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Expressions of the γ_2 chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis

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Chinese Journal of Cancer 2011年第1期30卷 69-78页

作者： Li-Yan Xue Shuang-mei Zou Shan Zheng Xiu-Yun Liu Peng Wen Yan-ling Yuan dong-mei lin Ning Lu Department of Pathology Cancer Institute/Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 P. R. China

Previous studies have shown that the expressions of the γ2 chain of laminin-5 and secreted protein acidic and rich in cysteine (SPARC) play important roles in oncogenesis and the development of carcinoma. To assess the expressions of laminin-5 γ2 chain and SPARC in esophageal squamous cell carcinoma (SCC), and to clarify the prognostic significance of the expressions of laminin-5 γ2 chain and SPARC in esophageal SCC, we detected the expressions of laminin-5 γ2 chain and SPARC in cancer tissue and corresponding normal mucosa from 116 patients with advanced (stages II-IV) esophageal SCC using the tissue microarray-based immunohistochemistry and analyzed the correlation of the expressions with clinicopathologic characteristics and survival. We found that in normal esophageal tissues, laminin-5 γ2 chain was expressed in the basement membrane, whereas in esophageal SCC tissues, laminin-5 γ2 chain was expressed in the cytoplasm of carcinoma cells, with a positive rate of 72.4%. SPARC was not detected in normal esophageal mucosa, but was expressed in stromal fibroblasts in 84.6% of esophageal SCC cases and in cancer cells in 7.8% of esophageal SCC cases. There was a significant correlation between laminin-5 γ2 chain and stromal SPARC expression in esophageal SCC (Spearman's rho = 0.423, P < 0.001). The expressions of both laminin-5 γ2 chain and stromal SPARC were correlated with survival (P = 0.032 and P = 0.034, respectively). In stage-II esophageal SCC, the expression of laminin-5 γ2 chain was significantly correlated with survival (P = 0.023), while the expression of SPARC was not significantly correlated with survival (P = 0.154). Patients with elevated levels of laminin-5 γ2 chain and SPARC expressions had a poorer prognosis than did those lacking elevated levels of laminin-5 γ2 chain expression and/or elevated levels of SPARC expression (P = 0.001). In stage-II esophageal SCC, patients with elevated levels of laminin-5 γ2 chain and SPARC expressions had a poorer prog

关键词：层粘连蛋白鳞状细胞癌食管癌半胱氨酸分泌蛋白链表预后蛋白表达

Feasibility of Transabdominal Real-time CDFI and HDFI Techniques for Fetal Pulmonary Vein Display in the First Trimester

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Current Medical Science 2022年第3期42卷 635-641页

作者： dong-mei lin Yun-xiao ZHU Ying TAN Yu-jun HUANG Kun YUAN Wen-fen LIU Zuo-feng XU Department of Medical Ultrasonics the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Medical Ultrasonics South China Hospital of Shenzhen UniversityShenzhen 518000China

Objective This study aimed to assess the feasibility and usefulness of transabdominal color Doppler flow imaging(CDFI)technology and the high-definition flow imaging(HDFI)technique in detecting fetal pulmonary veins(PVs)in the first trimester(11–13^(+6)weeks).Methods From December 2018 to October 2019,328 pregnant women with 328 normal singleton fetuses(crown-rump length:45–84 mm)who had undergone CDFI and HDFI scans for fetal heart and vessel examination were enrolled in this *** cases were divided into three groups according to the gestational age:group A,11^(+0)−11^(+6)weeks;group B,12^(+0)−12^(+6)weeks;and group C,13^(+0)−13^(+6)*** sonograms and CDFI and HDFI images were analyzed by two senior radiologists independently and *** abilities of CDFI and HDFI to display PVs were *** Successful PV display rates via CDFI and HDFI were 2.3%and 68.2%(P<0.01),22.4%and 82.4%(P<0.01),41.5%and 91.2%(P<0.01)for group A,group B,and group C,*** total successful display rates for the two methods were 28.9%(CDFI)and 84.8%(HDFI)(P<0.01).Conclusions The HDFI technique is more valuable than CDFI for detecting PVs in early pregnancy(11–13^(+6)weeks).HDFI can detect at least one PV in all cases and may be used to detect pulmonary venous anomalies early.

