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Role of laser scan strategies in defect control,microstructural evolution and mechanical properties of steel matrix composites prepared by laser additive manufacturing

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 462-474页

作者： Hong-yu Chen dong-dong gu Qing Ge Xin-yu Shi Hong-mei Zhang Rui Wang Han Zhang Konrad Kosiba College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Provincial Engineering Laboratory for Laser Additive Manufacturing of High-Performance Metallic Components Nanjing University of Aeronautics and AstronauticsNanjing 210016China Leibniz IFW Dresden Institute for Complex MaterialsHelmholtzstr.2001069 DresdenGermany

Steel matrix composites(SMCs)reinforced with WC particles were fabricated via selective laser melting(SLM)by employing various laser scan strategies.A detailed relationship between the SLM strategies,defect formation,microstructural evolution,and mechanical properties of SMCs was *** laser scan strategies can be manipulated to deliberately alter the thermal history of SMC during SLM ***,the involved thermal cycling,which encompassed multiple layers,strongly affected the processing quality of *** scan sequence combined with interlayer offset and orthogonal stagger mode can effectively eliminate the metallurgical defects and retained austenite within the produced ***,due to large thermal stress,microcracks that were perpendicular to the building direction formed within the *** employing the checkerboard filling(CBF)hatching mode,the thermal stress arising during SLM can be significantly reduced,thus preventing the evolution of interlayer *** compressive properties of fabricated SMCs can be tailored at a high compressive strength(~3031.5 MPa)and fracture strain(~24.8%)by adopting the CBF hatching mode combined with the optimized scan sequence and stagger *** study demonstrates great feasibility in tuning the mechanical properties of SLM-fabricated SMCs without varying the set energy input,e.g.,laser power and scanning speed.

关键词： laser additive manufacturing selective laser melting scan strategy defect control mechanical property

选区激光熔化铝合金基底表面形貌对轨道润湿行为的影响（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第2期19卷 111-121页

作者： Jie LIU dong-dong gu Hong-yu CHEN dong-hua DAI Han ZHANG College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Jiangsu Provincial Engineering Laboratory for Laser Additive Manufacturing of High-Performance Metallic Components Nanjing University of Aeronautics and Astronautics

目的:研究选区激光熔化(SLM)过程中形貌差异较大的块体表面单道成形工艺性,分析单道的润湿行为,为进一步揭示SLM加工过程中熔化轨迹的凝固行为提供理论基础。创新点:1.系统研究在不同加工参数下形成的不同表面形貌的块体上加工同一参数... 详细信息

目的:研究选区激光熔化(SLM)过程中形貌差异较大的块体表面单道成形工艺性,分析单道的润湿行为,为进一步揭示SLM加工过程中熔化轨迹的凝固行为提供理论基础。创新点:1.系统研究在不同加工参数下形成的不同表面形貌的块体上加工同一参数的单道;2.基于熔体流动理论,分析在SLM加工过程中已加工层存在的大量的热积累以及粗糙的成形表面对单道的润湿行为的影响。方法:1.对在不同形貌的块体上形成的单道进行分析,将单道形貌分为4种典型类型(图4)。2.通过分析单道横截面的几何尺寸(图5和6),研究表面形貌对单道成形工艺性的影响。3.基于Wenzel方程(公式(3))分析熔体在粗糙表面的润湿行为并基于Navier-Stokes方程(公式(12))和Marangoni方程(公式(13))分析熔体流动行为。结论:1.块体表面光滑、平整时,粉末在表面铺展均匀、熔化充分、润湿性好,有利于形成连续、规则的单道。2.单道附近的块体表面存在较大孔隙时,孔隙中会积累一定量的粉末。熔融金属的重力和表面张力共同驱使液体向孔隙流动,单道出现扩展效应:润湿角明显减小,熔池宽度和深度增加。3.块体表面球化颗粒及飞溅物增多时,表面凹凸不平,单道处熔化的粉末量减少,对基板的润湿性较差,熔池不稳定,导致单道出现颈缩。4.块体表面存在大量球化颗粒和飞溅物时,单道附近团聚的铝合金球化颗粒极易被氧化,氧化膜使得颗粒表面光滑,从而难以被熔融金属润湿。此外,熔融金属的较大的温度梯度对熔体流动方向也有显著影响,易诱导单道出现球化效应。

关键词：选区激光熔化(SLM) AlSi12 表面形貌单道

Effect of Mn addition and refining process on Fe reduction of Mg−Mn alloys made from magnesium scrap

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Transactions of Nonferrous Metals Society of China 2020年第11期30卷 2941-2951页

作者： dong-dong gu Jia-wen WANG Yu-bin CHEN Jian PENG State Key Laboratory of Mechanical Transmissions College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Chongqing Research Center for Advanced Materials Chongqing Academy of Science and TechnologyChongqing 401123China

The Fe reduction,microstructure evolution and corrosion susceptibility of Mg−Mn alloys made from magnesium scrap refining with Mn addition were *** results show that significant Fe content change occurs during near-solid-melt treatment(NSMT)process even in the absence of Mn,because of the high saturation of Fe in the ***,in the NSMT process,even a small amount of Mn addition can lead to a sharp deposition of Mn *** NSMT process can increase the growth rate of the Fe-rich particles,and then accelerate their sinking ***,the addition of Mn hinders the coarsening process of Fe-rich ***,the corrosion susceptibility of the alloys is mainly affected by the solubility of Fe,which can be significantly reduced by Mn ***,the presence of more Fe-rich particles does not necessarily increase the corrosion susceptibility of the ***,in the refining process of Mg−Mn alloys made from magnesium scrap,on the basis of NSMT process and adding an appropriate Mn content(about 0.5 wt.%),the purity of the melt can be improved,thereby obtaining an alloy with excellent corrosion resistance.

关键词： Fe reduction melt refining process magnesium scrap Fe-rich particle corrosion susceptibility

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong gu dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic