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Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

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Bioactive Materials 2023年第2期20卷 404-417页

作者： Jinping Wang Chang Qu Xinyue Shao Guoqiang Song Jingyu Sun donghong shi Ran Jia Hailong An Hongjun Wang Key Laboratory of Molecular Biophysics of Hebei Province Institute of BiophysicsSchool of Health Sciences and Biomedical EngineeringHebei University of Technology300401TianjinPR China Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030United States Department of Chemistry and Chemical Biology Stevens Institute of TechnologyHobokenNJ07030United States Center for Healthcare Innovation Stevens Institute of TechnologyHobokenNJ07030United States Key Laboratory of Molecular Biophysics of Hebei Province Institute of BiophysicsSchool of SciencesHebei University of Technology300401TianjinPR China State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Electrical EngineeringHebei University of TechnologyTianjin300130PR China

Human cancers typically express a high level of tumor-promoting mutant p53 protein(Mutp53)with a minimal level of tumor-suppressing wild-type p53 protein(WTp53).In this regard,inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor ***,a new carrier-free nanoprodrug(i.e.,Mn-ZnO_(2)nanoparticles)was developed for concurrent delivery of dual Zn-Mn ions and reactive oxygen species(ROS)within tumor to regulate the p53 protein for high anti-tumor *** response to the mild tumor acidic environment,the released Zn^(2+)and H_(2)O_(2)from Mn-ZnO_(2)NPs induced ubiquitination-mediated proteasomal degradation of Mutp53,while the liberative Mn^(2+)and increased ROS level activated the ATM-p53-Bax pathway to elevate WTp53 *** in vitro and in vivo results demonstrated that pH-responsive decomposition of Mn-ZnO2 NPs could effectively elevate the intracellular dual Zn-Mn ions and ROS level and subsequently generate the cytotoxic hydroxyl radical(·OH)through the Fenton-like *** the integration of multiple functions(i.e.,carrier-free ion and ROS delivery,tumor accumulation,p53 protein modulation,toxic·OH generation,and pH-activated MRI contrast)in a single nanosystem,Mn-ZnO_(2)NPs demonstrate its superiority as a promising nanotherapeutics for p53-mutated tumor therapy.

关键词： p53-mutated tumor therapy Wild-type p53 protein Carrier-free nanoprodrug Mn-ZnO_(2)nanoparticle Reactive oxygen species

Observation on the Clinical Effect of Emergency Interventional Therapy on Acute Severe Non- Variceal Upper Gastrointestinal Bleeding

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Proceedings of Anticancer Research 2023年第5期7卷 41-46页

作者： Bo Chen donghong shi Min Ai Longjiang Zhang Department of Medical Imaging General Hospital of the Eastern Theater CommandNanjing 210002Jiangsu ProvinceChina

Objective:To observe the clinical effect of emergency interventional therapy for patients with acute severe non-variceal upper gastrointestinal ***:78 patients with acute severe non-variceal upper gastrointestinal bleeding who were treated in the General Hospital of the Eastern Theater Command from May 2020 to May 2023 were randomly divided into two groups according to different treatment *** study group underwent emergency upper gastrointestinal angiography and interventional embolization therapy,the control group was treated with esomeprazole;the clinical data related to the two groups were compared,including the total effective rate of treatment,blood pressure stabilization time,bleeding control time,***:The effective rate of clinical treatment in the study group was 97.44%,which was higher than that in the control group,which was 79.49%(P0.05).Conclusion:Emergency interventional therapy can control bleeding more quickly,shorten bleeding control time and complete hemostasis time,shorten blood pressure stabilization time and abdominal pain relief time,and reduce rebleeding rate in patients with acute severe non-variceal upper gastrointestinal bleeding.

