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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

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Chinese Journal of Integrative Medicine 2022年第6期28卷 492-500页

作者： GAO Yang XIE Yan-ming WANG Gui-qian cai Ye-feng SHEN Xiao-ming ZHAO De-xi XIE Ying-zhen ZHANG Yin MENG Fan-xing YU Hai-qing JIANG Jun-jie WEI Rui-Li Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Neurology the Affiliated Hospital of Changchun University of Chinese MedicineChangchun130017China Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Neurology Taiyuan Hospital of Traditional Chinese MedicineTaiyuan140107China

Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in ***:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk ***,stroke recurrence was defined as a primary outcome ***:A total of 327(12.78%)patients endured recurrence events,1,681(65.72%)patients were men,and the average age was 63.33±9.45 *** 1,741(68.06%)patients suffered first-ever ischemic stroke,1,772(69.27%)patients reported to have hypertension,and1,640(64.11%)of them reported dyslipidemia,1,595(62.35%)patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST)***,1,271(49.69%)patients were considered as qi-deficient constitution,and 1,227(47.97%)patients were determined as stagnant blood *** were 1,303(50.94%)patients diagnosed as blood stasis syndrome,1,280(50.04%)patients exhibited phlegm and dampness syndrome and 1,012(39.56%)patients demonstrated qi deficiency *** 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%)patients reported carotid artery *** plaque in 1,508(41.36%)patients were of ***,41.09%of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c)***:Recurrence in minor and small-artery stroke cannot be ***,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke ***,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ***,***03174535)

关键词： noncardiogenic ischemic stroke Chinese medicine hospital onset characteristics recurrence

基于德尔菲法构建精神科护士医学保护性约束使用现状调查问卷

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护理研究 2021年第1期35卷 22-27页

作者：罗薇高静许冬梅邵静蔡壮张卫东高东芳李雪松北京回龙观医院北京100096

目的:构建精神科护士医学保护性约束使用现状调查问卷,为了解精神科医学保护性约束现状提供客观、科学的评价工具。方法:在文献回顾的基础上,结合临床经验,形成精神科护士医学保护性约束使用现状调查问卷,采用德尔菲法对16名专家进行2... 详细信息

目的:构建精神科护士医学保护性约束使用现状调查问卷,为了解精神科医学保护性约束现状提供客观、科学的评价工具。方法:在文献回顾的基础上,结合临床经验,形成精神科护士医学保护性约束使用现状调查问卷,采用德尔菲法对16名专家进行2轮函询。结果:2轮德尔菲函询专家积极系数均为100.00%;专家权威系数为0.929,0.947;专家的协调系数为0.113,0.106。最终构建了包含医学保护性约束前期、医学保护性约束执行期、医学保护性约束实施期、医学保护性约束停止期4个维度、30个条目的精神科护士医学保护性约束使用现状调查问卷。结论:基于德尔菲法构建的精神科护士医学保护性约束使用现状调查问卷可用于调查精神科护士医学保护性约束的使用现状。

关键词：保护性约束精神科评价工具德尔菲技术护理管理

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广域弹性订单制成人高等教育课程模式研究

汽车实用技术 2024年第3期49卷 143-147页

作者：付强张猛蔡明秀赵东方翟青春沈阳航空航天大学机电工程学院辽宁沈阳110136

针对成人高等教育课程模式中存在的问题,设计了广域弹性订单制课程创新模型。综合企业需求、学校资源、教师授课和个人兴趣制定多专业融合的、更灵活多样的订单制课程模块,分析工科4个专业课程组合模型的类型和实施课程方案一人一策的... 详细信息

