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Effects of host （Boettcherisca peregrina） copper exposure on development, reproduction and vitellogenesis of the ectoparasitic wasp, Nasonia vitripennis

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Insect Science 2009年第1期16卷 43-50页

作者： Gong-Yin Ye Sheng-Zhang dong hui dong Cui hu Zhi-Cheng Shen Jia-An Cheng State Key Laboratory of Rice Biology Institute of Insect Sciences Zhejiang University Hangzhou China

Effects of copper （Cu） accumulation by the flesh fly Boettcherisca peregrina （R.- D.）（Diptera： Sarcophagidae） on the ectoparasitic wasp Nasonia vitripennis （Walker）（Hymenoptera： Pteromalidae） were investigated experimentally by exposing host larvae to contaminated diets with final Cu concentrations of 400μg/g and 800μg/g diet fresh weight （DFW）, respectively. Results showed that Cu can be transferred along food chains to secondary consumers （parasitoids） in small amounts, resulting in negative effects on parasitoid growth and development （body weight and developmental duration） as well as fecundity （number of offspring per female）. Copper exposure also inhibited vitellogenesis ofparasitoids from Cu-contaminated host pupae. It is suggested that the decreased fecundity and inhibition of vitellogenesis ofN. vitripennis resulted from poor host nutritional state rather than from direct effects of Cu stress.

关键词： Boettcherisca peregrina copper fecundity Nasonia vitripennis vitellogenesis

Evaluation of the Pharmacokinetics and Renal Excretion of Ma-Zi-Ren-Wan in Health Subjects

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 8-15页

作者： dong-dong hu Linda Li-Dan Zhong Kun Wai huai-Xue Mu Cheng-Yuan Lin Ling Zhao Liang Dai Tao huang Zhao-Xiang Bian Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Hong Kong Baptist University Shenzhen Research Institute and Continuing Education

Background: Ma-Zi-Ren-Wan(MZRW) is a classic Chinese formula for treating human constipation. It is comprised of six *** previous studies have shown its great therapeutic effect. The absorbed compounds had been studied in rat, while there was no study about its components in human ***: To observe the components of MZRW absorbed in health subjects and study the pharmacokinetics of major compounds. At the same time, to observe the renal excretion of MZRW in health subjects based on the quantification of major ***: Health adults were randomly assigned to three dose groups(5 g, 7.5 g and 10 g q.d.) of MZRW. Blood samples were collected from the medial cubital vein just before and at 0.25, 0.5, 1, 2, 4, 8 and 12 h after administration. Urine samples were collected at 0 to 3 h, 3 to 6 h, 6 to 9 h and 9 to 12 h after MZRW administration, with the urine volume recorded for each time segment. Plasma and urine samples were analyzed by optimized LC-MSMS(Liquid chromatography-tandem mass spectrometry) method for pharmacokinetics and renal excretion study of ***: Ten compounds of MZRW were observed in 23 health subjects. Due to the low concentration in plasma at the current dose, only four compounds(Albiflorin, paeoniflorin, magnolol and rhein) were quantified in the plasma sample. Honokiol, aloe emodin and emodin could only meet the LLOQ at some time points of the high dose group. Hesperidin, naringin and amygdalin could not be detected in plasma sample. While seven compounds(Amygdalin, albiflorin, paeoniflorin, magnolol, honokiol, rhein and aloe emodin) could be quantified in urine, the renal excretion was well ***: MZRW was safe and well tolerated in this clinical study. Albiflorin, paeoniflorin, magnolol and rhein was well quantified in plasma. The renal excretion of paeoniflorin, albiflorin and rhein were dose dependent for doses ranging between 5 and 10 g.