关键词： Upper gastrointestinal bleeding Non-variceal veins Interventional embolization Esomeprazole

Effect of CT-Guided Microwave Ablation Combined with TACE on Liver Function and Survival of Patients with Primary Liver Cancer

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Journal of Clinical and Nursing Research 2024年第1期8卷 119-124页

作者： Bo Chen donghong shi Min Ai Longjiang Zhang Department of Medical Imaging Eastern Theater Command General HospitalNanjing 210002Jiangsu ProvinceChina

Objective:To explore the effect of transarterial chemoembolization(TACE)+CT-guided microwave ablation(MWA)on treating patients with primary liver ***:78 primary liver cancer cases were enrolled and divided into groups according to their assigned surgical *** control group was treated with TACE alone,and the observation group was treated with TACE+CT-guided *** efficacy of the treatment and the liver function indicators and follow-up results of the patients of the two groups were ***:The efficacy of the treatment received by the observation group was higher than that of the control ***,the patients in the observation group exhibited better improvement in liver function indicators after 3 months of ***,the survival rates of 1 and 2 years after surgery of the observation group were all higher than those of the control group(P<0.05).Conclusion:TACE combined with CT-guided MWA is more effective in treating primary liver cancer compared to TACE ***,it resulted in better improvement of liver function and long-term survival ***,this treatment regime should be popularized.

关键词： CT guidance Microwave ablation TACE Primary liver cancer Liver function Survival status

Arterial Embolization: A Superior Treatment for Massive Urinary Tract Bleeding in Emergency Care

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Proceedings of Anticancer Research 2024年第2期8卷 88-93页

作者： Bo Chen donghong shi Min Ai Longjiang Zhang Department of Medical Imaging General Hospital of the Eastern Theater Command of the Chinese People’s Liberation ArmyNanjing 210002China

Objective:To analyze the effect of arterial embolism(AE)in patients with massive urinary system bleeding(MBUS).Methods:From September 2018 to September 2023,175 cases of MBUS patients in the emergency department of the hospital were randomly selected and divided into groups according to the length of *** them,85 cases(September 2018–September 2020)underwent bladder irrigation treatment with aluminum potassium sulfate solution through a catheter(Group A),and 90 cases(October 2020–September 2023)underwent AE treatment(Group B).The treatment effects of the two groups were ***:The treatment effectiveness of Group B is higher than that of Group A(P<0.05).The urinary hemoglobin level of Group B is lower than that of Group A at 1,6,12,and 24 hours after treatment(P<0.05).Among the 90 cases treated with AE,7 cases had a fever,with body temperatures ranging from 37.3°C to 38.9℃,with a mean temperature of 38.2±0.3℃.Four cases experienced local pain,nausea,and vomiting,while two cases of intra-iliac AE showed transient buttock *** patients with adverse reactions were treated symptomatically for 7 *** patients recovered after *** urography of 87 patients in June showed that the renal pelvis and calyces were in good condition,the renal function returned to normal,and the blood urea nitrogen and blood creatinine test results were within the normal *** 1 year of follow-up,no hypertension ***:AE treats MBUS patients in the emergency department with remarkable *** has the advantages of less damage to the body,rapid hemostasis,high safety,and maximum preservation of organ function.

关键词： Emergency Arterial embolism Urinary tract bleeding

I COUGH综合气道管理在肝癌患者围术期中的应用

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科技通报 2017年第7期33卷 48-51页

作者：胡晨璐金琪何建红施冬虹徐彩娟浙江大学医学院附属第二医院杭州310009

目的:探讨I COUGH综合气道管理对肝癌手术患者呼吸道并发症的临床作用。方法:选取2015年1月至2016年6月本院外科行开放手术的肝癌患者113例进行研究,分为实验组53例与对照组60例,实验组围术期应用I COUGH综合气道管理,对照组围术期应用... 详细信息

目的:探讨I COUGH综合气道管理对肝癌手术患者呼吸道并发症的临床作用。方法:选取2015年1月至2016年6月本院外科行开放手术的肝癌患者113例进行研究,分为实验组53例与对照组60例,实验组围术期应用I COUGH综合气道管理,对照组围术期应用常规气道管理,对比分析两组间的术后呼吸系统并发症发生率和术后平均住院日。结果:实验组的肺不张发生率显著低于对照组(χ2=4.875,P=0.027),但其他呼吸系统并发症发生率并无显著差异(χ2=0.841,P>0.05)。实验组的术后平均住院日显著短于对照组(t=2.557,P=0.012),且实验组肺不张患者术后平均住院日显著短于对照组肺不张患者(t=2.099,P=0.044)。结论:I COUGH综合气道管理能够有效预防肝癌开放手术术后肺不张的发生,并且能够缩短此类并发症相关的术后平均住院日,从而减轻患者的经济负担。

