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Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology

World Journal of Gastroenterology 2023年第13期29卷 2034-2049页

作者： Xiao-Juan yang Xiao-Hong Wang Ming-Yue yang Hong-Yan Ren Hui Chen Xiao-Ya Zhang Qin-Fu Liu Ge yang Yi yang Xiao-Jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Emergency Medicine Affiliated Hospital of Jining Medical UniversityJining 272030Shandong ProvinceChina Shanghai Mobio Biomedical Technology Co. Ltd.Shanghai 201318China Department of Critical Care Medicine Southeast University School of MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Sepsis exacerbates intestinal microecological disorders leading to poor *** modalities of nutritional support can improve nutrition,immunity,and intestinal *** To identify the optimal modality of early nutritional support for patients with sepsis from the perspective of intestinal *** Thirty patients with sepsis admitted to the intensive care unit of the General Hospital of Ningxia Medical University,China,between 2019 and 2021 with indications for nutritional support,were randomly assigned to one of three different modalities of nutritional support for a total of 5 d:Total enteral nutrition(TEN group),total parenteral nutrition(TPN group),and supplemental parenteral nutrition(SPN group).Blood and stool specimens were collected before and after nutritional support,and changes in gut microbiota,short-chain fatty acids(SCFAs),and immune and nutritional indicators were detected and compared among the three *** In comparison with before nutritional support,the three groups after nutritional support presented:(1)Differences in the gut bacteria(Enterococcus increased in the TEN group,Campylobacter decreased in the TPN group,and Dialister decreased in the SPN group;all P<0.05);(2)different trends in SCFAs(the TEN group showed improvement except for Caproic acid,the TPN group showed improvement only for acetic and propionic acid,and the SPN group showed a decreasing trend);(3)significant improvement of the nutritional and immunological indicators in the TEN and SPN groups,while only immunoglobulin G improved in the TPN group(all P<0.05);and(4)a significant correlation was found between the gut bacteria,SCFAs,and nutritional and immunological indicators(all P<0.05).CONCLUSION TEN is recommended as the preferred mode of early nutritional support in sepsis based on clinical nutritional and immunological indicators,as well as changes in intestinal microecology.

关键词： Sepsis Nutritional support Intestinal microecology Short-chain fatty acids Nutritional and immunological indicators Total enteral nutrition Total parenteral nutrition Supplemental parenteral nutrition

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A review of the Cypriniform tribe Yunnanilini Prokofiev,2010 from China,with an emphasis on five genera based on morphologies and complete mitochondrial genomes of some species

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Zoological Research 2021年第3期42卷 310-334页

作者： Li-Na Du Jian yang Rui Min Xiao-Yong Chen Jun-Xing yang Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilinGuangxi 541004China Guangxi Key Laboratory of Rare and Endangered Animal Ecology College of Life ScienceGuangxi Normal UniversityGuilinGuangxi 541004China Key Laboratory of Environment Change and Resources Use in Beibu Gulf Nanning Normal UniversityNanningGuangxi 530001China Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyThe Innovative Academy of Seed DesignChinese Academy of SciencesKunmingYunnan 650223China Yunnan Key Laboratory of Plateau Fish Breeding Yunnan Engineering Research Center for Plateau-Lake Health and RestorationKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

The loach tribe Yunnanilini from China is reviewed here using morphological characters and complete mitochondrial genomes of select *** data suggest that the tribe Yunnanilini is not monophyletic and can be divided into three *** of the Yunnanilus nigromaculatus group form an independent genus and are placed in *** the phylogenetic tree,*** clusters with Paranemachilus genilepis,and *** clusters with Micronemacheilus cruciatus,indicating that *** and *** belong to Paranemachilus and Micronemacheilus,*** on while *** and ***,are placed in Paranemachilus and Micronemacheilus,*** niulanensis and *** are treated as junior synonyms of Eonemachilus ***,Micronemacheilus,and Yunnanilus are show short separation between anterior and posterior *** genera can be distinguished from each other by mouth structure,lateral line and cephalic lateral-line canals,and papillae on median part of both *** anterior and posterior nostrils of Heminoemacheilus and Paranemachilus are closely *** and Micronemacheilus are distinguished by cheeks covered with scales and lips with papillae,*** phylogenetic tree and morphological characters support Traccatichthys as a valid genus,which can be distinguished from Micronemacheilus by anterior and posterior nostrils closely set(*** separated).Four species are placed in Traccatichthys.

