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Burns & Trauma 2021年第1期9卷 707-715页

作者： Chen dong Minhui zhu Luguang Huang Wei Liu Hengxin Liu Kun Jiang Zhou Yu Xianjie Ma Department of Plastic Surgery Xijing HospitalFourth Military Medical UniversityXi’an710032ShaanxiPeople’s Republic of China Department of Burn and Plastic Surgery the Sixth Medical Center of Chinese PLA General HospitalBeijing100048People’s Republic of China Information Center Xijing HospitalFourth Military Medical UniversityXi’an710032ShaanxiPeople’s Republic of China

Background:Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes;however,the complications that emerge from tissue expansion hinder *** is considered a major complication of tissue *** study aimed to analyze the perioperative risk factors for expander ***:A large,retrospective,single-institution observational study was carried out over a 10-year *** study enrolled consecutive patients who had undergone tissue expansion for scar ***,etiological data,expander-related characteristics and postoperative infection were *** and multivariate logistic regression analysis were performed to identify risk factors for expander *** addition,we conducted a sensitivity analysis for treatment failure caused by infection as an ***:A total of 2374 expanders and 148 cases of expander infection were *** failure caused by infection occurred in 14 *** logistic regression analysis identified that disease duration of≤1 year(odds ratio(OR),2.07;p400ml vs200 ml,limb location and postoperative hematoma evacuation were independent risk factors for expander infection.

关键词： Tissue expansion Tissue expander Scar reconstruction Risk factors Infection

下调miR-223表达对脓毒症心肌病小鼠心肌的保护作用及机制研究

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现代生物医学进展 2024年第2期24卷 234-239,263页

作者：董玉杰王晓景阮国然任浩进陈诗阳黄海东张美春武汉科技大学医学院湖北武汉430080 武汉科技大学附属普仁医院心血管内科湖北武汉430080 武汉科技大学附属普仁医院风湿免疫科湖北武汉430080

目的:探讨下调miR-223表达对脓毒症心肌病(SCM)小鼠心肌的保护作用及其机制。方法:按随机数字表法将27只8-10周龄SPF级雄性C57BL/6小鼠分配至SCM模型(0 h,6 h,12 h,18 h,24 h)时相组、Normal组、SCM组、miR-223 antagomir NC组、miR-223... 详细信息

目的:探讨下调miR-223表达对脓毒症心肌病(SCM)小鼠心肌的保护作用及其机制。方法:按随机数字表法将27只8-10周龄SPF级雄性C57BL/6小鼠分配至SCM模型(0 h,6 h,12 h,18 h,24 h)时相组、Normal组、SCM组、miR-223 antagomir NC组、miR-223 antagomir组,每组3只。腹腔注射脂多糖(lipopolysaccharide,LPS)15 mg/kg构建SCM小鼠模型。miR-223 antagomir NC组与miR-223 antagomir组分别于建模前连续3天鼠尾静脉注射miR-223 antagomir NC、miR-223 antagomir预处理。采用反转录-聚合酶链反应(RT-PCR)研究SCM模型各个时相组小鼠心肌组织miR-223的表达情况。采用苏木素伊红(HE)染色法观察Normal组、SCM组、miR-223 antagomir NC组和miR-223 antagomir组小鼠心肌病理形态变化。采用酶联免疫吸附实验(ELISA)测定Normal组、SCM组、miR-223 antagomir NC组和miR-223 antagomir组小鼠血清cTnI、BNP、CK-MB、IL-6、IL-1β、TNF-α的含量并进行相关性分析。结果:SCM模型时相组小鼠随刺激时间延长,心肌组织miR-223表达水平逐渐升高。与Normal组比较,SCM组、miR-223 antagomir NC组、miR-223 antagomir组小鼠心肌组织出现不同程度损伤;血清心肌损伤标记物cTnI、BNP、CK-MB及炎性因子IL-6、IL-1β、TNF-α的表达水平均上升,差异具有统计学意义(P0.05);miR-223 antagomir组小鼠心肌组织病理损伤程度有所减轻,心肌损伤标记物cTnI、BNP、CK-MB及炎性因子IL-6、IL-1β、TNF-α水平下降,差异具有统计学意义(P<0.05)。相关性分析结果显示小鼠miR-223表达与心肌损伤标记物cTnI、BNP、CK-MB及炎性因子IL-6、IL-1β、TNF-α的表达呈正相关。结论:下调miR-223表达可通过减轻炎症反应对SCM小鼠心肌产生保护作用。

