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Actin Fringe Is Correlated with Tip Growth Velocity of Pollen Tubes

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Molecular Plant 2012年第5期5卷 1160-1162页

作者： Huaijian dong Weike Pei ren Haiyun Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education and College of Life Science Beijing Normal University Beijing 100875 China

Dear Editor, As an essential element for pollen tube tip growth, actJn cytoskeleton has been a focus for decades. Recently, both rapid-freeze and room-temperature fixation have revealed the presence of a subapical cortical F-actin （actin fringe） as a consistent feature of lily pollen tubes （Lovy-Wheeler et al., 2005）. The actin fringe consists of a palisade of short longitudinally oriented actin cables that start about 1-5~m behind the extreme apex and extend basally for an additional 5-10pm （Lovy-Wheeler et al., 2005）. MeanwhJJe, observations in live cells using Lifeact-mEGFP, an actin probe consisting of the first 17 amino acids from the budding yeast ABP-140 fused to GFP, which does not affect the dynamics of actin, compellingly support the presence of a cortical actin fringe in lilv pollen tubes ~Vidali et al.. 2009~.

关键词： F-肌动蛋白花粉管生长速度氨基酸组成必需元素顶端生长快速冷冻芽殖酵母

Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients

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Current Medical Science 2024年第5期44卷 1036-1046页

作者： Zi-qi ren ren-dong WANG Cong WANG Xiao-hui ren dong-guo LI Ya-ling LIU Qiu-hong YU Department of Hyperbaric Oxygen Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China School of Biomedical Engineering Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical ApplicationCapital Medical UniversityBeijing100069China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China

Objective The prognosis of glioblastoma is poor,and therapy-resistance is largely attributed to intratumor *** oxygen(HBO)effectively alleviates ***,the sole role of HBO in glioblastoma remains *** previously reported that HBO can promote apoptosis,shorten protrusions,and delay growth of glioblastoma,but the molecular mechanism is *** aimed to test candidate genes in HBO-exposed glioblastoma cells and to analyze their correlation with the survival of glioblastoma *** Glioblastoma cell lines exposed to repetitive HBO or normobaric air(NBA)were collected for RNA isolation and microarray data *** analysis,KEGG pathway analysis and survival analysis of the differentially expressed genes(DEGs)were *** HBO not only inhibited hypoxia-inducing genes including CA9,FGF11,PPFIA4,TCAF2 and SLC2A12,but also regulated vascularization by downregulating the expression of COL1A1,COL8A1,COL12A1,RHOJ and FILIP1L,ultimately attenuated hypoxic microenvironment of *** attenuated inflammatory microenvironment by reducing the expression of NLRP2,CARD8,MYD88 and *** prevented metastasis by downregulating the expression of NTM,CXCL12,CXCL13,CXCR4,CXCR5,CDC42,IGFBP3,IGFBP5,GPC6,MMP19,ADAMTS1,EFEMP1,PTBP3,NF1 and *** upregulated the expression of BAK1,PPIF,DDIT3,TP53I11 and FAS,whereas downregulated the expression of MDM4 and SIVA1,thus promoting *** upregulated the expression of CDC25A,MCM2,PCNA,RFC33,DSCC1 and CDC14A,whereas downregulated the expression of ASNS,CDK6,CDKN1B,PTBP3 and MAD2L1,thus inhibiting cell cycle *** these DEGs,17 indicator-genes of HBO prolonging survival were *** HBO is beneficial for *** patients with these predictive indicators may prolong survival with HBO *** potential therapeutic targets especially COL1A1,ADAMTS1 and PTBP3 deserve further validation.

关键词： glioblastoma hyperbaric oxygen differentially expressed gene gene enrichment analysis survival analysis

Bioactive glass sol as a dual function additive for chitosan-alginate hybrid scaffold

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Chinese Chemical Letters 2018年第3期29卷 395-398页

作者： Huihui ren Yang Cui Ailing Li dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.

关键词： Bioactive glass sol Chitosan Alginate Dual function additive Bioactivity

Effect of morphine preconditioning on neuronal apoptosis following cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2010年第15期5卷 1144-1149页

作者： He dong Xiangyu Ji dong Wang Yueyi ren Shiduan Wang Jianfang Song Department of Anesthesiology Affiliated Hospital of Qingdao University Medical College Qingdao 266003 Shandong Province China Women and Children Health Care Center of Qingdao Qingdao 266011 Shandong Province China

Apoptosis, a form of neuronal damage, takes place following cerebral ischemia/reperfusion injury and caspase-3 plays an important role in apoptosis. Studies have shown that morphine preconditioning influences neuronal apoptosis and related protein expression following cerebral ischemia/reperfusion injury. In the present study, neuronal degeneration was attenuated, and the number of apoptotic cells and caspase-3 expression decreased following morphine preconditioning in a rat model of cerebral ischemia/reperfusion injury. Moreover, pathological changes were attenuated with increasing morphine doses, as well as the number of apoptotic cells and caspase-3 expression. Results from the present study revealed that morphine preconditioning reduced ischemic brain injury and improved cerebral ischemic tolerance in a dose-dependent manner. The anti-apoptotic mechanism of morphine is closely related to Caspase-3.

关键词： morphine brain ischemia reperfusion hippocampus apoptosis Caspase-3 rats brain injury neural regeneration

Wiener Index, Hyper-Wiener Index, Harary Index and Hamiltonicity Properties of graphs

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Applied Mathematics(A Journal of Chinese Universities) 2019年第2期34卷 162-172页

作者： YU Gui-dong ren Li-fang LI Xing-xing School of Mathmatics and Computation Sciences Anqing Normal UniversityAnqing 246133China Basic Department Hefei Preschool Education CollegeHefei 230013China

In this paper, in terms of Wiener index, hyper-Wiener index and Harary index, we first give some sufficient conditions for a nearly balance bipartite graph with given minimum degree to be traceable. Secondly, we estab... 详细信息

关键词： Wiener index Hyper-Wiener index Harary index Traceable Hamilton-connected Traceable for every vertex

Formation of Transient Coronal Holes during the Eruption of a Quiescent Filament and its Overlying Sigmoid

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Chinese Journal of Astronomy and Astrophysics 2008年第3期8卷 329-336页

作者： Li-Heng Yang Yun-Chun Jiang dong-Bai ren National Astronomical Observatories / Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

By using Hα, He I 10830, EUV and soft X-ray （SXR） data, we examined a filament eruption that occurred on a quiet-sun region near the center of the solar disk on 2006 January 12, which disturbed a sigmoid overlying the filament channel observed by the GOES-12 SXR Imager （SXI）, and led to the eruption of the sigmoid. The event was associated with a partial halo coronal mass ejection （CME） observed by the Large Angle and Spectrometric Coronagraphs （LASCO） on board the Solar and Heliospheric Observatory （SOHO）, and resulted in the formation of two flare-like ribbons, post-eruption coronal loops, and two transient coronal holes （TCHs）, but there were no significantly recorded GOES or Hα flares corresponding to the eruption. The two TCHs were dominated by opposite magnetic polarities and were located on the two ends of the eruptive sigmoid. They showed similar locations and shapes in He I 10830, EUV and SXR observations. During the early eruption phase, brightenings first appeared on the locations of the two subsequent TCHs, which could be clearly identified on He I 10830, EUV and SXR images. This eruption could be explained by the magnetic flux rope model, and the two TCHs were likely to be the feet of the flux rope.

关键词： Sun filaments -- Sun chromosphere-- Sun coronal mass ejections (CMEs)

Local Influence Analysis for Semiparametric Reproductive Dispersion Nonlinear Models

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 75-90页

作者： Xue-dong CHEN Nian-sheng TANG Xue-ren WANG Department of Statistics Yunnan UniversityKunming 650091China

The present paper proposes a semiparametric reproductive dispersion nonlinear model （SRDNM） which is an extension of the nonlinear reproductive dispersion models and the semiparameter regression models. Maximum penalized likelihood estimates （MPLEs） of unknown parameters and nonparametric functions in SRDNM are presented. Assessment of local influence for various perturbation schemes are investigated. Some local influence diagnostics are given. A simulation study and a real example are used to illustrate the proposed methodologies.