关键词： Eonemachilus Heminoemacheilus Micronemacheilus,Paranemachilus,Yunnanilus Taxonomy

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Progress in high pressure EDXD system and research at Beijing Synchrotron Radiation Facility

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Chinese Science Bulletin 2000年第18期45卷 1659-1662页

作者： LIU Jing ZHAO Jing CHE Rongzheng yang yang Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100039China Institute of Physics Chinese Academy of SciencesBeijing 100080China

The synchrotron radiation from a new wiggler of BEPC has been used to high pressure research. Upgraded DAC apparatus and EDXD system have been operated to determine the pressure-induced phase transition of materials at BSRF since June 1998. The improved performance of the system and the preliminary results of the research were described.

关键词： synchrotron radiation high pressure diffraction DAC phase transition.

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A rapid, low-cost deep learning system to classify strawberry disease based on cloud service

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Journal of Integrative Agriculture 2022年第2期21卷 460-473页

作者： yang Guo-feng yang Yong HE Zi-kang ZHANG Xin-yu HE Yong Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Key Laboratory of Agricultural Big Data Ministry of Agriculture and Rural AffairsBeijing 100081P.R.China College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058P.R.China

Accurate and timely classification of diseases during strawberry planting can help growers deal with them in timely manner, thereby reducing losses. However, the classification of strawberry diseases in real planting environments is facing severe challenges, including complex planting environments, multiple disease categories with small differences, and so on. Although recent mobile vision technology based deep learning has achieved some success in overcoming the above problems, a key problem is how to construct a non-destructive, fast and convenient method to improve the efficiency of strawberry disease identification for the multi-region, multi-space and multi-time classification requirements. We develop and evaluate a rapid, low-cost system for classifying diseases in strawberry cultivation. This involves designing an easy-to-use cloudbased strawberry disease identification system, combined with our novel self-supervised multi-network fusion classification model, which consists of a Location network, a Feedback network and a Classification network to identify the categories of common strawberry diseases. With the help of a novel self-supervision mechanism, the model can effectively identify diseased regions of strawberry disease images without the need for annotations such as bounding boxes. Using accuracy, precision, recall and F1 to evaluate the classification effect, the results of the test set are 92.48, 90.68, 86.32 and 88.45%, respectively. Compared with popular Convolutional Neural Networks(CNN) and five other methods, our network achieves better disease classification effect. Currently, the client(mini program) has been released on the We Chat platform. The mini program has perfect classification effect in the actual test, which verifies the feasibility and effectiveness of the system, and can provide a reference for the intelligent research and application of strawberry disease identification.

关键词： deep learning strawberry disease image classification mini program cloud service

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Confidence Intervals of the Generalized Pareto Distribution Parameters Based on Upper Record Values

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 909-918页

作者： Xu ZHAO Wei-hu CHENG yang ZHANG Shao-jie WEI Zhen-hai yang College of Applied Sciences Beijing University of Technology China Department of Economics Rutgers University USA

In this paper, we proposed a new efficient approach to construct confidence intervals for the location and scale parameters of the generalized Pareto distribution(GPD) when the shape parameter is known. The superiority of our method is that the distributions of pivots are exact, but not approximate distributions. The proposed interval estimation provides the shortest interval for the GPD parameter whether or not the confident distribution of the pivot is symmetric. We first estimate the location and scale parameters of the GPD using least squares and then, construct confidence intervals based on the equal probability density principle. The results of various simulation studies illustrate that our interval estimators show the better performance than competing method.