关键词：脓毒症脓毒症心肌病 miR-223 miRNA 炎症反应

Successful Treatment of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome with Thalidomide: A Case Report

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International Journal of Dermatology and Venereology 2019年第2期2卷 99-102页

作者： Qian-Nan Xu Mu-Chi Xu Xiao-Qing Zhao Jie Zheng hai-Qin zhu Department of Dermatology Shanghai Ruijin Hospital NorthShanghai 201801China Department of Dermatology Shanghai Ruijin HospitalShanghai 200025China

IntroductionSynovitis,Acne,Pustulosis,Hyperostosis and Osteitis (SAPHO) syndrome is a rare clinical entity characterized by a wide range of dermatological and musculoskeletal *** condition has a heterogeneous presentation,at times chronic and relapsing,which results in diagnostic difficulties and delays as well as therapeutic challenges.

关键词： Case Report Synovitis Successful Treatment

基于早期时间序列分类的可解释实时机动识别算法

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计算机工程与科学 2024年第2期46卷 353-362页

作者：庞诺言关东海袁伟伟南京航空航天大学计算机科学与技术学院江苏南京211106

战斗机机动识别是判断战斗机战术意图的基础,然而现有的机动识别方法实时性不强且不具有可解释性,无法满足空战中对实时性的要求且不利于人机互信。设计基于早期时间序列分类的实时机动识别算法,将完整机动切分为机动单元,使用集成学习... 详细信息

战斗机机动识别是判断战斗机战术意图的基础,然而现有的机动识别方法实时性不强且不具有可解释性,无法满足空战中对实时性的要求且不利于人机互信。设计基于早期时间序列分类的实时机动识别算法,将完整机动切分为机动单元,使用集成学习算法对机动单元进行识别并实时监控,以满足实时性要求并获得高识别精度。算法使用可解释模型,通过特征贡献度进行模型解释,使模型更透明从而降低空战决策者的决策风险。选择盘旋、斤斗等9种不同机动动作进行仿真实验,结果表明:在完整机动动作执行到20%时,所提算法即可识别其机动类别,识别准确率可达93%。

关键词：早期时间序列分类机动识别可解释集成学习

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ID3算法的改进和简化

上海交通大学学报 2010年第7期44卷 883-886,891页

作者：朱颢东郑州轻工业学院计算机与通信工程学院郑州450002 中国科学院成都计算机应用研究所成都610041 中国科学院研究生院北京100039

针对ID3算法倾向于选择取值较多的属性的缺点,引进属性重要性来改进ID3算法,并根据改进的ID3算法中信息增益的计算特点,利用凸函数的性质来简化该算法.实验表明,优化的ID3算法与原ID3算法相比,在构造决策树时具有较高的准确率和更快的... 详细信息

针对ID3算法倾向于选择取值较多的属性的缺点,引进属性重要性来改进ID3算法,并根据改进的ID3算法中信息增益的计算特点,利用凸函数的性质来简化该算法.实验表明,优化的ID3算法与原ID3算法相比,在构造决策树时具有较高的准确率和更快的计算速度,并且构造的决策树还具有较少的平均叶子数.