针对成人高等教育课程模式中存在的问题,设计了广域弹性订单制课程创新模型。综合企业需求、学校资源、教师授课和个人兴趣制定多专业融合的、更灵活多样的订单制课程模块,分析工科4个专业课程组合模型的类型和实施课程方案一人一策的可行性。选取A-B、A-C和A-D三种专业方向的课程模块样本,经过继续教育学院车辆工程专业学生教学实践,提高了企业培养人才的参与度和学生学习的主动性,创新课程模块组学生平均专业课成绩提高了9.69%~12.23%,多专业融合满足了企业岗位的课程知识需求。验证了广域弹性订单制课程模型教学对于提高学生专业成绩的有效性,同时提升了企业对人才的满意度。

关键词：广域弹性订单制一人一策课程融合车辆工程

同方期刊数据库博看期刊评论

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福州市上下杭历史街区绿视率研究

热带农业工程 2019年第4期43卷 160-163页

作者：史云曼蔡情施磊陆东芳福建农林大学

以福州市上下杭历史街区为调查对象,将主景观道定距等分为16个点进行数据采集,并通过Photoshop软件进行绿视率的计算,得出上下杭街区的平均绿视率为25.10%,总体绿量较好,但仍存在一些问题。由此分析影响绿视率的因素,并提出提高历史街... 详细信息

以福州市上下杭历史街区为调查对象,将主景观道定距等分为16个点进行数据采集,并通过Photoshop软件进行绿视率的计算,得出上下杭街区的平均绿视率为25.10%,总体绿量较好,但仍存在一些问题。由此分析影响绿视率的因素,并提出提高历史街区绿视率的建议。

关键词：历史街区绿视率福州

Study on the Mechanism of Qingre Huoxue Prescription in the Intervention and Treatment of Acute Myocardial Infarction Based on Network Pharmacology

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World Journal of Traditional Chinese Medicine 2019年第4期5卷 220-227页

作者： cai-Xia Jia Jin-Ping Wang Fei-Long Zhang Xiao-Han Pang Wei-Lu Wang Paulin-Xue Xu Kuo Gao Jian-Xin Chen Pharmacology Major of Integrated Traditional Chinese and Western Medicine School of Preclinical MedicineBeijing University of Chinese Medicine Harvard Medical School 25 Shattuck Street BostonMA 02115USA Scientific Research and Experiment Center Dongfang HospitalBeijing University of Chinese MedicineBeijingChina

Objective:The objective is to study the mechanism of Qingre Huoxue prescription in the intervention and treatment of acute myocardial infarction(AMI)based on the method of network *** and Methods:Five databases were used to screen the chemical compounds and targets of Ligusticum wallichii(chuanxiong),Radix Paeoniae Rubra(chishao),Lignum acronychiae(jiangxiang),Safflower(honghua),Salvia miltiorrhiza(danshen),Scutellaria baicalensis(huangqin),and Ilex pubescens(mao dong qing)in Qingre Huoxue ***,Cytoscape-V3.2.1 software was used to construct the drug-component-target *** protein association networks'database and the Database for Annotation,Visualization,and Integrated Discovery(DAVID)were used to visualize the protein interaction,pathway enrichment,and ***:A total of 44 active ingredients were screened out in Qingre Huoxue *** them,178 targets and 41 compounds related to Qingre Huoxue prescription's function in treating AMI were *** the analysis of the drug-component-action target network on Qingre Huoxue prescription,14 key compounds and nine key targets with three scores above average were *** addition,pathway enrichment and biological processes were conducted with the aid of the DAVID;and 8 related pathways and 10 biological processes were associated with AMI and related diseases;the PI3 K-AKT signaling pathway,MAPK signaling pathway,and HIF-1 signaling pathway are the main pathways of Qingre Huoxue prescription for the treatment of AMI and related ***:Qingre Huoxue prescription could treat AMI by multiple components,targets,and *** study provides ideas and theoretical basis for further clinical studies on Qingre Huoxue prescription in treating AMI.

