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I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing li Yan-dong Wu Kai-Lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-Ying Jin Feng-li Sun Wei-dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

Investigation into enhanced performance of toluene and Hg0 stimulative abatement over Cr-Mn oxides co-modified columnar activated coke

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Journal of Environmental Sciences 2025年第2期148卷 88-106页

作者： Jiajie Wang Jie liu Lei Gao dong Xie Caiting li liping Xiang Huiyu Xiong Jiaqi Xie Tianren Zhang Yueguo Pan School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China National&Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings Hengyang 421001China Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province Hengyang 421001China College of Environmental Science and Engineering Hunan UniversityChangsha 410082China

In this study,a string of Cr-Mnco-modified activated coke catalysts(XCryMn1-y/AC)were prepared to investigate toluene and Hg0 removal *** characterizations including XRD,TEM,SEM,in situ DRIFTS,BET,XPS and H_(2)-TPR showed that 4%Cr0.5Mn0.5/AC had excellent physicochemical properties and exhibited the best toluene and Hg0 removal efficiency at 200◦*** varying the experimental gas components and conditions,it was found that too large weight hourly space velocity would reduce the removal efficiency of toluene and *** O_(2) promoted the abatement of toluene and Hg0,the inhibitory role of H_(2)O and SO_(2) offset the promoting effect of O_(2) to some *** significantly inhibited Hg0 removal,resulting from that toluene was present at concentrations orders of magnitude greater than mercury’s or the catalyst was more prone to adsorb toluene,while Hg0 almost exerted non-existent influence on toluene *** mechanistic analysis showed that the forms of toluene and Hg0 removal included both adsorption and oxidation,where the high-valent metal cations and oxygen vacancy clusters promoted the redox cycle of Cr^(3+)+Mn^(3+)/Mn^(4+)+Cr^(6+)+Mn^(2+),which facilitated the conversion and replenishment of reactive oxygen species in the oxidation process,and even the CrMn1.5O4 spinel structure could provide a larger catalytic interface,thus enhancing the adsorption/oxidation of toluene and ***,its excellent physicochemical properties make it a costeffective potential industrial catalyst with outstanding synergistic toluene and Hg0 removal performance and preeminent resistance to H_(2)O and SO_(2).

关键词： Toluene Element mercury Cr-Mn oxides Activated coke

Predicting Lactobacillus delbrueckii ***-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method

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Science China(life Sciences) 2025年第2期68卷 558-574页

作者： Shujuan Yang Mei Bai Weichi liu Weicheng li Zhi Zhong Lai-Yu Kwok Gaifang dong Zhihong Sun Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China College of Computer and Information Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application of Agriculture and Animal Husbandry Hohhot 010018China

Lactobacillus delbrueckii ***(***)and Streptococcus thermophilus(***)are commonly used starters in milk *** experiments revealed that *** interactions(Lb St I)substantially impact dairy product quality and *** biological humidity experiments are time-consuming and labor-intensive in screening interaction combinations,an artificial intelligence-based method for screening interactive starter combinations is ***,in the current research on artificial intelligence based interaction prediction in the field of bioinformatics,most successful models adopt supervised learning methods,and there is a lack of research on interaction prediction with only a small number of labeled ***,this study aimed to develop a semi-supervised learning framework for predicting Lb St I using genomic data from 362 isolates(181per species).The framework consisted of a two-part model:a co-clustering prediction model(based on the Kyoto Encyclopedia of Genes and Genomes(KEGG)dataset)and a Laplacian regularized least squares prediction model(based on K-mer analysis and gene composition of all isolates datasets).To enhance accuracy,we integrated the separate outcomes produced by each component of the two-part model to generate the ultimate Lb St I prediction results,which were verified through milk fermentation *** through milk fermentation experiments confirmed a high precision rate of 85%(17/20;validated with 20 randomly selected combinations of expected interacting isolates).Our data suggest that the biosynthetic pathways of cysteine,riboflavin,teichoic acid,and exopolysaccharides,as well as the ATP-binding cassette transport systems,contribute to the mutualistic relationship between these starter bacteria during milk ***,this finding requires further experimental *** presented model and data are valuable resources for academics an

关键词： Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus interaction prediction semi-supervised learning dairy starter artificial intelligence milk fermentation

Spatially confined synthesis of TiNb_(2)O_(7)quantum dots onto mesoporous carbon and Ti_(3)C_(2)T_(X)MXene for boosting lithium storage

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Green Energy & Environment 2025年第2期10卷 358-366页

作者： Daoguang Sun Cheng Tang Haitao li Xinlin Zhang Guanjia Zhu Zhen-dong Huang Aijun Du Haijiao Zhang Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneQLD4001Australia State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing210023China

TiNb_(2)O_(7)has been emerged as one of the most promising electrode materials for high-energy lithium-ion ***,limited by the slow electron/ion transport kinetics,and insufficient active sites in the bulk structure,the TiNb_(2)O_(7)electrode still suffers from unsatisfactory lithium storage ***,we demonstrate a spatially confined strategy toward a novel TiNb_(2)O_(7)-NMC/MXene composite through a triblock copolymer-directed one-pot solvothermal route,where TiNb_(2)O_(7)quantum dots with a particle size of 2-3 nm are evenly embedded into N-doped mesoporous carbon(NMC)and Ti_(3)C_(2)T_(X)***,the as-prepared TiNb_(2)O_(7)-NMC/MXene anode exhibits a high reversible capacity(486.2 mAh g^(-1)at 0.1 A g^(-1)after 100 cycles)and long cycle lifespan(363.4 mAh g^(-1)at ss1 A g^(-1)after 500 cycles).Both experimental and theorical results further demonstrate that such a superior lithium storage performance is mainly ascribed to the synergistic effect among 0D TiNb_(2)O_(7)quantum dots,2D Ti_(3)C_(2)T_(X)MXene nanosheets,and N-doped mesoporous *** strategy presented also opens up new horizon for space-confined preparation of high-performance electrode materials.

