检索结果-南通市图书馆

Frontiers of Medicine 2022年第5期16卷 808-814页

作者： Rongrong Wang Liwei Sun Xiaerbati Habulieti Jiawei Liu Kexin Guo Xueting Yang donglai ma Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China The First Affiliated Hospital of Xinjiang Medical University Urumqi 830001China Department of Dermatology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic DiseasesBeijing 100072China

Epidermolysis bullosa(EB)is a group of clinically and genetically heterogeneous diseases characterized by trauma-induced mucocutaneous fragility and blister ***,we investigated five Chinese families with EB,and eight variants including a novel nonsense variant(c.47G>A,p.W16*)in LAma3,a known recurrent variant(c.74C>T,p.P25L)in KRT5,2 novel(c.2531T>A,p.V844E;c.6811_6814del,p.R2271fs)and 4 known(c.6187C>T,p.R2063W;c.7097G>A,p.G2366D;c.8569G>T,p.E2857*;c.3625_3635del,p.S1209fs)variants in COL7A1 were ***,this study identified a nonsense variant in LAma3 that causes EB within the Chinese population and revealed that this variant resulted in a reduction in LAma3 mRNA and protein expression levels by nonsense-mediated mRNA *** study expands the mutation spectra of Chinese patients with EB.

关键词： epidermolysis bullosa LAma3 COL7A1 KRT5 Chinese families

Phenotypic and genetic characterization of novel variant in the NF1 gene underlying neurofibromatosis type 1 in five Chinese families

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第12期64卷 2206-2209页

作者： Xiaerbati Habulieti Liwei Sun Jiawei Liu Kexin Guo Xueting Yang Rongrong Wang donglai ma Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China The First Affiliated Hospital of Xinjiang Medical University Urumchi 830001China Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical ScienceBeijing 100072China

Dear Editor,Neurofibromatosis type 1(NF1;von Recklinghausen neurofibromatosis;OMIM 162200)is a neurocutaneous genetic disorder that affects approximately one in 2,500 people worldwide(Huson et al.,1989).NF1 is characterized by wide clinical variability,including multiple café-au-lait macules(CALMs),fibromatous tumors,axillary or inguinal freckling,Lisch nodules(iris hamartomas),skeletal anomalies,and cognitive impairments(Monroe et al.,2017).

关键词： NF1 impairment

Exploration of Hanshi Zufei prescription for treatment of COVID-19 based on network pharmacology

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2022年第2期14卷 294-302页

作者： Xinrui Li Zishuai Wen Mingdong Si Yuxin Jia Huixian Liu Yuguang Zheng donglai ma School of Pharmacy Hebei University of Chinese MedicineShijiazhuang 050200China Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province Shijiazhuang 050091China Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation Shijiazhuang 050091China

Objective:Network pharmacology combines drug and disease targets with biological information networks based on the integrity and systematicness of the interactions between drugs and disease *** study aims to explore the molecular basis of Hanshi Zufei formula for treatment of COVID-19 based on network pharmacology and molecular docking ***:Using TCMSP,the chemical constituents and molecular targets of Atractylodis Rhizoma,Citri Reticulatae Pericarpium,magnoliae Officinalis Cortex,Pogostemonis Herba,Tsaoko Fructus,Ephedrae Herba,Notopterygii Rhizoma et Radix,Zingiberis Rhizoma Recens,and Arecae Semen were *** predicted targets of novel coronavirus were screened using the NCBI and Gene Cards *** further screen the drug-disease core targets network,the corresponding target proteins were queried using multiple databases(Biogrid,DIP,and HPRD),a protein interaction network graph was constructed,and the network topology was *** molecular docking studies were also performed between the network’s top 15 compounds and the coronavirus(SARS-Co V-2)3 CL hydrolytic enzyme and angiotensin conversion enzymeⅡ(ACE2).Results:The herb-active ingredient-target network contained nine drugs,86 compounds,and 49 drugdisease *** ontology(GO)enrichment analysis resulted in 1566 GO items(P<0.05),among which 1438 were biological process items,35 were cell composition items,and 93 were molecular function *** signal pathways were obtained by enrichment screening of the KEGG pathway database(P<0.05).The molecular docking results showed that the affinity of the core active compounds with the SARS-CoV-23 CL hydrolase was better than for the other ***:Several core compounds can regulate multiple signaling pathways by binding with 3 CL hydrolase and ACE2,which might contribute to the treatment of COVID-19.

