检索结果-南通市图书馆

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi liu Wenping liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Predicting Lactobacillus delbrueckii ***-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 558-574页

作者： Shujuan Yang Mei Bai Weichi liu Weicheng Li Zhi Zhong Lai-Yu Kwok Gaifang dong Zhihong Sun Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China College of Computer and Information Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application of Agriculture and Animal Husbandry Hohhot 010018China

Lactobacillus delbrueckii ***(***)and Streptococcus thermophilus(***)are commonly used starters in milk *** experiments revealed that *** interactions(Lb St I)substantially impact dairy product quality and *** biological humidity experiments are time-consuming and labor-intensive in screening interaction combinations,an artificial intelligence-based method for screening interactive starter combinations is ***,in the current research on artificial intelligence based interaction prediction in the field of bioinformatics,most successful models adopt supervised learning methods,and there is a lack of research on interaction prediction with only a small number of labeled ***,this study aimed to develop a semi-supervised learning framework for predicting Lb St I using genomic data from 362 isolates(181per species).The framework consisted of a two-part model:a co-clustering prediction model(based on the Kyoto Encyclopedia of Genes and Genomes(KEGG)dataset)and a Laplacian regularized least squares prediction model(based on K-mer analysis and gene composition of all isolates datasets).To enhance accuracy,we integrated the separate outcomes produced by each component of the two-part model to generate the ultimate Lb St I prediction results,which were verified through milk fermentation *** through milk fermentation experiments confirmed a high precision rate of 85%(17/20;validated with 20 randomly selected combinations of expected interacting isolates).Our data suggest that the biosynthetic pathways of cysteine,riboflavin,teichoic acid,and exopolysaccharides,as well as the ATP-binding cassette transport systems,contribute to the mutualistic relationship between these starter bacteria during milk ***,this finding requires further experimental *** presented model and data are valuable resources for academics an

关键词： Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus interaction prediction semi-supervised learning dairy starter artificial intelligence milk fermentation

Compact source for quadripartite deterministically entangled optical fields

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2025年第1期5卷 132-137页

作者： liu, Yanhong Zhou, Yaoyao Wu, liang Qin, Jiliang Yan, Zhihui Jia, Xiaojun Department of Physics Taiyuan Normal University Jinzhong 030619 China Institute of Computational and Applied Physics Taiyuan Normal University Jinzhong 030619 China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-Electronics Shanxi University Taiyuan 030006 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006 China College of Information Engineering Shanxi Vocational University of Engineering Science and Technology Jinzhong 030619 China

Since entangled multiple optical fields were identified as the building blocks of quantum networks, the quadripartite entangled optical fields have been produced by using four degenerate optical parametric amplifiers or two nondegenerate optical parametric amplifiers (NOPAs). However, realizing an efficient and compact source for multiple quantum users has remained an outstanding challenge, hindering their practical applications. Here, we proposed a compact and feasible scheme to deterministically entangle four spatially separated optical fields, employing only a single NOPA. Accordingly, two-sided output NOPA-based optical fields were coupled on a beam splitter network to form the quadripartite entangled state, causing the deterministic generation of both the Greenberger–Horne–Zeilinger (GHZ) and the linear cluster states in this compact entanglement source. We also obtained the optimal experimental parameters based on the simulation results, thereby providing a direct reference for experimental implementation. Our findings propose that the resultant GHZ and linear cluster states can be potentially applied in quantum-enhanced information science, specifically in quantum secret sharing, controlled quantum teleportation networks, and quantum-entangled atomic ensemble networks. © 2022 The Authors

关键词： Cluster state Compact source GHZ state Quadripartite entanglement Single NOPA

Effect of acid fracturing fluid modifying coal microstructure stimulated by ultrasonic

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2025年第2期35卷 275-293页

作者： Shaojie Zuo Rui Gan Zhijie Wen liang Zhang Zhizhong Jiang Fuping Zhao Chengwei liu Kun Li Zhiyuan Xu College of Mining Guizhou UniversityGuiyang 550025China Shandong Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao 266590China School of Emergency Management Xihua UniversityChengdu 610039China Guizhou Research Institute of Oil&Gas Exploration and Development Engineering Guiyang 550022China liupanshui Normal University Liupanshui 553000China

The combination of ultrasonic and acid fracturing fluid can strengthen the modification effect on the micropore structure of the coal matrix,thereby enhancing the efficiency of the acid fracturing *** this research,acetic acid was utilized to formulate acid fracturing fluids with varying concentrations,and the evolutionary traits of both the acid fracturing fluids and ultrasonic waves in relation to coal samples were *** functional group structure,mineral composition,micropore structure and surface morphology of coal samples were characterized by FTIR,XRD,N_(2)adsorption at low temperature and *** results showed that aromatics(I)and branching parameters(CH_(2)/CH_(3))were reduced by 81.58%and 88.67%,respectively,after 9%acetic acid *** acid can dissolve carbonates and clay minerals in coal,create new pores,and increase porosity,pore volume and pore fractal *** modification by 7%acetic acid,the pore volume increased by 5.7 *** observation shows that the diameter of coal surface holes increases,EDS scanning shows that the content of mineral elements in coal decreases,the connectivity of coal holes increases,and the holes *** findings of this research offer theoretical direction for optimizing ultrasonic-enhanced acid fracturing fluid modification.

