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Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu Yan Jiawei Song dongdong Liu Zihan Liu Jialing Cheng Zhiyang Chen Yanfang Yang Weizhe Jiang Hongliang Wang Jun ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal function.Ramulus mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes mellitus.Accumulated evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in UC.However,the treatment of UC faces challenges due to low drug delivery efficiency and short retention time.To overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and 188.The thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 s.In a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal administration.Symptoms of UC were markedly reduced following rectal administration of SZ-A thermosensitive hydrogel.Furthermore,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the SZ-A thermo-sensitive hydrogel group.The integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive hydrogel.In conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal barrier.This approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis SZ-A Thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

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Selective C-C bonds formation,N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

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Chinese Chemical Letters 2022年第1期33卷 266-270页

作者： Guanxin Zhu Zheng-Chao Duan Haiyan Zhu dongdong ye Dawei Wang The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China School of Chemical and Environmental Engineering Hubei Minzu UniversityEnshi 445000China

Earth abundant metals are much less expensive,promising,valuable metals and could be served as catalysts for the borrowing hydrogen reaction,dehydrogenation and heterocycles synthesis,instead of noble metals.The uniformly dispersed zinc composites were designed,synthesized and carefully characterized by means of XPS,EDS,TEM and XRD.The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines,ketones with alcohols in water under base-free conditions,while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions.Importantly,it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions.Meanwhile,this zinc catalyst could be easily recovered and reused for at least five times.

关键词： Unsymmetrical Zinc Borrowing hydrogen Recyclability Selective

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Pd nano-catalyst supported on biowaste-derived porous nanofibrous carbon microspheres for efficient catalysis

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化学科学与工程前沿:英文版 2023年第9期17卷 1289-1300页

作者： Xianglin Pei Siyu Long Lingyu Zhang Zhuoyue Liu Wei Gong Aiwen Lei dongdong ye School of Materials and Architectural Engineering Guizhou Normal UniversityGuiyang550025China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan430072China School of Textile Materials and Engineering Wuyi UniversityJiangmen529020China Guizhou Key Laboratory of Inorganic Nonmetallic Functional Materials Guizhou Normal UniversityGuiyang550025China

Environmental pollution caused by the presence of aromatic aldehydes and dyes in wastewater is a serious global concern. An effective strategy for the removal of these pollutants is their catalytic conversion, possibly to valuable compounds. Therefore, the design of efficient, stable and long-lifetime catalysts is a worthwhile research goal. Herein, we used nanofibrous carbon microspheres (NCM) derived from the carbohydrate chitin present in seafood waste, and characterized by interconnected nanofibrous networks and N/O-containing groups, as carriers for the manufacture of a highly dispersed, efficient and stable Pd nano-catalyst (mean diameter ca. 2.52 nm). Importantly, the carbonised chitin’s graphitized structure, defect presence and large surface area could promote the transport of electrons between NCM and Pd, thereby endowing NCM supported Pd catalyst with high catalytic activity. The NCM supported Pd catalyst was employed in the degradation of some representative dyes and the chemoselective hydrogenation of aromatic aldehydes;this species exhibited excellent catalytic activity and stability, as well as applicability to a broad range of aromatic aldehydes, suggesting its potential use in green industrial catalysis.

关键词： biowaste chitin nanofibrous palladium nano-catalyst catalysis

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Raman imaging-assisted customizable assembly of MOFs on cellulose aerogel

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Nano Research 2022年第3期15卷 2599-2607页