关键词： COVID-19 Hanshi Zufei prescription molecular docking network pharmacology SARS-CoV-2

Application Study on Visible Human Computer Interaction System of Association Rule

在线全文

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2006年第3期3卷 100-101,113页

作者： Wenjing Zhang Yu Song donglai ma School of Computer Science and Technology North China Electric Power University Baoding 071003 China Software Engineer Department Software Institute ofHebei Baoding 071000 China College oflnformation Science and Technology Agricultural University ofHebei Baoding 071001 China

Comparison of Sulfur Dioxide Residue in Chinese Me-dicinal materials by Titration-fluorescence Spectrome-try and Pharmacopoeia Method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2017年第2期9卷 112-114页

作者： ma donglai Shen Zhengxian Du Huiru Zhang Zhidong Jiang Cuilan Wang Liang Li Jing Zheng Yuguang College of Pharmacy Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Development Center of Traditional Chinese Medicine Shiji-azhuang 050051China Hebei Chemical&Pharmaceutical College Shijiazhuang 050026China

With sulphur-fumigated Chinese medicinal materials （Fritillaria thunbergii , Isatis #utigotica , Asparagus cochinchinensis and Poria cocos ） as the test materials, sulfur dioxide or sulfite residue was determined by the method in Chinese Pharmacopoeia （2015 edition） and titration-fluorescence spectrometry, respec- tively. The results showed that there were significant differences in measured value between titration-fluorescence spectrometry and phmmacopoeia method. The t result of titration-fluorescence spectrometry was much closer to the actual content of sulfur dioxide in Chinese medicinal materials. Thus, titration-fluo- rescence spectrometry had higher application value

关键词： Titration-fluorescence spectrometry Chinese Pharmacopoeia Sulfur dioxide Chinese medicinal materials Residue

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

腹腔镜前入路右半肝切除术技术要点讨论

中华肝胆外科杂志 2023年第7期29卷 544-547页

作者：尹文泽马东来邰升哈尔滨医科大学附属第二医院普通外科六病房哈尔滨150086

与需要优先处理肝周韧带、翻转肝脏的传统手术方式不同,前入路右半肝切除在肝实质离断前未处理肝周韧带,不对肝脏进行翻转搬动。其优点是更加符合无瘤原则,减少不必要的游离;不足之处是肝脏劈离过程中出血的控制相对困难,腔静脉沟下部... 详细信息

与需要优先处理肝周韧带、翻转肝脏的传统手术方式不同,前入路右半肝切除在肝实质离断前未处理肝周韧带,不对肝脏进行翻转搬动。其优点是更加符合无瘤原则,减少不必要的游离;不足之处是肝脏劈离过程中出血的控制相对困难,腔静脉沟下部的处理存在一定风险。然而,随着腹腔镜的普及和应用,凭借其独特的尾背侧的视角优势,更精细的局部解剖结构显示和细微操作,较开放手术更加适合前入路右半肝切除术。本文探讨了腹腔镜前入路右半肝切除术的步骤和技术要点。

关键词：肝切除术腹腔镜检查前入路

在线全文

学校读者我要写书评

暂无评论

Janus酪氨酸激酶抑制剂在皮肤科的应用

中华皮肤科杂志 2018年第9期51卷 704-707页

作者：钱明彤马东来中国医学科学院北京协和医学院北京协和医院皮肤科北京100730

Janus酪氨酸激酶（JAK）一信号转导及转录激活子（STAT）途径是一种细胞内信号传导通路，是多种细胞因子如白细胞介素（IL）、干扰素（IFN）及其他分子进行细胞膜到细胞核信号传导的重要途径，依赖于JAK—STAT途径的可溶性炎症介质参与... 详细信息

Janus酪氨酸激酶（JAK）一信号转导及转录激活子（STAT）途径是一种细胞内信号传导通路，是多种细胞因子如白细胞介素（IL）、干扰素（IFN）及其他分子进行细胞膜到细胞核信号传导的重要途径，依赖于JAK—STAT途径的可溶性炎症介质参与了很多炎症性疾病的发病。因此，应用JAK抑制剂是治疗这类炎症性及免疫性疾病的新手段。目前临床上已用于治疗骨髓纤维化、真性红细胞增多症、类风湿性关节炎等疾病，并且越来越多的病例报告及临床研究证实，JAK抑制剂治疗特应性皮炎、斑秃、银屑病、白癜风等皮肤疾病也取得良好疗效。