关键词： generalized Pareto distribution upper record values least squares estimator equal probability density principle confidence interval

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A Universal Atomic Substitution Conversion Strategy Towards Synthesis of Large‑Size Ultrathin Nonlayered Two‑Dimensional Materials

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Nano-Micro Letters 2021年第11期13卷 79-91页

作者： Mei Zhao Sijie yang Kenan Zhang Lijie Zhang Ping Chen Sanjun yang yang Zhao Xiang Ding Xiaotao Zu Yuan Li Yinghe Zhao Liang Qiao Tianyou Zhai School of Physics University of Electronic Science and Technology of China(UESTC)Chengdu 610054People’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074People’s Republic of China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province Institute of New Materials and Industrial TechnologiesCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035People’s Republic of China

Nonlayered two-dimensional(2D)materials have attracted increasing attention,due to novel physical properties,unique surface structure,and high compatibility with microfabrication ***,owing to the inherent strong covalent bonds,the direct synthesis of 2D planar structure from nonlayered materials,especially for the realization of large-size ultrathin 2D nonlayered materials,is still a huge ***,a general atomic substitution conversion strategy is proposed to synthesize large-size,ultrathin nonlayered 2D *** nonlayered CdS as a typical example,large-size ultrathin nonlayered CdS single-crystalline flakes are successfully achieved via a facile low-temperature chemical sulfurization method,where pre-grown layered CdI2 flakes are employed as the precursor via a simple hot plate assisted vertical vapor deposition *** size and thickness of CdS flakes can be controlled by the CdI2 *** growth mechanism is ascribed to the chemical substitution reaction from I to S atoms between CdI2 and CdS,which has been evidenced by experiments and theoretical *** atomic substitution conversion strategy demonstrates that the existing 2D layered materials can serve as the precursor for difficult-to-synthesize nonlayered 2D materials,providing a bridge between layered and nonlayered materials,meanwhile realizing the fabrication of large-size ultrathin nonlayered 2D materials.

关键词： Nonlayered 2D materials Large-size ultrathin CdS flakes Atomic substitution conversion Layered-nonlayered structural transformation

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Roles of SET7/9 and LSD1 in the Pathogenesis of Arsenicinduced Hepatocyte Apoptosis

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 364-372页

作者： Bing Han Yi yang Lei Tang Qin yang Rujia Xie Department of Pathophysiology College of Basic Medical SciencesGuizhou Medical UniversityGuiyangGuizhouChina Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical UniversityGuiyangGuizhouChina Medical College of Guizhou University GuiyangGuizhouChina

Background and Aims:Multiple regulatory mechanisms play an important role in arsenic-induced liver *** investigate whether histone H3 lysine 4(H3K4)methyltransferase(SET7/9)and histone H3K4 demethyltransferase(LSD1/KDM1A)can regulate endoplasmic reticulum stress(ERS)-related apoptosis by modulating the changes of H3K4 methylations in liver cells treated with ***:Apoptosis,proliferation and cell cycles were quantified by flow cytometry and real-time cell *** expression of ERS-and epigenetic-related proteins was detected by Western blot *** antisense SET7/9 expression vector and the overexpressed LSD1 plasmid were used for transient transfection of LO_(2) *** effects of NaAsO_(2) on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein,activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation ***:The protein expression of LSD1(1.25±0.08 vs.1.77±0.08,p=0.02)was markedly decreased by treatment with 100μM NaAsO_(2),whereas the SET7/9(0.68±0.05 vs.1.10±0.13,p=0.002)expression level was notably increased,which resulted in increased H3K4me1/2(0.93±0.64,1.19±0.22 vs.0.71±0.13,0.84±0.13,p=0.03 and p=0.003).After silencing SET7/9 and overexpressing LSD1 by transfection,apoptosis rate(in percentage:3.26±0.34 vs.7.04±0.42,4.80±0.32 vs.7.52±0.38,p=0.004 and p=0.02)was significantly decreased and proliferation rate was notably increased,which is reversed after inhibiting LSD1(in percentage:9.31±0.40 vs.7.52±0.38,p=0.03).Furthermore,the methylation levels of H3 in the promoter regions of GRP78(20.80±2.40 vs.11.75±2.47,20.46±2.23 vs.14.37±0.91,p=0.03 and p=0.01)and CHOP(48.67±4.04 vs.16.67±7.02,59.33±4.51 vs.20.67±3.06,p=0.004 and p=0.001)were significantly increased in LO_(2) cells exposed to 100μM NaAsO_(2) for 24 ***:Histone methyltransferase SET7/9 and histone demethyltransferase LSD1 jointly regulate the changes of H3K4me1/me2 levels in