关键词： Ma-Zi-Ren-Wan LC-MS/MS Pharmacokinetics human plasma Renal Excretion

Chinese Herbal Medicine for Ulcerative Colitis:A Systematic Review Protocol

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 16-19页

作者： Hong Mi Linda Zhong Tao huang Cheng-yuan Lin Ling Zhao dong-dong hu Hai-tao Xiao Zhao-xiang Bian Feng-bin Liu Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese Medicine School of Chinese medicine Hong Kong Baptist University

Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and *** and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be *** of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager *** and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.

关键词： Chinese herbal medicine Ulcerative colitis Systematic review Protocol

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi hu Xiao-dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina huanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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太阳热水器静电除垢装置研制

太阳能学报 2002年第2期23卷 196-198页

作者：董金錩董振强胡洪伟山东大学能源与动力工程学院济南250061

太阳热水器在运行过程中的结垢和腐蚀等问题会造成传热恶化 ,严重影响热水器的各项性能指标。介绍了在太阳能热水器中安装采用静电阻垢、防腐蚀技术研制的小型静电水处理装置 ,该装置由脉冲高压直流电源和水处理器两部分组成。阻垢、防... 详细信息

太阳热水器在运行过程中的结垢和腐蚀等问题会造成传热恶化 ,严重影响热水器的各项性能指标。介绍了在太阳能热水器中安装采用静电阻垢、防腐蚀技术研制的小型静电水处理装置 ,该装置由脉冲高压直流电源和水处理器两部分组成。阻垢、防腐蚀对比试验在两台 12D18L太阳能热水器上进行 ,运行 3个月 ,一台安装静电水处理装置 ,一台不安装。测试表明 ,该装置能有效地起阻垢、除垢、防腐蚀作用 ,并具有制造运行费用低、效率高。

关键词：静电水处理器太阳能热水器静电除垢装置脉冲高压直流电源

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超燃冲压发动机喷焰辐射试验研究

兵工学报 2016年第9期37卷 1655-1661页

作者：曾学军石安华韩冬李向东胡华雨张军中国空气动力研究与发展中心高超声速冲压发动机技术重点实验室绵阳分部四川绵阳621000 中国空气动力研究与发展中心超高速空气动力研究所四川绵阳621000

介绍了超燃冲压发动机喷焰辐射特性试验与测量方法,在燃料为航空煤油、来流马赫数为6、当量油气比为0.8的试验状态下,获得了长1 m量级超燃冲压发动机喷焰辐射强度和光谱。喷焰辐射强度在发动机喷口附近随喷射距离缓慢下降;辐射强度显现... 详细信息

介绍了超燃冲压发动机喷焰辐射特性试验与测量方法,在燃料为航空煤油、来流马赫数为6、当量油气比为0.8的试验状态下,获得了长1 m量级超燃冲压发动机喷焰辐射强度和光谱。喷焰辐射强度在发动机喷口附近随喷射距离缓慢下降;辐射强度显现出的高频震荡、低频稳定特性,反映出燃料燃烧过程的微观脉动性和宏观稳定性。根据喷焰光谱,喷焰辐射能量集中在波长4.364 3μm附近,主要辐射源为CO_2.

关键词：航空、航天科学技术基础学科超燃冲压发动机喷焰辐射强度光谱

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao hu dong-Yi Yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Updated Meta-Analysis on Genetic Predisposition of Four Variants at NRAMP1(SLC11A1) Gene to Tuberculosis

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Updated Meta-Analysis on Genetic Predisposition of Four Vari...

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议

作者： dong-dong Li,Xin hu,Meng-na Zuo,Chuan-min Tao,Bing-wu Ying,Lan-lan Wang Department of lab med,West China Hospital of S.C.U.

OBJECTIVE A previous meta-analysis was performed to assess the association between variations in NRAMP1 and tuberculosis(TB) risk, but its limitations were that it did not report genotype comparative results,and not discuss the association with extra-pulmonary TB(EPTB).So, we carried out an updated meta-analysis to further investigate the association between NRAMP1 and TB susceptibility.

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng hu Long Yang Zitong Kan Biao dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning