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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Enhanced rate capability and cycle stability of Ti2C MXene for sodium storage through an aniline molecules welding strategy

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Tungsten 2025年第1期7卷 161-171页

作者： Hao Chen Ya-qin Wang dong-Ting Zhang Bei Zhao Min-Peng Li Chen-Yang Li Tian-Peng Xu Mao-Cheng Liu State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology School of Computer and Communication Technology Lanzhou University of Technology

MXenes obtained significant attention in the field of energy storage devices due to their characteristic layered structure,modifiable surface functional groups,large electrochemically active surface,and regulable interlayer ***,the self-restacking and sluggish ions diffusion kinetics performance of MXenes during the alkali metal ions insertion/extraction process severely impedes their cycle stability and rate *** paper proposes an aniline molecule welding strategy for welding p-phenylenediamine（PPDA） into the interlayers of Ti2C through a dehydration condensation *** welded PPDA molecules can contribute pillar effect to the layered structure of *** pillar effect effectively maintains the structural stability during the sodium ions insertion/extraction process and effectively expands the interlayer spacing of Ti2C from 1.16 to 1.38 nm,thereby enhancing ions diffusion kinetics performance and improving the long-term cycle *** Ti2C-PPDA demonstrates outstanding Na+storage capability,exhibiting a specific capacity of 100.2 mAh·g-1at a current density of 0.1 A·g-1over 960 cycles and delivering a remarkable rate capability 81.2 mAh·g-1at a current density of 5 A·*** study demonstrates that expanding interlayer spacing is a promising strategy to enhance the Na+storage capacity and improve long-term cycling stability,which provides significant guidance for the design of two-dimensional Na+storage materials with high-rate capability and cycle stability.

关键词： Diffusion kinetics Expanding interlayer spacing Rate capability Sodium ions storage Ti2C

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng dong He Qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Perovskite

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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Tensile stress enhanced dynamic oxygen vacancies on interlayer stretched Bi_(2)O_(2)CO_(3) as pivotal knobs to promote sustainable selective CO_(2) photoreduction

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Journal of Energy Chemistry 2023年第8期83卷 173-179,I0006页

作者： Xian Shi Weidong dai Xing'an dong.qin Ren Ping Yan Fan dong School of Chemistry and Environmental Engineering Sichuan University of Science&EngineeringZigong 643000SichuanChina Research Center for Carbon-Neutral Environmental&Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731SichuanChina State Centre for International Cooperation on Designer Low-Carbon and Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou450001HenanChina College of Architecture and Environment Sichuan UniversityChengdu 610065SichuanChina

Surface oxygen vacancies(OVs) with abundant localized electrons on bismuth-oxygen based photocatalysts are proved to have the ability to capture and activate CO_(2).However,the surface OVs are easily filled with oxygen-containing species and destroyed,losing their effects as active sites and hindering the subsequent CO_(2)*** realistic and sustainable CO_(2)photoreduction,constructing sustainable and stable surface OVs as active sites on photocatalysts is *** work shows the synthesis of interlayer stretched Bi_(2)O_(2)CO_(3) ultrathin nanosheets with tensile stress,which are beneficial to continuously generating light-induced dynamic *** sufficient active sites,excellent,stable,and selective photoreduction of CO_(2)to CO under simulated solar light is *** light-induced OVs can reduce the energy barrier of rate-determining step,resulting in the 100% product *** results presented herein demonstrate the effect of dynamic OVs induced by interlayer tensile strain on catalysts for the enhanced selective CO_(2)photoreduction process.

关键词： Ultrathin Bi_(2)O_(2)CO_(3) Dynamic oxygen vacancies Product selectivity Charge transfer CO_(2) phororeduction

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Predicting running time of aerodynamic jobs in HPC system by combining supervised and unsupervised learning method

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Advances in Aerodynamics 2021年第1期3卷 380-397页

作者： Hao Wang Yi-qin dai Jie Yu Yong dong College of Computer Science and Technology National University of Defense TechnologyChangshaChina China Aerodynamics Research and Development Center MianyangChina.

Improving resource utilization is an important goal of high-performance computing systems of supercomputing *** meet this goal,the job scheduler of high-performance computing systems often uses backfilling scheduling to fill short-time jobs into job gaps at the front of the *** scheduling needs to obtain the running time of the *** the past,the job running time is usually given by users and often far exceeded the actual running time of the job,which leads to inaccurate backfilling and a waste of computing *** particular,when the predicted job running time is lower than the actual time,the damage caused to the utilization of the system’s computing resources becomes more ***,the prediction accuracy of the job running time is crucial to the utilization of system *** use of machine learning methods can make more accurate predictions of the job running *** at the parallel application of aerodynamics,we propose a job running time prediction framework SU combining supervised and unsupervised learning and verify it on the real historical data of the high-performance computing systems of China Aerodynamics Research and Development Center(CARDC).The experimental results show that SU has a high prediction accuracy(80.46%)and a low underestimation rate(24.85%).