关键词： Acute myocardial infarction mechanism network pharmacology Qingre Huoxue prescription

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水环境中锑分析检测方法的研究进展

东华大学学报（自然科学版） 2024年第3期50卷 107-115页

作者：王冬芳李姜珊汪林颖程若瑶崔梦佳卢洪秀蔡冬清东华大学环境科学与工程学院上海上海污染控制与生态安全研究院上海上海农林职业技术学院生物医药与健康系上海

锑(Sb)是广泛存在于水环境中的一种重金属,不断被证实对人和动植物等有慢性毒性和致癌风险。在监测和治理水环境中的Sb污染方面,建立快速、高灵敏度的Sb检测分析方法至关重要。重点阐述了分光光度法、原子荧光光谱法(AFS)、电感耦合等... 详细信息

锑(Sb)是广泛存在于水环境中的一种重金属,不断被证实对人和动植物等有慢性毒性和致癌风险。在监测和治理水环境中的Sb污染方面,建立快速、高灵敏度的Sb检测分析方法至关重要。重点阐述了分光光度法、原子荧光光谱法(AFS)、电感耦合等离子体质谱法(ICP-MS)、电感耦合等离子体原子发射光谱法(ICP-OES)、原子吸收光谱法(AAS)和电化学分析法在Sb分析检测中的相关研究及应用进展,探讨了水环境中Sb检测存在的问题和面临的挑战,如检测方法灵敏度低、间接测定Sb耗时且不准确、还原剂昂贵且有毒等。此外,对Sb检测未来的发展方向进行展望。未来Sb检测趋势是发展电化学分析方法。通过电极修饰和纳米材料设计提高传感器性能,如碳基材料、金属纳米颗粒和硅基材料。有机配体、纳米复合材料和裸电极的功能化可增强灵敏度和选择性,促进传感器小型化。未来Sb检测将迈向小型化、芯片化和快速化。

关键词：锑水环境原子荧光光谱法电感耦合等离子体法研究进展

生命周期视角下城市碳足迹核算及实现碳中和的路径建议——以深圳市为例

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北京师范大学学报（自然科学版） 2022年第6期58卷 878-885页

作者：孟凡鑫樊兆宇王东方郭文卿刘耕源蔡博峰杨志峰北京师范大学环境学院环境模拟与污染控制国家重点联合实验室北京100875 生态环境部环境规划院北京100012 广东工业大学生态环境与资源学院大湾区城市环境安全与绿色发展教育部重点实验室广东广州510006

基于生命周期视角构建了城市碳足迹核算框架及方法学模型,系统地核算及追溯了碳排放在开放的城市“自然-经济-社会复合生态系统”中的足迹,主要涵盖城市地域边界内的直接生产碳排放以及跨境间接碳排放(主要包括城市所需的关键支撑物质... 详细信息

基于生命周期视角构建了城市碳足迹核算框架及方法学模型,系统地核算及追溯了碳排放在开放的城市“自然-经济-社会复合生态系统”中的足迹,主要涵盖城市地域边界内的直接生产碳排放以及跨境间接碳排放(主要包括城市所需的关键支撑物质、排放的主要废弃物,以及跨境交通分别在上游、下游产生的间接碳排放),并选取深圳市作为案例进行分析.结果表明,2015年深圳市碳足迹总量为6566.19万t CO_(2e),具体为:1)城市内主要产业部门及居民消费的能源活动及非能源活动引起的直接碳排放量(Scope 1)为3282.38万t CO_(2e),占深圳市碳足迹总量的49.99%,其中工业能源部门占比最大,为36.95%;2)城市外调电力消费引起的间接碳排放(Scope 2)占城市碳足迹总量的18.89%;3)跨境运输、关键支撑物质的上游产业链以及废弃物在下游处理过程中隐含的间接碳排放(Scope 3)占城市碳足迹总量的31.12%,其中5.37%来自跨境交通,22.26%来自主要物质上游供应链,3.49%来自下游废弃物处理.由此可知,2015年深圳市在城市上下游跨边界的间接碳排放量与城市内部的直接排放量相当,不容忽视.研究结果可为厘清城市自身碳排放现状及应对碳中和战略提供政策建议及管理启示.

