏传导疾病

星状神经节阻滞改善更年期大鼠抑郁行为及加速清除脑内损伤相关模式分子

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临床麻醉学杂志 2021年第7期37卷 747-751页

作者：张猛彭飞飞程应湘周脉涛邵东华江苏大学医学院镇江市212000 解放军第904医院麻醉科镇江市第一人民医院麻醉科

目的探讨星状神经节阻滞(SGB)对更年期大鼠抑郁行为及脑内损伤相关模式分子(DAMPs)中主要分子浓度的影响。方法清洁级健康成年雌性SD大鼠40只,2月龄,体重180~220 g。将大鼠随机分为四组:对照组(C组),更年期大鼠抑郁模型组(M组),星状神... 详细信息

目的探讨星状神经节阻滞(SGB)对更年期大鼠抑郁行为及脑内损伤相关模式分子(DAMPs)中主要分子浓度的影响。方法清洁级健康成年雌性SD大鼠40只,2月龄,体重180~220 g。将大鼠随机分为四组:对照组(C组),更年期大鼠抑郁模型组(M组),星状神经节注射生理盐水组(MN组)和星状神经节注射罗哌卡因组(MR组),每组10只。C组大鼠正常喂养;M组、MN组和MR组行双侧卵巢摘除术建立更年期大鼠模型,术后第8~28天行慢性束缚应激实验(CRS)建立更年期大鼠抑郁模型。术后第29~49天每日同一时点MN组于右侧星状神经节注射生理盐水0.2 ml,MR组于相同位置注射0.25%罗哌卡因0.2 ml。于手术当天、术后第7、14、21、28、35、42、49天行体重测量和糖水偏好实验,术后第28、35、42、49天行强迫游泳实验。术后第49天各项行为学测试结束后取大鼠海马组织,采用ELISA法检测DAMPs主要分子高迁移率族蛋白B1(HMGB1)、热休克蛋白70(HSP70)、S100钙结合蛋白B(S100B)、ATP和尿酸(UA)浓度。结果与C组比较,M组、MN组和MR组术后第7、14、21、28、35、42、49天体重明显减少(P<0.05),糖水偏好百分比明显降低(P<0.05),术后第28、35、42、49天强迫游泳不动时间明显延长(P<0.05);M组和MN组术后第49天海马组织HMGB1、HSP70、S100B、ATP浓度明显升高(P<0.05)。与MN组比较,MR组术后第35、42、49天体重明显增加(P<0.05),术后第42、49天糖水偏好百分比明显升高(P<0.05),术后第35、42、49天强迫游泳不动时间明显缩短(P<0.05),术后第49天海马组织HMGB1、HSP70、S100B、ATP浓度明显降低(P<0.05)。结论星状神经节阻滞可以改善更年期大鼠抑郁行为,其机制可能与加速清除脑内DAMPs有关。

关键词：星状神经节阻滞更年期抑郁损伤相关模式分子大鼠