作者： Zhanhong Yuan Dingding Meng Yingzhu Wu Guangqing Tang Ping Liang John HXin dongdong ye School of Textile Materials and Engineering Wuyi UniversityJiangmen 529020China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China Institute of Textiles&Clothing The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Because of a weak interface-bonding force between metal–organic frameworks(MOFs)and substrates and the loss of customization in structural designs owing to the lack of the regulation of ion sites,MOFs tend to escape from the constructed composite template.In this study,the as-prepared 2,2,6,6-tetramethylpiperidyl-1-oxyl(TEMPO)-oxidized algae cellulose nanofibers(TACFs)were used to chelate metal ions at controllable sites and subsequently firmly entangle the assembled MOF crystals.The distribution of ions and synthesized MOFs inside the gel was monitored using Raman imaging technology,which provided an intuitive approach for visually observing the ions and MOF distribution.Using this technology,the synthesized customizable TACFs@ZIF-67 aerogels exhibited a high specific surface area(734.7 m^(2)/g),low density(6.18 mg/cm^(3)),controlled particle distribution,good underwater structural stability,and excellent adsorption of dyes.This study provides a way for solving the dispersion problem of MOFs in nanofibrous aerogels using Raman imaging technology–assisted microcosmic fixed-point design.

关键词： cellulose nanofiber aerogel Raman imaging ion distribution metal–organic framework

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3D-printed mechanically strong and extreme environment adaptable boron nitride/cellulose nanofluidic macrofibers

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Nano Research 2023年第5期16卷 7609-7617页

作者： Le Yu Tingting Gao Ruiyu Mi Jing Huang Weiqing Kong Dapeng Liu Zhiqiang Liang dongdong ye Chaoji Chen School of Resource and Environmental Sciences Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key LaboratoryWuhan UniversityWuhan 430079China Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai 201620China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing 100083China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China School of Textile Materials and Engineering Wuyi UniversityJiangmen 529020China

Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.However,the large-scale preparation of fibrous nanofluidic materials with desirable mechanical strength and good environment adaptability for practical use remains challenging.Herein,by fully taking advantage of the attractive mechanical,structural,chemical features of boron nitride(BN)nanosheet and nanofibrillated cellulose(NFC),a scalable and cost-effective three-dimensional(3D)printed macrofiber featuring abundant vertically aligned nanofluidic channels is demonstrated to exhibit a good combination of high tensile strength of 100 MPa,thermal stability of up to 230℃,ionic conductivity of 1.8×10^(−4)S/cm at low salt concentrations(<10^(−3)M).In addition,the versatile surface chemistry of cellulose allows us to stabilize the macrofiber at the molecular level via a facile postcross-linking method,which eventually enables the stable operation of the modified macrofiber in various extreme environments such as strong acidic,strong alkaline,high temperature.We believe this work implies a promising guideline for designing and manufacturing fibrous nanodevices towards extreme environment operations.

关键词： three-dimensional(3D)printing nanofluidic boron nitride cellulose macrofiber

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Inertinite in coal and its geoenvironmental significance:Insights from AI and big data analysis

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Science China Earth Sciences 2024年第6期67卷 1779-1801页

作者： Longyi SHAO Jiamin ZHOU Timothy PJONES Fanghui HUA Xiaotao XU Zhiming YAN Haihai HOU dongdong WANG Jing LU State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources and College of Geoscience and Surveying Engineering China University of Miningand Technology(Beijing)Beijing 100083China School of Earth and Environmental Sciences Cardiff UniversityCardiff CF103YEWalesEngland General Prospecting Institute of China National Administration of Coal Geology Beijing 100039China Institute of Architectural Engineering Weifang UniversityWeifang 261061China College of Mining Liaoning Technical UniversityFuxin 123000China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Inertinite,as an important and abundant maceral group in coal,is critical for the study of palaeowildfires and their roles in the Earth’s ecosystems.Recently,there has been a significant amount of research on the relationship between palaeowildfire,palaeoclimate change and palaeovegetation evolution based on inertinite data.The reflectance of fusinite and semifusinite has been used to estimate the combustion temperature and type of palaeowildfires,and then to evaluate the combustion characteristics of different types of palaeowildfires.The relative abundance of inertinite can be used to estimate the atmospheric oxygen contents.The rapid development of artificial intelligence(AI)and online tools to search scientific databases has presented an opportunity for us to find,collect,arrange,and analyse data from the earliest to latest publications on inertinite.The data extraction tool Deep Shovel is used to collect and analyse global inertinite data from the Silurian to the Neogene.The software programs such as Gplates,ArcGIS pro and Tableau are then applied to model the relative abundance of inertinite over geological time,which can be correlated with other parameters such as atmospheric oxygen contents,plant evolution and palaeoclimate changes.The distribution of inertinite in coals varied over different geological periods,being typified by the“high inertinite content-high atmospheric oxygen level”period in the Permian and the“low inertinite content-low atmospheric oxygen level”period in the Cenozoic.This study has proposed a possible model of the positive and negative feedbacks between inertinite characteristics and palaeoenvironmental factors,and has revealed the exceptional role of inertinite in palaeoenvironmental studies.Future research on inertinite will be focused on the integrated study of organic petrology and organic geochemistry of inertinite,the big data-driven research on the temporal and spatial distribution of the global inertinite,the exploration of the functions of palaeowildfires in the Earth system