关键词： Arsenic SET7/9 LSD1 H3K4me1/2 ER stress

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异戊二烯在裂解碳五馏分分离过程中损失的原因分析

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石油炼制与化工 2011年第11期42卷 52-56页

作者：钟晓图苏萍杨屹李东风北京化工大学理学院北京100029 中国石化北京化工研究院

采用封管合成的方法,对碳五馏分热二聚过程中环戊二烯(CPD)和异戊二烯(IP)的共二聚物及自二聚物进行定性和定量分析,从产物追溯反应物的变化,探讨IP在热二聚过程中的损失原因。结果显示:CPD与IP的共二聚是导致IP损失的主要原因;而在高... 详细信息

采用封管合成的方法,对碳五馏分热二聚过程中环戊二烯(CPD)和异戊二烯(IP)的共二聚物及自二聚物进行定性和定量分析,从产物追溯反应物的变化,探讨IP在热二聚过程中的损失原因。结果显示:CPD与IP的共二聚是导致IP损失的主要原因;而在高温度段(110～130℃),IP的自二聚反应是导致高温段IP转化率增加的主要原因。综合上述两个原因,在进行二聚反应装置的设计时应尽量避免CPD与IP的接触,反应应在较低温度和较短停留时间下进行,110℃以下较为适宜。

关键词：碳五馏分热二聚异戊二烯共二聚物环戊二烯

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Study on blockchain technology from an information system perspective

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High Technology Letters 2021年第2期27卷 146-152页

作者： Zhang Caiming Lu yang Department of Labour Relations and Human Resourcing Management China University of Labour RelationsBeijing 100048P.R.China

Blockchain,as a decentralized platform and distributed ledger technology,will complement and promote the existing centralized system to form a relatively comprehensive ecosystem.A systematic review of blockchain research on information system(IS)disciplines during the five years from 2016 to 2020 selected dozens of papers from 16 leading IS *** technological characteristics and implementation models of blockchain are introduced,highlighting and discussing its research status and development in ***,the future research directions for blockchain in IS are *** aims to discuss the decentralized and emerging technology of blockchain in its early development stage and to depict the relevant IS issues that are worthy of further investigation.

关键词： information system(IS) business value,blockchain cryptocurrency Bitcoin supply chain management

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利用超高能中子诊断惯性约束聚变的燃烧

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计算物理 2012年第1期29卷 82-86页

作者：李树田东风邓力北京应用物理与计算数学研究所北京100088 中国工程物理研究院四川绵阳621900

惯性约束聚变靶丸中,高能中子相互之间发生碰撞将导致超高能中子的产生.本文讨论超高能中子产生与聚变燃烧速率的关系.数值模拟理想模型,分析超高能中子产生量与平均烧氚体积的关系,讨论利用出壳超高能中子流与烧氚量诊断二维效应和混... 详细信息

惯性约束聚变靶丸中,高能中子相互之间发生碰撞将导致超高能中子的产生.本文讨论超高能中子产生与聚变燃烧速率的关系.数值模拟理想模型,分析超高能中子产生量与平均烧氚体积的关系,讨论利用出壳超高能中子流与烧氚量诊断二维效应和混合效应.进一步分析出壳超高能中子流与平均烧氚率的关系,探讨利用超高能中子诊断平均烧氚温度并判断是否发生非平衡效应问题.

关键词：惯性约束聚变中子碰撞超高能中子烧氚诊断

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