关键词： local influence analysis maximum penalized likelihood estimate nonlinear reproductive dispersionmodels semiparametric regression model

SCENARIOS SIMULATION OF COUPLING SYSTEM BETWEEN URBANIZATION AND ECO-ENVIRONMENT IN JIANGSU PROVINCE BASED ON SYSTEM DYNAMICS MODEL

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Chinese Geographical Science 2005年第3期15卷 219-226页

作者： LIU Yao-bin LI ren-dong LI Chun-hua School of Management China University of Mining and Technology Xuzhou 221008 P. R. China Institute of Geodesy and Geophysics Research Chinese Academy of Sciences Wuhan 430077 P. R. China Institute of Resource Beijing Normal University Beijing 100875 P. R. China

By means of ISM (Interpretative Structural Modeling) and SD (System Dynamics) methods, this paper made a system dynamics model of urbanization and eco-environment coupling in Jiangsu Province according to the implication and PSR (Pressure State Response) framework of urbanization and eco-environment coupling. Moreover, five typical scenarios during 2000-2015 have been simulated and analyzed based on the time serial statistical data during 1990-2003 in Jiangsu, which indicates: firstly, there are significant differences between the results and the scenarios, and the five coupling models all have comparative advantages and drawbacks; secondly, in terms of the characteristics and regional development disparities of Jiangsu and the general rule of world urbanization process, this paper reveals that only when either population urbanization model or social urbanization model to be correspondingly adopted, the sustainable development among population, economy, urbanization and eco-environment can be realized.

关键词： urbanization eco-environment system dynamics model simulation Jiangsu Province

Infection Behaviour of Melampsora larici-populina on the Leaf Surface of Populus purdomii

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Agricultural Sciences in China 2011年第10期10卷 1562-1569页

作者： YU Zhong-dong PENG Shao-bing ren Zheng-zheng WANG dong-mei CAO Zhi-min Forestry College Northwest A＆F University Yangling 712100 P.R.China Science College. Northwest A＆F University Yangling 712100 P.R. China

Behaviours of urediospore germtube in Melampsora larici-populina on the leaf surface of Populus purdomii were studied by light microscope, scanning electron microscope （SEM）, transmission electron microscope （TEM）, and fluorescence microscope. Crab-like fusion cells on leaf surface, intercellular hyphal cells in leaf tissues, as well as nucleus states, were observed and counted up in this study. Under unsaturated humidity, 32% of germinated tubes fused into a distinguishable swollen crab-shaped cell at the merging site, and 10.5% of observed crab-like cells had more than three nuclei. Wedge-shaped mycelia developed and then penetrated the leaf surface directly, or indirectly through stomata. Tips of germtube passed through the intercellular cells of poplar leaves directly were found in TEM. Aniline blue dyeing also showed that the infecting hyphae could invade into the cuticle and epidemic cell wall directly. For the case of infection through stomata, there were two different situations. Short branches and wedge hyphae usually penetrated the leaf surface via opened stomata, whereas, some germtube branches and wedge hyphae penetrated leaves through the guard cell walls or stoma lips. In the latter case, the stomata were always closed. The samples from wild forestlands had the same fused cells and wedge hyphae, but the occurrence rate was much higher than that in the chamber. Even under the saturated air humidity, germtubes could roll back and formed fusion structure, or merged together with their tips. The fusion cells might centralize the plasma of merged germtubes and have a strong survival capacity to protect germtubes from dying under arid circumstances, and provide a chance of genetic variation as well.

关键词： Melampsora larici-populina germtube infection behaviour fusion cell nuclear