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Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第11期12卷 875-883页

作者： Jin-xing LIN Yu-dong JIA Cai-qiao zhang Key Laboratory of Animal Epidemic Etiology ＆ Immunological Prevention of the Ministry of Agriculture Department of Veterinary Medicine College of Animal Sciences Zhejiang University Hangzhou 310058 China

The development of ovarian follicular cells is controlled by multiple circulating and local hormones and factors, including follicle-stimulating hormone （FSH） and epidermal growth factor （EGF）. In this study, the stagespecific effect of EGF on FSH-induced proliferation of granulosa cells was evaluated in the ovarian follicles of egg-laying chickens. Results showed that EGF and its receptor （EGFR） mRNAs displayed a high expression in granulosa cells from the prehierarchical follicles, including the large white follicle （LWF） and small yellow follicle （SYF）, and thereafter the expression decreased markedly to the stage of the largest preovulatory follicle. SYF represents a turning point of EGF/EGFR mRNA expression during follicle selection. Subsequently the granulosa cells from SYF were cultured to reveal the mediation of EGF in FSH action. Cell proliferation was remarkably increased by treatment with either EGF or FSH （0.1-100 ng/ml）. This result was confirmed by elevated proliferating cell nuclear antigen （PCNA） expression and decreased cell apoptosis. Furthermore, EGF-induced cell proliferation was accompanied by increased mRNA expressions of EGFR, FSH receptor, and the cell cycle-regulating genes （cyclins D1 and El, cyclin-dependent kinases 2 and 6） as well as decreased expression of luteinizing hormone receptor mRNA. However, the EGF or FSH-elicited effect was reversed by simultaneous treatment with an EGFR inhibitor AG1478. In conclusion, EGF and EGFR expressions manifested stage-specific changes during follicular development and EGF mediated FSH-induced cell proliferation and retarded cell differentiation in the prehierarchical follicles. These expressions thus stimulated follicular growth before selection in the egg-laying chicken.

关键词： Epidermal growth factor Follicle-stimulating hormone Granulosa cell Proliferation Chicken

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Phase field study on crystal orientation effects in eutectoid phase transformation

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China Foundry 2017年第5期14卷 435-442页

作者： dong-qiao zhang Ya-jun Yin Jian-xin Zhou Zhi-xin Tu State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China

In this present work, a multi-phase field model was used to simulate the eutectoid transformation process, and on the basis of the nucleation model that was previously proposed by our research team, anisotropic and orientation relationship models were introduced to study the growth mechanism of the pearlite lamellae with anisotropy. It was found that the growth direction of the pearlite lamellae is related to its orientation and spacing. In the process of lamellar growth, deflection growth of pearlite will appear along with the adjustment of lamellar spacing, and the deflection angle is equal to the orientation difference between the austenite and the pearlite. Comparison between experimental and numerical results indicates a good consistency in pearlite morphology.

关键词： simulation phase field lamellar growth pearlite morphology growth direction

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Multi-scale coupling simulation in directional solidification of superalloy based on cellular automaton-finite difference method

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China Foundry 2017年第5期14卷 398-404页

作者： Zhao Guo Jian-xin Zhou Ya-jun Yin dong-qiao zhang Xiao-yuan Ji Xu Shen State Key Laboratory of Materials Processing and Die&Mould Technology Ituazhong Universityof Science and TechnologyWuhan 430074China

Casting microstructure evolution is difficult to describe quantitatively by only a separate simulation of dendrite scale or grain scale, and the numerical simulation of these two scales is difficult to render compatible. A three-dimensional cellular automaton model couplling both dendritic scale and grain scale is developed to simulate the microstructure evolution of the nickel-based single crystal superalloy DD406. Besides, a macro–mesoscopic/microscopic coupling solution algorithm is proposed to improve computational efficiency. The simulation results of dendrite growth and grain growth of the alloy are obtained and compared with the results given in previous reports. The results show that the primary dendritic arm spacing and secondary dendritic arm spacing of the dendritic growth are consistent with the theoretical and experimental results. The mesoscopic grain simulation can be used to obtain results similar to those of microscopic dendrites simulation. It is indicated that the developed model is feasible and effective.