关键词： I COUGH 综合气道管理围术期呼吸系统并发症

HFHD对尿毒症患者FGF-23、iPTH水平及心肺功能的影响

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实验与检验医学 2018年第4期36卷 485-488页

作者：刘云马东红崔艳石岩新乡医学院第一附属医院肾病科河南卫辉453100

目的探讨高通量血液透析(HFHD)对尿毒症患者血清成纤维细胞生长因子-23(FGF-23)、全段甲状旁腺激素(i PTH)水平及心肺功能的影响。方法选取在我院实施血液透析治疗的78例尿毒症患者,采用随机数字表法分为常规组和研究组各39例,收治时间2... 详细信息

目的探讨高通量血液透析(HFHD)对尿毒症患者血清成纤维细胞生长因子-23(FGF-23)、全段甲状旁腺激素(i PTH)水平及心肺功能的影响。方法选取在我院实施血液透析治疗的78例尿毒症患者,采用随机数字表法分为常规组和研究组各39例,收治时间2015年1月-2016年12月,常规组应用常规血液透析治疗,研究组采用HFHD方法治疗,均每周透析3次,2个月后实施效果对比。结果治疗前,常规组和研究组的肺功能指标VC、FVC、TLC及RV差异无统计学意义(P>0.05);治疗后,研究组的VC、FVC、TLC显著高于常规组(P0.05);治疗后,研究组的血清FGF-23、iPTH水平显著的低于常规组(P0.05);治疗后,研究组的BNP、LVEDd、LVESD显著的低于常规组(P<0.05),研究组的LVEF值显著的高于常规组(P<0.05)。结论 HFHD有利于改善尿毒症患者肺功能、心功能,同时降低血清FGF-23、i PTH的水平。

关键词：高通量血液透析尿毒症肺功能成纤维细胞生长因子-23 全段甲状旁腺激素心功能

基于电磁导航辅助经皮肝穿刺胆管引流术的技术探索

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医学研究与战创伤救治 2023年第5期36卷 503-508页

作者：杨涛高大志许潭潭史东宏刘丽陈佳海许健徐州医科大学医学影像学院徐州221004 东部战区总医院介入治疗科南京210002 联勤保障部队第九一〇医院肿瘤科泉州362000

目的对比IQQA-Guide智能穿刺导航系统辅助下的经皮肝穿刺胆管引流术(PTBD)与同期的传统PTBD在治疗梗阻性黄疸方面的优劣,为进一步拓展电磁导航辅助PTBD的临床研究及运用提供依据。方法回顾性分析2022年3月至2023年1月56例因恶性梗阻性... 详细信息

目的对比IQQA-Guide智能穿刺导航系统辅助下的经皮肝穿刺胆管引流术(PTBD)与同期的传统PTBD在治疗梗阻性黄疸方面的优劣,为进一步拓展电磁导航辅助PTBD的临床研究及运用提供依据。方法回顾性分析2022年3月至2023年1月56例因恶性梗阻性黄疸于东部战区总医院介入治疗科行PTBD治疗的患者临床资料。按术中穿刺胆管引导方式的不同分为电磁导航组(n=20)、传统透视组(n=36)。分析比较两组患者术前规划穿刺胆管分级及直径、术中穿刺胆管次数、术中透视时间、术中辐射剂量、术后并发症、术后血常规、肝功能等指标改变。结果电磁导航组穿刺的胆管直径小于透视组(P<0.01)。术中电磁导航组在穿刺胆管针数、透视时间、辐射剂量明显优于透视组(P<0.01)。电磁导航组及透视组PTBD的术后TBIL、ALP较术前显著下降(P<0.01)。电磁导航组HB术后变化值较透视组小(P<0.01)。电磁导航组术后3天的CRP、CRP术后变化值低于透视组(P<0.05)。透视组术后HB较术前降低,术后3天CRP较术前升高(P<0.01)。电磁导航组总体并发症发生率明显低于透视组(P<0.05)。结论经电磁导航辅助PTBD术操作简单,安全可行,能有效提高胆管穿刺成功率,减少透视时间及术中辐射,减少患者术后并发症,值得在临床中进一步推广。

