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Clinical and genetic characteristics of a child with Sotos syndrome and attention-deficit/hyperactivity disorder:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5131-5139页

作者： Ya-Jing Yang Bei-Yi Li Ke-Xin Gan Jing Liu Xiu-Qin Lv dong-mei zhang Hui-Juan Ma Department of Internal Medicine North China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Internal Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Endocrinology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of Hebei Medical UniversityShijiazhuang 050023Hebei ProvinceChina

BACKGROUND Sotos syndrome is an autosomal dominant disorder,whereas attention-deficit/hyperactivity disorder(ADHD)is a neurodevelopmental *** report aimed to summarize the clinical and genetic features of a pediatric case of Soros syndrome and ADHD in a child exhibiting precocious *** SUMMARY The patient presented with accelerated growth and advanced skeletal maturation;however,she lacked any distinct facial characteristics related to specific genetic *** analyses revealed a paternally inherited heterozygous synonymous mutation[c.4605C>T(***1535Arg)].Functional analyses suggested that this mutation may disrupt splicing,and bioinformatics analyses predicted that this mutation was likely *** an initial diagnosis of Sotos syndrome,the patient was diagnosed with ADHD during the follow-up period at the age of 8 years and 7 *** The potential for comorbid ADHD in Sotos syndrome patients should be considered to avoid the risk of a missed diagnosis.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Nuclear receptor binding SET domain protein 1 Case report Developmental disabilities Diagnosis Como rbidity Management

A practical ANN model for predicting the excavation-induced tunnel horizontal displacement in soft soils

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Underground Space 2022年第2期7卷 278-293页

作者： Zhong-Kai Huang dong-mei zhang Xiao-Chuang Xie Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Department of Geotechnical EngineeringTongji UniversityShanghaiChina

The objective of this study is to propose an artificial neural network(ANN)model to predict the excavation-induced tunnel horizontal displacement in soft *** this purpose,a series of finite element data sets from rigorously verified numerical models were collected to be utilized for the development of the ANN *** excavation width,the excavation depth,the retaining wall thickness,the ratio of the average shear strength to the vertical effective stress,the ratio of the average unloading/reloading Young’s modulus to the vertical effective stress,the horizontal distance between the tunnel and retaining wall,and the ratio of the buried depth of the tunnel crown to the excavation depth were chosen as the input variables,while the excavation-induced tunnel horizontal displacement was considered as an output *** results demonstrated the feasibility of the developed ANN model to predict the excavation-induced tunnel horizontal *** proposed ANN model in this study can be applied to predict the excavation-induced tunnel horizontal displacement in soft soils for practical risk assessment and mitigation decision.

关键词： Artificial neural network Excavation Tunnel horizontal displacement Soft soils

A machine learning-based study of multifactor susceptibility and risk control of induced seismicity in unconventional reservoirs

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Petroleum Science 2023年第4期20卷 2232-2243页

作者： Gang Hui zhang-Xin Chen Hai Wang Zhao-Jie Song Shu-Hua Wang Hong-Liang zhang dong-mei zhang Fei Gu National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249PR China Department of Chemical and Petroleum Engineering University of CalgaryCalgaryABT2N1N4Canada Eastern Institute for Advanced Study Ningbo315200ZhejiangPR China Computer Modeling Group Ltd.Calgary ABT2L2M1Canada CNOOC Research Institute Beijing100028PR China China University of Geoscience(Wuhan) Wuhan430074HubeiPR China Research Institute of Petroleum Exploration and Development Beijing10083PR China

A comprehensive dataset from 594 fracturing wells throughout the Duvernay Formation near Fox Creek, Alberta, is collected to quantify the influences of geological, geomechanical, and operational features on the distribution and magnitude of hydraulic fracturing-induced seismicity. An integrated machine learning-based investigation is conducted to systematically evaluate multiple factors that contribute to induced seismicity. Feature importance indicates that a distance to fault, a distance to basement, minimum principal stress, cumulative fluid injection, initial formation pressure, and the number of fracturing stages are among significant model predictors. Our seismicity prediction map matches the observed spatial seismicity, and the prediction model successfully guides the fracturing job size of a new well to reduce seismicity risks. This study can apply to mitigating potential seismicity risks in other seismicity-frequent regions.

关键词： Induced seismicity Hydraulic fracturing Seismicity susceptibility Risk control Machine learning

Soil effect on the bearing capacity of a double-lining structure under internal water pressure

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第11期23卷 863-881页

作者： dong-mei zhang Xiang-hong BU Jian PANG Wen-ding ZHOU Yan JIANG Kai JIA Guang-hua YANG Department of Geotechnical Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Minister of Education Tongji UniversityShanghai 200092China State Grid Tianjin Electric Power Company Construction Branch Tianjin 300143China Guangdong Research Institute of Water Resources and Hydropower Guangzhou 510610China School of Water Conservancy Engineering Zhengzhou UniversityZhengzhou 450001China

Water conveyance tunnels usually experience high internal water pressures and complex soil ***,shield tunnels with double-lining structure have been adopted because of their high bearing *** effect of the interface between the segmental and inner linings on the bearing capacity has been widely investigated;however,the effect of soil on the internal water pressure bearing capacity has not been emphasized ***,in this study,model tests and an analytical solution are presented to elucidate the effect of soil on the internal water pressure bearing ***,model tests are conducted on double-lining models under sandy soil and highly weathered argillaceous siltstone *** internal force and earth pressure under these different soil conditions are then compared to reveal the contribution of soil to the internal water pressure bearing *** this,an analytical solution,considering the soil–double-lining interaction,is proposed to further investigate the contribution of the *** analytical solution is verified with model *** analytical solution is in good agreement with the model test results and can be used to evaluate the mechanical behavior of the double-lining and soil *** effect of soil on the bearing capacity is found to be related with the elastic modulus of the soil and the deformation state of the *** the double-lining cracks,the sandy soil contributes 3.7%of the internal water pressure but the contribution of the soil rises to 10.4%when it is the highly weathered argillaceous *** the double-lining cracks,the soil plays an important role in bearing internal water *** soil contributions of sandy soil and highly weathered argillaceous siltstones are 10.5%and 27.8%,*** effect of soil should be considered in tunnel design with the internal water pressure.

关键词： Shield tunnel Double-lining Bearing capacity Soil condition Internal water pressure

Observed response of maglev structure undercrossed by three shield tunnels in soft soil

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Underground Space 2022年第4期7卷 636-661页

作者： dong-mei zhang Xiao-Chuang Xie Zhong-Kai Huang Mao-Zhu Peng Hong-Xin Zhu Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghai 200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Centre for Offshore Foundation Systems University of Western Australia35 Stirling HighwayCrawleyPerthWA 6009Australia Shanghai Municipal Engineering Design Institute(Group)Co. Ltd.China

This paper investigates the response of a maglev structure to three under-crossing tunnels of the Shanghai Metro Line *** minimal distance between the tunnels and pile groups of the maglev structure is only 1.5 m,thus the deformations of the maglev structure are strictly controlled for the serviceability of the operating maglev *** displacements of maglev piers and ground settlements during different tunnelling stages are monitored with an automatic measuring *** on the observed data,the ground settlement trough and displacements of maglev piers caused by the three shield tunnelling procedures are analyzed and *** maximal ground settlement after the completion of the three tunnelling procedures is -43 *** operate the existing maglev safely,practical construction control methods are applied,including synchronous grouting,adjustment of the shield status,shield-advancing speed control,and stabilisation of the soil chamber *** these countermeasures,the tunnel-induced deformations of maglev piers are well below the predefined *** piers heave under the strict deformation criterion of 2.0 *** crossing project is finally completed without interruptions of the maglev operations by monitoring the *** presented project is a valuable example for the evaluation of shield tunnelling effects on the adjacent maglev structures and establishes criteria for similar projects in the future.

关键词： Maglev Multi-crossing Shield tunnelling Ground settlement Pier displacement

Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

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Chinese Journal of Polymer Science 2024年第8期42卷 1185-1197页

作者： Zhi-Ying Zhao Hao Jiang Xiao-dong Li Xu-dong zhang Xing Su mei-Shuai Zou School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external *** polyurethane microcellular elastomers(PUMEs)can absorb energy through cell collapse and molecular chain *** this study,PUMEs with different densities were investigated by scanning electron microscopy,dynamic mechanical analysis and dynamic compression *** exhibited significant im pact resistance and the maximum peak stress attenuation ratio reached 73.33%.The protective equipment was made by PUME with the optimal density of 600 kg/m^(3),and then the acceleration sensing device installed with the same protective equipment fell from a height of 3,5 and 10 m to evaluate the energy-absorbing property and reusability of *** results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%,with a maximum deviation of 9%between actual test and simulation,and shortened the impact time of first landing by 57.39%.In addition,the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance

Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

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World Journal of Gastroenterology 2024年第11期30卷 1609-1620页

作者： Jun-Tao Li Hong-mei zhang Wei Wang dong-Qing Wei College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007Henan ProvinceChina College of Computer and Information Engineering Henan Normal UniversityXinxiang 453007Henan ProvinceChina State Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

BACKGROUND Liver cancer is one of the deadliest malignant tumors *** has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual *** immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival *** several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately *** To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy *** Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related *** active immune cells were identified by intersecting the highly active cell groups with B cells and T *** significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related *** genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression ***,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene *** The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell *** effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltrat

关键词： Liver cancer Cell-cell communication Gene signature Prognosis Immunotherapy Single-cell RNA sequencing

Effect of Acupuncture on Endometrial Blood Flow in Women Undergoing in vitro Fertilization Embryo Transfer: A Single Blind, Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第1期30卷 10-17页

作者： dong Hao-xu Wu Xiao ZHOU Qin HUANG dong-mei zhang Ming-min HUANG Guang-ying YANG Wei Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Department of Obstetrics and Gynecoiogy Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Institute of Integrated Traditional Chinese and Western Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Department of Reproductive Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China

Objective: To evaluate the effect of manual acupuncture on endometrial blood flow parameters by three-dimensional(3D) power Doppler ultrasound in women undergoing in vitro fertilization embryo transfer(IVF-ET). Methods: Seventy patients undergoing IVF-ET were equally randomized into traditional or sham acupuncture treatment group for totally 4 days(from the day of oocyte aspiration to the day of embryo transfer) of treatment by random envelope method at the Reproductive Medicine Center and Outpatient Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology from January 2013 to December 2015. Patients in the traditional acupuncture group accepted traditional acupuncture methods with manual acupuncture, and Zhongji(CV3), Qihai(CV 6), Sanyinjiao(SP6), Taichong(LR 3), Tianshu(ST 25), Guilai(ST 29) and Zusanli(ST 36) were chosen. Patients at the sham acupuncture group accepted shallow acupuncture methods at 4 non-meridian points at each shoulder and upper arm. Outcome measures included endometrial ultrasonic indices such as vascularization index(VI), flow index(FI) and vascularization flow index(VFI), endometrial thickness and volume, subendometrial VI(sVI), subendometrial FI(sFI), subendometrial VFI(sVFI), implantation rate, clinical pregnancy rate, abortion rate, live birth rate and number of live births. Results: Finally, 34 patients in the traditional acupuncture group and 35 in the sham acupuncture group completed this trial. VI, FI and VFI of the traditional acupuncture group were significantly higher than those in the sham acupuncture group(P0.05). Conclusions: Manual acupuncture performed after oocyte aspiration and before transplantation improved the endometr

关键词： acupuncture endometrial blood flow endometrial receptivity in vitro fertilization randomized controlled trial

Distributed H_∞ PID Feedback for Improving Consensus Performance of Arbitrary-delayed Multi-agent System

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International Journal of Automation and computing 2014年第2期11卷 189-196页

作者： Lin-Lin Ou Jun-Jie Chen dong-mei zhang Lin-zhang Wei-dong zhang Department of Automation Zhejiang University of Technology Department of Automation Shanghai Jiaotong University

The H∞ proportional-integral-differential(PID) feedback for arbitrary-order delayed multi-agent system is investigated to improve the system performance. The closed-loop multi-input multi-output(MIMO) control framework with the distributed PID controller is firstly described for the multi-agent system in a unified way. Then, by using the matrix theory, the prescribed H∞performance criterion of the multi-agent system is shown to be equivalent to several independent H∞ performance constraints of the single-input single-output(SISO) subsystem with respect to the eigenvalues of the Laplacian matrix. Subsequently, for each subsystem,the set of the PID controllers satisfying the required H∞ performance constraint is analytically characterized based on the extended Hermite-Biehler theorem. Finally, the three-dimensional set of the decentralized H∞ PID control parameters is derived by finding the intersection of the H∞ PID regions for all the decomposed subsystems. The simulation results reveal the effectiveness of the proposed method.

关键词： Multi-agent system proportional-integral-differential(PID) controller H∞ performance index parametric space consensus.