关键词：酪氨酸激酶抑制剂应用胞内信号传导通路 Janus酪氨酸激酶皮肤科真性红细胞增多症炎症性疾病可溶性炎症介质

一种基于数据属性的Apriori算法的改进方法

在线全文

学校读者我要写书评

暂无评论

中国农机化学报 2014年第4期35卷 253-256页

作者：马冬来张文静河北软件职业技术学院河北保定071003 河北农业大学信息科学与技术学院河北保定071000

Apriori算法是最著名、应用最广泛的关联规则挖掘算法。文章阐述了Apriori算法的基本理论,研究了Apriori算法的不足及多种改进算法,最后提出了一种基于数据属性的改进算法,并利用农业病害数据对改进后的算法进行了测试。实验证明,新算... 详细信息

Apriori算法是最著名、应用最广泛的关联规则挖掘算法。文章阐述了Apriori算法的基本理论,研究了Apriori算法的不足及多种改进算法,最后提出了一种基于数据属性的改进算法,并利用农业病害数据对改进后的算法进行了测试。实验证明,新算法提高了原算法的挖掘效率,并且挖掘出了指定要求形式的规则。

关键词：数据挖掘关联规则 Apriori算法决策规则

微波促进Wittig-Michael串级反应立体专一性合成ω-氨基-β-D-呋喃核糖酸衍生物

在线全文

学校读者我要写书评

暂无评论

高等学校化学学报 2014年第5期35卷 959-964页

作者：马东来李小六郝乐张平竹陈华赵影河北大学化学与环境科学学院河北省化学生物学重点实验室保定071002 河北农业大学理学院保定071001

以D-核糖为原料,在微波促进下,利用2,3-O-异丙叉基-D-核糖2与叶立德3(Ph3P CHCOOEt)的Wittig反应和Michael加成,立体专一性地合成了β-D-呋喃核糖酸酯类化合物,再经叠氮化及还原反应,得到ω-氨基-β-D-呋喃核糖酸衍生物.在微波辐射下,该... 详细信息

以D-核糖为原料,在微波促进下,利用2,3-O-异丙叉基-D-核糖2与叶立德3(Ph3P CHCOOEt)的Wittig反应和Michael加成,立体专一性地合成了β-D-呋喃核糖酸酯类化合物,再经叠氮化及还原反应,得到ω-氨基-β-D-呋喃核糖酸衍生物.在微波辐射下,该Wittig-Michael串级反应的效率得到显著提高,反应时间由12 h缩短为10 min,收率达到91%.反应具有非常好的β-立体选择性,在碱性条件下处理后,α-异构体可转变成热力学稳定的β-异构体,从而得到单一的β-异构体.计算结果表明,β-异构体4b比α-异构体4a具有更高的热力学稳定性.

关键词：氨基呋喃核糖酸酯微波促进反应 Wittig-Michael串级反应

在线全文

学校读者我要写书评

暂无评论

自身免疫性孕酮皮炎的研究进展

中华皮肤科杂志 2018年第10期51卷 771-773页

作者：刘佳玮刘薇马东来中国医学科学院北京协和医学院北京协和医院皮肤科北京100730

自身免疫性孕酮皮炎（autoimmune progesterone derma-titis，APD）是一种孕酮引发的自身免疫反应，也称为孕酮超敏反应（progestogen hypersensitivity），本病最早于1921年由Geber等报道。1964年，Shelley等命名为自身免疫性孕酮皮炎... 详细信息

自身免疫性孕酮皮炎（autoimmune progesterone derma-titis，APD）是一种孕酮引发的自身免疫反应，也称为孕酮超敏反应（progestogen hypersensitivity），本病最早于1921年由Geber等报道。1964年，Shelley等命名为自身免疫性孕酮皮炎。多见于育龄女性，常在月经前10d出现皮疹，月经前达到高峰，月经开始后皮疹自行缓解。皮疹形态以荨麻疹最为常见，也可以表现为丘疹、丘疱疹、水疱、脓疱、紫癜、固定性药疹、环形红斑和多形红斑样。皮疹主要累及躯干、四肢，累及黏膜时主要表现为口腔黏膜糜烂溃疡。

关键词：自身免疫性孕酮皮炎自身免疫反应黏膜糜烂固定性药疹月经前超敏反应