关键词： Inertinite Palaeowildfires Atmospheric oxygen Palaeoclimates Palaeoecosystems

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Securing Parked Vehicle Assisted Fog Computing With Blockchain and Optimal Smart Contract Design

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 426-441页

作者： Xumin Huang dongdong ye Rong Yu Lei Shu School of Automation Guangdong University of TechnologyGuangzhou 510006 Guangdong Key Laboratory of IoT Information Technology Guangdong University of TechnologyGuangzhou 510006China Guangdong-Hong Kong-Macao Joint Laboratory for Smart Discrete Manufacturing Guangzhou 510006China College of Engineering Nanjing Agricultural UniversityNanjing 210095China School of Engineering University of LincolnLincoln LN67TSUK

Vehicular fog computing(VFC)has been envisioned as an important application of fog computing in vehicular networks.Parked vehicles with embedded computation resources could be exploited as a supplement for VFC.They cooperate with fog servers to process offloading requests at the vehicular network edge,leading to a new paradigm called parked vehicle assisted fog computing(PVFC).However,each coin has two sides.There is a follow-up challenging issue in the distributed and trustless computing environment.The centralized computation offloading without tamper-proof audit causes security threats.It could not guard against false-reporting,free-riding behaviors,spoofing attacks and repudiation attacks.Thus,we leverage the blockchain technology to achieve decentralized PVFC.Request posting,workload undertaking,task evaluation and reward assignment are organized and validated automatically through smart contract executions.Network activities in computation offloading become transparent,verifiable and traceable to eliminate security risks.To this end,we introduce network entities and design interactive smart contract operations across them.The optimal smart contract design problem is formulated and solved within the Stackelberg game framework to minimize the total payments for users.Security analysis and extensive numerical results are provided to demonstrate that our scheme has high security and efficiency guarantee.

关键词： Blockchain parked vehicle smart contract Stackelberg game vehicular fog computing(VFC)

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Quaternized chitosan-assisted in situ synthesized CuS/cellulose nanofibers conductive paper for flexible electrode

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Nano Research 2021年第7期14卷 2390-2397页

作者： Xiujie Huang Bichong Luo Chuanfu Liu Linxin Zhong dongdong ye Xiaoying Wang State Key Laboratory of Pulp and Paper Engineering South China University of Technology381 Wushan RoadGuangzhou 510640China School of Textile Materials and Engineering Wuyi UniversityJiangmen 529020China

Cellulose nanofibers(CNF)are considered to be a potential substrate of energy material for energy storage devices due to the foldable,lightweight,recyclable and environmentally friendly feature.However,the energy materials tend to distribute unevenly or fall off from CNF easily,resulting in the decrease of the devices’overall performance.Here,for the first time,we used quaternized chitosan(QCS)as stabilizer and adhesive to in situ synthesize and deposite copper sulfide nanocrystals(CuS-NCs)on CNF and further obtained the conductive paper for flexible supercapacitors.In the presence of QCS,CuS-NCs deposited in situ on CNF can be capped and stabilized by the QCS molecular chains for uniform distribution,which is conducive to the capacitive behavior and electrochemical stability of composite paper.The result shows that the specific capacitance of the composite paper was as high as 314.3 F/g at a current density of 1 A/g,a high rate capacitance of 252.6 F/g was achieved even at a high current density of 10 A/g.It reveals that the composite paper exhibited better electrochemical performance than many other CuS-based electrode materials for supercapacitor.More importantly,the composite paper performed well in various folding state without changing much electrochemical performance.Therefore,this work provides a novel strategy to in situ fabricate paper-based electrode for nextgeneration flexible energy-storage system.