关键词：决策树 ID3算法属性重要性信息增益凸函数

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2581-2592页

作者： Jin-Tao Li hai Yang Ming-zhu Lei Wei-Ping zhu Ying Su Kai-Yue Li Wen-Ying zhu Jian Wang Lei Zhang Jia Qu Lei Lv Hao-Jie Lu Zheng-Jun Chen Lu Wang Miao Yin Qun-Ying Lei Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences Cancer Institutes Key Laboratory of Breast Cancer in Shanghai Shanghai Key Laboratory of Radiation Oncology the Shanghai Key Laboratory of Medical EpigeneticsDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032People’s Republic of China Department of Hepatic Surgery Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan UniversityShanghai 200032People’s Republic of China

Folic acid,served as dietary supplement,is closely linked to one-carbon metabolism and methionine *** clinical evidence indicated that folic acid supplementation displays dual effect on cancer development,promoting or suppressing tumor formation and ***,the underlying mechanism remains to be ***,we report that high-folate diet significantly promotes cancer development in mice with hepatocellular carcinoma(HCC)induced by DEN/high-fat diet(HFD),simultaneously with increased expression of methionine adenosyltransferase 2A(gene name,MAT2A;protein name,MATIIα),the key enzyme in methionine metabolism,and acceleration of methionine cycle in cancer *** contrast,folate-free diet reduces MATIIαexpression and impedes HFD-induced HCC ***,methionine metabolism is dynamically reprogrammed with valosin-containing protein p97/p47 complex-interacting protein(VCIP135)which functions as a deubiquitylating enzyme to bind and stabilize MATIIαin response to folic acid ***,upregulation of MATIIαexpression is positively correlated with increased VCIP135 protein level in human HCC tissues compared to adjacent ***,liver-specific knockout of Mat2a remarkably abolishes the advocating effect of folic acid on HFD-induced HCC,demonstrating that the effect of high or free folate-diet on HFD-induced HCC relies on ***,folate and multiple intermediate metabolites in one-carbon metabolism are significantly decreased in vivo and in vitro upon Mat2a ***,folate promotes the integration of methionine and one-carbon metabolism,contributing to HCC development via hijacking MATIIαmetabolic *** study provides insight into folate-promoted cancer development,strongly recommending the tailor-made folate supplement guideline for both sub-healthy populations and patients with cancer expressing high level of MATIIαexpression.

关键词： metabolism cancer methionine

Progress of research on the biomechanics of aorta and stent graft

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Chinese Medical Journal 2013年第20期126卷 3982-3984页

作者： Li Yong-sheng dong Zhi-hui zhu Hua-gang Fu Wei-guo Wang Yu-qi Anhui Med Univ Affiliated Hosp 1 Dept Vasc Surg Hefei 230022 Anhui Peoples R China Fudan Univ Inst Vasc Surg Zhongshan Hosp Dept Vasc Surg Shanghai 200032 Peoples R China

With improvements in the technology of clinical diagnosis of aortic diseases, more and more cases have been found on such vascular lesions as aortic dissection and abdominal aortic aneurysm, which lead to aortic biomechanical changes. Aortic biomechanics research will become a hot spot in the near future. At the same time, stent grafts （SGs） are widely used in the endovascular treatment of vascular diseases. The biomechanical properties of SGs will also become a focus of research. Understanding the relation between the aorta and SGs will better cater to clinical services by improving the success rate of surgery for aortic diseases and reducing intraoperative and postoperative complications. This article reviews researches on the biomechanics of the aorta and SGs.

关键词： biomechanics aorta, stent graft

自体造血干细胞移植对CAR-T治疗复发/难治性多发性骨髓瘤疗效的影响

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中华内科杂志 2024年第6期63卷 587-592页

作者：丁美静接星星李护君徐志怡年丽齐昆明闫志凌朱锋曹江张焕新徐开林程海李振宇徐州医科大学附属医院血液科徐州221006

目的评价自体造血干细胞移植(ASCT)对抗原嵌合受体-T细胞(CAR-T)治疗复发/难治性多发性骨髓瘤(RRMM)疗效的影响。方法回顾性队列研究。收集2020年1月3日至2022年9月13日于徐州医科大学附属医院血液科接受CAR-T治疗的168例RRMM患者的临... 详细信息