关键词： pulmonary vein first trimester prenatal sonography high-definition flow imaging color Doppler flow imaging

Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors

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Chinese Medical Journal 2019年第5期132卷 551-561页

作者： Hai-Yue Wang Zhong-Wu Li Wei Sun Xin Yang Li-Xin Zhou Xiao-Zheng Huang ling Jia dong-mei lin Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Pathology Peking University Cancer Hospital Institute Beijing 100142 China

Background: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by presence of necrosis and number of mitoses per 2 mm^2. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. This study was to investigate the potentially diagnostic value of Ki-67 in pNETs. Methods: We retrieved 159 surgical specimens of pNETs, including 35 typical carcinoids (TCs), 2 atypical carcinoid (ACs), 28 largecell neuroendocrine carcinomas (LCNECs), 94 small-cell lung cancers (SCLCs). Manual conventional method (MCM) and computer-assisted image analysis method (CIAM) were used to calculate the Ki-67 proliferative index. In CIAM, 6 equivalent fields lly annotated for digital image analysis. Results: The Ki-67 index among the 4 groups with ranges of 0.38% to 12.66% for TC, 4.34% to 29.48% for AC, 30.67% to 93.74% for LCNEC, and 40.71% to 96.87% for SCLC. The cutoff value of Ki-67 index to distinguish low grade with high grade was 30.07%. For the univariate survival analyses in pNETs, both the overall survival and progression-free survival correlated with Ki-67 index. In addition, the Ki-67 index performed by CIAM was proved to be of great positive correlation with MCM.(500 ×500 μm) at 10× magnification were manua Conclusions: Ki-67 index counted by CIAM is a reliable method and can be a useful adjunct to classify the low- and high-grade NETs.

关键词： Antigen Ki-67 Computer-assisted numerical analysis Neuroendocrine tumor Prognostic factor

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun Xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-lin Jiang Bao-Xia dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

孤东油田七区中馆4—馆6砂层组储层非均质性及其对剩余油分布的控制作用

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石油大学学报（自然科学版） 2002年第1期26卷 8-10,15页

作者：窦之林董春梅林承焰石油大学地球资源与信息学院山东东营257061

根据孤东油田七区中馆 4—馆 6砂层组河流相疏松砂岩储层特征 ,将储层参数、流体性质的非均质性与生产动态紧密结合 ,分析了储层非均质性对注水开发效果的影响以及对剩余油分布的控制作用。研究结果表明 ,孤东油田七区中馆 4—馆 6砂岩... 详细信息

根据孤东油田七区中馆 4—馆 6砂层组河流相疏松砂岩储层特征 ,将储层参数、流体性质的非均质性与生产动态紧密结合 ,分析了储层非均质性对注水开发效果的影响以及对剩余油分布的控制作用。研究结果表明 ,孤东油田七区中馆 4—馆 6砂岩储层非均质性强 ,对剩余油的分布具有明显的控制作用。在平面上 ,非主力相带砂体边缘和废弃河道的砂体以及高渗向低渗的过渡带形成了剩余油饱和度相对高值区。在垂向上 ,非主力小层砂岩分布局限 ,储层物性差 ,油层厚度薄 ,尽管其剩余油饱和度相对较高 ,但其剩余油储量有限 ;相反 ,主力小层的剩余油饱和度相对较低 ,但可采剩余油储量较大。储层层内非均质性包括简单正韵律、复杂正韵律、均质韵律、反韵律和复合韵律 5种形式。其中简单正韵律和复杂正韵律层内剩余油较富集 ,前者主要富集在层序中上部 ,而后者在层序内较多层段富集剩余油。

关键词：孤东油田七区中馆4-馆6砂层组储层非均质性剩余油分布

基于Agent决策行为模型的地下矿火灾疏散

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消防科学与技术 2016年第10期35卷 1376-1381页

作者：卢娜刘冬梅要天林西安航空学院经济管理学院陕西西安710077

构建了基于Agent决策行为的地下矿火灾疏散仿真复合模型,模型包含地下矿环境火灾子模型和人员疏散子模型。结合Agent自学习适应性的特点,建立了基于前景理论的区间直觉模糊多属性Agent决策行为模型。通过EVAC simulators仿真测试,实现... 详细信息