关键词： multi-scale coupling dendritic growth grain growth directional solidification cellular automata numerical simulation

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An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan dong Wenzheng An Zihu Wang dongzhi zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

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岩石应变软化变形特性及损伤本构模型研究

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岩土力学 2017年第10期38卷 2901-2908页

作者：刘冬桥王焯张晓云中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100083 中国岩石力学与工程学会北京100029 中国矿业大学(北京)力学与建筑工程学院北京100083 绍兴文理学院土木工程学院浙江绍兴312000

对滇藏铁路三江段的花岗岩进行了单轴和常规三轴压缩试验,研究了岩石在不同围压条件下的变形特性及其损伤演化规律。试验结果表明:该岩石压缩变形过程中,内部裂隙的演化经历了无起裂、起裂并稳定扩展、加速扩展、扩展变缓以及扩展停止5... 详细信息

对滇藏铁路三江段的花岗岩进行了单轴和常规三轴压缩试验,研究了岩石在不同围压条件下的变形特性及其损伤演化规律。试验结果表明:该岩石压缩变形过程中,内部裂隙的演化经历了无起裂、起裂并稳定扩展、加速扩展、扩展变缓以及扩展停止5个阶段,且围压对岩石变形特性有显著影响。在此基础上,提出了基于有损微元生成的损伤演化模型,建立了三轴压缩条件下岩石应变软化损伤本构模型。该模型能够统一描述岩石峰前及峰后全部变形特性及其损伤演化规律,且损伤方程形式简单、参数物理意义明确。理论结果和试验数据具有很好的一致性,且参数分析结果也表明了该模型的合理性。

关键词：岩石三轴压缩应变软化损伤演化本构模型

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei zhang Jian Wu Hui Hong Wei Quan Xinyu qiao Chun Cui Chenmeng qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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堆积层斜坡地震动地形效应试验研究

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岩石力学与工程学报 2017年第3期36卷 587-598页

作者：黄栋乔建平张小刚陈宇龙中国科学院山地灾害与地表过程重点实验室四川成都610041 中国科学院水利部成都山地灾害与环境研究所四川成都610041 东京大学土木工程系

地震中已经观测到斜坡的地震响应会受地形的影响。因此,在划分堆积层斜坡坡面类型的基础上,开展不同坡形振动台模型试验。试验结果表明:输入强度较强的地震波时,斜坡表面加速度响应峰值放大系数大于斜坡内部,且斜坡中上部及表面曲率变... 详细信息

地震中已经观测到斜坡的地震响应会受地形的影响。因此,在划分堆积层斜坡坡面类型的基础上,开展不同坡形振动台模型试验。试验结果表明:输入强度较强的地震波时,斜坡表面加速度响应峰值放大系数大于斜坡内部,且斜坡中上部及表面曲率变化较大处(AC2)加速度放大效应更为显著。坡形的变化影响着斜坡自振频率,表现为上凸下凹型斜坡的自振频率接近于5 Hz,其他坡形斜坡接近于10 Hz。模型破坏的临界加速度阈值为500~700 Gal与斜坡稳定性计算结果基本一致。坡形影响斜坡的滑动面位置及厚度,曲率半径越大(凸型为正、凹型为负)的坡形滑动面厚度越大。滑动距离(与坡脚的距离)量测显示:直线型和上凹下凸型斜坡滑动距离最远危害范围大,凸型和上凸下凹型斜坡运动距离较远危害范围较大,凹型坡运动距离较近危害范围较小。因此,直线型和上凹下凸型斜坡的危险性(危害性)最高,凸型和上凸下凹型斜坡危险性较高,凹坡危险性最低。本研究的意义在于加强地震力作用下地形效应对斜坡稳定性研究的认识,为防灾减灾和灾害风险评价提供科学依据。

关键词：边坡工程地形效应振动台模型试验动力响应加速度响应峰值

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing qiao Guo Hui Bojing Sun dongfang Hou Meidi Wang Xueqian Wu Tao Wu dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

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Oncology research 2025年第1期33卷 83-102页

作者： Yuezhou zhang Zhao zhang Jinxin dong Changan Liu Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical University Chongqing 400016 China. Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China.

Background:Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized.Methods:We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental validation studies focused on liver cancer.Results:Our analysis revealed that HNRNPC is overexpressed in a wide range of common malignancies, including liver and lung cancers, and is strongly linked to unfavorable outcomes. Furthermore, HNRNPC was observed to be closely linked to tumor immunity. Through immune checkpoint analysis and immune cell infiltration assessment, HNRNPC emerged as a potential target for modulating tumor immunotherapy. Notably, silencing of HNRNPC markedly inhibited the proliferation, metastasis, and infiltration of liver cancer cells.Conclusion:In summary, our findings highlight HNRNPC as a prognostic marker in various cancers, including liver cancer, and suggest its involvement in shaping the tumor immune microenvironment. These insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression, particularly through immunotherapeutic strategies.

关键词： Hepatocellular carcinoma Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Immunotherapeutic target Pan-cancer analysis Prognostic biomarker Tumor immunity

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