关键词： copper sulfide nanocrystals cellulose nanofiber quaternized chitosan supercapacitors flexible devices

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泥河湾盆地中更新世气候转型期人类的适应行为

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人类学学报 2024年第1期43卷 19-39页

作者：裴树文徐哲叶芷马东东贾真秀中国科学院脊椎动物演化与人类起源重点实验室中国科学院古脊椎动物与古人类研究所北京100044 中国科学院大学北京100049 西班牙高级科学研究委员会(CSIC)历史研究所马德里28037 中国科学院青藏高原研究所北京100101

中更新世气候转型期(1.25-0.7 MaBP)是晚新生代最重要的气候变化时段之一。该时期大陆内部干旱化加剧,北半球冬季温度迅速下降,动植物群发生变化,对古人类的环境适应能力提出新的挑战。泥河湾盆地发育我国北方第四纪典型的河湖相沉积体... 详细信息

中更新世气候转型期(1.25-0.7 MaBP)是晚新生代最重要的气候变化时段之一。该时期大陆内部干旱化加剧,北半球冬季温度迅速下降,动植物群发生变化,对古人类的环境适应能力提出新的挑战。泥河湾盆地发育我国北方第四纪典型的河湖相沉积体系,其间富集众多早-中更新世旧石器时代遗址,是探讨更新世环境变化与人类适应行为的关键区域。本文选取盆地内岑家湾台地飞梁、麻地沟、岑家湾和东谷坨等重要遗址,通过多指标的统计分析,解读中更新世气候转型期古人类的适应策略。研究结果显示,因地制宜、就地取材是古人类获取石器原料的途径,不同遗址利用者对不同原料的选择和利用主要和遗址距离原料的远近有直接关系,而针对不同原料类型采取的差异化开发策略,预示着古人类认知能力的提高。尽管锤击法是古人类常用的剥片技术,但是砸击技术可能与本地原料质量具有更直接的关系;作为锤击法的有效补充,砸击技术的运用或许与古人类的认知水平提高存在关联。石核和石片的特征表明,该时期古人类对石核开发利用程度显著提高,剥片技术多样化,灵活性增强,展示了计划性和认知能力的提高。对优质燧石原料的青睐一直是古人类制作石器的主要策略,该时期修理类产品不仅种类增多,加工方式多样化程度也相对较高,加工精细的小型刮削器、钻、尖状器、凹缺器、齿状器和多边修理工具等产品增多指示对多种功能的适应,暗示古人类对区域生态景观多元化的积极响应。古人类灵活的技术多样化策略可能与其认知水平的提高存在关联,而气候与环境波动造成的生存压力等多方面叠加因素,可能共同作用于古人类的认知行为上,促使人类调整技术,适应多变的区域环境。本研究对探讨泥河湾盆地更新世古人类生存行为演化与环境关系、人类对东亚高纬度半干旱区适应策略具有重要意义。

关键词：泥河湾盆地中更新世气候转型期人类适应行为环境变动

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电力通信网运行质量评价指标体系构建及评价方法研究

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科学技术创新 2024年第3期 206-209页

作者：叶东东郭焕国网西藏电力有限公司拉萨公司西藏拉萨国网西藏电力有限公司信息通信公司西藏拉萨

电力通信网作为电力系统的重要组成部分,支撑着电力系统稳定运行,是专门服务于电力系统的通信网络。本文结合电力通信网运行过程,从线路、设备、运维以及业务四个方面分析影响电力通信网运行质量的因素,构建指标构建评价指标体系并进行... 详细信息

电力通信网作为电力系统的重要组成部分,支撑着电力系统稳定运行,是专门服务于电力系统的通信网络。本文结合电力通信网运行过程,从线路、设备、运维以及业务四个方面分析影响电力通信网运行质量的因素,构建指标构建评价指标体系并进行评价,为电力通信网运维提供参考依据。

关键词：电力通信网评价指标体系层次分析法

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