关键词： Acidic fracturing fluid Ultrasonic Coalbed methane Microstructure

A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2025年第1期67卷 11-14页

作者： Tongtong Zhu Xuefeng Wu Guixin Yuan dongli Wang Vijai Bhadauria You-liang Peng Junfeng liu Xin Zhang The State Key Laboratory of Maize Bio-breeding Joint International Research Laboratory of Crop Molecular BreedingMinistry of Agriculture Key Laboratory for Crop Pest Monitoring and Green ControlCollege of Plant ProtectionChina Agricultural UniversityBeijing 100193China Joint International Research Laboratory of Crop Molecular BreedingChina Agricultural UniversityBeijing 100193China Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Sanya 572025China

To defend against pathogens,plants have evolved an innate immune system,encompassing pattern-triggered immunity(PTI)and effector-triggered immunity(ETI).Nucleotide-binding leucine-rich repeat receptors(NLRs)detect pat... 详细信息

关键词： immunity specificity pattern

Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao liuRui ZHENG liang DENG Jiahui ZHANG Wenzheng HUO Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute Shanghai 201108China National Key Laboratory of Marine Engine Science and Technology Shanghai 201108China Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm)and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC)with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT)imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： dual-orifice nozzle nozzle structure atomization spray flame asymmetry

ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第2期68卷 687-693页

作者： Min Hou liang Sun Tianyu Ren Mingda Li Chao Hu Rong liu Shuang Gu Mingyan Jiang Jian-Hui Jiang Jianjun He College of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine College of Biomedical SciencesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Xiangtan Central Hospital Xiangtan 411199China

Transcription factors(TFs)play vital roles in regulating gene *** or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug ***,TFs are considered undruggable by conventional inhibitor-based *** recently emerged proteolysis targeting chimeras(PROTACs)have exhibited great potential in tackling *** particular,DNA-ligand chimeras that arm E3 ligase-recruiting ligands to TF-binding double-strand DNA represent a promising strategy for the targeted proteolysis of ***,we report a DNAzyme-inducible PROTAC(DzTAC)that selectively degrades NF-κB in a zinc ion-dependent *** further applied zinc-imidazolate metal–organic framework90(ZIF-90)to encapsulate DzTAC(ZIF-90@DzTAC),facilitating its delivery into cancer cells while self-supplying Zn2+via adenosine triphosphate(ATP)-triggered ZIF-90 ***,ZIF-90@DzTAC can enhance the treatment efficacy of doxorubicin-based chemotherapy in tumor-bearing *** developed DzTAC provides specific modulation over TF activity and opens an avenue for more functional nucleic acid-based control over targeted protein degradation.

关键词： inducible proteolysis DNAzyme transcription factor ZIF-90 NF-κB

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie liu Qinghua Zeng Qing Tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Development of Gravity Theories in the View of TRAPPIST-1e

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2025年第1期25卷 143-161页

作者： Nan Wang Lu-Yao Lu Hui-Gen liu An-dong Chen Tiger Lu Ao-Ran Cui Jun-Kai Wang Marine Science and Technology College Zhejiang Ocean University Key Laboratory of Modern Astronomy and Astrophysics Ministry of Education Zhoushan Astronomical Society School of Astronomy and Space Science Nanjing University Department of Astronomy Yale University Kuang Yaming Honors School Nanjing University School of Physics Nanjing University

Contrary to the solar system, most exoplanet systems detected hitherto are close-in and compact. One typical system is TRAPPIST-1, which has seven nearly co-planar terrestrial planets all within the orbit of Mercury,including three in the habitable zone. To evaluate the differences in developing sophisticated gravity theories from the solar system, we use N-body integrations to simulate ephemeris and reproduce some important astronomy phenomena observed on the potentially habitable planet TRAPPIST-1e. Retrograde motions of other planets last1–2 orders of magnitude shorter than in the solar system, but occur much more frequently. Transit events of all inner planets can be observed steadily. Except for Kepler's first law, which is hard to notice for low eccentricities of planets, the other two laws can then be precisely verified in 102days, because the areas swept by planets vary by?0.01% and the observed semimajor axes and periods result in constants with theoretical and observation accuracies both ?2%. However, the mean motion correlation implies that the Great Inequality is not always apparent between one pair of planets like Jupiter and Saturn. Furthermore, general relativity can hardly be discovered because it gives rise to perihelion precession of inner planets only ～0.1% of gravity precession, dozens of times smaller than Mercury. Our results support the possibility of developing part of gravity theories by potential exo-civilizations in compact systems like TRAPPIST-1.

关键词： ephemerides extraterrestrial intelligence gravitation planets and satellites: terrestrial planets