关键词：恶性梗阻性黄疸经皮肝穿刺胆管引流术电磁导航影像融合技术

151例高通量测序无创产前筛查高风险胎儿的产前诊断结果分析

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中华医学遗传学杂志 2017年第5期34卷 759-763页

作者：贾颐舫张燕郝万晓石东红孟金来赵和永连岩谢鲁文王谢桐山东大学附属省立医院产前诊断中心山东省妇幼保健院国家卫生和计划生育委员会生育调控技术重点实验室济南250021

目的评估联合应用胎儿染色体核型分析及染色体微阵列分析（chromosomal microarray analysis，CMA）明确151例高通量测序无创产前筛查（noninvasive prenatal screening，NIPS）提示高风险的病例的临床意义。方法以高通量测序NIPS提示胎... 详细信息

目的评估联合应用胎儿染色体核型分析及染色体微阵列分析（chromosomal microarray analysis，CMA）明确151例高通量测序无创产前筛查（noninvasive prenatal screening，NIPS）提示高风险的病例的临床意义。方法以高通量测序NIPS提示胎儿13、18、21、性染色体非整倍体高风险以及胎儿染色体拷贝数变异（copy number variations，CNVs）高风险、需进行产前诊断的孕妇为研究对象。在征得知情同意后，经羊膜腔穿刺或脐静脉穿刺获取胎儿细胞，进行染色体核型及CMA分析。结果在151例胎儿中，有142例为非整倍体高风险，其中21三体高风险83例、18三体高风险17例、13三体高风险2例、性染色体非整倍体高风险40例，经染色体核型和CMA分析确认21三体81例、18三体15例、47，XXY10例、47，XXX4例、47，XYY2例、46，X，del（X）（q26．1）1例，其余2例21三体高风险、2例18三体高风险、2例13三体高风险、23例性染色体非整倍体高风险病例经染色体核型和CMA检测均为46，XN；另外9例高通量测序提示CNVs高风险，其中13号染色体微缺失1例、18号染色体微重复1例、18号染色体部分缺失1例均经CMA证实，1例2号染色体重复30Mb合并8号染色体重复25Mb病例CMA未发现拷贝数变异，胎儿脐血染色体核型为46，XX，dup（2）（***25．3）[13]／46，xx[87]，其余5例经检测均未见异常。结论高通量测序NIPS高风险的胎儿，仍有必要通过介入性产前诊断进行胎儿染色体核型联合CMA分析，以区分真阳性与假阳性的结果。

关键词：高通量测序无创产前筛查染色体核型分析染色体微阵列分析产前诊断

Simulation of Morphological Development of Soil Cracks in Yuanmou Dry-hot Valley Region, Southwest China

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Chinese Geographical Science 2010年第2期20卷 112-122页

作者： XIONG donghong YAN Dongchun LONG Yi LU Xiaoning HAN Jianning HAN Xueqin shi Liangtao Key Laboratory of Mountain Hazards and Surface Process Chinese Academy of Sciences Chengdu 610041 China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Department of Environmental Engineering Chengdu University of Information Technology Chengdu 610225 China Institute of Tropical Eco-agricultural Sciences Yunnan Academy of Agricultural Sciences Yuanmou 651300 China

Soil cracking is an important process influencing water and solutes transport in the Yuanmou Dry-hot Valley region of Southwest China. Studying the morphological development of soil cracks helps to further reveal the close relationship between the soil cracking process and water movement in such semi-arid regions. Here we report regular changes on surface morphology of soil cracks with decreasing water in four different soils (Typ-Ustic Ferrisols,Ver-Ustic Ferrisols,Tru-Ustic Vertisols and Typ-Ustic Vertisols) through simulation experiments. Our results indicate the following: 1) Different soils ultimately have different development degrees of soil cracks,according to their various values of crack area density. Soil cracks in Typ-Ustic Ferrisols can only develop to the feeble degree,while those in the other three soils are capable of developing into the intensive degree,and even into the extremely intensive degree. 2) Soil crack complexity,as expressed by the value of the area-weighted mean of crack fractal dimension (AWMFRAC),is found to continuously decrease as a whole through the whole cracking process in all the studied soils. 3) Soil crack connectivity shows a uniform trend in the studied soils,that is to say,connectivity gradually increases with soil crack development.

关键词： soil cracks morphological development simulation experiment Yuanmou Dry-hot Valley region Southwest China