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Characterization of CD8＋CD57＋ T cells in patients wit acute myocardial infarction

Cellular & Molecular Immunology 2015年第4期12卷 466-473页

作者： Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee choi Sungha Park donghoon choi Jong-Won Ha Eui-Cheol Shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and Engineering KAIST Daejeon Republic of Korea Cardiology Division Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Republic of Korea Department of Bio and Brain Engineering KAIST Daejeon Republic of Korea ' ' The first two authors contributed equally to this article

Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction （MI）. We studied the immunological characteristics and clinical impact of CD8＋CD57＋ T cells in acute MI patients. The frequency of CD57＋ cells among CD8＋ T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57＋ cells in the CD8＋ T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8＋CD57＋ T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8＋CD57＋ T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8＋CD57＋ T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8＋ T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8＋ T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

关键词： acute myocardial infarction CD8+CD57+ T cells immunosenescence

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Synthesis and Characterization of a New Bifunctional Dye Containing Spirobenzopyran and Cinnamoyl Moiety

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Chinese Journal of Chemical Engineering 2005年第1期13卷 85-90页

作者：申凯华崔东熏 State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China College of Environment & Applied Chemistry Institute of Natural Sciences Kyung Hee University 1 Seocheon-ri Kiheung-up Yongin-shi Kyungki 449-701 Korea

A novel bifunctional dye containing spirobenzopyran and cinnamoyl moiety has been prepared and its photochromic behavior following irradiation at different wavelengths of monochrome UV light was investigated. The colourless bifunctional dye in film or solution exhibits unusual photochromism through structural and geometrical transformation from spirobenzopyran to merocyanine accompanying with photocrosslinking reaction in cinnamoyl moieties. Two kinds of photochemical reaction were achieved by irradiation at the different wavelengths of monochrome UV light (275 nm, 365 nm) selectively. The photochromic process of the bifunctional dye was discussed and the dynamic behaviors of the decolorization process were investigated.

关键词： spirobenzopyran cinnamoyl moiety photochromism

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