关键词： High-performance computing Job scheduling Job running time prediction Machine learning Prediction accuracy Underestimation rate

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Collaborative Service Provisioning for UAV-Assisted Mobile Edge Computing

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Chinese Journal of Electronics 2024年第6期33卷 1504-1514页

作者： Yuben QU Zhenhua WEI Zhen qin Tao WU Jinghao MA Haipeng dai Chao dong The Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Ministry of Industry and Information Technology Colllege of Electronic and Information Engineering Nanjing University of Aeronautics and Astronautics Xi'an Research Institute of High Technology Department of Information and Communication Noncommissioned Officer Academy of PAP National University of Defense Technology Department of Computer Science and Technology Nanjing University

Unmanned aerial vehicle(UAV)-assisted mobile edge computing(MEC), as a way of coping with delaysensitive and computing-intensive tasks, is considered to be a key technology to solving the challenges of terrestrial MEC networks. In this work, we study the problem of collaborative service provisioning(CSP) for UAV-assisted MEC. Specifically, taking into account the task latency and other resource constraints, this paper investigates how to minimize the total energy consumption of all terrestrial user equipments, by jointly optimizing computing resource allocation, task offloading, UAV trajectory, and service placement. The CSP problem is a non-convex mixed integer nonlinear programming problem, owing to the complex coupling of mixed integral variables and non-convexity of CSP. To address the CSP problem, this paper proposes an alternating optimization-based solution with the convergence guarantee as follows. We iteratively deal with the joint service placement and task offloading subproblem, and UAV movement trajectory subproblem, by branch and bound and successive convex approximation, respectively,while the closed form of the optimal computation resource allocation can be efficiently obtained. Extensive simulations validate the effectiveness of the proposed algorithm compared to three baselines.

关键词： Energy consumption Multi-access edge computing Collaboration Programming Autonomous aerial vehicles Minimization Trajectory Resource management Optimization Convergence

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Optimal Deployment Density for Maximum Coverage of Drone Small Cells

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China Communications 2018年第5期15卷 25-40页

作者： Chao dong Jiejie Xie Haipeng dai Qihui Wu Zhen qin Zhiyong Feng The College of Communication Engineering Army Engineering University of PLANanjing 210007China The Unit 31106 of PLA Nanjing 210007China The Department of Computer Science and Technology Nanjing UniversityNanjing 210093China The College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Beijing University of Posts and Telecommunications Beijing 100876China

With the proliferation of small and mini drones, Drone Small Cells(DSCs) can cooperative multiple drones to provide communication service for ground users as emergency means or supplementary ones of traditional terrestrial cellular networks. In this paper, we study the fundamental problem of optimizing the deployment density of DSCs to achieve the maximum coverage performance. Most related works do not consider cumulative inter-cell interference when studying the coverage performance of DSCs. First, we derive an approximate and closed-form expression of the cumulative inter-cell interference which comes from both probabilistic Line-of-Sight(Lo S) and Non-Line-of-Sight(NLo S) links. Then, we analyze the coverage performance of DSCs and derive the transcendental function of optimal deployment density to obtain the maximum coverage. Last, we propose an algorithm to get the optimal deployment density with low complexity. We conduct both field experiments and Matlab simulations to verify the correctness of theoretical analysis. In addition, we show the impact of some factors on the relation between the deployment density and coverage performance through extensive numerical simulations.

关键词： drone small cells deployment density coverage ratio inter-cell interference

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Interpolation Technique for the Underwater DEM Generated by an Unmanned Surface Vessel

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 3157-3172页

作者： Shiwei qin Zili dai Department of Civil Engineering Shanghai UniversityShanghai200444China

High-resolution underwater digital elevation models(DEMs)are important for water and soil conservation,hydrological analysis,and river channel *** this work,the underwater topography of the Panjing River in Shanghai,China,was measured by an unmanned surface *** different interpolation methods were used to generate the underwater DEM and their precision and applicability for different underwater landforms were analyzed through *** results showed that there was a positive correlation between the interpolation error and the terrain surface *** five interpolation methods were all appropriate for the survey area,but their accuracy varied with different surface *** on the analysis results,an integrated approach was proposed to automatically select the appropriate interpolation method according to the different surface roughness in the surveying *** approach improved the overall interpolation *** suggested technique provides a reference for the selection of interpolationmethods for underwater DEMdata.

关键词： Underwater DEM interpolation technique unmanned surface vessel surface roughness

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Development of a Novel Parallel-spool Pilot Operated High-pressure Solenoid Valve with High Flow Rate and High Speed

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Chinese Journal of Mechanical Engineering 2015年第2期28卷 369-378页

作者： dong dai LI Xiaoning School of Mechanical Engineering Nanjing University of Science and Technology

High-pressure solenoid valve with high flow rate and high speed is a key component in an underwater driving ***,traditional single spool pilot operated valve cannot meet the demands of both high flow rate and high speed simultaneously.A new structure for a high pressure solenoid valve is needed to meet the demand of the underwater driving system.A novel parallel-spool pilot operated high-pressure solenoid valve is proposed to overcome the drawback of the current single spool *** models of the opening process and flow rate of the valve are *** response time of the valve is subdivided into 4 parts to analyze the properties of the opening *** formulas to solve 4 parts of the response time are *** factors that influence the opening response time are *** to the mathematical model of the valve,a simulation of the opening process is carried out by *** are chosen based on theoretical analysis to design the test prototype of the new type of *** response time of the designed valve is tested by verifying response of the current in the coil and displacement of the main valve *** experimental results are in agreement with the simulated results,therefore the validity of the theoretical analysis is *** opening response time of the valve is 48.3 ms at working pressure of 10 *** flow capacity test shows that the largest effective area is 126 mm2 and the largest air flow rate is 2320 L/*** to the result of the load driving test,the valve can meet the demands of the driving *** proposed valve with parallel spools provides a new method for the design of a high-pressure valve with fast response and large flow rate.

关键词： high-pressure pneumatic solenoid valve parallel-spool high flow rate high speed opening response time

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