构建了基于Agent决策行为的地下矿火灾疏散仿真复合模型,模型包含地下矿环境火灾子模型和人员疏散子模型。结合Agent自学习适应性的特点,建立了基于前景理论的区间直觉模糊多属性Agent决策行为模型。通过EVAC simulators仿真测试,实现地下矿安全疏散仿真实验。该模型实现了在火灾蔓延情境下,Agent充分考虑人的内在生理、心理行为偏好与不确定性信息,做出快速准确疏散决策的智能行为。

关键词：应急疏散多智能体技术行为决策模型区间直觉模糊多属性前景理论

早期整形修复对烧伤整形患者治疗疗效及二次手术率的影响分析

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系统医学 2020年第5期5卷 37-39页

作者：董美林刘源连云港市第二人民医院烧伤整形科江苏连云港222000

目的探讨早期整形修复对烧伤整形患者治疗疗效及二次手术率的影响。方法选择该院烧伤整形外科2017年1月-2019年10月收治的50例烧伤患者作为研究对象,按照随机数字表法分为每组25例,对照组在烧伤10 d后实施整形修复,实验组在烧伤10 d内... 详细信息

目的探讨早期整形修复对烧伤整形患者治疗疗效及二次手术率的影响。方法选择该院烧伤整形外科2017年1月-2019年10月收治的50例烧伤患者作为研究对象,按照随机数字表法分为每组25例,对照组在烧伤10 d后实施整形修复,实验组在烧伤10 d内实施整形修复,两组比较临床疗效、皮片成活率、外观平整度、二次手术率、术后并发症发生率、生活质量评分。结果实验组临床总有效率为96.00%,高于对照组的76.00%,差异有统计学意义(χ^2=4.152,P=0.041 <0.05)。实验组皮片成活率100.00%高于对照组84.00%(χ^2=4.347,P=0.037 <0.05),实验组外观平整度92.00%高于对照组68.00%(χ^2=4.500,P=0.033 <0.05)。实验组二次手术率0.00%低于对照组16.00%(χ^2=4.347,P=0.037 <0.05),实验组术后并发症发生率0.00%低于对照组20.00%(χ^2=5.555,P=0.018 <0.05)。治疗后,两组生活质量评分与治疗前相比均明显增高,而实验组评分与对照组相比更高(P<0.05)。结论早期整形修复可提高烧伤患者的整形手术效果,减少二次手术、术后并发症,有利于提高患者生活质量。

关键词：烧伤整形外科烧伤整形修复手术

Population-based study of DNA image cytometry as screening method for esophageal cancer

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World Journal of Gastroenterology 2012年第4期18卷 375-382页

作者： lin Zhao,Wen-Qiang Wei,Xin-Qing Li,Guo-Qing Wang,Qi Shang,You-lin Qiao,Department of Cancer Epidemiology,Cancer Institute/Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China De-Li Zhao,Department of Epidemiology,Feicheng People’s Hospital,Feicheng 271600,Shandong Province,China Chang-Qing Hao,Department of Endoscopy,linzhou Cancer Hospital,linzhou 456500,Henan Province,China dong-mei lin,Qin-Jing Pan,Department of Pathology,Cancer Institute/Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China Fu-Hua Lei,Department of Pathology,Feicheng People’s Hospi-tal,Feicheng 271600,Shandong Province,China Jin-Wu Wang,Department of Pathology,linzhou Cancer Hospi-tal,linzhou 456500,Henan Province,China Department of Cancer Epidemiology Cancer Institute/Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China.

AIM:To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esopha-geal squamous precancerous ***:This study was designed as a population-based screening study.A total of 582 local residents aged 40 years-69 years were recruited from linzhou in Henan and Feicheng in ***,only 452 subjects had results of liquid-based cytology,DNA-ICM and *** sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or ***:Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%,86.36%,79.55% and 77.27%,respectively,which were better than that of liquid-based cytology (75%).Specifici-ties of DNA-ICM were 70.83%,84.07%,92.65% and 96.81%,but the specificity of liquid-based cytology was 91.91%.The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%,***:It is possible to use DNA-ICM tech-nique as a primary screening method for esophageal squamous precancerous lesions.

关键词： DNA image cytometry Aneuploidy Screen-ing Esophageal cancer Precancerous lesions