关键词：碳中和碳足迹城市混合生命周期

A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Treating Ulcerative Colitis by the Integration Method of Heat-Clearing, Damp-Excreting, Spleen-Strengthening, and Stasis-Removing of Traditional Chinese Medicine with Western Medicine

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World Journal of Traditional Chinese Medicine 2020年第1期6卷 74-82页

作者： Zi-Jun Jia Zhen-Huan Yang cai-Xia Jia Kun-Min Xiao Yi-Qun Niu Jie Chen Shao-Jie Duan Shu-Kun Yao Yan Li Department of Gastroenterology Clinical Medical College of China-Japan Friendship HospitalBeijing University of Chinese Medicine Department of Gastroenterology China-Japan Friendship Hospital Department of Pharmacology of Integrated Chinese and Western Medicine School of Preclinical MedicineBeijing University of Chinese Medicine Department of Cardiovascular Medicine Dongfang HospitalThe Second Clinical Medical College of Beijing University of Chinese MedicineBeijingChina

Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis(UC).Materials and Methods:The databases China National Knowledge Infrastructure,China Biology Medicinedisc(CBMdisc),WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat,draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results:In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR]=1.27, 95%confidence interval [CI]:1.21, 1.35, Z=8.74, P <0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR=1.24, 95%CI:1.15, 1.33, Z=5.88, P <0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR=1.30, 95%CI:1.12, 1.50, Z=3.52, P=0.0004).The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR=1.18, 95%CI:1.05, 1.33, Z=2.86, P=0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR=-4.23, 95%CI:-4.93,-3.53, Z=11.84, P <0.00001)

关键词： Clearing heat draining dampness invigorating spleen meta-analysis removing stasis ulcerative colitis

溶栓后转运PCI与PCI对急性心肌梗死合并COPD患者的临床疗效比较

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中国继续医学教育 2020年第24期12卷 119-122页

作者：蔡小龙陈东方刘树峰况成宏襄阳市中西医结合医院心血管内科湖北襄阳441004 襄阳市中西医结合医院急诊医学科湖北襄阳441004

目的比较溶栓后转运PCI与PCI对急性心肌梗死合并肺部感染患者的临床疗效。方法随机选取2010年1月—2019年1月在华中科技大学同济医学院附属协和医院心血管内科病房进行急性心肌梗死合并肺部感染治疗的患者150例进行临床研究,根据转运至... 详细信息

目的比较溶栓后转运PCI与PCI对急性心肌梗死合并肺部感染患者的临床疗效。方法随机选取2010年1月—2019年1月在华中科技大学同济医学院附属协和医院心血管内科病房进行急性心肌梗死合并肺部感染治疗的患者150例进行临床研究,根据转运至我院行PCI治疗前是否给予溶栓治疗分为观察组66例和对照组84例,对照组患者确诊后直接转运PCI,观察组患者在转运PCI前给予溶栓治疗,比较两组患者治疗前和治疗后7 d心功能、炎症因子的变化情况,并观察两组患者术后心性死亡、再梗死、心源性休克、心功能不全、心绞痛等心血管不良事件发生率。结果两组患者治疗前LVEDD、LVESD、LVEF差异无统计学意义(P>0.05),治疗后两组患者上述指标与治疗前均有明显改善(P0.05),治疗后两组患者上述指标与治疗前均有明显改善(P<0.05),但观察组患者PCT、CRP明显低于对照组(P<0.05),观察组患者不良事件发生率为6.06%,明显低于对照组19.05%(P<0.05)。结论对于急性心肌梗死合并肺部感染患者给予溶栓后转运PCI能够明显改善患者的心功能,降低患者炎症因子水平,并且降低术后不良事件发生率。

关键词：溶栓经皮冠状动脉介入治疗急性心肌梗死心绞痛炎症因子肺部感染慢性阻塞性肺疾病