关键词： TiNb_(2)O_(7)quantum dots Ti_(3)C_(2)T_(X)MXene Mesoporous carbon Confined synthesis lithium-ion batteries

Gut microbial characteristics of the damp-heat constitution:a population-based multicenter cross-sectional study

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Journal of Traditional Chinese Medicine 2025年第1期45卷 140-151页

作者： li Tianxing ZHU linghui WANG Xueke TANG Jun YANG lingling PANG Guoming li Huang WANG liying dong Yang ZHAO Shipeng li Yingshuai li lingru Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese Medicine the Second Clinical Medical College Henan University of Chinese Medicine Department of Hepatobiliary Spleen and Stomach the First Affiliated Hospital of Zhejiang Chinese Medical University Henna Province Hospital of Traditional Chinese Medicine Department of Endocrinology Kaifeng Hospital of traditional Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine College of Chinese Medicine Beijing University of Chinese Medicine Graduate School of China Academy of Chinese Medical Sciences

OBJECTIVE: To investigate the difference in gut microbiota between population with damp-heat constitution(DHC) and balanced constitution(BC). METHODS: A multi-centered cross-sectional casecontrol study was conducted, which included 249 participants with damp-heat constitution or balanced constitution. Baseline information of participants was collected, and stool samples were collected for gut microbiota analysis. Principal coordinate analysis, linear discriminant analysis effect size analysis, receiver operating characteristic, random forest model, and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution. RESULTS: Compared to those in the BC group, the richness and diversity of the microbiota, specifically those of several short-chain fatty acid producing genera such as Barnesiella, Coprobacter, and Butyricimonas, were significantly decreased in the DHC group. Regarding biological functions, flavonoid biosynthesis, propanoate metabolism, and nucleotide sugar metabolism were suppressed, while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group. Finally, a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations. CONCLUSION: The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation, metabolic disorders, and liver steatosis, which is consistent with clinical observations, thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.

关键词： PICRUSt Traditional Chinese medicine constitution balanced constitution cross-sectional studies damp-heat constitution inflammatory microbiota multicenter study

Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu li-Jun Xu Sheng-Xia Zhang Peng-Fei Zhai ling Lv Xiao-Yu Yan Zong-Zhen li Yan-Rong Cao Xue-Feng Zheng Jian Zeng Yuan He Jie liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

Merging polymers of intrinsic microporosity and porous carbon-based zinc oxide composites in novel mixed matrix membranes for efficient gas separation

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Green Energy & Environment 2025年第1期10卷 203-213页

作者： Muning Chen Jiemei Zhou Jing Ma Weigang Zheng Guanying dong Xin li Zhihong Tian Yatao Zhang Jing Wang Yong Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou450001HenanChina State Key Laboratory of Materials-Oriented Chemical Engineering and College of Chemical Engineering Nanjing Tech UniversityNanjing211816JiangsuChina Singapore Membrane Technology Centre Nanyang Environment and Water Research InstituteNanyang Technological UniversitySingapore637141Singapore Engineering Research Center for Nanomaterials Henan UniversityKaifeng475004HenanChina State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Energy and Environment Southeast UniversityNanjing210096JiangsuChina

Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of ***,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and *** this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate *** dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting ***,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in *** a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH_(4) selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper ***,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@*** summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.

关键词： Mixed matrix membranes Polymers of intrinsic microporosity CO_(2)separation Porous carbon materials

Applicability of Different Indices for Delineating the Boundary of Arid Region:A Case Study in Northwestern China

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Journal of Earth Science 2025年第1期36卷 212-222页

作者： Xue Peng Xiang li Yingyibing Shen Xuehua Che Shipei dong Zhuolun li Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesCenter for Glacier and Desert ResearchLanzhou UniversityLanzhou 730030China

Arid regions are vital components of Earth’s land *** the area/boundary of arid region is crucial for comprehending area changes and potential ***,the accuracy and applicability of arid region boundary delineated by different indices remain *** this study,the annual precipitation(AP),humidity index(H),and aridity index(K)were calculated for delineating arid region of China using 106 meteorological stations during 1990–*** results suggest that AP and H can accurately delineate arid region,because they are consistent with the distribution of typical soil and vegetation in arid region,whereas K is ***,AP is the best index for delineating arid region in regions with limited meteorological data,especially in studying long-term patterns and mechanisms of area *** accuracy of delineating arid region using H is enhanced in regions with abundant meteorological *** the past 30 years,influenced by the increase of atmospheric moisture influx and precipitation,the area in arid region of northwestern China decreased by 70×10^(3)–90×10^(3)km^(2),resulting in the present area of approximately 1.55×10^(6)km^(2).This study provides appropriate indices for delineating arid region,contributing to improving our knowledge of regional responses difference to climate change.

关键词： climate regionalization arid region climate change northwestern China Earth Science