目的评价自体造血干细胞移植(ASCT)对抗原嵌合受体-T细胞(CAR-T)治疗复发/难治性多发性骨髓瘤(RRMM)疗效的影响。方法回顾性队列研究。收集2020年1月3日至2022年9月13日于徐州医科大学附属医院血液科接受CAR-T治疗的168例RRMM患者的临床资料,依据既往是否接受ASCT分为移植组(47例)与未移植组(121例),采用χ^(2)检验、Kaplan-Meier生存分析及独立样本t检验等方法统计分析两组患者客观缓解率(ORR)、无进展生存(PFS)时间、总生存(OS)时间,以及两组患者CAR-T输注前CD3、CD4、CD8、CD19、CD56、自然杀伤(NK)细胞水平。结果168例RRMM患者中,男性98例(58.3%),发病中位年龄57岁(范围30~70岁)。两组患者输注CAR-T细胞后,未移植组ORR为89.3%(92/103),移植组ORR为72.9%(27/37);1年后再次评估疗效,未移植ORR为78.1%(75/96),移植组ORR为59.4%(19/32),未移植组ORR均优于移植组ORR(χ^(2)=5.71、4.32,P=0.017、0.038)。未移植组患者中位OS及PFS时间均大于移植组患者(OS:30个月比20个月,PFS:26个月比12个月;均P0.05)。结论在接受CAR-T治疗的RRMM患者中,未行ASCT患者的疗效明显好于既往行ASCT患者,可能与接受CAR-T治疗前CD4水平有关。

关键词：多发性骨髓瘤造血干细胞移植嵌合抗原受体T细胞 T细胞

Rejuvenation in Hot-Drawn Micrometer Metallic Glassy Wires

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Chinese Physics Letters 2020年第1期37卷 60-63页

作者： Jie dong Yi-Hui Feng Yong Huan Jun Yi Wei-Hua Wang hai-Yang Bai Bao-An Sun Institute of Physics Chinese Academy of SciencesBeijing 100190 College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049 State Key Laboratory of Nonlinear Mechanics(LNM) Institute of MechanicsChinese Academy of SciencesBeijing 100190 Institute of Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444 Songshan Lake Materials Laboratory Dongguan 523808

We report an enhanced rejuvenation in hot-drawn micrometer metallic glassy wires(MG wires)with the size *** to metallic glasses(MGs)in bulk form,the modulus and hardness for the micro-scale MG wires,tested by nanoindentation methods,are much lower and decrease with the decreasing size,with a maximum decrease of〜26%in modulus and^17%in *** pronounced rejuvenation is evidenced by the larger sub-Tg relaxation enthalpy of the MG *** pronounced rejuvenation is physically related to the higher energy state induced by a combined effect of severely thermomechanical shearing and freezing the shear How into a constrained small-volume *** results reveal that the internal states and properties of MGs can be dramatically changed by a proper modulation of temperature,flow stress and size.

关键词： metallic modulus shearing

Microstructures and properties of A356-10%SiC particle composite castings at different solidification pressures

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Transactions of Nonferrous Metals Society of China 2013年第8期23卷 2222-2228页

作者：董普云赵海东陈飞帆李俊文华南理工大学国家金属材料近净成形工程技术研究中心广州510640

A356-based metal matrix composites with 10% SiC particles of 10 rtm were fabricated by stir casting and direct squeeze casting process under applied pressures of 0.1 （gravity）, 25, 50 and 75 MPa. The microstructures and mechanical properties of the as-cast and T6 heat-treated castings were investigated. The results show that as the applied pressures increase, the casting defects as particle-porosity clusters reduce and the incorporation between the particles and matrix can be improved. The tensile strength, hardness, and coefficients of thermal expansion （CTE） increase with the increase of the pressures. Compared with the as-cast composite castings, the tensile strength and hardness of the heat-treated casting are improved whereas CTEs tend to decrease in T6-treated condition. For the gravity cast composites, there are some particle-porosity clusters on the fracture surface, and the clusters are hardly detected on the fracture surface of the samples solidified at the external pressures. Different fracture behaviors are found between the composites solidified at the gravity and imposed pressures.

关键词： metal matrix composites squeeze casting microstructures mechanical properties